Abstract:
BACKGROUND:Acute graft dysfunction caused by ischemia-reperfusion injury is recognized as a major source of morbidity and mortality following adult heart transplantation. The aim of this study was to determine whether treating the donor and recipient with cariporide, an inhibitor of the sodium-hydrogen exchanger, could reduce ischemia-reperfusion injury. METHODS:A porcine model of donor brain death, hypothermic ischemic preservation, and orthotopic cardiac transplantation was used. Allografts in both the control group (CON, n=6) and treatment group (CAR, n=6) were arrested and stored for 4 hours in the extracellular crystalloid cardioplegia currently used in the clinical transplantation program at our institution. In addition, both the donor and recipient animals in the CAR group received a single intravenous dose of cariporide (2 mg/kg) 15 minutes before harvesting and reperfusion, respectively. RESULTS:The initial rate of troponin I release was significantly lower in recipients of CAR hearts than in recipients of CON hearts (P =0.020). All hearts were weaned successfully from bypass. More CAR hearts were weaned successfully at the first attempt, at 1 hour post-reperfusion, than CON hearts (6 of 6 vs 3 of 6), but this did not achieve statistical significance. Left ventricular contractility (preload recruitable stroke-work relationship) and left ventricular compliance (end-diastolic pressure-volume relationship) were significantly better preserved in CAR hearts than CON hearts (both P <0.0001). CONCLUSIONS:Myocardial injury was reduced, and contractile function was better preserved in allografts that received cariporide, compared with allografts that received conventional preservation alone.
journal_name
Transplantationjournal_title
Transplantationauthors
Ryan JB,Hicks M,Cropper JR,Garlick SR,Kesteven SH,Wilson MK,Feneley MP,Macdonald PSdoi
10.1097/01.TP.0000054619.13962.30subject
Has Abstractpub_date
2003-03-15 00:00:00pages
625-31issue
5eissn
0041-1337issn
1534-6080journal_volume
75pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::Recipient dogs were conditioned with 9.2 Gy of total-body irradiation followed by the infusion of bone marrow and peripheral blood leukocytes from a DLA-haploidentical littermate (N = 10) or a completely allogeneic unrelated donor (n = 9). Graft-vs.-host disease (GVHD) prophylaxis consisted of methotrexate (MTX) and c...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198711000-00006
更新日期:1987-11-01 00:00:00
abstract:BACKGROUND:A widely held view is that any increase in the potency of an immunosuppressive agent will lead to an increase in infection and malignancy, such as life-threatening Epstein-Barr virus (EBV) induced posttransplant lymphoproliferative disorders (PTLD). We tested this paradigm by studying the effect of adding mo...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/00007890-199905150-00002
更新日期:1999-05-15 00:00:00
abstract:BACKGROUND:Specific tolerance after combined kidney and bone marrow transplantation for multiple myeloma with end-stage renal disease through mixed lymphohematopoietic chimerism has been achieved, as evidenced by prolonged normal renal function without ongoing immunosuppression. METHODS:To achieve potent antimyeloma r...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31820a3068
更新日期:2011-03-27 00:00:00
abstract:BACKGROUND:Current grading systems in acute graft-versus-host disease (GVHD) are not able to identify patients with poor prognosis at time of onset, because they take into account maximal grade. The aim of this study was to evaluate potential predictors for overall survival at disease onset. METHODS:The study sample w...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181bc2583
更新日期:2009-11-15 00:00:00
abstract:BACKGROUND:Recent evidence has suggested that inconsistencies in human-islet yields after collagenase digestion are attributed to the activation of endogenous enzymes of the cadaveric donor pancreas. Inhibition of protease activity by Pefabloc (0.4 mM; Roche Biochemicals Inc., Indianapolis, IN) has recently been shown ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000046537.47139.CE
更新日期:2003-02-27 00:00:00
abstract::It was the objective of these experiments to study the time-related changes in the responsiveness of the cellular elements of the immune system following contact with single non-H-2 or multiple H-2 histocompatibility antigens. The reactivity of spleen cells from mice that received injections of spleen cells bearing H-...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198802000-00047
更新日期:1988-02-01 00:00:00
abstract:BACKGROUND:Gastrointestinal complications are common in patients who undergo kidney transplantation and may affect posttransplant outcomes. We examined the incidence and predictors of gastroesophageal reflux disease (GERD) and dyspepsia and their associations with graft survival and mortality after transplant. METHODS...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318160d4c4
