Abstract:
:Despite human leukocyte antigen (HLA) identity between donor and recipient, several patients develop acute graft-versus-host disease (aGVHD) after hematopoetic stem cell transplantation (HSCT) because of minor histocompatibility antigen (mHag) incompatibilities. The impact of multiple mHag disparities on the clinical outcome after HSCT still remains to be determined. We studied the genomic polymorphisms of HA-1, CD31, and CD49b and correlated mHag distribution with the occurrence of aGVHD after HSCT from HLA-matched sibling and unrelated donors. All 163 patients examined in our single-center study underwent HSCT for chronic myeloid leukemia in the first chronic phase. HA-1 and CD31 disparities are associated with increased aGVHD incidence in a subgroup of patients who test HLA-B44 supertype positive in univariate analysis. However, in a multivariate analysis, only increased patient age was confirmed as an independent aGVHD risk factor. Our findings indicate that the impact of mHag disparity on aGVHD development in HSCT from HLA-matched sibling and unrelated donors seems to be subordinated to classic aGVHD risk factors.
journal_name
Transplantationjournal_title
Transplantationauthors
Heinemann FM,Ferencik S,Ottinger HD,Beelen DW,Grosse-Wilde Hdoi
10.1097/01.tp.0000120175.25116.cbsubject
Has Abstractpub_date
2004-04-15 00:00:00pages
1103-6issue
7eissn
0041-1337issn
1534-6080pii
00007890-200404150-00027journal_volume
77pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::The role of TNF in the expression of GVHD and GVHD-related immunodeficiency was studied in a well-established murine GVHD model of bone marrow transplantation across minor histocompatibility barriers (B10.BR-->GBA/J) both in vitro and in vivo. Splenocytes from animals with GVHD profoundly inhibited the proliferation o...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199401001-00021
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Human herpesvirus 6 (HHV-6) is susceptible to latency and reactivation in hematopoietic stem cell transplant (HSCT) recipients. We investigated the incidence of HHV-6 DNAemia and factors related to HHV-6 DNAemia and death after allogeneic stem cell transplantations. We also explored the relationship between ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318289958b
更新日期:2013-05-27 00:00:00
abstract:BACKGROUND:Selective inhibition of lymphocyte activation through abrogation of signal 3-cytokine transduction emerges as a new strategy for immunosuppression. This is the first report on the novel Janus kinase (JAK)1/3 inhibitors R507 and R545 for prevention of acute allograft rejection. METHODS:Pharmacokinetic and in...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182660496
更新日期:2012-10-15 00:00:00
abstract:BACKGROUND:Currently, many transplantation centers do not follow former living kidney donors on a long-term basis. Several potential barriers have been identified to provide this follow-up of former living kidney donors, including concerns that donor insurance will not reimburse transplantation centers or primary care ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31826cc9a1
更新日期:2012-11-27 00:00:00
abstract::Rat liver transplantation was utilized to study the effect of hepatic iron on the control of iron absorption. Six iron-loaded and six normal livers were transplanted into normal or iron-loaded animals. Iron absorption was measured pretransplant and 10 days posttransplant by total-body counting (59Fe). The animals were...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198907000-00005
更新日期:1989-07-01 00:00:00
abstract:BACKGROUND:To date, the outcomes of transplant tourism have not been reported extensively. In addition, data about the accuracy of urine cytology for the detection and the role of the BK virus (BKV) in the carcinogenesis of urothelial carcinoma (UC) after renal transplantation are lacking. METHODS:Three hundred seven ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000023
更新日期:2014-07-15 00:00:00
abstract::The humoral theory states that antibodies cause the rejection of allografts. From 1917 to 1929, extensive efforts were made to produce antibodies against tumors. It was finally realized that the antibodies were produced against the transplant antigens present on transplantable tumors, not against the tumor-specific an...
