Lethal post-transplantation calcinosis.

Abstract:

:The case studies of four patients with post-transplantation calcinosis are presented. Three of the four patients died of inanition and sepsis secondary to infection of extensive soft tissue ulcers and diffuse cutaneous vascular calcification with gangrene. The fourth patient survived following removal of all four parathyroid glands and autografting of approximately one-half of one gland. Common to the patients was secondary hyperparathyroidism, elevated mean serum calcium levels after transplantation, and radiographic evidence of small and medium vessel calcification. No other differences could be found between these patients and other patients with post-transplantation hyperparathyroidism without calcinosis. In the face of apparently minor complaints of lower extremity discomfort, elevated parathyroid hormone levels (PTH) and positive xerography may indicate subtotal parathyroidectomy regardless of the serum calcium level.

journal_name

Transplantation

journal_title

Transplantation

authors

Perloff LJ,Spence RK,Grossman RA,Barker CF

doi

10.1097/00007890-197901000-00006

subject

Has Abstract

pub_date

1979-01-01 00:00:00

pages

21-5

issue

1

eissn

0041-1337

issn

1534-6080

journal_volume

27

pub_type

杂志文章
  • Conversion from cyclosporine A to tacrolimus in pediatric kidney transplant recipients with chronic rejection: changes in the immune responses.

    abstract:BACKGROUND:Tacrolimus (Tac) has immunosuppressant properties similar to those of cyclosporine A (CsA), but it is more potent. At present, however, its immunosuppressive activity in renal transplant recipients with ongoing chronic rejection has not been clarified. METHODS:We studied changes in kidney function, mixed ly...

    journal_title:Transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1097/01.tp.0000112438.46472.38

    authors: Ferraris JR,Tambutti ML,Cardoni RL,Prigoshin N

    更新日期:2004-02-27 00:00:00

  • Sequential antilymphoblast globulin and cyclosporine for renal transplantation.

    abstract::The nephrotoxic effects of cyclosporine (CsA) seem to be augmented by co-existing renal injury. A high rate of prolonged delayed function (acute tubular necrosis [ATN]) and non-function (NF) has been associated with the use of CsA prior to and following renal transplantation. Cyclosporine has also been associated with...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198701000-00019

    authors: Sommer BG,Henry M,Ferguson RM

    更新日期:1987-01-01 00:00:00

  • Should All Status 1A Patients Be Prioritized Over High MELD Patients? Concept of Risk Stratification in Extremely Ill Liver Transplant Recipients.

    abstract:BACKGROUND:Status 1A patients are prioritized over liver disease patients regardless of Model for End-stage Liver Disease (MELD) score. We aimed to identify groups with high waitlist mortality in Status 1A and MELD ≥40 patients to determine who would most benefit from transplantation. METHODS:Data on patients listed a...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000002651

    authors: Safwan M,Nwagu U,Collins K,Abouljoud M,Nagai S

    更新日期:2019-10-01 00:00:00

  • Management of posttransplant lymphoproliferative disease in pediatric liver transplant recipients receiving primary tacrolimus (FK506) therapy.

    abstract:BACKGROUND:Posttransplant lymphoproliferative disease (PTLD) after pediatric liver transplantation has been associated with high mortality rates. METHODS:The present study examined 282 consecutive pediatric liver transplant recipients from October 1989 to June 1996 who received primary tacrolimus immunosuppression. Th...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199810270-00014

    authors: Cacciarelli TV,Green M,Jaffe R,Mazariegos GV,Jain A,Fung JJ,Reyes J

    更新日期:1998-10-27 00:00:00

  • Use of renal allografts from donors positive for hepatitis B core antibody confers minimal risk for subsequent development of clinical hepatitis B virus disease.

