A new T-cell receptor transgenic model of the CD4+ direct pathway: level of priming determines acute versus chronic rejection.

abstract：BACKGROUND:Natural antibodies that react with galactose-alpha(1,3)galactose [galalpha(1,3)gal] carbohydrate epitopes exist in humans and Old World primates because of the inactivation of the alpha1,3-galactosyltransferase (alpha1,3GT) gene in these species and the subsequent production of antibodies to environmental mi...

journal_title：Transplantation

authors： Nozawa S,Xing PX,Wu GD,Gochi E,Kearns-Jonker M,Swensson J,Starnes VA,Sandrin MS,McKenzie IF,Cramer DV

更新日期：2001-07-15 00:00:00

abstract：:Gliotoxin is an immunosuppressive secondary metabolite produced by several pathogenic fungi. It has previously been shown to prevent graft-versus-host disease in transplantation of allogeneic mouse bone marrow and to reduce the immunogenicity of human fetal pancreas. We here report on the effect of gliotoxin on the pr...

journal_title：Transplantation

authors： Sutton P,Moreland A,Hutchinson IV,Müllbacher A

更新日期：1995-11-15 00:00:00

abstract：:Recent reports document the efficacy of transjugular intrahepatic portocaval shunts (TIPS) for the prevention of portal hypertensive bleeding and have advocated its use as a bridge to liver transplantation. There are no reports, however, analyzing liver transplant results for patients with indwelling TIPS. We reviewed...

journal_title：Transplantation

authors： Freeman RB Jr,FitzMaurice SE,Greenfield AE,Halin N,Haug CE,Rohrer RJ

更新日期：1994-08-15 00:00:00

abstract：:Cyclosporine CsA nephrotoxicity was examined in male Sprague-Dawley rats with or without prior uninephrectomy, injected daily with 12.5 mg/kg CsA, and fed a salt-depleted or normal diet for 3-10 weeks. Control rats received the CsA vehicle. CsA induced a fall in creatinine clearance in salt-depleted rats, from 1.3 +/-...

journal_title：Transplantation

authors： Rosen S,Greenfeld Z,Brezis M

更新日期：1990-02-01 00:00:00

abstract：BACKGROUND:Angiogenesis contributes to the repair process after renal ischemia/reperfusion (I/R) injury. In the present study, we tested the role of miR-21 in the angiogenesis induced by hypoxia inducible factor (HIF)-1α through inhibiting a predicted target gene thrombospondin 1 (TSP-1). METHODS:To stabilize HIF-1α, ...

journal_title：Transplantation

authors： Xu X,Song N,Zhang X,Jiao X,Hu J,Liang M,Teng J,Ding X

更新日期：2017-08-01 00:00:00

abstract：:Three groups of patients were reviewed. Primary carcinomas were found in donors kidneys of 47 recipients. In 30 instances a tumor was present at harvesting. When a neoplasm was removed immediately pretransplantation or early posttransplantation there were no recurrences in 14 recipients. In another two instances, a tu...

journal_title：Transplantation

authors： Penn I

更新日期：1995-02-27 00:00:00

abstract：:Chronic pulmonary disease is associated with varying degrees of cardiac dysfunction. Because of the potentially predominant effect of severe lung disease on right ventricular (RV) size and function, a reliable method to assess RV mechanics before and after lung transplantation may provide information of long-term sign...

journal_title：Transplantation

authors： Vigneswaran WT,McDougall JC,Olson LJ,Breen JF,McGregor CG,Rumberger JA

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:The vast majority of polyomavirus nephropathy (PVN) are due to BK virus, but rare cases result from JC virus reactivation. To date, only a handful of biopsy-proven JC-PVN cases have been reported. Here, we describe the clinical and pathologic findings in 7 patients with biopsy-proven JC-PVN. METHODS:Search ...

journal_title：Transplantation

authors： Wiegley N,Walavalkar V,Aujla H,Chen LX,Huang Y,Lee BK,Jen KY

更新日期：2020-06-17 00:00:00

abstract：BACKGROUND:Acute graft dysfunction caused by ischemia-reperfusion injury is recognized as a major source of morbidity and mortality following adult heart transplantation. The aim of this study was to determine whether treating the donor and recipient with cariporide, an inhibitor of the sodium-hydrogen exchanger, could...

journal_title：Transplantation

authors： Ryan JB,Hicks M,Cropper JR,Garlick SR,Kesteven SH,Wilson MK,Feneley MP,Macdonald PS

更新日期：2003-03-15 00:00:00

abstract：:A study was designed to determine if cold preservation induces an increase in lymphocyte adherence to liver sinusoids on reperfusion. Rat livers were stored at 1 degree C in University of Wisconsin solution for 45 min, 8 hr, or 30 hr, and then reperfused for 90 min at 37 degrees C in an isolated perfused rat liver app...