更新日期:2008-02-15 00:00:00
abstract::The early detection of allograft rejection remains elusive after solitary pancreas transplantation (PTX). We have previously described a modified technique of cystoscopic transduodenal PTX biopsy using the Biopty gun under ultrasound guidance. During the last 2 years, we performed 24 solitary PTXs with prospective pro...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199560120-00011
更新日期:1995-12-27 00:00:00
abstract:BACKGROUND:Immunosuppression involves the nature of the immunosuppressive agents and individual differences in patient factors. We investigated whether the effect of mycophenolate mofetil (MMF) is measurable using an in vitro measure of immunocompetence and related its effects to cyclosporine (CsA) in vitro. METHODS:L...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200108150-00011
更新日期:2001-08-15 00:00:00
abstract:BACKGROUND:Suppressive dendritic cells (DCs) are a promising tool for tolerance induction in transplantation. A human DCs subpopulation, which constitutively expresses indoleamine-2,3-dioxygenase (IDO), a molecule shown to prevent the rejection of fetus during pregnancy, has recently been described. This subset, charac...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000251646.09702.ec
更新日期:2007-02-27 00:00:00
abstract:BACKGROUND:Immunogenicity of a graft depends on its expression of major histocompatability complex (MHC) antigens and adhesion molecules and on the amount of intragraft leukocytes, the so-called passenger leukocytes. Although long-term culture reduces passenger leukocytes, permanent acceptance is not necessarily observ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200208270-00003
更新日期:2002-08-27 00:00:00
abstract::In a retrospective review of fifty heart, lung, and heart-lung recipients receiving cyclosporine, forty-six (92%) were hypertensive. This hypertension was managed with either prazosin (n = 29) or nifedipine (n = 17). Renal function was assessed by creatinine clearance estimation and found to be significantly better in...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198909000-00015
更新日期:1989-09-01 00:00:00
abstract::Influenza vaccination has been strongly recommended for immunosuppressed renal transplant recipients. However, immunosuppression may lead to impaired antibody responses. We studied the antibody response to an inactivated trivalent influenza vaccine in 59 renal transplant recipients with life-sustaining kidney function...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198610000-00009
更新日期:1986-10-01 00:00:00
abstract::Natural killer (NK) lymphocytes are powerful effector cells of the peripheral immune system. NK cell functions are controlled by the expression of a variety of cell surface receptors with either inhibitory or activating roles. The genetic and functional diversity of this repertoire of receptors and the role of human l...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.tp.0000123764.10461.4c
更新日期:2004-07-15 00:00:00
abstract:BACKGROUND:Alpha-glutathione-S-transferase (alphaGST) has been suggested as a sensitive marker of acute cellular rejection in liver transplantation. This study evaluated the usefulness of alphaGST as a marker of acute rejection in comparison with standard liver function tests. METHODS:Daily measurements of liver funct...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199802150-00019
更新日期:1998-02-15 00:00:00
abstract::The recent introduction of a variety of techniques for removing T cells from bone marrow grafts has reduced the incidence of graft-versus-host disease (GVHD)-associated morbidity and mortality. Whether this advance will be translated into improved patient survival is unclear at present, mainly because these procedures...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198704000-00009
更新日期:1987-04-01 00:00:00
abstract:BACKGROUND:There is a lack of information about survival after dropout from the liver transplant waiting list. Therefore, we aimed to assess the overall survival, and risk factors for death, after waiting list dropout due to hepatocellular carcinoma (HCC) progression. METHODS:We assessed patients who dropped out of th...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002616
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:We studied whether T-cell clones, which appear in the periphery as a result of the failure of thymic negative selection during graft-versus-host disease (GVHD), have any in vivo anti-host reactivity and can cause GVHD in an adoptive transfer model. METHODS:We performed our studies in a murine model (B10.BR ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200002150-00026
更新日期:2000-02-15 00:00:00
