Abstract:
BACKGROUND:Vaccine-preventable viral infections are associated with increased risk of morbidity and mortality in immunocompromised patients. Current guidelines recommend routine screening and vaccination of all patients before solid organ transplantation. We studied rates of immunity against vaccine-preventable viruses in liver transplantation (LT) recipients. METHODS:We retrospectively studied consecutive adult patients who underwent first deceased donor LT at a single center between August 2008 and October 2017. Viruses studied were hepatitis A (HAV), hepatitis B (HBV), varicella zoster virus (VZV), measles, and mumps. Hepatitis B surface antibody (anti-HBs) <10 IU/mL in HBV surface antigen-negative patients and negative IgG to other viruses was regarded as absent immunity. RESULTS:Five hundred and fifty-five patients underwent LT (72.4% male; median age, 55.0 y). Percentages of patients who lacked immunity to vaccine-preventable infections were HAV (31.8%), HBV (63.8%), measles (1.4%), mumps (6.6%), and VZV (3.8%). Age was positively associated with immunity (from either past exposure or vaccination) against most viruses, including HAV, measles, mumps, and VZV (P < 0.05 for all). In contrast, older age was marginally associated with anti-HBs <10 IU/mL (P = 0.046). No significant changes in immunity rates were observed during the study period. CONCLUSIONS:A substantial number of patients undergoing LT are not immune to vaccine-preventable viruses at the time of assessment. This presents an opportunity for pre-LT vaccination and in particular younger patients may need to be targeted.
journal_name
Transplantationjournal_title
Transplantationauthors
Gardiner A,Liu K,Bonnichsen M,Joshi V,Davis RJ,Strasser SIdoi
10.1097/TP.0000000000002722subject
Has Abstractpub_date
2019-11-01 00:00:00pages
2318-2322issue
11eissn
0041-1337issn
1534-6080journal_volume
103pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract:BACKGROUND:The use of lung grafts from non-heart-beating donors (NHBD) is one way of solving the donor organ shortage problem. In this experiment, we studied the effect of retrograde flush (RF) from the left atrium before harvest, inhaled nitric oxide (NO), and gabexate mesilate (FOY), a protease inhibitor, in the lung...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200005270-00008
更新日期:2000-05-27 00:00:00
abstract:BACKGROUND:Encapsulation of islets has been widely investigated as a treatment for diabetes. The characteristics and dynamics of insulin secretion by encapsulated islets in response to glucose and other secretagogues are not well understood. METHODS:In our study, macroencapsulated syngeneic islets at 3-4 wk after tran...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200101270-00006
更新日期:2001-01-27 00:00:00
abstract:BACKGROUND:The ability to induce tolerance, or at least minimize the need for immunosuppressive therapy, is a high priority in organ transplantation. Accomplishing this goal requires a novel method for determining when a patient has become tolerant to or is rejecting their graft. Here, we sought to develop an efficient...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182696a5b
更新日期:2012-10-27 00:00:00
abstract::Mice immunized with allogeneic cells exhibit a local component of cellular immunity that is confined to lymph nodes draining the site of immunization. After immunization of C3H mice by skin grafting or by i.p. or footpad injection of F1 hybrid spleen cells, draining lymph nodes show increased responsiveness toward the...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198107000-00006
更新日期:1981-07-01 00:00:00
abstract::Infectious complications in patients with recurrent hepatitis C virus (HCV) hepatitis after liver transplantation were prospectively assessed and compared with those of all other liver transplant recipients without HCV hepatitis operated on during the same period. Major infections occurred in 64% (14/22) of the patien...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199602150-00014
更新日期:1996-02-15 00:00:00
abstract:BACKGROUND:The deceased donor score (DDS), expanded criteria donor (ECD) definition, and resistive index (RI) were developed for pretransplant evaluation of donors. DDS and ECD are determined by a calculation of risk from donor variables, while RI is determined from flow characteristics of kidneys during machine preser...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000173798.04043.af
更新日期:2005-10-15 00:00:00
abstract:BACKGROUND:Strong alloreactive T cell responses are a menace in transplantation surgery and their menagement requires understanding the basis of alloreactivity. Alloantigen recognition can be peptide independent, peptide specific, or peptide dependent. The mechanisms influencing each recognition pattern are largely unk...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200203150-00024