journal_title:Transplantation
pub_type: 历史文章,杂志文章
doi:10.1097/TP.0b013e3182483713
更新日期:2012-04-27 00:00:00
abstract:BACKGROUND:Registry databases offer the statistical power to analyze differences in graft survival rates that may not be detected in randomized clinical trials. This study analyses 2-year graft survival using tacrolimus (tac) or cyclosporine (CsA) with mycophenolate mofetil (MMF) and steroids. METHODS:Data reported to...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000079965.62765.1A
更新日期:2003-07-15 00:00:00
abstract::We have studied organ allograft survival in rhesus monkeys conditioned with myeloablative total-body irradiation and T cell-depleted autologous bone marrow transplantation then given a heterotopic MHC-mismatched cardiac allograft in the immediate postmyeloablative period. This model has enabled us to investigate the r...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198911000-00009
更新日期:1989-11-01 00:00:00
abstract::The addition of prostaglandin to the single-flush technique of lung preservation is considered to enhance subsequent graft function. We have evaluated the use of the prostacyclin analog, Iloprost, in an animal model of unilateral lung transplantation. Group 1 (n = 5) received Iloprost as a pretreatment intravenously (...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199003000-00003
更新日期:1990-03-01 00:00:00
abstract:BACKGROUND:Acid sphingomyelinase knock-out (ASMKO) mice are a model of types A and B Niemann-Pick disease. In the present study, we evaluated whether bone marrow transplantation (BMT) carried out on newborn ASMKO mice could prevent or alter the Niemann-Pick disease phenotype. METHODS:Previous work from our laboratory ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199804150-00005
更新日期:1998-04-15 00:00:00
abstract:BACKGROUND:Many recipients of lung transplants from brain-dead donors develop bronchiolitis obliterans, a manifestation of chronic rejection. It has been shown that brain death increases inflammatory mediators and accelerates acute rejection in kidney, liver, and heart transplants. In this study, the authors investigat...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000142679.45418.96
更新日期:2004-11-15 00:00:00
abstract::Requirements for sustained engraftment of fetal liver hematopoietic stem cells were evaluated in 45 dogs. Pretransplant preparative treatment with total-body irradiation, 14.7 Gy, permitted engraftment of DLA-compatible fetal liver cells. Radiation alone was inadequate in DLA-haploidentical or DLA-mismatched transplan...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198712000-00004
更新日期:1987-12-01 00:00:00
abstract:BACKGROUND:We developed a nonviral gene transfer method using rapid injection of naked DNA targeting the liver and applied it in a rat model of liver transplantation. METHODS:Inbred Dark Agouti and Lewis rats were used. To test the efficacy and adverse effects of systemic or local (catheter-based) injection, different...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000118404.66106.e8
更新日期:2004-04-15 00:00:00
abstract::This study was undertaken to examine the humoral immune response against endothelial antigens of the donor kidney in human renal allograft recipients. Sera from 61 transplant recipients who received 62 grafts were studied for the presence of circulating endothelial antibodies (CEAb) using an indirect immunofluorescenc...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197903000-00007
更新日期:1979-03-01 00:00:00
abstract::Human epidermal cells were grown serially in surface culture by inoculation of suspensions of disaggregated cells. Single cells grew into colonies and the colonies fused to make a confluent epithelium. The epithelium was detached as a unit and transplanted onto a graft bed prepared in athymic mice. Such grafts formed ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198004000-00010
更新日期:1980-04-01 00:00:00
abstract:BACKGROUND:We are presently investigating the therapeutic potential of herpes simplex-thymidine kinase-expressing donor T cells in the setting of a T cell-depleted allogeneic bone marrow transplantation. The generation, expansion, and selection of the gene-modified T cells require a 12-day ex vivo culture period in hig...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199805270-00014
更新日期:1998-05-27 00:00:00
abstract::A series of rat monoclonal antibodies against the human leukocyte-common antigen were isolated and, by means of competitive binding assays with purified antigen, two distinct groups were defined that recognize different epitopes of the molecule. None of these antibodies were lytic with human complement, but when antib...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198511000-00013
更新日期:1985-11-01 00:00:00
