Abstract:
:The recent introduction of a variety of techniques for removing T cells from bone marrow grafts has reduced the incidence of graft-versus-host disease (GVHD)-associated morbidity and mortality. Whether this advance will be translated into improved patient survival is unclear at present, mainly because these procedures increase the risk of graft failure. Since 1983 we have transplanted 25 consecutive leukemia patients with HLA-identical sibling grafts purged of T cells by a single incubation with the monoclonal antibody Campath-1 and donor complement. This approach was successful in reducing T cell contamination of the graft and preventing acute and chronic GVHD. In this group of patients two suffered irreversible graft failure and one developed reversible graft failure. In a similarly sized group of patients previously transplanted with unpurged marrow according to the Seattle protocol, no episodes of graft failure occurred. Since other causes of graft failure, such as drug toxicity or viral infections, could be largely excluded, this suggested that the graft failures were specifically related to the purging process. In haploidentical bone marrow transplantation (BMT) O'Reilly has identified residual host-versus-graft activity (HVG) as a cause of graft failure. The causes and mechanisms of graft failure in T-depleted HLA-identical sibling transplants have not been extensively investigated to date. In the three graft failures observed by us, the loss of the graft was preceded by the appearance of a population of activated lymphocytes. We have determined the phenotype and origin of this population and investigated its interactions with donor hemopoietic tissue in vitro.
journal_name
Transplantationjournal_title
Transplantationauthors
Bunjes D,Heit W,Arnold R,Schmeiser T,Wiesneth M,Carbonell F,Porzsolt F,Raghavachar A,Heimpel Hdoi
10.1097/00007890-198704000-00009subject
Has Abstractpub_date
1987-04-01 00:00:00pages
501-5issue
4eissn
0041-1337issn
1534-6080journal_volume
43pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::The overall incidence of malignancy in renal transplant recipients is 100-fold higher compared with age matched controls. Routine clinical evaluation therefore often includes the determination of serum tumor markers AFP, CA19-9, CEA, CA125, CA15-3, PSA, and calcitonin. We evaluated the specificity and the sensitivity ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199611270-00021
更新日期:1996-11-27 00:00:00
abstract::Fine-needle aspiration biopsies were used for clinical monitoring of liver allografts; 21 patients with an inflammatory episode of acute rejection (12.0 +/- 3.3 CIU at the peak) were studied; all episodes were reversible. The inflammatory infiltrate consisted mainly of lymphoid cells, including lymphoid blasts, with i...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199011000-00011
更新日期:1990-11-01 00:00:00
abstract:BACKGROUND:Allogeneic hematopoietic stem cell transplantation is a potentially curative therapy for many malignant and nonmalignant hematologic diseases. However, acute graft-versus-host disease (aGVHD) is a lethal complication of hematopoietic stem cell transplantation, which limits its application. Cytokines such as ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31827e6b23
更新日期:2013-03-15 00:00:00
abstract:BACKGROUND:Deciphering the mechanisms of tolerance and chronic rejection (CR) remains a major goal in transplantation. Data in rodents suggest that Toll-like receptors (TLR), regulators of innate immune responses, play a role in determining graft outcome. However, few studies have focused on TLR expression in human kid...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31817b8dc5
更新日期:2008-07-15 00:00:00
abstract::Allograft recipients who have preformed antibodies to MHC determinants or develop these antibodies post-transplantation have a higher incidence of cellular rejection and graft loss. It is unclear whether this association is an etiologic one or whether the presence of these antibodies solely identifies individuals with...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND:Hemostatic complications are not uncommon after bone marrow transplantation (BMT). However, little is known about the frequency, localization, determinants, and outcome of hemostatic events in autologous and allogeneic BMT. METHODS:Four hundred forty-seven patients (364 allogeneic, 83 autologous transplants...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200211150-00018
更新日期:2002-11-15 00:00:00
abstract:BACKGROUND:Although proportionally more veterans live in rural areas compared to nonveterans, the impact of rurality status on kidney transplantation (KTP) access among veterans is unknown. Our objective was to study KTP rates among veterans listed for KTP and to compare the impact of rurality status on KTP rates among...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002624
