Local cellular immunity in the draining lymph nodes of mice after immunization with histocompatibility alloantigens.

abstract：:The properties of rat liver dendritic cells (DC) were analyzed after collagenase digestion of the tissue and enrichment with density gradient centrifugation. The liver macrophages (Kupffer cells) were eliminated by adherence before the gradient centrifugation. The morphology of isolated DC in May-Grunwald-Giemsa (MGG)...

journal_title：Transplantation

authors： Lautenschlager I,Halttunen J,Häyry P

更新日期：1988-05-01 00:00:00

abstract：:Thirteen renal allograft recipients (6 patients on cyclosporine/7 patients on azathioprine) participated in a short-term oral protein-loading study to determine the effect of cyclosporine on an allograft's functional reserve. The baseline glomerular filtration rate of the two groups were similar (52 +/- 18 ml/min/1.73...

journal_title：Transplantation

authors： Nunley JR,King A,Comstock T,Posner M,Marshall C,Sica DA

更新日期：1991-01-01 00:00:00

abstract：:Complement plays important roles in both ischemia-reperfusion injury (IRI) and antibody-mediated rejection (AMR) of solid organ allografts. One approach to possibly improve outcomes after transplantation is the use of C1 inhibitor (C1-INH), which blocks the first step in both the classical and lectin pathways of compl...

journal_title：Transplantation

authors： Berger M,Lefaucheur C,Jordan SC

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Anti-thymocyte globulin (ATG) is used frequently as induction therapy in renal transplant recipients. It has been standard practice that the various polyclonal anti-lymphocyte preparations be administered via central line, vascular shunt, or arteriovenous fistula to avoid thrombophlebitis. METHODS:We have s...

journal_title：Transplantation

authors： Rahman GF,Hardy MA,Cohen DJ

更新日期：2000-05-15 00:00:00

abstract：:A portable hypothermic perfusion system for storage of hearts has been developed. The system uses the airlift pump principle, whereby the flow of gas maintains circulation of the perfusate through the heart; no other energy source is required. Performance on ex vivo functional testing of 10 pig hearts stored for 20 to...

journal_title：Transplantation

authors： Wicomb WN,Cooper DK,Barnard CN

更新日期：1982-11-01 00:00:00

abstract：:Endothelial chimerism in transplanted organs is a fascinating phenomenon, indicative of a mechanism by which progenitor recipient cells replace the donor endothelium. It has been hypothesized that this replacement could lead to a decrease in alloreactivity and thus would positively influence graft outcome. However, re...

journal_title：Transplantation

authors： Koopmans M,Kremer Hovinga IC,Baelde HJ,de Heer E,Bruijn JA,Bajema IM

更新日期：2006-07-15 00:00:00

abstract：:The absorption of oral cyclosporine (CsA) was studied in a canine small intestinal transplantation model. Absorption of CsA was almost absent in bowel-resected dogs. Autotransplanted dogs showed a persisting malabsorption of CsA (mean peak of 687 +/- 348 ng/ml vs. 1683 +/- 154 ng/ml in control dogs). Allotransplanted ...

journal_title：Transplantation

authors： Wassef R,Cohen Z,Nordgren S,Langer B

更新日期：1985-05-01 00:00:00

abstract：BACKGROUND:Deoxyspergualin (DSG), a potent immunosuppressive drug, has been clinically used as a rescue therapy for acute graft rejection. However, DSG has severe adverse effects that limits its use. Here, we examined the optimized therapeutic protocol for DSG using chronopharmacological profiles of it. METHODS:First,...

journal_title：Transplantation

authors： Uchida H,Kobayashi E,Matsuda K,Mizuta K,Sugimoto K,Kawarasaki H,Hashizume K,Fujimura A

更新日期：1999-05-15 00:00:00

abstract：BACKGROUND:Previous studies have shown that posttransplant total lymphoid irradiation, anti-thymocyte globulin, and an intravenous donor blood cell infusion induce tolerance to ACI heart allografts in Lewis rat hosts. METHODS:In the current study, fresh ACI monocytes and dendritic cell precursors, derived from short-t...

journal_title：Transplantation

authors： Hayamizu K,Huie P,Sibley RK,Strober S

更新日期：1998-11-27 00:00:00

abstract：:Anti-CD3 mAbs are potent inhibitors of T cell function; however, administration of mitogenic mAb can cause significant morbidity secondary to T cell activation and cytokine release. Nonmitogenic anti-CD3 mAb is immunosuppressive in mice without inducing detectable morbidity, and may thus be preferable for in vivo T ce...

journal_title：Transplantation

authors： Sawchuk SS,Gates R,Hirsch R

更新日期：1995-12-15 00:00:00

abstract：:Experimental evidence suggests storing lungs inflated with oxygen and with oxidizable substrate improves results of lung transplantation. Glucose is included in the low-potassium-dextran (LPD) solution Perfadex to achieve this goal. The authors hypothesized that other substrates might be more effective. Rat lungs were...

