Abstract:
:Infectious complications in patients with recurrent hepatitis C virus (HCV) hepatitis after liver transplantation were prospectively assessed and compared with those of all other liver transplant recipients without HCV hepatitis operated on during the same period. Major infections occurred in 64% (14/22) of the patients with recurrent HCV hepatitis versus 38% (30/78) of all other patients (P = 0.04). Patients with recurrent HCV hepatitis had significantly more episodes of major infections (mean 1.45 episodes/patient vs. 0.51 episodes/patients, P = .003) and were more likely to have recurrent episodes of major infections (45%, 10/22, vs. 10%, 8/78, P = 0.005) than all other patients, respectively. The incidence of major bacterial infections was not higher in patients with recurrent HCV hepatitis (41% vs. 28%, P = NS); however, incidence of fungal infections was higher (18% vs. 6%, P = 0.10) and incidence of cytomegalovirus disease was significantly higher (32% vs. 9%, P = 0.012) in patients with recurrent HCV hepatitis as compared with all other patients. Late infections, i.e., those occurring > 6 months after transplantation, were significantly higher in patients with recurrent HCV (27% vs. 6%, P = 0.011). Rejection episodes occurring within 6 months after transplantation were higher in patients with recurrent HCV hepatitis (P = 0.09); however, the intensity of immunosuppression as measured by corticosteroid boluses and cycles was not significantly different in these patients when compared with all other patients. Aminotransferase levels were significantly higher in patients with HCV recurrence than in other patients. We conclude that recurrent HCV hepatitis after liver transplantation is associated with a high incidence of infections due to pathogens associated with depressed cell-mediated immunity. Future studies should assess the exact nature of the suppressive effect on host defense in recurrent HCV hepatitis.
journal_name
Transplantationjournal_title
Transplantationauthors
Singh N,Gayowski T,Wagener MM,Marino IRdoi
10.1097/00007890-199602150-00014subject
Has Abstractpub_date
1996-02-15 00:00:00pages
402-6issue
3eissn
0041-1337issn
1534-6080journal_volume
61pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::The stability of HLA alloantibodies was studied in 128 antibody-positive, potential kidney transplant recipients over an average period of 3 years. Antibody detection was performed using an anti-human globulin-complement-dependent cytotoxicity technique. In this study, the specificity of antibodies was categorized as ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199703270-00015
更新日期:1997-03-27 00:00:00
abstract::The effects of dietary (10% calories) safflower (SAF), evening primrose (EPO), and fish oil (F) as sources of linoleic acid (control), gamma-linolenic acid, and long-chain n-3 fatty acids, respectively, on cardiovascular and renal responses to chronic (5 weeks) cyclosporine administration were studied in male borderli...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199203000-00030
更新日期:1992-03-01 00:00:00
abstract::A murine IgG1 antibody specific for the IL-2-binding site on the human lymphocyte IL-2 receptor beta chain (CD25) was evaluated in 11 patients who developed acute graft-versus-host disease following allogeneic marrow transplantation. All patients had received cyclosporine and methotrexate for prophylaxis of GVHD, eith...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199007000-00010
更新日期:1990-07-01 00:00:00
abstract::CD18 antibodies react with the common beta chain of the human leukocyte function antigen (LFA1)* and thus block the functions mediated by the three identified molecules in humans. A murine CD18 monoclonal antibody was infused in 8 leukemic patients receiving allogeneic T-depleted bone marrow transplantation in order t...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198903000-00014
更新日期:1989-03-01 00:00:00
abstract:BACKGROUND:Systemic inhibition of serum CD26/dipeptidylpeptidase (DPP IV) enzymatic activity abrogated acute rejection of pulmonary allografts, whereas organ-specific inhibition ameliorated ischemia/reperfusion injury in syngeneic transplants. Here, we analyze the effect of allograft-specific inhibitor preconditioning ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181b08e77
更新日期:2009-08-27 00:00:00
abstract::The nephrotoxic effects of cyclosporine (CsA) seem to be augmented by co-existing renal injury. A high rate of prolonged delayed function (acute tubular necrosis [ATN]) and non-function (NF) has been associated with the use of CsA prior to and following renal transplantation. Cyclosporine has also been associated with...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198701000-00019
更新日期:1987-01-01 00:00:00
abstract::Alemtuzumab is a humanized CD52-specific monoclonal antibody that is increasingly used off-label as an induction agent in solid organ transplantation, particularly in the setting of maintenance immunosuppression minimization protocols. In this review, we briefly discuss this agent's mechanisms of action and summarize ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000296680.75175.67
更新日期:2007-12-27 00:00:00
abstract::Donation physicians are specialists with expertise in organ and tissue donation and have been recognized internationally as a key contributor to improving organ and tissue donation services. Subsequent to a 2011 Canadian Critical Care Society-Canadian Blood Services consultation, the donation physician role has been g...
