Abstract:
BACKGROUND:The impact of recipient body mass index on graft and patient survival after pancreas transplantation is not well known. METHODS:We have analyzed data from all pancreas transplant recipients reported in the Scientific Registry of Transplant Recipients between 1987 and 2011. Recipients were categorized into BMI classes, as defined by the World Health Organization. Short-term (90 days) and long-term (90 days to 5 years) patient and graft survivals were analyzed according to recipient BMI class using Kaplan-Meier estimates. Hazard ratios were estimated using Cox proportional hazard models. RESULTS:A total of 21,075 adult recipients were included in the analysis. Mean follow-up was 5 ± 1.1 years. Subjects were overweight or obese in 39%. Increasing recipient BMI was an independent predictor of pancreatic graft loss and patient death in the short term (P<0.001), especially for obese class II patient survival (hazard ratio, 2.07; P=0.009). In the long term, obesity, but not overweight, was associated with higher risk of graft failure (P=0.01). Underweight was associated with a higher risk of long-term death (P<0.001). CONCLUSION:These results question the safety of pancreas transplantation in obese patients and suggest that they may be directed to alternate therapies, such as behavioral modifications or bariatric surgery, before pancreas transplantation is considered.
journal_name
Transplantationjournal_title
Transplantationauthors
Bédat B,Niclauss N,Jannot AS,Andres A,Toso C,Morel P,Berney Tdoi
10.1097/TP.0000000000000226subject
Has Abstractpub_date
2015-01-01 00:00:00pages
94-9issue
1eissn
0041-1337issn
1534-6080journal_volume
99pub_type
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