Zoom endoscopic evaluation of rejection in living-related small bowel transplantation.

Abstract:

BACKGROUND:This study evaluated zoom endoscopic findings according to four components in comparison with the histologic findings of acute cellular rejection (ACR) in a living-related small bowel transplantation (SBTx) patient. METHODS:A 16-year-old boy with microvillus inclusion disease underwent SBTx with a 150-cm-long ileal graft from a blood-identical living-related donor. The endoscope was inserted into the distal stoma of the graft, and the mucosal architecture was observed under zoom. The observed findings were expressed by the following four components and graded as 0 to 2: H, homogeneity of mucosal change, minimal (H-0), patchy (H-1), diffuse (H-2); V, appearance of villi, stringlike (V-0), tonguelike (V-1), domelike (V-2); W, widening of crypt area, narrow (W-0), slightly widened within a width of one villus (W-1), markedly widened beyond a width of one villus (W-2); E, erythema in crypt area: no redness (E-0), sporadic erythema (E-1), diffuse erythema (E-2). RESULTS:Histologic ACR was grade 0 in 27, grade 1 in 6, grade 2 in 3, and grade 3 in 0 occasions during 11 months after SBTx. In grade 0, 1, and 2 histology, H-0/H-1/H-2 was 85.2%/14.8%/0%, 33.3%/66.7%/0%, and 0%/100%/0%, respectively, with a significant difference among the groups by grade (P<0.05). V-0/V-1/V-2 was 48.1%/51.9%/0%, 0%/100%/0%, and 0%/66.7%/33.3% (P<0.05), W-0/W-1/W-2 was 85.2%/14.8%/0%, 0%/100%/0%, and 0%/66.7%/33.3% (P<0.05), and E-0/E-1/E-2 was 100%/0%/0%, 66.7%/33.3%/0%, and 0%/100%/0% (P<0.05), respectively. CONCLUSION:Zoom endoscopic findings, graded on four components, may reflect the histologic severity of ACR and minimize the performance of biopsies in SBTx.

journal_name

Transplantation

journal_title

Transplantation

authors

Sasaki T,Hasegawa T,Nakai H,Kimura T,Okada A,Musiake S,Doi R

doi

10.1097/00007890-200202270-00013

subject

Has Abstract

pub_date

2002-02-27 00:00:00

pages

560-4

issue

4

eissn

0041-1337

issn

1534-6080

journal_volume

73

pub_type

杂志文章
  • Long-term persistence of transferred PPD-reactive T cells after allogeneic bone marrow transplantation.

    abstract::T cells play an important role in protective immunity against tuberculosis. As patients are not reimmunized with BCG after BMT, the question arises as to whether PPD-specific memory T cells are transferred from the marrow donor to the recipient and persist in the long-term. We studied long-term survivors of non-T cell...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199301000-00014

    authors: Rouleau M,Senik A,Leroy E,Vernant JP

    更新日期:1993-01-01 00:00:00

  • Thrombotic microangiopathy in living-donor liver transplantation.

    abstract:BACKGROUND:Thrombotic microangiopathy (TMA) is a fatal complication characterized by microvascular occlusive disorder resulting in systemic or intrarenal platelet aggregation, severe thrombocytopenia, and microangiopathic hemolytic anemia. Only sporadic case reports of TMA after cadaveric or living-donor liver transpla...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000165048.00487.8e

    authors: Tamura S,Sugawara Y,Matsui Y,Kishi Y,Akamatsu N,Kaneko J,Makuuchi M

    更新日期:2005-07-27 00:00:00

  • Renal transplantation in multiple myeloma. Case report and review of the literature.

    abstract::A patient with end-stage renal disease and known benign monoclonal gammopathy underwent kidney transplantation at Westchester County Medical Center, Valhalla, NY. After surgery, during routine follow-up, the patient had laboratory evidence of frank multiple myeloma. However, she did not show any clinical signs or symp...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/00007890-199612150-00008

    authors: Dagher F,Sammett D,Abbi R,Tomasula JR,Delaney V,Butt KM

    更新日期:1996-12-15 00:00:00

  • Mutagenicity of cyclosporine. Induction of sister chromatid exchange in human cells.