journal_title：Transplantation

authors： Clavien PA,Morgan GR,Sanabria JR,Petrunka C,Levy GA,Robert P,Harvey C,Strasberg SM

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:Human leukocyte antigen (HLA) antibodies produced after transplantation are frequently measured in transplant recipients, because they are strongly associated with humoral rejection and graft loss. However, antibodies can be induced by posttransplant blood transfusions rather than by the graft, casting doubt...

journal_title：Transplantation

authors： Scornik JC,Schold JD,Bucci M,Meier-Kriesche HU

更新日期：2009-05-15 00:00:00

abstract：BACKGROUND:Cold preservation is the most practical method to maintain the viability of isolated lungs. However, rapid cooling may affect pulmonary endothelial function. We examined the effects of microtubule stabilization with paclitaxel on pulmonary endothelial barrier integrity under cold temperature. METHODS:Human ...

journal_title：Transplantation

authors： Suzuki S,Bing H,Sugawara T,Matsuda Y,Tabata T,Hoshikawa Y,Saijo Y,Kondo T

更新日期：2004-08-27 00:00:00

abstract：:CD18 antibodies react with the common beta chain of the human leukocyte function antigen (LFA1)* and thus block the functions mediated by the three identified molecules in humans. A murine CD18 monoclonal antibody was infused in 8 leukemic patients receiving allogeneic T-depleted bone marrow transplantation in order t...

journal_title：Transplantation

authors： Baume D,Kuentz M,Pico JL,Beaujean F,Cordonnier C,Vernant JP,Hayat M,Bernard A

更新日期：1989-03-01 00:00:00

abstract：:We have done a comparative analysis of two consecutive clinical trials at our center: the first in 56 patients who received blood transfusions from their prospective donors (DST group), and the second in 36 patients who received such transfusions while they were taking Imuran in an attempt to reduce the incidence of s...

journal_title：Transplantation

authors： Glass NR,Miller DT,Sollinger HW,Belzer FO

更新日期：1983-12-01 00:00:00

abstract：:The interactions of steroid hormones and human peripheral blood lymphocytes (PBLs) have been investigated following glass-wool column separation of PBLs and incubation in a serum-free medium in the presence of phytohemagglutinin (PHA). Addition of hydrocortisone or progesterone above physiological concentrations resul...

journal_title：Transplantation

authors： Neifeld JP,Tormey DC

更新日期：1979-05-01 00:00:00

abstract：BACKGROUND:The piggyback technique of orthotopic liver transplantation is an attractive alternative that preserves the recipient inferior vena cava and allows uninterrupted venous blood return during the anhepatic phase. As with other transplantation techniques, the vascular anastomoses required by the piggyback techni...

journal_title：Transplantation

authors： Sze DY,Semba CP,Razavi MK,Kee ST,Dake MD

更新日期：1999-08-15 00:00:00

abstract：:Portal vein (PV) complications after living donor liver transplant (LDLT) have been a major concern in pediatric liver transplantation. The incidence of PV complications is more in pediatric (0%-33%) than in adult recipients. Early diagnosis and treatment of PV complications may ensure optimal graft function and good ...

journal_title：Transplantation

authors： Cheng YF,Ou HY,Yu CY,Tsang LL,Huang TL,Chen TY,Concejero A,Wang CC,Wang SH,Lin TS,Liu YW,Yang CH,Yong CC,Chiu KW,Jawan B,Eng HL,Chen CL

更新日期：2014-04-27 00:00:00

abstract：BACKGROUND:The deleterious effect of steatosis on transplanted livers is mainly related to a microcirculation impairment. We investigated the effect of preservation duration on the recovery of isolated perfused rat steatotic livers and tested the effect of pentoxifylline (PTX), known to have a beneficial effect on hepa...

journal_title：Transplantation

authors： Arnault I,Bao YM,Sebagh M,Anjo A,Dimicoli JL,Lemoine A,Delvart V,Adam R

更新日期：2003-07-15 00:00:00

abstract：BACKGROUND:We have previously shown that recognition of human erythrocytes by porcine Kupffer cells is mediated by a carbohydrate-dependent mechanism. The present study explores the possible ligands existing on human glycophorin A and tests their ability to inhibit erythrocyte rosette formation. METHODS:Human erythroc...

journal_title：Transplantation

authors： Burlak C,Twining LM,Rees MA

更新日期：2005-08-15 00:00:00

abstract：BACKGROUND:The terminal Gal alpha1,3Galactose (alphaGal) determinant is present on all porcine glycoproteins and glycolipids, but is not expressed by human cells. Consequently human sera contain anti-alphaGal natural antibodies. The human blood group B antigen [Gal alpha1,3(Fuc1,2)Galactose] is differentiated from the ...

