Factors affecting graft survival after liver transplantation from donation after cardiac death donors.

abstract：:The interactions of rapamycin (Rapa), CsA, and donor-specific transfusion (DST) were examined in an ACI to Lewis rat heterotopic cardiac allograft model. Survival data were truncated at 175 days for the purpose of statistical comparisons. Vehicle (Veh)-treated animals rejected at a mean of 7.3 +/- 0.2 days. Treatment ...

journal_title：Transplantation

authors： Davies CB,Madden RL,Alexander JW,Cofer BR,Fisher RA,Anderson P

更新日期：1993-05-01 00:00:00

abstract：:Cadaveric kidney transplants with delayed graft function have poorer graft survival by an unknown mechanism. Nitric oxide, produced by nitric oxide synthase (NOS), has a proven role in both recovery of ischemia and promotion of rejection. We therefore wished to study the patterns of NOS activity in a model of renal is...

journal_title：Transplantation

authors： Shoskes DA,Xie Y,Gonzalez-Cadavid NF

更新日期：1997-02-27 00:00:00

abstract：:Hematopoietic growth factors (HGF) mobilize potential tolerogenic cells in transplant donors. Fms-like tyrosine kinase 3 ligand (Flt3L) mobilizes stem cells and dendritic cells (DCs) in human and nonhuman primate blood. Blood and renal and liver biopsies were obtained from untreated and Flt3L-mobilized rhesus macaques...

journal_title：Transplantation

authors： Morelli AE,Coates PT,Shufesky WJ,Barratt-Boyes SM,Fung JJ,Demetris AJ,Thomson AW

更新日期：2007-03-15 00:00:00

abstract：BACKGROUND:Dendritic cells (DC) can exert powerful immune stimulatory as well as regulatory functions and are therefore important tools for therapeutic strategies. Dexamethasone (Dex) was previously shown to inhibit DC maturation and to induce regulatory properties both in vitro and in vivo. Here, we investigated the i...

journal_title：Transplantation

authors： Stax AM,Gelderman KA,Schlagwein N,Essers MC,Kamerling SW,Woltman AM,van Kooten C

更新日期：2008-11-15 00:00:00

abstract：BACKGROUND:Translational research in a relevant preclinical model is recommended before Treg-inducing protocols can be implemented in humans. We have characterized rhesus monkey CD25 cells phenotypically and functionally. METHODS:The phenotype of CD4(+)CD25(high) cells was determined by FACS, focusing on established m...

journal_title：Transplantation

authors： Haanstra KG,van der Maas MJ,'t Hart BA,Jonker M

更新日期：2008-04-27 00:00:00

abstract：BACKGROUND:Recent data indicate that factors other than erythropoietin (EPO), such as insulin-like growth factor 1 (IGF-1), can promote erythropoiesis in vitro and correct the anemia of chronic renal failure in vivo. IGF-1 is produced by the liver under growth hormone control, as well as by other sources, including the...

journal_title：Transplantation

authors： Morrone LF,Di Paolo S,Logoluso F,Schena A,Stallone G,Giorgino F,Schena FP

更新日期：1997-09-27 00:00:00

abstract：:Hepatic artery thrombosis (HAT) after liver transplantation (LTx) usually mandates retransplantation. Prolonged preservation with Eurocollins solution has been associated with HAT. We reviewed our experience with 359 LTx patients to identify risk factors for HAT. All grafts were preserved in University of Wisconsin so...

journal_title：Transplantation

authors： Mor E,Schwartz ME,Sheiner PA,Menesses P,Hytiroglou P,Emre S,Kishikawa K,Chiodini S,Miller CM

更新日期：1993-12-01 00:00:00

abstract：:The mechanism (or mechanisms) underlying the indefinite survival of DBA/2 islet allografts in strongly histoincompatible (C57BL/6xA)F1 (B6AF1) mice, induced either by the combined use of Ficoll-prepared crude islets and treatment of recipients with antilymphocyte serum (ALS), or by the use of handpicked, purified isle...

journal_title：Transplantation

authors： Gotoh M,Porter J,Monaco AP,Maki T

更新日期：1988-02-01 00:00:00

abstract：:Because of the inherent difficulties in allele assignment with HLA-DR serological typing, in 1993 our organ procurement organization-based HLA laboratory replaced serology with the molecular method of polymerase chain reaction using sequence-specific primer mixes (PCR-SSP) to type for DR and DQ at a resolution level e...

journal_title：Transplantation

authors： Bryan CF,Harrell KM,Nelson PW,Pierce GE,Ross G,Shield CF 3rd,Warady BA,Aeder MI,Helling TS,Landreneau MD,Luger AM

更新日期：1996-12-27 00:00:00

abstract：:Whole-body irradiation has been extensively used to ablate immune responsiveness in rodent recipients in adoptive allograft assays. This study was undertaken to determine the relative radioresistance and the tempo of regeneration, following whole-body irradiation, of cells involved in the allograft response. Six disti...