    abstract::To examine whether cyclosporine (CsA) has mutagenic potential against human cells, we analyzed sister chromatid exchange (SCE) induction by CsA using human lymphocytes in vitro. SCE frequencies increased significantly in the lymphocytes treated with 1 microgram/ml and 5 micrograms/ml CsA, though the frequencies seemed...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: Yuzawa K,Kondo I,Fukao K,Iwasaki Y,Hamaguchi H

    更新日期:1986-07-01 00:00:00

  • Potential feasibility of early bone marrow cell injection into the spleen for creating functional hepatocytes.

    abstract:BACKGROUND:Bone marrow cells (BMCs) are believed to have the ability to generate functional hepatocytes and have some merits as a therapeutic modality for metabolic liver diseases. However, the appearance of BMC-derived hepatocytes (BMDHs) is low. We hypothesized that early BMC injection would be feasible for creating ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e31819e0528

    authors: Misawa R,Soeda J,Ise H,Takahashi M,Kubota K,Mita A,Nakata T,Miyagawa S

    更新日期:2009-04-27 00:00:00

  • Rituximab, IVIG, and plasma exchange without graft local infusion treatment: a new protocol in ABO incompatible living donor liver transplantation.

    abstract:BACKGROUND:Although graft local infusion (GLI) treatment via the portal vein or the hepatic artery has been the pivotal strategy in ABO incompatible (ABOi) living donor liver transplantation (LDLT) in Japan, the procedure is associated with a high rate of catheter-associated complications. METHODS:A new ABOi-LDLT prot...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3181adcae6

    authors: Ikegami T,Taketomi A,Soejima Y,Yoshizumi T,Uchiyama H,Harada N,Iguchi T,Hashimoto N,Maehara Y

    更新日期:2009-08-15 00:00:00

  • Flow cytometry cross-match: a method for predicting graft rejection.

    abstract::Long-term graft survival is mainly influenced by early graft rejection and posttransplant graft function. The ability of both complement-dependent cytotoxicity cross-match (CDC) and flow cytometry cross-match (FCXM) to predict acute rejection episodes has been evaluated by cross-matching 40 patients who received cadav...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199702270-00012

    authors: Utzig MJ,Blümke M,Wolff-Vorbeck G,Lang H,Kirste G

    更新日期:1997-02-27 00:00:00

  • Double genetic modification of adenovirus fiber with RGD polylysine motifs significantly enhances gene transfer to isolated human pancreatic islets.

    abstract:BACKGROUND:New strategies for improving durable functional islet mass will be instrumental in facilitating islet transplantation as a cure for type 1 diabetes mellitus. The ability to transfer immunoregulatory or cytoprotective genes into pancreatic islets may enhance survival. Adenoviral vectors (Ad5) have been used w...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.TP.0000066361.02042.CA

    authors: Contreras JL,Wu H,Smyth CA,Eckstein CP,Young CJ,Seki T,Bilbao G,Curiel DT,Eckhoff DE

    更新日期:2003-07-15 00:00:00

  • The functional roles of porcine CD80 molecule and its ability to stimulate and regulate human anti-pig cellular response.

    abstract:BACKGROUND:The pig is currently considered to be the most likely candidate for a xenogenic-organ source. Anti-pig human T-cell response via co-stimulatory molecules has been studied with great interest. The soluble form of porcine CD80 has recently been cloned and characterized, but the sequence of the transmembrane fo...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.TP.0000065298.81277.D9

    authors: Wada M,Amae S,Sasaki H,Ishii T,Sano N,Nio M,Hayashi Y,Ohi R

    更新日期:2003-06-15 00:00:00

  • OSAKA trial: a randomized, controlled trial comparing tacrolimus QD and BD in kidney transplantation.

    abstract:BACKGROUND:The once-daily (QD), prolonged-release formulation of tacrolimus has been shown to improve adherence versus twice-daily (BD) tacrolimus. Treatment nonadherence in transplant recipients has been associated with poor graft outcomes. METHODS:This open-label, parallel-group study randomized adults with end-stag...

    journal_title:Transplantation

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/TP.0b013e3182a203bd

    authors: Albano L,Banas B,Klempnauer JL,Glyda M,Viklicky O,Kamar N,Optimising immunoSuppression After Kidney transplantation with ADVAGRAF Study Group.