    abstract:BACKGROUND:The risk associated with transplantation of renal allografts from hepatitis B virus core antibody-positive (HBcAb(+)), hepatitis B virus surface antigen-negative (HBsAg(-)) donors is not well defined. METHODS:Over 4 years, we performed 45 kidney transplants from IgG HBcAb(+), IgM HBcAb(-), HBsAg(-) donors i...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199712270-00027

    authors: Madayag RM,Johnson LB,Bartlett ST,Schweitzer EJ,Constantine NT,McCarter RJ Jr,Kuo PC,Keay S,Oldach DW

    更新日期:1997-12-27 00:00:00

  • FDA perspective: enrolment of elderly transplant recipients in clinical trials.

    abstract::Since 1989, the U.S. Food and Drug Administration (FDA) has encouraged the study of new drug and therapeutic products in elderly patients. However, despite the aging population in the United States, elderly patients continue to be underrepresented in clinical trials across a variety of therapeutic areas, including tra...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e31828279d9

    authors: Meyer JM,Archdeacon P,Albrecht R

    更新日期:2013-04-15 00:00:00

  • Propagation of lymphocytes infiltrating human liver allografts. Correlation with histologic diagnosis of rejection.

    abstract::In this study, we have investigated whether lymphocyte growth from 196 liver transplant biopsies is correlated with the histologic diagnosis of graft rejection. One fragment of each biopsy was cultured in IL-2 to expand activated T cells, and the remainder of the biopsy was analyzed histologically. A significantly hig...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199001000-00024

    authors: Saidman SL,Demetris AJ,Zeevi A,Duquesnoy RJ

    更新日期:1990-01-01 00:00:00

  • Prophylaxis with caspofungin for invasive fungal infections in high-risk liver transplant recipients.

    abstract:OBJECTIVE:The aim of this prospective, multicenter, noncomparative, open-label trial was to evaluate the prophylactic use of caspofungin in adult liver transplant recipients at high risk of developing invasive fungal infections (IFI). METHODS:Patients received caspofungin for at least 21 days. A successful treatment o...

    journal_title:Transplantation

    pub_type: 杂志文章,多中心研究

    doi:10.1097/TP.0b013e3181932e76

    authors: Fortún J,Martín-Dávila P,Montejo M,Muñoz P,Cisneros JM,Ramos A,Aragón C,Blanes M,San Juan R,Gavaldá J,Llinares P,GESITRA Study Group.

    更新日期:2009-02-15 00:00:00

  • Long-term discordant xenogeneic (porcine-to-primate) bone marrow engraftment in a monkey treated with porcine-specific growth factors.

    abstract:BACKGROUND:Mixed allogeneic hematopoietic chimerism has previously been reliably achieved and shown to induce tolerance to fully MHC-mismatched allografts in mice and monkeys. However, the establishment of hematopoietic chimerism has been difficult to achieve in the discordant pig-to-primate xenogeneic model. METHODS:...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199904150-00007

    authors: Sablinski T,Emery DW,Monroy R,Hawley RJ,Xu Y,Gianello P,Lorf T,Kozlowski T,Bailin M,Cooper DK,Cosimi AB,Sachs DH

    更新日期:1999-04-15 00:00:00

  • Rituximab, IVIG, and plasma exchange without graft local infusion treatment: a new protocol in ABO incompatible living donor liver transplantation.

    abstract:BACKGROUND:Although graft local infusion (GLI) treatment via the portal vein or the hepatic artery has been the pivotal strategy in ABO incompatible (ABOi) living donor liver transplantation (LDLT) in Japan, the procedure is associated with a high rate of catheter-associated complications. METHODS:A new ABOi-LDLT prot...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3181adcae6

    authors: Ikegami T,Taketomi A,Soejima Y,Yoshizumi T,Uchiyama H,Harada N,Iguchi T,Hashimoto N,Maehara Y

    更新日期:2009-08-15 00:00:00

  • Characterizing lung metabolism with carbon-13 magnetic resonance spectroscopy in a small-animal model: evidence of gluconeogenesis during hypothermic storage.