journal_title：Transplantation

authors： Farnsworth A,Wotherspoon JS,Dorsch SE

更新日期：1988-09-01 00:00:00

abstract：:Antihuman lymphocyte rabbit (or horse) gamma globulins used in recipients of organ transplantation are prepared against thymocytes or immortalized cell lines, the only two sources so far allowing enough antigen preparation. These cells lack, however, the surface determinants characteristic of alloreactive blasts invol...

journal_title：Transplantation

authors： Bonneville M,Carcagne J,Vie H,Moreau JF,Chevalier S,Latour M,Carosella E,Soulillou JP

更新日期：1989-08-01 00:00:00

abstract：:Pulmonary thrombus formation in the region of atrial anastomosis following lung transplantation has been reported by several authors. Such patients typically present immediately after surgery with significant hemodynamic compromise causing pulmonary edema and hypoxemia. We describe a patient who presented with bilater...

journal_title：Transplantation

authors： Stang MR,Hinderliter AL,Gott KK,Paradowski LJ,Aris RM

更新日期：1996-09-15 00:00:00

abstract：BACKGROUND:Success of human pancreatic islet isolation depends largely on the techniques used during pancreas procurement and the quality of the gland. Warm ischemia of the pancreas of any duration during organ procurement may be detrimental to subsequent islet yield and functional viability of the islets. The aim of t...

journal_title：Transplantation

authors： Lakey JR,Kneteman NM,Rajotte RV,Wu DC,Bigam D,Shapiro AM

更新日期：2002-04-15 00:00:00

abstract：:Longitudinal studies over an eight-month period have been performed to follow the T killer response restoration after allogeneic bone marrow transplantation (BMT). The capacity of the patient's peripheral blood mononuclear cells (PBM) to develop cytotoxic effector cells directed either against allogeneic cells or agai...

journal_title：Transplantation

authors： Tilkin AF,Bagot M,Dreyfus F,Kayibanda M,Cordonnier C,Vernant JP,Levy JP

更新日期：1987-08-01 00:00:00

abstract：BACKGROUND:In the present study, we investigated whether the soluble form of CD30 (sCD30), a marker for T helper 2-type cytokine-producing T cells, is increased in sera of potential kidney graft recipients. We also investigated whether the pretransplantation serum sCD30 content is related to kidney graft survival. MET...

journal_title：Transplantation

authors： Pelzl S,Opelz G,Wiesel M,Schnülle P,Schönemann C,Döhler B,Süsal C

更新日期：2002-01-15 00:00:00

abstract：BACKGROUND:Immunosuppression involves the nature of the immunosuppressive agents and individual differences in patient factors. We investigated whether the effect of mycophenolate mofetil (MMF) is measurable using an in vitro measure of immunocompetence and related its effects to cyclosporine (CsA) in vitro. METHODS:L...

journal_title：Transplantation

authors： Ogawa N,Nagashima N,Nakamura M,Shalabi A,Maley WR,Burdick JF

更新日期：2001-08-15 00:00:00

abstract：OBJECTIVE:The purpose of this study was to identify pretransplantation and posttransplantation indicators for the development of diabetes mellitus in the first 2 months after renal transplantation and to examine the influence of a cyclosporine A (CsA)-based versus a tacrolimus-based immunosuppressive regimen on these r...

journal_title：Transplantation

authors： Sato T,Inagaki A,Uchida K,Ueki T,Goto N,Matsuoka S,Katayama A,Haba T,Tominaga Y,Okajima Y,Ohta K,Suga H,Taguchi S,Kakiya S,Itatsu T,Kobayashi T,Nakao A

更新日期：2003-11-15 00:00:00

abstract：BACKGROUND:Isolated transient elevation of alkaline phosphatase (ALP) in the absence of bone or liver disease has been reported in children including liver transplant patients. Specific isoenzyme patterns have been associated with this phenomenon in healthy children but have not been reported after liver transplantatio...

journal_title：Transplantation

authors： O'Riordan S,Baker AJ,Sherwood RA

更新日期：2002-10-15 00:00:00

abstract：BACKGROUND:We are presently investigating the therapeutic potential of herpes simplex-thymidine kinase-expressing donor T cells in the setting of a T cell-depleted allogeneic bone marrow transplantation. The generation, expansion, and selection of the gene-modified T cells require a 12-day ex vivo culture period in hig...

journal_title：Transplantation

authors： Contassot E,Murphy W,Angonin R,Pavy JJ,Bittencourt MC,Robinet E,Reynolds CW,Cahn JY,Hervé P,Tiberghien P

更新日期：1998-05-27 00:00:00

abstract：:Liver transplantation is the most effective treatment for selected patients with hepatocellular carcinoma. However, cancer recurrence, posttransplantation, remains to be the critical issue that affects the long-term outcome of hepatocellular carcinoma recipients. In addition to tumor biology itself, increasing evidenc...