    更新日期:2013-11-27 00:00:00

  • Sirolimus inhibits oxidative burst activity in transplant recipients.

    abstract::Increased susceptibility to bacterial infection is a recognized side-effect of sirolimus treatment after transplantation, which could be caused by inhibition of neutrophil activation. Blood from 24 healthy subjects was equilibrated with 0 to 50 ng/mL sirolimus or 60 microg/mL propofol. Blood was also collected from 23...

    journal_title:Transplantation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/01.TP.0000093995.08240.49

    authors: Gee I,Trull AK,Charman SC,Alexander GJ

    更新日期:2003-12-27 00:00:00

  • A regional experience with emergency liver transplantation.

    abstract::Liver transplantation for patients requiring life-support results in the lowest survival and highest costs. A ten year (1983-1993) regional experience with liver transplantation for critically ill patients was undertaken to ascertain the fate of several subgroups of patients. Of the 828 liver transplants performed at ...

    journal_title:Transplantation

    pub_type: 杂志文章,多中心研究

    doi:10.1097/00007890-199601270-00013

    authors: Washburn WK,Bradley J,Cosimi AB,Freeman RB,Hull D,Jenkins RL,Lewis WD,Lorber MI,Schweizer RT,Vacanti JP,Rohrer RJ

    更新日期:1996-01-27 00:00:00

  • Evaluation of the drug interaction between intravenous high-dose fluconazole and cyclosporine or tacrolimus in bone marrow transplant patients.

    abstract::The purpose of this open-label, prospective study was to compare steady state concentrations and clearances of intravenously administered cyclosporine or tacrolimus with and without concomitant high-dose (400 mg/day) fluconazole in allogeneic BMT patients. Twenty-one patients were evaluable. The mean steady state cycl...

    journal_title:Transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1097/00007890-199604270-00026

    authors: Osowski CL,Dix SP,Lin LS,Mullins RE,Geller RB,Wingard JR

    更新日期:1996-04-27 00:00:00

  • Gastrointestinal Endoscopy Is Safe in Patients Before and After Lung or Heart Transplantation.

    abstract:BACKGROUND:Gastrointestinal complications are common in patients after lung and heart transplantation. Endoscopy is a standard method for the assessment of gastrointestinal morbidities. The aim of this study was to analyze the number and type of complications during endoscopic procedures in patients before and after lu...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000000517

    authors: Lenzen H,Cieplik N,Elkharsawi AR,Negm AA,Avsar M,Bara CL,Gottlieb J,Manns MP,Lankisch TO

    更新日期:2015-07-01 00:00:00

  • The mechanism of injury in a steatotic liver graft during cold preservation.

    abstract:BACKGROUND:Fatty livers are more prone to primary nonfunction after transplantation. It is known that cell injury is strongly associated with alterations in the content and composition of membrane lipids. We assumed that plasma membrane (PM) fluidity, which is the most important property of the membrane, differed betwe...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199901270-00002

    authors: Fukumori T,Ohkohchi N,Tsukamoto S,Satomi S

    更新日期:1999-01-27 00:00:00

  • Human allogeneic vascular rejection after arterial transplantation and peripheral lymphoid reconstitution in severe combined immunodeficient mice.

    abstract:BACKGROUND:Interspecies differences create important shortcomings in existing animal models used to describe in vivo events responsible for allograft rejection. Alloimmune destruction of human dermal microvessels, histologically consistent with rejection, has been demonstrated in human skin-grafted severe combined immu...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199903270-00018

    authors: Lorber MI,Wilson JH,Robert ME,Schechner JS,Kirkiles N,Qian HY,Askenase PW,Tellides G,Pober JS

    更新日期:1999-03-27 00:00:00

  • Serial evaluation of cell surface markers for immune activation after acute renal allograft rejection by urine flow cytometry--correlation with clinical outcome.

