Abstract:
:P-31 nuclear magnetic resonance (NMR) spectroscopy was used to evaluate heterotropic cardiac allograft rejection in the rat. To enable optimal application of NMR spectroscopy for the in vivo study of myocardial metabolism in the transplanted organ, an accessory heart transplantation to groin in the rat was used. The allografts were studied in a 1.89 Tesla horizontal bore magnet. Each spectrum was obtained by Fourier transform of 512 scans using 60-degree pulses with 2-sec delays. Changes in phosphocreatine (PCr), adenosine 5-triphosphate (ATP), and inorganic phosphate (Pi) and intracellular pH as determined by P-31 NMR were compared with rejection process as judged by histological studies. Allografts treated with cyclosporine (CsA) did not show any rejection (NR) and had relatively high levels of PCr, and low levels of Pi. Allografts that did not receive any CsA revealed both vascular and cellular rejection. These rejected allografts (R) had relatively low levels of PCr and high levels of Pi. It is concluded that P-31 NMR spectroscopy may have potential application to the clinical diagnosis of cardiac allograft rejection.
journal_name
Transplantationjournal_title
Transplantationauthors
Haug CE,Shapiro JI,Chan L,Weil R 3rddoi
10.1097/00007890-198708000-00002subject
Has Abstractpub_date
1987-08-01 00:00:00pages
175-8issue
2eissn
0041-1337issn
1534-6080journal_volume
44pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract:BACKGROUND:An artificial neural networks (ANNs) model was developed to predict 5-year graft survival of living-donor kidney transplants. Predictions from the validated ANNs were compared with Cox regression-based nomogram. METHODS:Out of 1900 patients with living-donor kidney transplant; 1581 patients were used for tr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31818b221f
更新日期:2008-11-27 00:00:00
abstract:BACKGROUND:We studied whether T-cell clones, which appear in the periphery as a result of the failure of thymic negative selection during graft-versus-host disease (GVHD), have any in vivo anti-host reactivity and can cause GVHD in an adoptive transfer model. METHODS:We performed our studies in a murine model (B10.BR ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200002150-00026
更新日期:2000-02-15 00:00:00
abstract::The effect of protein depletion on immune responsiveness was examined using a skin allograft model. Protein depletion was induced in adult Fischer (F344) male rats by the ad libitum provision of a 5% protein diet. Total serum protein, total body weight, total body nitrogen, and total body lipid were all markedly decre...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198009000-00012
更新日期:1980-09-01 00:00:00
abstract:BACKGROUND:Suppressive dendritic cells (DCs) are a promising tool for tolerance induction in transplantation. A human DCs subpopulation, which constitutively expresses indoleamine-2,3-dioxygenase (IDO), a molecule shown to prevent the rejection of fetus during pregnancy, has recently been described. This subset, charac...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000251646.09702.ec
更新日期:2007-02-27 00:00:00
abstract::Patients receiving allogeneic marrow transplantation for hematologic malignancies commonly are conditioned with total body irradiation (TBI) and given methotrexate (MTX) in an attempt to prevent graft-versus-host disease. To study the effects of TBI with or without MTX on bronchoalveolar cells and proteins, we perform...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198404000-00003
更新日期:1984-04-01 00:00:00
abstract:BACKGROUND:Tacrolimus is a potent immunosuppressive agent that provides higher freedom from acute and chronic rejection than cyclosporine after liver transplantation (LTx). Initially, a steroid-free state was observed in about 70% of patients at 1 year; this did not change over the next 5 years. The present study ident...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200104270-00016
更新日期:2001-04-27 00:00:00
abstract::A prospective controlled study was carried out in 60 consecutive cadaver renal donors comparing cold storage to pulsatile machine-perfusion preservation. Each donor served as its own control, by allocating one of the kidneys to each of the two preservation methods. There were 51 evaluable pairs of kidneys. Recipient a...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199008000-00011
更新日期:1990-08-01 00:00:00
abstract::T cells must be activated before they can elicit damage to allografts, through interaction of their T cell receptor (TCR) with peptide-MHC complex and through accessory molecules. Signaling through accessory molecules or costimulatory molecules is a critical way for the immune system to fine tune T cell activation. An...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0b013e31826d4672
