Early immune reaction after reduced-intensity cord-blood transplantation for adult patients.

Abstract:

BACKGROUND:To investigate immune reactions after reduced-intensity cord-blood transplantation (RI-CBT). MATERIALS AND METHODS:We reviewed medical records of 57 adult RI-CBT recipients. Preparative regimen comprised fludarabine, total-body irradiation, and either melphalan (n=51) or busulfan (n=6). Graft-versus-host disease (GvHD) prophylaxis was cyclosporine. PostRI-CBT immune reactions were classified according to time course: pre-engraftment immune reactions (PIR), engraftment syndrome (ES), and GvHD. RESULTS:Forty-five patients achieved engraftment at a median of day 19. PIR was characterized by high-grade fever and weight gain and developed on a median of day 9 in 35 of the 45 evaluable patients, including 3 who did not achieve engraftment. PIR subsided spontaneously in 12 patients, whereas corticosteroids were required in the other 23. ES and grade I to IV acute GvHD developed in 36 and 29 patients, respectively. GvHD could not be distinguished from preceding PIR or ES in 10 patients. Causes of the 32 nonrelapse mortalities included GvHD (n=5) and PIR (n=1). There were no significant differences in relapse and nonrelapse deaths between patients with PIR and those without it (18% vs. 5%, and 60% vs. 65%, respectively). CONCLUSIONS:Immune reactions after RI-CBT can be categorized into three distinct subtypes.

journal_name

Transplantation

journal_title

Transplantation

authors

Kishi Y,Kami M,Miyakoshi S,Kanda Y,Murashige N,Teshima T,Kusumi E,Hara S,Matsumura T,Yuji K,Masuoka K,Wake A,Morinaga S,Kanemaru M,Hayashi T,Tanaka Y,Taniguchi S,Tokyo Stem Cell Transplant Consortium.

doi

10.1097/01.tp.0000163289.20406.86

subject

Has Abstract

pub_date

2005-07-15 00:00:00

pages

34-40

issue

1

eissn

0041-1337

issn

1534-6080

pii

00007890-200507150-00008

journal_volume

80

pub_type

杂志文章
  • Early up-regulation of macrophages and myofibroblasts: a new marker for development of chronic renal allograft rejection.

    abstract:BACKGROUND:Increased numbers of macrophages and myofibroblasts are observed to occur in chronic renal allograft rejection (CR). The aim of this study was to examine the expression of cellular markers for the macrophage and myofibroblast in early renal transplant biopsy specimens and correlate these findings with allogr...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200006270-00028

    authors: Pilmore HL,Painter DM,Bishop GA,McCaughan GW,Eris JM

    更新日期:2000-06-27 00:00:00

  • Prolongation of renal allograft survival in the rat by pretreatment with donor antigen and cyclosporin A.

    abstract::Pretreatment of LEW rats with cyclosporin A (10 mg/kg/day orally for 14 days) plus 10(8) DA or (DA X LEW)F1 spleen lymphocytes on two occasions markedly prolonged the survival of subsequent DA renal allografts. The lymphocytotoxic antibody response was suppressed completely and renal biopsies showed a marked mononucle...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198106000-00004

    authors: Homan WP,Williams KA,Millard PR,Morris PJ

    更新日期:1981-06-01 00:00:00

  • Failure patterns of cryopreserved vein grafts in liver transplantation.

    abstract::Reports of early success with cryopreserved saphenous veins (CSV) as arterial conduits led us to develop cryopreserved iliac veins (CIV) as interposition grafts for portal vein reconstruction in living-related liver transplantation (LRLT). Despite encouraging short-term results, retrospective analysis of long-term cry...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/00007890-199609270-00007

    authors: Kuang AA,Renz JF,Ferrell LD,Ring EJ,Rosenthal P,Lim RC,Roberts JP,Ascher NL,Emond JC

    更新日期:1996-09-27 00:00:00

  • Reasons for non-use of recovered kidneys: the effect of donor glomerulosclerosis and creatinine clearance on graft survival.