    abstract:BACKGROUND:The use of urine flow cytometry (UFC) as a noninvasive tool for the diagnosis of acute and chronic rejection of the renal allograft has been previously reported. METHODS:We analyzed the expression of various cell surface antigens during a 30-day period after the diagnosis and treatment of 24 acute rejection...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200105150-00024

    authors: Roberti I,Reisman L

    更新日期:2001-05-15 00:00:00

  • Maturation and function of human fetal pancreatic cells after cryopreservation.

    abstract::If transplantation of endocrine tissue is to become a therapy for a significant number of insulin-dependent diabetic individuals, tissue sources other than adult human islets will be required. Because human fetal pancreatic cells may offer that alternative, we have tried to find the optimal combination of tissue cultu...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199312000-00011

    authors: Beattie GM,Otonkoski T,Lopez AD,Hayek A

    更新日期:1993-12-01 00:00:00

  • Long-term survival of donor-specific pancreatic islet xenografts in fully xenogeneic chimeras (WF rat----B10 mouse).

    abstract::We recently reported that reconstitution of lethally irradiated B10 mouse recipients with 40 x 10(6) untreated WF rat bone marrow cells resulted in stable fully xenogeneic chimerism (WF rat----B10 mouse). In these animals, the tolerance induced for skin xenografts was highly MHC specific in that donor-specific WF rat ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199202010-00005

    authors: Zeng YJ,Ricordi C,Tzakis A,Rilo HL,Carroll PB,Starzl TE,Ildstad ST

    更新日期:1992-02-01 00:00:00

  • Mediators involved in the immunomodulatory effects of apoptotic cells.

    abstract::Immunomodulatory properties are attributed to apoptotic cells. These properties have been used to modulate allogeneic immune responses in experimental transplantation settings. In independent studies, apoptotic cell infusion has been shown to favor hematopoietic cell engraftment, to increase heart graft survival, and ...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/01.tp.0000269113.59857.d6

    authors: Saas P,Bonnefoy F,Kury-Paulin S,Kleinclauss F,Perruche S

    更新日期:2007-07-15 00:00:00

  • A Call for Research on Individuals Who Opt Out of Living Kidney Donation: Challenges and Opportunities.

    abstract::In light of the transplant community's efforts to increase living donation, preserving donor autonomy is essential. Understanding how often and the reasons why potential living kidney donors opt out of the donor evaluation process for nonmedical reasons is important for assessing donor voluntariness. The experiences o...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/TP.0000000000001408

    authors: Thiessen C,Kulkarni S,Reese PP,Gordon EJ

    更新日期:2016-12-01 00:00:00

  • Complement inhibition with an anti-C5 monoclonal antibody prevents hyperacute rejection in a xenograft heart transplantation model.

    abstract:BACKGROUND:The present study was undertaken to determine whether anti-complement 5 (C5) monoclonal antibodies (mAb) prevent hyperacute rejection (HAR) in a rat-to-presensitized mouse heart transplantation model and whether these mAb, combined with cyclosporine (CsA) and cyclophosphamide (CyP), can achieve long-term gra...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199912150-00007

    authors: Wang H,Rollins SA,Gao Z,Garcia B,Zhang Z,Xing J,Li L,Kellersmann R,Matis LA,Zhong R

    更新日期:1999-12-15 00:00:00

  • Islet graft survival and function: concomitant culture and transplantation with vascular endothelial cells in diabetic rats.

    abstract:BACKGROUND:Human islet transplantation is a great potential therapy for type I diabetes. To investigate islet graft survival and function, we recently showed the improved effects after co-culture and co-transplantation with vascular endothelial cells (ECs) in diabetic rats. METHODS:ECs were isolated, and the viability...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3182356ca7

    authors: Pan X,Xue W,Li Y,Feng X,Tian X,Ding C

    更新日期:2011-12-15 00:00:00

  • The graft-versus-host reaction and immune function. II. Recruitment of pre-T-cells in vivo by graft-versus-host-induced dysplastic thymuses following irradiation and bone marrow treatment.

    abstract::The graft-versus-host (GVH) reaction induces thymic dysplasia and an arrest in T cell differentiation. Studies were performed to test the effect of irradiation and reconstitution with bone marrow on GVH-induced thymic dysplasia and T cell differentiation. GVH reactions were induced in CBAxAF1 adult mice by the injecti...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: Seddik M,Seemayer TA,Lapp WS