更新日期:2013-02-27 00:00:00
abstract:BACKGROUND:After cold ischemia, electrons transferred in the electron transport chain may leak out of the mitochondria in proportion to the deterioration of mitochondrial oxidative phosphorylation. This seems to be one major cause of the lipid peroxidation that occurs mainly in the hepatocytes at reperfusion in liver t...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199904270-00015
更新日期:1999-04-27 00:00:00
abstract:BACKGROUND:Hepatic ischemia-reperfusion (IR) injury is frequently followed by cholestatic liver disease. Cytokines released by Kupffer cells following hepatic IR injury may subsequently regulate hepatic transporter expression. The purpose of this study was to determine whether hepatic IR injury and the resultant Kupffe...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000226243.69023.54
更新日期:2006-07-27 00:00:00
abstract::The early detection of allograft rejection remains elusive after solitary pancreas transplantation (PTX). We have previously described a modified technique of cystoscopic transduodenal PTX biopsy using the Biopty gun under ultrasound guidance. During the last 2 years, we performed 24 solitary PTXs with prospective pro...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199560120-00011
更新日期:1995-12-27 00:00:00
abstract::ICAM-1 is an inducible glycoprotein important in the adhesion, activation, and transmigration of circulating leukocytes across the vascular endothelial monolayer, and it likely plays a key role in the allogeneic response. To determine the reproducibility and significance of variations in resting levels of cell surface...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199410270-00015
更新日期:1994-10-27 00:00:00
abstract::Since calcium channel blocking agents and CsA exert an antiproliferative effect upon T cell mitogenesis, we have compared and characterized their immunosuppressive properties at the level of gene activation. Verapamil (greater than or equal to 30 microM), which blocks T cell mitogenesis and a rise in cytosolic calcium...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198902000-00029
更新日期:1989-02-01 00:00:00
abstract::The purpose of this study was to describe the clinical presentation, treatment, and outcome of Mycobacterium haemophilum infection in patients undergoing bone marrow transplantation at a cancer center. Bone marrow transplant recipients with M haemophilum infection were identified upon culture of the organism by implem...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1995-11-15 00:00:00
abstract::The benefits of cytomegalovirus (CMV) prophylaxis in preventing the direct effects of CMV infection and disease are well established; however, the impact of exposure to antiviral agents on preventing the indirect effects of CMV infection are poorly defined. This article reviews the results of current studies demonstra...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.tp.0000230459.22968.26
更新日期:2006-07-27 00:00:00
abstract:BACKGROUND:Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) is a distinct form of glomerulonephritis that often recurs after kidney transplantation causing severe graft injury and often failure. METHODS:We describe post transplant outcomes and response to therapy in 20 recipients with ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002577
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Monocarboxylate transporter (MCT)-1, a member of a family of molecules, transports monocarboxylates such as lactate. Inhibiting MCT-1 leads to long-term graft survival in rodent heart transplantation and induces tolerance. We evaluated an MCT-1 inhibitor, AS2495674, in a rat heart transplant model and analyz...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181ff8818
更新日期:2010-12-27 00:00:00
abstract:BACKGROUND:Ischemia-reperfusion (I/R) injury is the major cause of delayed renal graft function in kidney transplantation. To date, there are no effective therapeutic approaches for preventing I/R injury. We previously reported that treatment of animals with small interference RNA (siRNA) would prevent warm I/R injury ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000960
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Orthotopic liver transplantation (OLT) has been associated with major blood loss and the need for blood product transfusions. During the last decade, improved surgical and anesthetic management has reduced intraoperative blood loss and blood product transfusions. A first report from our group published in 20...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318250fc25