journal_title：Transplantation

authors： Li CX,Man K,Lo CM

更新日期：2017-11-01 00:00:00

abstract：:Graft-versus-host disease (GvHD), a life-threatening complication of bone marrow transplantation, is initiated by donor T cells reacting to recipient dendritic cells (DC). GvHD can be controlled by attenuating donor T cells, but few strategies exist to target DC, particularly resident tissue DC, despite recent evidenc...

journal_title：Transplantation

authors： Collin MP,Munster D,Clark G,Wang XN,Dickinson AM,Hart DN

更新日期：2005-03-27 00:00:00

abstract：BACKGROUND:There is a lack of information about survival after dropout from the liver transplant waiting list. Therefore, we aimed to assess the overall survival, and risk factors for death, after waiting list dropout due to hepatocellular carcinoma (HCC) progression. METHODS:We assessed patients who dropped out of th...

journal_title：Transplantation

authors： Gorgen A,Rosales R,Sadler E,Beecroft R,Knox J,Dawson LA,Ghanekar A,Grant D,Greig PD,Sapisochin G

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Renal allografts were performed in rhesus monkeys using FN18-CRM9, a potent immunotoxin capable of depleting T cells to less than 1% of baseline levels in blood and lymph nodes, as a preparative agent. We have recently reported that animals pretreated with FN18-CRM9 1 week before transplantation without furt...

journal_title：Transplantation

authors： Fechner JH Jr,Vargo DJ,Geissler EK,Graeb C,Wang J,Hanaway MJ,Watkins DI,Piekarczyk M,Neville DM Jr,Knechtle SJ

更新日期：1997-05-15 00:00:00

abstract：BACKGROUND:In 2013, the public health service (PHS) changed the criteria intended to identify organ donors that put the associated organ recipients at increased risk for acquiring human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV). The changing donor demographics, organ utilization...

journal_title：Transplantation

authors： Pruett TL,Clark MA,Taranto SE

更新日期：2017-07-01 00:00:00

abstract：:Preformed recipient HLA-specific antibodies can cause hyperacute rejection of a transplanted kidney if they are directed against mismatched donor HLA antigens. To avoid hyperacute rejection it is essential that recipient antibodies be identified during patient workup for transplantation and HLA antigens to which a pat...

journal_title：Transplantation

authors： Martin S

更新日期：2001-05-27 00:00:00

abstract：:Although liver transplantation (LT) is the best treatment for patients with localized hepatocellular carcinoma (HCC), recurrence occurs in 6%-18% of patients. Several factors, particularly morphological criteria combined with dynamic parameters, known before LT modify this risk and combined in prediction models may be...

journal_title：Transplantation

authors： Berenguer M,Burra P,Ghobrial M,Hibi T,Metselaar H,Sapisochin G,Bhoori S,Kwan Man N,Mas V,Ohira M,Sangro B,van der Laan LJW

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:In kidney transplantation, dynamic prediction of patient and kidney graft survival (DynPG) may help to promote therapeutic alliance by delivering personalized evidence-based information about long-term graft survival for kidney transplant recipients. The objective of the current study is to externally valida...

journal_title：Transplantation

authors： Lenain R,Dantan E,Giral M,Foucher Y,Asar Ö,Naesens M,Hazzan M,Fournier MC

更新日期：2021-02-01 00:00:00

abstract：:Despite growing evidence that reactive oxygen species are responsible for deleterious effects of ischemia-reperfusion (I/R) injury of the liver, there exists, until now, no reliable antioxidant therapeutics applicable in the clinical setting. We investigated the effects of free radical scavenger, 3-methyl-1-phenyl-2-p...

journal_title：Transplantation

authors： Ninomiya M,Shimada M,Harada N,Shiotani S,Hiroshige S,Soejima Y,Suehiro T,Sugimachi K

更新日期：2002-11-27 00:00:00

abstract：:The monoclonal antibodies (MoAb) CR11-351 and KS1 are secreted by hybridomas generated with splenocytes from BALB/c mice immunized with the cultured human B lymphoid cells LG-2 (HLA-A2,A2,B27,B27). The 2 monoclonal antibodies immunoprecipitated components with a superimposable 2-dimensional gel electrophoretic profile...

journal_title：Transplantation

authors： Tsujisaki M,Sakaguchi K,Igarashi M,Richiardi P,Perosa F,Ferrone S

更新日期：1988-03-01 00:00:00

abstract：:We investigated whether right lobe (RL) liver donation is associated with a higher incidence or severity of donor complications than left lobe (LL) liver and left lateral segment (LLS) liver donations. We studied 80 living donors: 35 RL liver donors and 45 LL/LLS liver donors. A modification of the Clavien classificat...

journal_title：Transplantation

authors： Salvalaggio PR,Baker TB,Koffron AJ,Fryer JP,Clark L,Superina RA,Blei AT,Abecassis MM

更新日期：2004-06-15 00:00:00