    abstract::Experimental evidence suggests storing lungs inflated with oxygen and with oxidizable substrate improves results of lung transplantation. Glucose is included in the low-potassium-dextran (LPD) solution Perfadex to achieve this goal. The authors hypothesized that other substrates might be more effective. Rat lungs were...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000169129.45433.b6

    authors: Peltz M,He TT,Adams GA 4th,Chao RY,Meyer DM,Jessen ME

    更新日期:2005-08-15 00:00:00

  • Cytomegalovirus PP65 antigenemia monitoring as a guide for preemptive therapy: a cost effective strategy for prevention of cytomegalovirus disease in adult liver transplant recipients.

    abstract:BACKGROUND:The aim of the study was to assess the incidence of cytomegalovirus (CMV) infection and disease in adult liver transplant recipients, using routine preemptive therapy guided by the pp65 antigenemia test. METHODS:Antigenemia was monitored weekly after liver transplantation (OLTX) for the first 3 months, and ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199910270-00011

    authors: Kusne S,Grossi P,Irish W,St George K,Rinaldo C,Rakela J,Fung J

    更新日期:1999-10-27 00:00:00

  • Randomized trial of mycophenolate mofetil versus enteric-coated mycophenolate sodium in primary renal transplant recipients given tacrolimus and daclizumab/thymoglobulin: one year follow-up.

    abstract:BACKGROUND:It was of interest to compare enteric-coated mycophenolate sodium (EC-MPS) versus mycophenolate mofetil (MMF) among renal transplant recipients receiving a tacrolimus-based immunosuppressive regimen. METHODS:Between December 2004 and February 2006, a single-center, open-label randomized trial of MMF (group ...

    journal_title:Transplantation

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/TP.0b013e3181734b4a

    authors: Ciancio G,Burke GW,Gaynor JJ,Roth D,Sageshima J,Kupin W,Tueros L,Hanson L,Rosen A,Ruiz P,Miller J

    更新日期:2008-07-15 00:00:00

  • Absence of specific mixed leukocyte culture reactivity during graft-versus-host disease and following bone marrow transplant rejection.

    abstract::Retrospective mixed leukocyte culture studies were performed in eight patients who had either rejected their marrow grafts or experienced graft-versus-host disease and in seven patients with successful marrow engraftment. In tests of pre-and post-transplant lymphocytes we found no evidence that rejection or graft-vers...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-197611000-00010

    authors: Opelz G,Gale RP

    更新日期:1976-11-01 00:00:00

  • Lung transplantation after allogeneic marrow transplantation in pediatric patients: the Memorial Sloan-Kettering experience.

    abstract:BACKGROUND:Chronic lung disease and pulmonary failure are complications that can occur after bone marrow transplantation (BMT) and are associated with severe morbidity and mortality. METHODS:We report on four patients who developed chronic, progressive, and irreversible lung disease 1 to 3 years after allogeneic BMT i...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200112270-00020

    authors: Heath JA,Kurland G,Spray TL,Kernan NA,Small TN,Brochstein JA,Gillio AP,Boklan J,O'Reilly RJ,Boulad F

    更新日期:2001-12-27 00:00:00

  • Kidney Transplant in the Era of Modern Therapy for Multiple Myeloma.

    abstract::Chronic kidney disease is common in patients with multiple myeloma. Historically, individuals with end-stage renal disease and multiple myeloma did poorly with renal transplantation due to higher mortality rates from the malignancy itself or associated comorbidities. However, over the past 2 decades, there have been s...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/TP.0000000000002449

    authors: Huskey JL,Heilman RL,Khamash H,Fonseca R

    更新日期:2018-12-01 00:00:00

  • Race, Relationship and Renal Diagnoses After Living Kidney Donation.

    abstract:BACKGROUND:In response to recent studies, a better understanding of the risks of renal complications among African American and biologically related living kidney donors is needed. METHODS:We examined a database linking U.S. registry identifiers for living kidney donors (1987-2007) to billing claims from a private hea...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000000733

    authors: Lentine KL,Schnitzler MA,Garg AX,Xiao H,Axelrod D,Tuttle-Newhall JE,Brennan DC,Segev DL