journal_title:Transplantation
pub_type: 杂志文章,实务指引
doi:10.1097/TP.0000000000001694
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:Infections are a major cause of morbidity and mortality in kidney allograft recipients. In this post hoc analysis of a randomized clinical trial which tested the effect of denosumab on bone mineral density, we assessed the impact of this drug on the incidence and severity of infections in the first year afte...
journal_title:Transplantation
pub_type: 杂志文章,随机对照试验
doi:10.1097/TP.0000000000001547
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Little is known about innate lymphoid cell (ILC) populations in the human gut, and the turnover of these cells and their subsets after transplantation has not been described. METHODS:Intestinal samples were taken from 4 isolated intestine and 3 multivisceral transplant recipients at the time of any operativ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001593
更新日期:2017-10-01 00:00:00
abstract::Requirements for sustained engraftment of fetal liver hematopoietic stem cells were evaluated in 45 dogs. Pretransplant preparative treatment with total-body irradiation, 14.7 Gy, permitted engraftment of DLA-compatible fetal liver cells. Radiation alone was inadequate in DLA-haploidentical or DLA-mismatched transplan...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198712000-00004
更新日期:1987-12-01 00:00:00
abstract::Pulmonary complications are often lethal components of acute graft-vs.-host disease (GVHD). Although interstitial pneumonitis and lymphocytic bronchitis have been implicated as elements of acute GVHD, previous studies have not determined a correlation between the onset of these histopathologies or their contribution t...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1994-07-27 00:00:00
abstract::A patient with end-stage renal disease and known benign monoclonal gammopathy underwent kidney transplantation at Westchester County Medical Center, Valhalla, NY. After surgery, during routine follow-up, the patient had laboratory evidence of frank multiple myeloma. However, she did not show any clinical signs or symp...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/00007890-199612150-00008
更新日期:1996-12-15 00:00:00
abstract::Ranolazine is a new drug with a novel mode of action as a metabolic modulator and membrane stabilizer. In this prospective randomized double-blind trial, a porcine model of renal autotransplantation was used to assess the effects of this drug during preservation and reperfusion of kidneys cold-stored for 24 hr in phos...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199011000-00004
更新日期:1990-11-01 00:00:00
abstract::The humoral theory states that antibodies cause the rejection of allografts. From 1917 to 1929, extensive efforts were made to produce antibodies against tumors. It was finally realized that the antibodies were produced against the transplant antigens present on transplantable tumors, not against the tumor-specific an...
journal_title:Transplantation
pub_type: 历史文章,杂志文章
doi:10.1097/TP.0b013e3182483713
更新日期:2012-04-27 00:00:00
abstract:BACKGROUND:Membrane CD30 is an important costimulatory molecule for activated T lymphocytes, and serum level of soluble CD30 (sCD30) is considered a marker for predicting outcome in kidney transplantation. METHODS:We investigated the kinetics of CD30 expression on CD4 and CD8 T-cell populations and the source of sCD30...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318296fd69
更新日期:2013-07-27 00:00:00
abstract::Preformed recipient HLA-specific antibodies can cause hyperacute rejection of a transplanted kidney if they are directed against mismatched donor HLA antigens. To avoid hyperacute rejection it is essential that recipient antibodies be identified during patient workup for transplantation and HLA antigens to which a pat...