journal_title：Transplantation

authors： Peltz M,He TT,Adams GA 4th,Chao RY,Meyer DM,Jessen ME

更新日期：2005-08-15 00:00:00

abstract：:Liver transplantation (LT) is the most effective treatment for small and unresectable hepatocellular carcinomas (HCCs). With scarcity of deceased donor livers, living donor LT (LDLT) is the alternative to deceased donor LT (DDLT). Animal studies have suggested that regeneration of the partial liver graft encourages HC...

journal_title：Transplantation

authors： Chan SC

更新日期：2014-04-27 00:00:00

abstract：BACKGROUND:HLA-specific antibodies detected by solid phase assays are increasingly used to define unacceptable HLA antigen mismatches (UAM) before renal transplantation. The accuracy of this approach is unclear. METHODS:Day of transplant sera from 211 complement-dependent cytotoxicity crossmatch-negative patients were...

journal_title：Transplantation

authors： Zecher D,Bach C,Preiss A,Staudner C,Utpatel K,Evert M,Jung B,Bergler T,Böger CA,Spriewald BM,Banas B

更新日期：2018-06-01 00:00:00

abstract：:A prospective randomized trial was performed comparing survival of cadaveric grafts allocated by HLA-A+B matching and HLA-DR matching. The two allocation methods resulted in very similar graft survivals. HLA-A matching had no significant effect on graft survival. HLA-B and HLA-DR matching were shown to have approximat...

journal_title：Transplantation

authors： d'Apice AJ,Sheil AG,Tait BD,Bashir HV

更新日期：1984-07-01 00:00:00

abstract：:The presence of anti-GOR was determined in paired pre-orthotopic liver transplantation (pre-OLT) and post-OLT sera from 87 OLT patients with hepatitis C virus infection. Before OLT, 48/87 patients were seropositive for anti-GOR, but this marker had no relationship with the clinical and biochemical parameters, or virem...

journal_title：Transplantation

authors： Reiser M,Terrault N,Nelson DR,Mizokami M,Ferrell L,Lake JR,Roberts JP,Ascher NL,Wright TL,Lau JY

更新日期：1997-02-27 00:00:00

abstract：BACKGROUND:Early enteral nutrition with solutions containing prebiotics (fiber) and probiotics (Lactobacillus) is suggested to reduce bacterial translocation and minimize the incidence of infections after liver transplantation. METHODS:In a prospective, randomized placebo-controlled trial consisting of 95 patients, we...

journal_title：Transplantation

authors： Rayes N,Seehofer D,Hansen S,Boucsein K,Müller AR,Serke S,Bengmark S,Neuhaus P

更新日期：2002-07-15 00:00:00

abstract：:The immunosuppressive effects of cyclosporin A were tested in a DA (RT-1a) to Lewis (RT-1(1) rat renal allograft model, which represents a very strong histocompatibility barrier. Dose-response studies established that oral doses of 5 mg/kg/day or higher gave complete suppression of rejection, while oral doses of 2 mg/...

journal_title：Transplantation

authors： Homan WP,Fabre JW,Williams KA,Millard PR,Morris PJ

更新日期：1980-05-01 00:00:00

abstract：BACKGROUND:Injection of neonatal BALB/c mice with semi-allogeneic splenocytes leads to antigen-specific tolerance lasting into adulthood. Tolerant mice accept A/J skin grafts and fail to generate CD8 cytotoxic T lymphocyte (CTL) activity against A/J targets. Anergic CD8 T cells are present in tolerant mice, and CD4 reg...

journal_title：Transplantation

authors： Gao Q,Rouse TM,Kazmerzak K,Field EH

更新日期：1999-12-27 00:00:00

abstract：BACKGROUND:Immunosuppressive drugs that target T cells are useful for prolonging allograft survival. The anti-CD3 immunotoxin FN18-CRM9 has been shown to effectively prolong renal allograft survival in a rhesus monkey model of transplantation. However, immunotoxin-treated monkeys showed increased levels of inflammatory...

journal_title：Transplantation

authors： Hamawy MM,Tsuchida M,Manthei ER,Dong Y,Fechner JE,Knechtle JS

更新日期：1999-09-15 00:00:00

abstract：BACKGROUND:The emergence of a ganciclovir (GCV)-resistant human cytomegalovirus (HCMV) strain in a heart transplant recipient (HTR) coinfected by multiple HCMV strains was investigated. METHODS:A HTR with primary HCMV infection was treated with three induction courses of intravenous GCV followed by a 2-month maintenan...

journal_title：Transplantation

authors： Baldanti F,Simoncini L,Sarasini A,Zavattoni M,Grossi P,Revello MG,Gerna G