更新日期:2019-09-01 00:00:00
abstract::The beneficial effect of deoxyspergualin (DSG, NKT-01) on lethal graft-versus-host disease in mice has been studied in a major histoincompatible donor-recipient combination. Suppression of the effector mechanisms responsible for the lethal outcome in this GVHD model is also noted. This study reveals: (1) DSG has a mar...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199103000-00032
更新日期:1991-03-01 00:00:00
abstract:BACKGROUND:Primary hyperoxaluria is a rare autosomal recessive metabolic disease that often progresses to end-stage renal disease (ESRD). Liver transplantation is curative for patients with the alanine: glyoxylate aminotransferase deficiency. For oxalosis patients with minor enzyme deficiencies, renal transplantation m...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/00007890-200209150-00020
更新日期:2002-09-15 00:00:00
abstract::Although solid organ transplant results have improved significantly in recent decades, a pivotal cause of impaired long-term outcome is the development of antibody-mediated rejection (AMR), a condition characterized by the presence of donor specific antibodies to human leukocyte antigen (HLA) or non-HLA antigens. High...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003551
更新日期:2020-11-17 00:00:00
abstract:BACKGROUND:Allogeneic bone marrow transplantation is under investigation for a range of nonmalignant indications, including tolerance induction through mixed chimerism. This strategy has so far been tested experimentally only in young recipients. Due to immunosenescence, older patients have an increase in memory T cell...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182954618
更新日期:2013-06-27 00:00:00
abstract:BACKGROUND:Patients at greatest risk of posttransplant lymphoproliferative disorder (PTLD) are those who acquire primary Epstein-Barr virus (EBV) infection after solid organ transplantation. The incidence of PTLD among patients who are EBV-seropositive before transplant is lower, and little is known about the differenc...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002898
更新日期:2019-11-01 00:00:00
abstract::Influenza vaccination has been strongly recommended for immunosuppressed renal transplant recipients. However, immunosuppression may lead to impaired antibody responses. We studied the antibody response to an inactivated trivalent influenza vaccine in 59 renal transplant recipients with life-sustaining kidney function...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198610000-00009
更新日期:1986-10-01 00:00:00
abstract:BACKGROUND:This study addresses the question of the mechanism for maintaining tolerance to donor alloantigen in the absence of antigen and the role of secondary lymphoid tissues. METHODS:Depleting anti-CD4 antibody administration in conjunction with allogeneic heart transplantation generates donor-specific operational...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000259928.16003.aa
更新日期:2007-05-15 00:00:00
abstract::Pregnancy after solid organ transplantation, although considered high risk for maternal, fetal, and neonatal complications, has been quite successful. Tacrolimus pharmacokinetic changes during pregnancy make interpretation of whole blood trough concentrations particularly challenging. There are multiple factors that c...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0b013e318278d367
更新日期:2013-04-15 00:00:00
abstract::The results of OKT3 use for steroid-resistant rejection rescue in adult liver transplantation were analyzed retrospectively from a single transplant center. Comparison was made with concurrent patients who had no rejection (NR) or steroid-responsive rejections (SR). The records of 290 patients who underwent 323 liver ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199301000-00017
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:According to a pooled analysis of three randomized clinical studies concerning the prevention of acute rejection in cadaveric renal transplantation, mycophenolate mofetil (MMF) proved superior to azathioprine or placebo in conjunction with cyclosporine (CsA) and steroids. MMF-treated patients showed reduced ...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007890-199908270-00023
更新日期:1999-08-27 00:00:00
abstract::Cyclosporine prevents the development of diabetes in spontaneously diabetic BB rats and NOD mice. However, islet transplants have been shown to be subject to immunologic destruction in hosts treated with CsA and anti-CD4 antibody or those rendered tolerant to donor antigens. This study determines whether the minimum d...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199005000-00001
更新日期:1990-05-01 00:00:00