    更新日期:2015-08-01 00:00:00

  • Expression of HLA system antigens on placenta.

    abstract::The levels of HLA-A and -B antigens expressed by placenta have been assessed relative to parental and other A and B antigen types that were not shared by the foetus. A purified preparation of placenta plasma membrane was used to estimate the antigen activities. The results indicate that maternally and paternally inher...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-197612000-00009

    authors: Goodfellow PN,Barnstable CJ,Bodmer WF,Snary D,Crumpton MJ

    更新日期:1976-12-01 00:00:00

  • Evaluation of renal function in potential living kidney donors.

    abstract:BACKGROUND:Most transplant centers in the United States, including our own, use creatinine clearance (Ccr) to estimate glomerular filtration rate (GFR) in potential living kidney donors. The purpose of this study was to evaluate our experience with estimation of donor GFR by Ccr and to explore other potential strategie...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200101270-00016

    authors: Bertolatus JA,Goddard L

    更新日期:2001-01-27 00:00:00

  • The importance of the effect of underlying disease on rejection outcomes following orthotopic liver transplantation.

    abstract::Despite major advances in immunopharmacology, virtually all patients receive the same center-specific immunosuppressive regimen following orthotopic liver transplantation (OLT). The present analysis was performed on the hypothesis that the original disease representing the indication for OLT leads to a different initi...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199602270-00007

    authors: Berlakovich GA,Imhof M,Karner-Hanusch J,Gotzinger P,Gollackner B,Gnant M,Hanelt S,Laufer G,Muhlbacher F,Steininger R

    更新日期:1996-02-27 00:00:00

  • High dose bone marrow transplantation induces deletion of antigen-specific T cells in a Fas-independent manner.

    abstract:BACKGROUND:Monoclonal antibody induced tolerance to high doses of multiple lymphocyte stimulating (MLS)+minor mismatched bone marrow has recently been associated with clonal deletion, as reported in fully allogeneic models of bone marrow transplantation. FasL-induced apoptosis has been shown to mediate antigen-specific...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200004270-00025

    authors: Honey K,Bemelman F,Cobbold SP,Waldmann H

    更新日期:2000-04-27 00:00:00

  • Increased expression of endoarterial vascular cell adhesion molecule-1 mRNA in an experimental model of lung transplant rejection: diagnosis by pulmonary arterial biopsy.

    abstract:BACKGROUND:Early detection of rejection after lung transplantation may prevent allograft failure. This study determines if mRNA from the cell adhesion molecules intercellular adhesion molecule-1, vascular cell adhesion molecule (VCAM)-1, and E-selectin in pulmonary endovascular tissue samples could be markers of early ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.TP.0000057530.32397.6D

    authors: Rothman A,Mann D,Behling CA,McGraw M,Seslar S,Shiu P,Zhang L,Kriett JM

    更新日期:2003-04-15 00:00:00

  • Evidence of intragraft interleukin-2-activated killer cells and allospecific cytolytic T lymphocytes in rejecting lung allografts.

    abstract::In vivo cell-mediated effector mechanisms of allograft destruction were investigated in a canine single-lung transplantation model. This large animal model permits direct longitudinal studies of immune effector cells from the grafts of individual recipients by bronchoalveolar lavage (BAL). Evidence was obtained that t...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198911000-00026

    authors: Norin AJ,Kamholz SL

    更新日期:1989-11-01 00:00:00

  • Reversal of hyperglycemia in mice after subcutaneous transplantation of macroencapsulated islets.

    abstract:BACKGROUND:Macroencapsulated islets can reverse hyperglycemia in diabetic animals when transplanted i.p. or into the fat pad. The s.c. space is an attractive site for such transplantation because macrocapsules can be implanted with local anesthesia and be easily removed or reloaded with fresh islets. METHODS:Immunopro...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199903150-00005

    authors: Tatarkiewicz K,Hollister-Lock J,Quickel RR,Colton CK,Bonner-Weir S,Weir GC