更新日期:2002-03-15 00:00:00
abstract::Loss of renal mass has been associated with the development of glomerular sclerosis in animals and human beings. The pathophysiology of this renal injury is unknown, but glomerular sclerosis in animals can be aggravated or accelerated following exposure to nephrotoxic antibodies, puromycin aminoglycoside or renal irra...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198410000-00006
更新日期:1984-10-01 00:00:00
abstract::The aim of this study was to assess the efficacy of an enteral diet fortified with arginine, RNA, and fish oil (Impact), alone and in combination with cyclosporine (CsA) and donor-specific transfusion (DST) on allograft survival in the ACI:Lewis rat cardiac transplant model. Animals were fed ad libitum with either sta...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1995-10-27 00:00:00
abstract::Renal vasoconstriction has been implicated as a major contributing factor for the nephrotoxic effects of cyclosporine. In an attempt to assess the relative contribution of thromboxane (Tx), the effects of coadministering CsA with the selective Tx synthetase inhibitor, Dazmegrel (DAZ) (Pfizer, Inc.), were determined. R...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199111000-00016
更新日期:1991-11-01 00:00:00
abstract::We developed a new and simplified donor-specific blood transfusion (DSBT) protocol for prospective kidney transplant recipients from one-haplotype-mismatched related donors. Prospective kidney donors gave 450 ml of blood in a quad-pack unit, and the blood was stored in a blood bank. Twenty-five patients were transfuse...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198411000-00012
更新日期:1984-11-01 00:00:00
abstract:BACKGROUND:Monoclonal antibody induced tolerance to high doses of multiple lymphocyte stimulating (MLS)+minor mismatched bone marrow has recently been associated with clonal deletion, as reported in fully allogeneic models of bone marrow transplantation. FasL-induced apoptosis has been shown to mediate antigen-specific...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200004270-00025
更新日期:2000-04-27 00:00:00
abstract::The aim of this study was to assess directly the function of isolated hepatocytes 1 year after transplantation into the spleen, using an original model of isolated rat-spleen perfusion. Three specific liver functions, albumin synthesis, indocyanine-green clearance, and antipyrine oxidation, were studied. Five x 10(6) ...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1990-04-01 00:00:00
abstract:BACKGROUND:The infiltration of epithelium by CD8+ T lymphocytes in human renal or liver allografts is a critical feature of acute rejection. CD103 expression can be acquired in vitro by CD8+ cytotoxic T lymphocytes in response to allogeneic renal epithelial cells and promotes their adhesion to epithelium and subsequent...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:2000-07-15 00:00:00
abstract:BACKGROUND:Lipid peroxidation by free radicals is a key step in the development of atherosclerosis. Chronic graft nephropathy (CGN) is a common cause of allograft failure and shares many histologic features with atherosclerosis. Although hyperlipidemia is a common finding in renal transplant recipients, not all patient...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000090750.47058.24
更新日期:2003-10-15 00:00:00
abstract::Late deaths (after more than 1 year) after liver transplantation were analyzed in a series of 464 consecutive patients who received liver grafts between 1982 and 1993. Recipients who survived the first posttransplant year (n = 365) had actuarial 5- and 10-year survival rates of 92% and 84%, respectively. Thirty-five p...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199605150-00016
更新日期:1996-05-15 00:00:00
abstract:BACKGROUND:Our objective was to evaluate graft equilibration with high viscosity (University of Wisconsin solution [UW]) or low viscosity (Bretschneider's histidine-tryptophan-ketoglutarate [HTK]) during liver procurement from non-heart beating donors (NHBD) and the potential impact of a preceding fibrinolysis with str...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200106270-00015
更新日期:2001-06-27 00:00:00
abstract::To investigate whether graft-versus-host reactivity (GVHR) and the graft-versus-leukemia (GVL) effect can be differentiated, C3H-->AKR mixed bone marrow (BM) chimeras were prepared using two different conditioning regimens. Total body irradiation (TBI) chimeras were induced by infusing 5 x 1O(6) T cell depleted syngen...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199603150-00025
更新日期:1996-03-15 00:00:00
abstract:BACKGROUND:Acute myeloid leukemia (AML) after solid organ transplantation is rare, with only six AML cases after liver transplantation (LT) being reported. METHODS:Characteristics of three AML cases observed among 799 recipients of LT in the authors' institution and estimation of the standardized incidence ratio (SIR)...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.TP.0000102549.40531.13
