Abstract:
BACKGROUND:Isolated transient elevation of alkaline phosphatase (ALP) in the absence of bone or liver disease has been reported in children including liver transplant patients. Specific isoenzyme patterns have been associated with this phenomenon in healthy children but have not been reported after liver transplantation. The discovery of the isoenzyme pattern associated with benign transient hyperphosphatasemia in one child prompted a study of all our posttransplant patients. METHODS:Retrospective analysis of ALP isoenzymes by polyacrylamide gel electrophoresis on banked serum samples. RESULTS:The incidence of isolated transient hyperphosphatasemia was 4.3%. All 11 children demonstrated the isoenzyme pattern associated with benign transient hyperphosphatasemia. In one child, the hyperphosphatasemia occurred on a background of chronic cholangiopathy and in a second, shortly after an episode of probable cytomegalovirus hepatitis. CONCLUSIONS:Isolated elevation of serum ALP after liver transplantation in children is common. Analysis of ALP isoenzymes, looking for the pattern of benign transient hyperphosphatasemia, can assist in the management of these children.
journal_name
Transplantationjournal_title
Transplantationauthors
O'Riordan S,Baker AJ,Sherwood RAdoi
10.1097/00007890-200210150-00023subject
Has Abstractpub_date
2002-10-15 00:00:00pages
1030-4issue
7eissn
0041-1337issn
1534-6080journal_volume
74pub_type
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