abstract::Seventy-two dog kidneys were stored under hypothermia as described by Collins and Sacks between 24 and 72 hr and then transplanted. The immediate function of the kidneys was measured by p-aminohippuric acid and inulin clearances. Twenty-four hr proved to be the maximum safe preservation time with both methods. The imm...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197705000-00009
更新日期:1977-05-01 00:00:00
abstract:BACKGROUND:The use of lung grafts from non-heart-beating donors (NHBD) is one way of solving the donor organ shortage problem. In this experiment, we studied the effect of retrograde flush (RF) from the left atrium before harvest, inhaled nitric oxide (NO), and gabexate mesilate (FOY), a protease inhibitor, in the lung...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200005270-00008
更新日期:2000-05-27 00:00:00
abstract:BACKGROUND:The mitochondrial respiratory chain is implicated as a major target of kidney damage after ischemia-reperfusion. This study measures changes in integrated mitochondrial function and in the activity of enzymes of the respiratory chain after cold storage and transplantation-reperfusion in vivo. METHODS:Mitoch...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200004150-00011
更新日期:2000-04-15 00:00:00
abstract::Pre- and post transplant sera from 51 cases of bone marrow transplants performed for severe aplastic anemia were tested on monocytes (M) and corresponding B cells (B) from a panel of unrelated donors. One-third of the sera were cytotoxic for B and M either from different or from the same individuals, while 45% reacted...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198206000-00006
更新日期:1982-06-01 00:00:00
abstract:BACKGROUND:Despite effective antiviral treatment, hundreds of kidneys from deceased donors with hepatitis C virus (HCV) are discarded annually. Little is known about the determinants of willingness to accept HCV-infected kidneys among HCV-negative patients. METHODS:At 2 centers, 189 patients undergoing initial or reev...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002099
更新日期:2018-04-01 00:00:00
abstract::Portal vein thrombosis is the most common cause of portal hypertension in noncirrhotic patients. Variceal bleeding is difficult to treat in these patients, especially those with prehepatic diffuse portal mesenteric thrombosis. In a patient with refractory esophagogastroduodenal variceal bleeding as a result of diffuse...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000168344.16547.da
更新日期:2005-08-27 00:00:00
abstract:BACKGROUND:Neuromuscular blockade (NMB) reversal with neostigmine and glycopyrrolate has been reported to cause cardiac arrest in patients with a history of cardiac transplantation. The purpose of this study was to examine the safety of NMB reversal with acetylcholinesterase inhibitors and muscarinic anticholinergics i...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001060
更新日期:2016-12-01 00:00:00
abstract::Predictors of survival after lung transplant were analyzed in a large cohort of 990 lung transplanted patients from a single center. The overall survival was 41.6%, (41.5% in males, and 41.8% in females), the average length of the follow up was 45.84+/-51.98 months (range 0-282.47 months). Females tend to live longer ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31816c2fae
更新日期:2008-04-27 00:00:00
abstract:BACKGROUND:Renal warm ischemic injury and immunosuppression with cyclosporin A (CsA) may contribute to chronic allograft nephropathy after cadaveric transplantation. This study establishes whether CsA can sensitize the kidney to injury and fibrosis induced by renal warm ischemia (RWI). METHODS:The left kidney of Sprag...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000113850.34945.dc
更新日期:2004-03-15 00:00:00
abstract:BACKGROUND:A combined liver and kidney transplantation (CLKT) is advocated for selected individuals with chronic kidney disease undergoing liver transplantation (LT). The aim was to develop a risk score to identify the patients whose estimated glomerular filtration rate (eGFR) would decline during the year post-LT to a...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181d9e195
更新日期:2010-06-15 00:00:00
abstract:BACKGROUND:Altered expression of murine MD-1, a molecule controlling expression of members of the interleukin (IL)-1 receptor family of signaling proteins, regulates antigen-presenting cell-induced alloreactions. We investigated the effect of treatment with antisense deoxyoligonucleotides or antibodies to MD-1 in vivo ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200206150-00013
更新日期:2002-06-15 00:00:00
abstract:BACKGROUND:Obliterative bronchiolitis poses a primary obstacle for long-term survival of lung transplant recipients and manifests clinically as bronchiolitis obliterans syndrome (BOS). Establishing a molecular level screening method to detect BOS-related proteome changes before its diagnosis by forced expiratory volume...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318224c109
更新日期:2011-08-27 00:00:00