    更新日期:1984-03-01 00:00:00

  • Activity of syngeneic complement for revealing antibody-induced cytotoxicity against a rat hepatoma.

    abstract::The cytotoxicity of tumour-bearer serum against a transplanted aminoazodye-induced rat hepatoma was revealed using normal rat serum as the source of complement as assessed using a short-term 51Cr release test. The tumour-bearing rat was not deficient in a functional complement system and direct cytolysis against hepat...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-197908000-00014

    authors: Price MR,Höffken K,Baldwin RW

    更新日期:1979-08-01 00:00:00

  • T cells receptor beta-chain repertoires are nonrandomly selected in responses to HLA-DR1.

    abstract::T cell receptor (TCR) beta-chain usage by HLA-DR1 alloreactive T cell lines was examined to determine whether common TCR gene segments were used preferentially. We have demonstrated previously that a DR1-specific, human renal allograft-derived T cell line and replicate, anti-DR1 mixed lymphocyte reactions (MLR), estab...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199604150-00017

    authors: Hand SL,Alter MD,Finn OJ

    更新日期:1996-04-15 00:00:00

  • Transesophageal echocardiography during orthotopic liver transplantation in patients with esophagoastric varices.

    abstract:BACKGROUND:Hemodynamic monitoring using transesophageal echocardiography (TEE) in patients with signs of portal hypertension undergoing orthotopic liver transplantation (OLT) carries potential risk of esophageal and gastric variceal hemorrhage. The aim of our retrospective analysis was to evaluate the safety of intraop...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e31825475c2

    authors: Burger-Klepp U,Karatosic R,Thum M,Schwarzer R,Fuhrmann V,Hetz H,Bacher A,Berlakovich G,Krenn CG,Faybik P

    更新日期:2012-07-27 00:00:00

  • Everolimus versus mycophenolate mofetil in the prevention of rejection in de novo renal transplant recipients: a 3-year randomized, multicenter, phase III study.

    abstract:BACKGROUND:This 36-month, randomized, parallel-group study compared safety and efficacy of two doses of everolimus with mycophenolate mofetil (MMF) in de novo renal-transplant recipients. METHODS:Renal-allograft recipients received 1.5 mg/day or 3 mg/day of everolimus or 2 g/day of MMF, plus full-dose cyclosporine (Cs...

    journal_title:Transplantation

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1097/01.tp.0000164352.65613.24

    authors: Lorber MI,Mulgaonkar S,Butt KM,Elkhammas E,Mendez R,Rajagopalan PR,Kahan B,Sollinger H,Li Y,Cretin N,Tedesco H,B251 Study Group.

    更新日期:2005-07-27 00:00:00

  • Shorter Height Is Associated With Lower Probability of Liver Transplantation in Patients With Hepatocellular Carcinoma.

    abstract:BACKGROUND:The effect of height and sex on liver transplantation (LT) for hepatocellular carcinoma (HCC) remains unclear. METHODS:Using United Network for Organ Sharing (UNOS) data, 14 844 HCC patients listed for LT from 2005 to 2015 were identified. Cumulative incidence of waitlist events (LT and dropout for death or...

    journal_title:Transplantation

    pub_type: 杂志文章,多中心研究

    doi:10.1097/TP.0000000000002975

    authors: Lee E,Sarkar M,Dodge J,Kohi M,Mehta N

    更新日期:2020-05-01 00:00:00

  • Nosocomial Pneumocystis jirovecii pneumonia: lessons from a cluster in kidney transplant recipients.

    abstract:BACKGROUND:Pneumocystis jirovecii pneumonia (PJP) is an important infection-related complication, whose mode of transmission remains uncertain. METHODS:We investigated a nosocomial cluster of 14 PJP cases (11 confirmed and 3 probable) in kidney transplant recipients using epidemiological and genotyping methods. RESUL...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3182384b57

    authors: Phipps LM,Chen SC,Kable K,Halliday CL,Firacative C,Meyer W,Wong G,Nankivell BJ

    更新日期:2011-12-27 00:00:00