    abstract:BACKGROUND:In 2000, the United Network for Organ Sharing/Organ Procurement and Transplantation Network Registry reported 540 recovered kidneys were discarded because of biopsy results, and 210 were discarded because of poor organ function. We compared the percentage of glomerulosclerosis (GS) and creatinine clearance (...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000123080.19145.59

    authors: Edwards EB,Posner MP,Maluf DG,Kauffman HM

    更新日期:2004-05-15 00:00:00

  • Comparison of sirolimus-based calcineurin inhibitor-sparing and calcineurin inhibitor-free regimens in cadaveric renal transplantation.

    abstract:INTRODUCTION:This study examines the efficacy and toxicity of sirolimus used as primary immunosuppression in combination with reduced dose tacrolimus (calcineurin inhibitor [CI]-sparing regimen) or mycophenolate mofetil (CI-free regimen) in high-risk cadaveric renal transplantation. METHODS:Seventy subjects were treat...

    journal_title:Transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1097/01.tp.0000121504.69676.5e

    authors: Lo A,Egidi MF,Gaber LW,Amiri HS,Vera S,Nezakatgoo N,Gaber AO

    更新日期:2004-04-27 00:00:00

  • Anemia after kidney transplantation; its prevalence, risk factors, and independent association with graft and patient survival: a time-varying analysis.

    abstract:INTRODUCTION:Posttransplant anemia and its association with transplant outcomes have not been properly studied. METHODS:We examined 530 renal allograft recipients transplanted at our center and followed up for 31.0±14.1 months. Hemoglobin (Hb), serum bicarbonate, and creatinine; use of erythropoiesis-stimulating agent...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e31824b36fa

    authors: Jones H,Talwar M,Nogueira JM,Ugarte R,Cangro C,Rasheed H,Klassen DK,Weir MR,Haririan A

    更新日期:2012-05-15 00:00:00

  • Skeletal reconstruction by vascularized allogenic bone transplantation: effects of statin in rats.

    abstract:BACKGROUND:Some statins have been reported to suppress the immune system and increase the expression of bone morphogenetic protein-2 gene that plays a pivotal role in bone regeneration. METHODS:The effects of cerivastatin on skeletal reconstruction by vascularized bone allograft were investigated in a rat tibia-fibula...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.TP.0000074992.49236.58

    authors: Ohno T,Shigetomi M,Ihara K,Matsunaga T,Hashimoto T,Kawano H,Sugiyama T,Kawai S

    更新日期:2003-09-15 00:00:00

  • Increased risk of graft failure in kidney transplant recipients after a diagnosis of dyspepsia or gastroesophageal reflux disease.

    abstract:BACKGROUND:Gastrointestinal complications are common in patients who undergo kidney transplantation and may affect posttransplant outcomes. We examined the incidence and predictors of gastroesophageal reflux disease (GERD) and dyspepsia and their associations with graft survival and mortality after transplant. METHODS...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e318160d4c4

    authors: Neri L,Rocca Rey LA,Pinsky BW,Lentine KL,Salvalaggio PR,Machnicki G,Willoughby L,Burroughs TE,Takemoto SK,Schnitzler MA

    更新日期:2008-02-15 00:00:00

  • Combined liver-kidney transplantation in primary hyperoxaluria type 1. Bone histopathology and oxalate body content.

    abstract::In three patients with end-stage renal failure due to primary hyperoxaluria type 1, successful combined liver-kidney transplantation enabled us to assess the insoluble oxalate pool, which was compared with the histopathological changes observed in iliac crest biopsy specimens. Good correlation was observed between the...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199506270-00010

    authors: Toussaint C,Vienne A,De Pauw L,Gelin M,Janssen F,Hall M,Schurmans T,Pasteels JL

    更新日期:1995-06-27 00:00:00

  • Long-term follow-up of recipients of combined human leukocyte antigen-matched bone marrow and kidney transplantation for multiple myeloma with end-stage renal disease.