更新日期:2012-06-27 00:00:00
abstract::Pre-existing alloantibodies against the mismatched HLA-A and HLA-B antigens of the donor, when present in current sera, are believed to be detrimental to kidney graft survival. When these antibodies are present only in historical sera, their immunoglobulin class has reported to be important with respect to the expecte...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199405150-00018
更新日期:1994-05-15 00:00:00
abstract::We present a case report of a pediatric orthotopic liver transplant recipient who developed lymphoma with hypercalcemia on cyclosporine and prednisone immunosuppression. This is the first reported posttransplant lymphoproliferative disorder complicated by hypercalcemia, with a finding of an elevated 1,25 dihydroxyl vi...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198912000-00022
更新日期:1989-12-01 00:00:00
abstract::Transient pure red cell aplasia (PRCA) in three consecutive patients receiving ATG for management of kidney graft rejection prompted a systematic study of the effects on erythropoiesis of the ATG preparation used at our institution. We found that 90% of patients treated with rabbit anti-T lymphoblast globulin develope...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199105000-00017
更新日期:1991-05-01 00:00:00
abstract:BACKGROUND:The objective of the study was to determine surveillance criteria for renal transplant recipients (RTRs) at highest risk for immunosuppressant therapy nonadherence. METHODS:Retrospective analyses were performed on follow-up data in the United States Renal Data System. Those who received transplants between ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000287189.33074.c8
更新日期:2007-11-15 00:00:00
abstract::Cell-mediated cytotoxicity directed toward pancreatic islets plays a significant role in the pathogenesis of type 1 diabetes mellitus. Histologically, autoimmune insulitis appears as mononuclear infiltrates that precede actual beta cell loss. Experimental studies by Bartlett et al. on the BB rat model suggest that who...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199612270-00014
更新日期:1996-12-27 00:00:00
abstract::To evaluate the efficacy of University of Wisconsin (UW) solution for lung preservation, we performed canine lung allotransplantation with lungs preserved in UW solution. Donor lungs from eight dogs were flushed with UW solution and lungs from four dogs with Euro-Collins solution, and these were preserved for 24 hr in...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199301000-00004
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:The purpose of this study is to examine the effects of the coronavirus disease 2019 (COVID-19) pandemic on adult lung transplants and report practice changes in the United States. METHODS:A retrospective analysis of a public dataset from the United Network for Organ Sharing was performed regarding adult lun...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003522
更新日期:2021-01-01 00:00:00
abstract:INTRODUCTION:Immune privilege provides a natural paradigm for potentially down-regulating allogeneic and xenogeneic inflammatory immune responses. Fas ligand has been suggested as a general underlying mechanism of immune privilege; the human Fas ligand has been shown to ligate murine Fas in vitro. METHODS:In this stud...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200003270-00010
更新日期:2000-03-27 00:00:00
abstract:BACKGROUND:Registry databases offer the statistical power to analyze differences in graft survival rates that may not be detected in randomized clinical trials. This study analyses 2-year graft survival using tacrolimus (tac) or cyclosporine (CsA) with mycophenolate mofetil (MMF) and steroids. METHODS:Data reported to...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000079965.62765.1A
更新日期:2003-07-15 00:00:00
abstract::Islet isolation is a time-consuming process. Islet yields vary, and previous in vitro studies suggest that Ficoll may be an islet toxin. Here, we describe an alternative, Ficoll-free method to purify murine islets by filtration through a cell strainer. Collagenase digestion of pancreata was carried out using standard ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200209270-00023
更新日期:2002-09-27 00:00:00
abstract::Cadaveric kidney transplants with delayed graft function have poorer graft survival by an unknown mechanism. Nitric oxide, produced by nitric oxide synthase (NOS), has a proven role in both recovery of ischemia and promotion of rejection. We therefore wished to study the patterns of NOS activity in a model of renal is...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199702270-00002
更新日期:1997-02-27 00:00:00