journal_title:Transplantation
pub_type: 评论,杂志文章
doi:10.1097/00007890-200105270-00002
更新日期:2001-05-27 00:00:00
abstract::The aim of this study was to assess the feasibility of detecting anti-HLA antibodies in eluates from needle core biopsies of renal transplants with chronic allograft nephropathy. Two methods of screening, the enzyme-linked immunosorbent assay (ELISA) and flow cytometry (FlowPRA) were compared. Twenty renal transplants...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000156164.54216.de
更新日期:2005-05-27 00:00:00
abstract:BACKGROUND:Kidney donors and transplant recipients may be at risk of complications from glomerular hyperfiltration of the single kidney. It has been assumed that tests of the existence of renal functional reserve [delta glomerular filtration rate (deltaGFR), delta effective renal plasma flow (deltaERPF)] can be used to...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200011150-00013
更新日期:2000-11-15 00:00:00
abstract::We have analyzed PBL from 7 children exposed to CsA in utero and 4 children exposed to AZA in utero. Expression of CD3, CD4, CD8, and CD20 were normal for both groups of children; however, significant differences were detected in the expression of CD45RA, CD45R0, and CD29. While CsA-exposed children had higher density...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199401000-00021
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Natural antibodies that bind the carbohydrate antigen Galalpha1-3Galbeta1-4GlcNAc-R (alphaGal) mediate rigorous rejection of porcine xenografts and represent a major immunological hurdle to successful discordant xenotransplantation. However, little is known about how production of antibodies specific for alp...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200205270-00007
更新日期:2002-05-27 00:00:00
abstract::Adult bone marrow-derived mesenchymal stem cells (MSCs) are multipotential cells capable of regenerating injured tissues. In addition to their multipotency, MSCs inhibit natural killer cell cytotoxicity and T-lymphocyte alloproliferation. Several immunosuppressive mechanisms have been described, including indoleamine ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181a2a4b3
更新日期:2009-05-15 00:00:00
abstract::Despite human leukocyte antigen (HLA) identity between donor and recipient, several patients develop acute graft-versus-host disease (aGVHD) after hematopoetic stem cell transplantation (HSCT) because of minor histocompatibility antigen (mHag) incompatibilities. The impact of multiple mHag disparities on the clinical ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000120175.25116.cb
更新日期:2004-04-15 00:00:00
abstract:BACKGROUND:Humanized Fc receptor (FcR)-nonbinding antibodies against CD3 are promising immunosuppressive agents that may overcome both the neutralizing response to and the cytokine release syndrome seen with conventional monoclonal antibodies against CD3. In addition, evidence from several murine models suggests that t...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200104150-00020
更新日期:2001-04-15 00:00:00
abstract:BACKGROUND:Extended partial hepatectomy (PH) in patients is leading to portal hyperperfusion but reduced hepatic arterial perfusion (HAP), and is invariably causing focal hepatic venous outflow obstruction (FHVOO). We observed in a rat model that PH in combination with right median hepatic vein ligation (RMHV-L) caused...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000089
更新日期:2014-05-27 00:00:00
abstract::Kidney transplantation in elderly patients is a good therapeutic option, but the incidence of infections compared to younger patients must be studied. Case and control study was performed with 40 cases (patients older than 65) and 40 controls (younger than 65) receiving a kidney transplant between January 2000 and Aug...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000173822.05877.d7
更新日期:2005-10-15 00:00:00
abstract:BACKGROUND:Black American heart transplant recipients receiving cyclosporine-based primary immunoprophylaxis suffer higher rates of allograft rejection with hemodynamic compromise, infections, and posttransplant coronary artery disease. We examined the hypothesis that a combination of tacrolimus and mycophenolate mofet...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007890-200212150-00014
更新日期:2002-12-15 00:00:00
abstract:BACKGROUND:As T-cell receptor-major histocompatibility complex (MHC) class I/self peptide interaction regulates T-cell development in the thymus, we reasoned that presentation of peptides by self dendritic cells (DC) to developing T cells in the thymus might induce acquired thymic tolerance. This hypothesis is based on...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200001270-00005
更新日期:2000-01-27 00:00:00
abstract::The use of cyclosporine has been associated with an increased incidence of thrombosis and endothelial cell perturbation. To explore possible mechanisms involved, we examined the effects of CSA on the activation of protein C by thrombomodulin. Cultured bovine aortic endothelial cell monolayers were incubated for 24 hr ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199103000-00030
更新日期:1991-03-01 00:00:00
abstract:BACKGROUND:Hepatic ischemia-reperfusion (IR) injury is frequently followed by cholestatic liver disease. Cytokines released by Kupffer cells following hepatic IR injury may subsequently regulate hepatic transporter expression. The purpose of this study was to determine whether hepatic IR injury and the resultant Kupffe...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000226243.69023.54
更新日期:2006-07-27 00:00:00