    abstract:BACKGROUND:Specific tolerance after combined kidney and bone marrow transplantation for multiple myeloma with end-stage renal disease through mixed lymphohematopoietic chimerism has been achieved, as evidenced by prolonged normal renal function without ongoing immunosuppression. METHODS:To achieve potent antimyeloma r...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e31820a3068

    authors: Spitzer TR,Sykes M,Tolkoff-Rubin N,Kawai T,McAfee SL,Dey BR,Ballen K,Delmonico F,Saidman S,Sachs DH,Cosimi AB

    更新日期:2011-03-27 00:00:00

  • Evaluation of the drug interaction between intravenous high-dose fluconazole and cyclosporine or tacrolimus in bone marrow transplant patients.

    abstract::The purpose of this open-label, prospective study was to compare steady state concentrations and clearances of intravenously administered cyclosporine or tacrolimus with and without concomitant high-dose (400 mg/day) fluconazole in allogeneic BMT patients. Twenty-one patients were evaluable. The mean steady state cycl...

    journal_title:Transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1097/00007890-199604270-00026

    authors: Osowski CL,Dix SP,Lin LS,Mullins RE,Geller RB,Wingard JR

    更新日期:1996-04-27 00:00:00

  • Initial liver involvement in acute GVHD is predictive for nonrelapse mortality.

    abstract:BACKGROUND:Current grading systems in acute graft-versus-host disease (GVHD) are not able to identify patients with poor prognosis at time of onset, because they take into account maximal grade. The aim of this study was to evaluate potential predictors for overall survival at disease onset. METHODS:The study sample w...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3181bc2583

    authors: Robin M,Porcher R,de Castro R,Fisher G,de Latour RP,Ribaud P,Petropoulou AD,Rocha V,Devergie A,Mary JY,Socié G

    更新日期:2009-11-15 00:00:00

  • Isolation of large numbers of mesenchymal stem cells from the washings of bone marrow collection bags: characterization of fresh mesenchymal stem cells.

    abstract:BACKGROUND:Bone marrow (BM) is an excellent source of mesenchymal stem cells (MSC) which can be expanded in vitro for further use. However, large volumes of BM specimens are not routinely available. We hypothesized that the normally discarded BM collection kits might be a convenient source of large numbers of MSC. MET...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000259752.13304.0b

    authors: Mageed AS,Pietryga DW,DeHeer DH,West RA

    更新日期:2007-04-27 00:00:00

  • Six consecutive cases of successful adult ABO-incompatible living donor liver transplantation: a proposal for grading the severity of antibody-mediated rejection.

    abstract:BACKGROUND:The clinical symptoms, histological findings, and treatments for antibody-mediated rejection (AMR), which is the leading cause of graft loss in adult ABO-incompatible liver transplantation (ABO-I-LT), have rarely been discussed. METHODS:We performed adult living donor ABO-I-LT on six patients. We used anti-...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e31815e9672

    authors: Morioka D,Togo S,Kumamoto T,Takeda K,Matsuo K,Inayama Y,Yamanaka S,Tanaka K,Endo I,Maegawa J,Shimada H

    更新日期:2008-01-27 00:00:00

  • A Comprehensive Overview of the Clinical Relevance and Treatment Options for Antibody-Mediated Rejection Associated With non-HLA Antibodies.

    abstract::Although solid organ transplant results have improved significantly in recent decades, a pivotal cause of impaired long-term outcome is the development of antibody-mediated rejection (AMR), a condition characterized by the presence of donor specific antibodies to human leukocyte antigen (HLA) or non-HLA antigens. High...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000003551

    authors: Kardol-Hoefnagel T,Otten HG

    更新日期:2020-11-17 00:00:00

  • Hypersensitivity reactions in the small intestine. 6. Pathogenesis of the graft-versus-host reaction in the small intestinal mucosa of the mouse.

    abstract::The intestinal phase of the graft-versus-host reaction (GVHR) has been investigated in adult F1 mice bearing grafts of fetal gut using an H-2-incompatible and an H-2-compatible, Mls-incompatible combination. The results indicate that the mitotic activity of the intestinal crypts and the number of intraepithelial lymph...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198109000-00011

    authors: Mowat AM,Ferguson A

    更新日期:1981-09-01 00:00:00

  • Divergent patterns of ELAM-1, ICAM-1, and VCAM-1 expression on cytomegalovirus-infected endothelial cells.