    更新日期:1999-03-15 00:00:00

  • Analysis of factors affecting recurrence of hepatocellular carcinoma after liver transplantation with a special focus on inflammation markers.

    abstract:BACKGROUND:Systemic inflammation markers, such as neutrophil-to-lymphocyte ratio (NLR), have recently emerged as the prognostic factors for recurrence of liver tumors. METHODS:We assessed the ability of NLR and of other variables to predict the outcomes of orthotopic liver transplantation (OLT) for hepatocellular carc...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3182187cf0

    authors: Bertuzzo VR,Cescon M,Ravaioli M,Grazi GL,Ercolani G,Del Gaudio M,Cucchetti A,D'Errico-Grigioni A,Golfieri R,Pinna AD

    更新日期:2011-06-15 00:00:00

  • Functional evaluation of T helper, T suppressor, and B lymphocytes in lethally irradiated rhesus monkeys injected with autologous bone marrow.

    abstract::Lethally irradiated rhesus monkeys were treated with autologous bone marrow that had either been (1) nontreated, i.e., normal; (2) depleted of T lymphocytes with a monoclonal antibody directed against rhesus T lymphocytes; (3) fractionated with the soybean agglutinin (SBA- fraction); or (4) fractionated with SBA and f...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199206000-00027

    authors: Gengozian N,Moriarty C,Good RA

    更新日期:1992-06-01 00:00:00

  • Levosimendan treatment after primary organ failure in heart transplantation: a direct way to recovery?

    abstract::Heart transplantation is considered nowadays the gold standard in the therapy of chronic and terminal heart insufficiency. Primary organ failure after heart transplantation is a severe complication generally related to prolonged ischemia time, poor quality of the organ, or acute rejection. All these factors can potent...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000233845.15508.89

    authors: Beiras-Fernandez A,Weis FC,Fuchs H,Meiser BM,Reichart B,Weis M

    更新日期:2006-10-27 00:00:00

  • Six consecutive cases of successful adult ABO-incompatible living donor liver transplantation: a proposal for grading the severity of antibody-mediated rejection.

    abstract:BACKGROUND:The clinical symptoms, histological findings, and treatments for antibody-mediated rejection (AMR), which is the leading cause of graft loss in adult ABO-incompatible liver transplantation (ABO-I-LT), have rarely been discussed. METHODS:We performed adult living donor ABO-I-LT on six patients. We used anti-...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e31815e9672

    authors: Morioka D,Togo S,Kumamoto T,Takeda K,Matsuo K,Inayama Y,Yamanaka S,Tanaka K,Endo I,Maegawa J,Shimada H

    更新日期:2008-01-27 00:00:00

  • Genetic determinants of delayed graft function after kidney transplantation.

    abstract:BACKGROUND:Intracellular concentration of reactive oxygen species is held within tight physiological limits by enzymes with scavenging and repair functions. Under extreme conditions such as prolonged cold ischemia, these enzymes may be unable to adequately protect the organ, resulting in reperfusion injury that renders...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200209270-00013

    authors: St Peter SD,Imber CJ,Jones DC,Fuggle SV,Watson CJ,Friend PJ,Marshall SE

    更新日期:2002-09-27 00:00:00

  • A randomized prospective trial of cold storage versus pulsatile perfusion for cadaver kidney preservation.

    abstract::In a randomized trial conducted in 9 Ontario transplant centers, 107 cadaver kidney donors were randomized so that both kidneys were preserved either by simple cold storage (CS) or by pulsatile perfusion (PP). After exclusions and losses to follow-up, there were 90 patients in the CS group and 91 in the PP group. Tota...

    journal_title:Transplantation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Halloran P,Aprile M

    更新日期:1987-06-01 00:00:00