journal_title：Transplantation

authors： McMorrow IM,Comrack CA,Nazarey PP,Sachs DH,DerSimonian H

更新日期：1997-08-15 00:00:00

abstract：BACKGROUND:Persistent massive ascites (PMAS) longer than 14 days after living donor liver transplantation is not uncommon and associated with worse outcome. A predictive risk scoring system was constructed after analysis of recipient, graft, and surgery-related factors. METHODS:We retrospectively reviewed adult living...

journal_title：Transplantation

authors： Wu YJ,Wang SH,Elsarawy AM,Chan YC,Chen CL,Cheng BC,Li LC,Chiu CH,Lee YW,Lin YC,Wee SY,Pan CC,Kao YY,Chen YH,Lin HW,Lin LM,Lin CC

更新日期：2018-06-01 00:00:00

abstract：:The mortality rates for CVDs in transplant recipients are greater than those in the general population (13). CVDs are a major cause of both patient and graft loss in renal transplant recipients, and improving cardiovascular health may help to extend both patient and graft survival. A complication of chronic renal fail...

journal_title：Transplantation

authors： Wheeler DC,Steiger J

更新日期：2000-12-15 00:00:00

abstract：:In recent years there have been major advances in the technology for the detection and definition of human leukocyte antigen antibodies. In this overview we describe the evolution in laboratory technology, the techniques currently available and consider their application in antibody specificity definition and in under...

journal_title：Transplantation

authors： Fuggle SV,Martin S

更新日期：2008-08-15 00:00:00

abstract：BACKGROUND:Membrane CD30 is an important costimulatory molecule for activated T lymphocytes, and serum level of soluble CD30 (sCD30) is considered a marker for predicting outcome in kidney transplantation. METHODS:We investigated the kinetics of CD30 expression on CD4 and CD8 T-cell populations and the source of sCD30...

journal_title：Transplantation

authors： Velásquez SY,García LF,Opelz G,Alvarez CM,Süsal C

更新日期：2013-07-27 00:00:00

abstract：BACKGROUND/AIM:It remains uncertain whether autoimmune hepatitis (AIH), as an original indication for orthotopic liver transplantation (OLTX), predisposes to the development of chronic rejection (CR) after surgery and published reports on heterogeneous groups of patients provided conflicting data. In this work we analy...

journal_title：Transplantation

authors： Milkiewicz P,Gunson B,Saksena S,Hathaway M,Hubscher SG,Elias E

更新日期：2000-08-15 00:00:00

abstract：:Two infants born to mothers who had been given a renal transplant and who were receiving azathioprine and prednisone have been followed up for over 2 years. Initially both had lower than normal lymphocyte counts and cortisol levels. Chromosomal aberrations similar to those found in the lymphocytes of the mothers were ...

journal_title：Transplantation

authors： Price HV,Salaman JR,Laurence KM,Langmaid H

更新日期：1976-04-01 00:00:00

abstract：BACKGROUND:Individuals undergoing therapeutic immunosuppression are at risk of severe varicella-zoster virus (VZV) infection, particularly those without evidence of previous infection. METHODS:Eleven children, median age 10 months (range 5.5 months to 7 years and 9 months) received one dose of varicella vaccine (Varil...

journal_title：Transplantation

authors： Donati M,Zuckerman M,Dhawan A,Hadzic N,Heaton N,North-Lewis P,Mieli-Vergani G

更新日期：2000-11-15 00:00:00

abstract：BACKGROUND:African American kidney transplant recipients generally exhibit poor long-term graft survival compared with other ethnic groups. The combination of sirolimus, tacrolimus, and corticosteroids has proven to be effective in reducing rejection episodes in high-risk organ and islet cell transplant recipients but ...

journal_title：Transplantation

authors： Hricik DE,Anton HA,Knauss TC,Rodriguez V,Seaman D,Siegel C,Valente J,Schulak JA

更新日期：2002-07-27 00:00:00

abstract：BACKGROUND:Deep venous thrombosis (DVT) is a common problem with potentially devastating results in patients undergoing major surgical procedures. Certain renal transplant recipients are particularly at risk for allograft loss as a consequence of renal vein and artery thrombosis. Over the past few years, low molecular ...

journal_title：Transplantation

authors： Alkhunaizi AM,Olyaei AJ,Barry JM,deMattos AM,Conlin MJ,Lemmers MJ,Bennett WM,Norman DJ

更新日期：1998-08-27 00:00:00

abstract：BACKGROUND:This study evaluated the prognostic impact of pretransplant donor-specific anti-human leukocyte antigen antibodies (DSA) detected by single-antigen beads and compared the three generations of crossmatch (XM) tests in kidney transplantation. METHODS:Thirty-seven T-cell complement-dependent cytotoxicity cross...

journal_title：Transplantation

authors： Riethmüller S,Ferrari-Lacraz S,Müller MK,Raptis DA,Hadaya K,Rüsi B,Laube G,Schneiter G,Fehr T,Villard J

更新日期：2010-07-27 00:00:00