    abstract::Endothelial cells, one of several in vivo host cells for cytomegalovirus (CMV), participate in solid organ allograft rejection in part through the expression of leukocyte adhesion molecules. The hypothesis that CMV infection alters the constitutive and induced expression of ELAM-1, ICAM-1, and VCAM-1 on infected human...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: Sedmak DD,Knight DA,Vook NC,Waldman JW

    更新日期:1994-12-27 00:00:00

  • Relationship between CD8+ T-cell phenotype and function, Epstein-Barr virus load, and clinical outcome in pediatric renal transplant recipients: a prospective study.

    abstract:BACKGROUND:The authors studied the relationship between the dynamics of Epstein-Barr virus (EBV) load, CD8 T-cell activation and differentiation, and EBV-associated symptoms in 25 children after kidney transplantation (Tx). METHODS:Twenty-two patients were enrolled at the time of Tx and three at diagnosis of EBV-induc...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000131168.21930.5c

    authors: Baudouin V,Dehée A,Pédron-Grossetete B,Ansart-Pirenne H,Haddad E,Maisin A,Loirat C,Sterkers G

    更新日期:2004-06-15 00:00:00

  • Immunosuppression with a combination of the leflunomide analog, FK778, and microemulsified cyclosporine for renal transplantation in mongrel dogs.

    abstract:BACKGROUND:The leflunomide analog, FK778, is a selective pyrimidine synthesis inhibitor. In rodent models, FK778 is efficacious in the prevention of allograft and xenograft rejection, and a combination of FK778 and cyclosporine has synergistic immunosuppressive efficacy. METHODS:Heterotopic renal transplantation was p...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.TP.0000061789.97072.12

    authors: Kyles AE,Gregory CR,Griffey SM,Bernsteen L,Pierce J,Lilja HS,Morris RE

    更新日期:2003-04-27 00:00:00

  • Long-term survival of hamster-to-rat cardiac xenografts in the absence of a Th2 shift.

    abstract:BACKGROUND:In hamster-to-rat cardiac xenografts, long-term survival (LTS) is obtained in 60% of recipients if vascular rejection is overcome by cobra venom factor and cyclosporine (CsA). It has been suggested that this accommodation state could be due to the Th2 response. METHODS:We examined the infiltrate by using im...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199806270-00004

    authors: Brouard S,Blancho G,Moreau A,Heslan JM,Cuturi MC,Soulillou JP

    更新日期:1998-06-27 00:00:00

  • Transplantomics: Toward Precision Medicine in Transplantation Research.

    abstract::Precision medicine is an emerging integrative approach for disease prevention, early detection, and treatment which takes into account individual variability in genetic and other molecular measurements, medical history, environmental exposures, and lifestyle. The development and availability of genomic and other molec...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/TP.0000000000001664

    authors: Sirota M,Sarwal MM

    更新日期:2017-08-01 00:00:00

  • Tacrolimus or cyclosporine: which is the better partner for mycophenolate mofetil in heart transplant recipients?

    abstract:BACKGROUND:The aim of this single-center study was to investigate whether trough level adjusted mycophenolate mofetil (MMF) is more efficacious in combination with tacrolimus (TAC) or cyclosporine (CsA) and to evaluate the impact of either drug on MMF dosage. METHODS:Sixty patients (TAC, n = 30; CsA, n = 30) undergoin...

    journal_title:Transplantation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/01.tp.0000129814.52456.25

    authors: Meiser BM,Groetzner J,Kaczmarek I,Landwehr P,Müller M,Jung S,Uberfuhr P,Fraunberger P,Stempfle HU,Weis M,Reichart B

    更新日期:2004-08-27 00:00:00

  • Ketorolac-based analgesia improves outcomes for living kidney donors.

    abstract:BACKGROUND:To reduce the morbidity of living kidney donors we introduced ketorolac-based analgesia for patients undergoing open donor nephrectomy in August 1999. There are no prior reports on the use of ketorolac for patients undergoing donor nephrectomy. METHODS:We conducted a retrospective review of all 198 consecut...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200203150-00014

    authors: Freedland SJ,Blanco-Yarosh M,Sun JC,Hale SJ,Elashoff DA,Litwin MS,Smith RB,Rajfer J,Gritsch HA