更新日期：1998-08-15 00:00:00

abstract：:Programmed cell death (PCD) is currently one of the most intensively studied areas in cell biology. Substantial evidence now exists demonstrating the integral role of PCD in many fundamental immunologic processes; therefore, understanding the mechanisms of PCD may provide advances with broad implications in immunobiol...

journal_title：Transplantation

authors： Woodle ES,Kulkarni S

更新日期：1998-09-27 00:00:00

abstract：BACKGROUND:For cyclosporine (CsA), 2-hr postdose level (C2) is the best single time point predictor of the area under the curve and a critical measure for effective dosing. The therapeutic CsA microemulsion (Neoral) C2 range in de novo heart transplant patients remains to be determined. PURPOSE:The purpose of this stu...

journal_title：Transplantation

authors： Cantarovich M,Ross H,Arizón JM,Gómez MA,Straatman L,Orús J,Alonso-Pulpón L,Molina BD,Wang S,Lage E,Crespo MG,Manito N,Howlett J,Haddad H,Motown Study Group.

更新日期：2008-04-15 00:00:00

abstract：:Mandatory continuous monitoring of early transplant outcome with centralized oversight was introduced in 2004 for all 23 UK adult kidney transplant units. Risk-adjusted cumulative sum charts are used to assess 30-day graft and patient survival against past performance for each center, and change in transplant center p...

journal_title：Transplantation

authors： Collett D,Sibanda N,Pioli S,Bradley JA,Rudge C

更新日期：2009-10-27 00:00:00

abstract：:To evaluate the efficacy of University of Wisconsin (UW) solution for lung preservation, we performed canine lung allotransplantation with lungs preserved in UW solution. Donor lungs from eight dogs were flushed with UW solution and lungs from four dogs with Euro-Collins solution, and these were preserved for 24 hr in...

journal_title：Transplantation

authors： Kawahara K,Itoyanagi N,Takahashi T,Akamine S,Kobayashi M,Tomota M

更新日期：1993-01-01 00:00:00

abstract：:The particular T cell subsets involved in the rejection of tumor allografts were examined in mice using two different approaches. In the first, EL4 lymphoma cells or B16 melanoma cells were given to ATXBM-CBA/H mice which had been reconstituted with either naive or sensitized T cells selectively depleted with either L...

journal_title：Transplantation

authors： Loveland BE,McKenzie IF

更新日期：1982-02-01 00:00:00

abstract：:Orthotopic liver transplantation is frequently associated with a complex coagulation disorder, influencing the outcome of the procedure. In this respect, disseminated intravascular coagulation (DIC) had been suggested to be of causative importance for bleeding complications after reperfusion of the liver graft. In 10 ...

journal_title：Transplantation

authors： Riess H,Jochum M,Machleidt W,Himmelreich G,Blumhardt G,Roissaint R,Neuhaus P

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:Reactivation of cytomegalovirus (CMV) is frequently observed in recipients of solid organs and bone marrow transplants and is associated with increased risk of acute and chronic allograft rejection, opportunistic infection, graft failure, and patient mortality. The molecular mechanisms by which reactivation ...

journal_title：Transplantation

authors： Zhang Z,Li Z,Yan S,Wang X,Abecassis M

更新日期：2009-09-15 00:00:00

abstract：:Recent reports document the efficacy of transjugular intrahepatic portocaval shunts (TIPS) for the prevention of portal hypertensive bleeding and have advocated its use as a bridge to liver transplantation. There are no reports, however, analyzing liver transplant results for patients with indwelling TIPS. We reviewed...

journal_title：Transplantation

authors： Freeman RB Jr,FitzMaurice SE,Greenfield AE,Halin N,Haug CE,Rohrer RJ

更新日期：1994-08-15 00:00:00

abstract：:Liver transplantation for patients requiring life-support results in the lowest survival and highest costs. A ten year (1983-1993) regional experience with liver transplantation for critically ill patients was undertaken to ascertain the fate of several subgroups of patients. Of the 828 liver transplants performed at ...

journal_title：Transplantation

authors： Washburn WK,Bradley J,Cosimi AB,Freeman RB,Hull D,Jenkins RL,Lewis WD,Lorber MI,Schweizer RT,Vacanti JP,Rohrer RJ

更新日期：1996-01-27 00:00:00

abstract：BACKGROUND:Chronic red cell aplasia can develop in immunocompromised patients including transplant recipients infected with parvovirus B19 (PV B19). Renal involvement with PV B19 infection is not well-recognized. METHODS:We diagnosed erythroid hypoplasia associated with PV B19 infection in three renal transplant recip...

journal_title：Transplantation

authors： Moudgil A,Shidban H,Nast CC,Bagga A,Aswad S,Graham SL,Mendez R,Jordan SC

更新日期：1997-12-27 00:00:00