更新日期:2004-01-27 00:00:00
abstract::Immunosuppression with sirolimus and low-dose tacrolimus has facilitated successful clinical islet transplantation (CIT). Because the long-term effects on the kidney are unknown and immunosuppressant drugs can be nephrotoxic, CIT is currently restricted to patients with preserved renal function or a functioning renal ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000134971.15093.07
更新日期:2004-09-27 00:00:00
abstract:BACKGROUND:The expression of xenogeneic epitopes and the activation of human complement by adult pig islets after prolonged culture have hitherto not been described. MATERIALS AND METHODS:Freshly isolated and cultured islets were analyzed by fluorescence-activated cell sorter analysis, fluorescence microscopy, and imm...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199705270-00015
更新日期:1997-05-27 00:00:00
abstract:BACKGROUND:Human leukocyte antigen (HLA) antibodies, especially those that fix complement, are associated with antibody-mediated rejection and graft failure. The C1q assay on single antigen beads detects a subset of HLA antibodies that can fix complement and precede C4d deposition. The aim of this study was to determin...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318203fd26
更新日期:2011-02-15 00:00:00
abstract:BACKGROUND:Both number and origin (donor vs. host) of dendritic cells (DC) are associated with acute graft-versus-host disease (aGvHD), relapse and graft failure after human allogeneic hematopoietic cell transplantation (aHCT). METHODS:We prospectively and simultaneously investigated skin and blood DC subtypes, their ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000203318.16224.57
更新日期:2006-03-27 00:00:00
abstract:BACKGROUND:A kidney transplant recipient inadvertently contracted donor-origin melanoma, which was found to be very advanced at presentation. Withdrawal of immunosuppression failed to induce rejection, and interferon-alpha was required. When florid allograft rejection was in progress, the allograft was removed, before ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199809150-00020
更新日期:1998-09-15 00:00:00
abstract:BACKGROUND:Clinical studies suggest that the immunosuppressant mycophenolate mofetil is associated with anemia. However, the mechanism for this is not known. Here, we studied the effect of mycophenolic acid (MPA), the active metabolite of mycophenolate mofetil, on erythropoiesis in vitro. METHODS:Both UT-7 cells and p...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318238da98
更新日期:2011-12-27 00:00:00
abstract::Renal transplantation is the preferred treatment for end-stage renal disease in children. Most transplant failures are due to allograft rejection. To date, only histopathological findings on renal biopsy can establish this diagnosis. Prior to the availability of cyclosporine, technetium-99m sulfur colloid nuclear scan...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199212000-00005
更新日期:1992-12-01 00:00:00
abstract:BACKGROUND:Infections and acute graft-versus-host disease (GvHD) represent major complications of allogeneic stem-cell transplantation (SCT). Dendritic cells (DCs) display an extraordinary capacity to induce innate and adaptive immune responses. Therefore, they play a crucial role in the elimination of pathogens and in...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31824fd8b4
更新日期:2012-06-27 00:00:00
abstract:BACKGROUND:Neutrophilic tubulitis accompanied by intratubular neutrophil clusters in the renal allograft is a surrogate marker for urinary tract infection (UTI). Overlapping histologic findings can occur in antibody-mediated rejection, which is characterized by peritubular capillary (PTC) deposition of C4d. This study ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31819ca304
更新日期:2009-04-15 00:00:00
abstract::Preventing hyperacute rejection (HAR) is a difficult and unsolved problem in xenotransplantation. This may be due, in part, to a lack of therapies that can suppress production of natural antibodies (NA), which are thought to be critical mediators of HAR. This study examined the effect of 15-deoxyspergualin (DSPG) and ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199207000-00004
更新日期:1992-07-01 00:00:00
abstract:BACKGROUND:The literature indicates few studies on kidney patients' perception of the donor kidney. In light of this fact, we decided to explore this issue with adult patients. METHODS:We carried out a phenomenological study with 40 adult kidney patients. RESULTS:In this study, three main themes became apparent: the ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000168149.95310.6e
更新日期:2005-08-27 00:00:00