abstract::Experiments have been carried out to investigate whether the continued survival of rat kidney allografts induced by two different methods-namely, immunological enhancement or a limited course of drug treatment with cyclosporine or cyclophosphamide, is maintained by similar mechanisms. (AS X AUG)F1 or AUG strain kidney...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198508000-00008
更新日期:1985-08-01 00:00:00
abstract:BACKGROUND:Liver transplantation from donation after cardiac death (DCD) donors is an increasingly common approach for expansion of the donor organ supply. However, transplantation with DCD livers results in inferior graft survival. In this study, we examined donor and recipient characteristics that are associated with...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000250936.73034.98
更新日期:2006-12-27 00:00:00
abstract:BACKGROUND:Two patients underwent cadaver transplantation with kidneys from a donor with a history of World Health Organization Class IV/V lupus nephritis, and we report their clinical and pathological outcome. METHODS:The donor had a diagnosis of lupus nephritis made by renal biopsy 5 years before donation. At the ti...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200003270-00030
更新日期:2000-03-27 00:00:00
abstract::We reviewed coded autopsy material from 71 dogs, 46 receiving allogeneic and 25 receiving autologous bone marrow transplants, to evaluate the hypothesis that lymphocytic bronchitis is associated with severe acute graft-versus-host disease (GVHD). We found no significant correlation between the presence of lymphocytic ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198403000-00003
更新日期:1984-03-01 00:00:00
abstract::Endothelial cells, one of several in vivo host cells for cytomegalovirus (CMV), participate in solid organ allograft rejection in part through the expression of leukocyte adhesion molecules. The hypothesis that CMV infection alters the constitutive and induced expression of ELAM-1, ICAM-1, and VCAM-1 on infected human...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1994-12-27 00:00:00
abstract:BACKGROUND:Liver transplant (LT) for nonalcoholic steatohepatitis (NASH) related hepatocellular carcinoma (HCC) is not well characterized in the literature. The aim of the study was to examine characteristics and outcomes of patients who had LT for NASH-HCC (NASH) versus HCC from other liver diseases (non-NASH). METHO...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/TP.0000000000002043
更新日期:2018-04-01 00:00:00
abstract::Lethally irradiated rhesus monkeys were treated with autologous bone marrow that had either been (1) nontreated, i.e., normal; (2) depleted of T lymphocytes with a monoclonal antibody directed against rhesus T lymphocytes; (3) fractionated with the soybean agglutinin (SBA- fraction); or (4) fractionated with SBA and f...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199206000-00027
更新日期:1992-06-01 00:00:00
abstract::In a canine model of acute ischemic lung injury, a hypertonic citrate solution (HTC) widely used for renal preservation in the United Kingdom, was compared with modified Euro-Collins' solution (ECS) currently the most widely clinically used pulmonary perfusate. Ten beagle dogs underwent left thoracotomy and exclusion ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199105000-00022
更新日期:1991-05-01 00:00:00
abstract:BACKGROUND:We explored the efficacy of the Oxford classification for assessing native immunoglobulin A nephropathy (IgAN) in posttransplantation patients compared with the glomerular injury score and Haas classification. METHODS:A total of 125 renal allograft biopsies obtained from 114 patients diagnosed with IgAN reg...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318291de65
更新日期:2013-06-27 00:00:00
abstract::Forty-three human liver allograft biopsies and normal liver were directly analyzed for inflammatory and immunoregulatory cytokine gene expression by polymerase chain reaction (PCR). IL-5 gene expression was predominantly present in biopsies from liver allografts with histopathological evidence of acute rejection. IL-2...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199202010-00035
更新日期:1992-02-01 00:00:00
abstract:INTRODUCTION:We investigated the putative candidate biomarkers of graft rejection in peripheral blood of intestinal transplant patients. MATERIALS AND METHODS:Peripheral blood gene expression analysis was performed in intestinal transplant patients. The results were matched with concurrent graft biopsies using bioinfo...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182370db1
更新日期:2011-12-27 00:00:00
abstract::The recent introduction of a variety of techniques for removing T cells from bone marrow grafts has reduced the incidence of graft-versus-host disease (GVHD)-associated morbidity and mortality. Whether this advance will be translated into improved patient survival is unclear at present, mainly because these procedures...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198704000-00009
更新日期:1987-04-01 00:00:00