abstract::Based upon encouraging experimental results, we began employing a synthetic perfusate for cadaver kidney preservation. The new perfusate contains hydroxyethyl starch (HES) as the sole colloid for oncotic support; 107 cadaver kidneys were preserved and transplanted (93 primary, 14 nonprimary) using the HES solution and...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198901000-00008
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Intestinal transplantation is known to be associated with a high risk of early complications and mortality. METHODS:We analyzed prospective data of 51 primary small bowel transplantations from December 1999 to August 2009 and identified perioperative factors that impact on early mortality (≤6 months after t...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318265c508
更新日期:2012-10-27 00:00:00
abstract::Cell-mediated cytotoxicity directed toward pancreatic islets plays a significant role in the pathogenesis of type 1 diabetes mellitus. Histologically, autoimmune insulitis appears as mononuclear infiltrates that precede actual beta cell loss. Experimental studies by Bartlett et al. on the BB rat model suggest that who...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199612270-00014
更新日期:1996-12-27 00:00:00
abstract:BACKGROUND:Previous reports have established the feasibility of using livers from controlled, non-heart-beating donors (CNHBD) with good immediate graft function. This has been largely borne out of necessity because of the donor shortage. METHODS:Retrospective database review for the last 7 years (1995-2002), encompas...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000128327.95311.e3
更新日期:2004-07-27 00:00:00
abstract::The influence of continuous immunosuppression on the immune system of 2 neonates born to heart-lung transplant recipients was analyzed. T cells, T cell subpopulations, B cells and cyclosporine levels were measured in maternal and cord blood at the time of delivery. Cyclosporine, both parent compound, and metabolites w...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198908000-00008
更新日期:1989-08-01 00:00:00
abstract:BACKGROUND:Adult orthotopic liver transplantation is associated with significant use of allogenic blood products, which places considerable demands on finite resources. This could be reduced by autologous red cell salvage use, and we evaluated its cost effectiveness in this prospective study. METHODS:Intraoperative au...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000199318.17013.c5
更新日期:2006-02-27 00:00:00
abstract:BACKGROUND:The impact of recipient body mass index on graft and patient survival after pancreas transplantation is not well known. METHODS:We have analyzed data from all pancreas transplant recipients reported in the Scientific Registry of Transplant Recipients between 1987 and 2011. Recipients were categorized into B...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000226
更新日期:2015-01-01 00:00:00
abstract::The term "accommodation" was invoked to describe endothelial cell resistance to antibody-mediated rejection after ABO-incompatible kidney or experimental xenograft transplantation. Currently, there is much interest in how to achieve successful human leukocyte antigen (HLA)-incompatible allograft transplantation in HLA...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31823f468c
更新日期:2012-02-15 00:00:00
abstract:BACKGROUND:DBA/2J kidney allografts, but not heart allografts, are spontaneously accepted indefinitely in C57BL/6 (B6) mice, through regulatory tolerance mechanism dependent on Foxp3 cells. In contrast, B6 kidneys are rejected within a week in DBA/2J recipients. We hypothesized that the tolerogenic difference of the ki...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002867
更新日期:2020-01-01 00:00:00
abstract::To establish the impact of transplantation on the course of chronic hepatitis B liver disease we performed a prospective study of the clinical and pathological sequelae of hepatitis B disease in all 22 patients who had renal allografts that functioned for more than 1 year and who were hepatitis B surface antigen (HBsA...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198506000-00007
更新日期:1985-06-01 00:00:00
abstract:BACKGROUND:The effective use of new steroid-sparing immunosuppressive regimens may lower cumulative glucocorticoid use among renal transplant recipients. However, it is unknown what effect this therapeutic trend has had on bone disease. METHODS:Unselected newly transplanted inpatients (n=45) were identified and compre...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200301150-00009
更新日期:2003-01-15 00:00:00
abstract:BACKGROUND:Increasing long-term allograft survival is the main challenge in organ transplantation, and allograft loss due to chronic rejection has been found to correlate with episodes of early acute rejection. It is important to understand the mechanisms that maintain the donor-specific hyporesponsive state. This stud...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/TP.0b013e3181af20fd
更新日期:2009-08-15 00:00:00