    更新日期:2002-03-15 00:00:00

  • The effect of mismatching for HLA-DR in recipients of renal allografts sharing one HLA-ABC haplotype with related donors.

    abstract::The effects of mismatching for DR antigens on renal allograft survival rates have largely been restricted to analyses of cadaver transplant results. Analyses of HLA matching in recipients of transplants from related donors have focused on the number of haplotypes shared between the recipients without regard to DR, or ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198336060-00011

    authors: Sutherland DE,Morrow CE,Kaufman D,Fryd DS,Najarian JS,Burke M,Noreen H,Segall M,Bach FH

    更新日期:1983-12-01 00:00:00

  • Studies on heterophile antibodies in transplantation sera.

    abstract::By means of double diffusion in gel reactions, "heterophile" antibodies were demonstrated in human renal transplantation sera. Of thirty-two recipients of renal allografts, 12 (37 per cent) had antibodies to extract of bovine erythrocyte stromata, and 5 (19 per cent) of 26 recipients produced antibodies to extract of ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-197501000-00004

    authors: Kano K,Loza U,Gerbasi JR,Milgrom F

    更新日期:1975-01-01 00:00:00

  • Vitamin D deficiency in lung transplant patients: is it important?

    abstract:BACKGROUND:Vitamin D deficiency has been reported in different chronic pulmonary diseases like asthma and chronic obstructive pulmonary disease, but little is known in lung transplant recipients. METHODS:Serum 25-hydroxyvitamin D (25-OHD) levels and pulmonary function (forced expiratory volume in 1 sec [FEV(1)] %predi...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e31823d98bc

    authors: Verleden SE,Vos R,Geenens R,Ruttens D,Vaneylen A,Dupont LJ,Verleden GM,van Raemdonck DE,Vanaudenaerde BM

    更新日期:2012-01-27 00:00:00

  • Variability in donation after cardiac death protocols: a national survey.

    abstract::As donation after cardiac death practices expand, the number of institutional policies is increasing. We contacted organ procurement organizations throughout the United States and requested protocols in hospitals in their donor service areas. Sixty-four protocols were obtained with representation from 16 different sta...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e318204ee96

    authors: Fugate JE,Stadtler M,Rabinstein AA,Wijdicks EF

    更新日期:2011-02-27 00:00:00

  • Utilization of Donor Kidneys With Acute Kidney Injury in Pediatric Kidney Transplant Recipients.

    abstract:BACKGROUND:An elevated terminal creatinine is frequently used as a reason for organ refusal in pediatric kidney transplantation. There is increasing evidence that adults who receive kidneys from donors with moderate to severe acute kidney injury (AKI) have similar outcomes to recipients who receive kidneys from donors ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000002827

    authors: Solomon S,Hayde N

    更新日期:2020-03-01 00:00:00

  • Normalization of circadian blood pressure profiles after renal transplantation.

    abstract::Most patients with secondary hypertension due to renal disease or on maintenance hemodialysis have lost the physiologic fall of blood pressure during sleep. To test the notion that kidney transplantation normalizes the blood pressure profile, we monitored ambulatory blood pressure over 24 hr in 45 patients (29 males a...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: Gatzka CD,Schobel HP,Klingbeil AU,Neumayer HH,Schmieder RE

    更新日期:1995-05-15 00:00:00

  • The prognostic significance of positive CMV cultures during surveillance of renal transplant recipients.

    abstract::Renal transplant recipients are at risk of severe morbidity and mortality from CMV disease. We have undertaken routine surveillance for CMV shedding on 133 transplant recipients, using a rapid culture technique, in order to assess the incidence of CMV infection and disease in these patients and to assess the prognosti...

    journal_title:Transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1097/00007890-199307000-00019

    authors: Pillay D,Ali AA,Liu SF,Kops E,Sweny P,Griffiths PD

    更新日期:1993-07-01 00:00:00