Islet filtration: a simple and rapid new purification procedure that avoids ficoll and improves islet mass and function.

abstract：BACKGROUND:New insights into mechanisms of injury in orthotopic liver transplantation (OLT) often come from experiments in small animal models. Mice are particularly suitable because of the growing availability of gene-altered animals and specific antibodies. A validated model of OLT in mice is not available and, in pa...

journal_title：Transplantation

authors： Tian Y,Rüdiger HA,Jochum W,Clavien PA

更新日期：2002-11-15 00:00:00

abstract：BACKGROUND:Translational research in a relevant preclinical model is recommended before Treg-inducing protocols can be implemented in humans. We have characterized rhesus monkey CD25 cells phenotypically and functionally. METHODS:The phenotype of CD4(+)CD25(high) cells was determined by FACS, focusing on established m...

journal_title：Transplantation

authors： Haanstra KG,van der Maas MJ,'t Hart BA,Jonker M

更新日期：2008-04-27 00:00:00

abstract：BACKGROUND:Activation of the renin angiotensin system may contribute to the development of delayed graft function after renal transplantation. We, therefore, examined the impact of pretransplant treatment with blockers of the renin angiotensin system on early graft function after renal transplantation. METHOD:The case...

journal_title：Transplantation

authors： Stevens KK,Patel RK,Clancy M,Jardine AG

更新日期：2010-03-27 00:00:00

abstract：:Alloreactive T cells are often specific for individual peptides that are bound to allogeneic major histocompatibility complex (MHC) molecules. Other alloreactive T cells are reported to be peptide-independent or to recognize MHC conformational changes that are induced by multiple peptides. We tested 12 anti-HLA-B7 all...

journal_title：Transplantation

authors： Smith KD,Huczko E,Engelhard VH,Li YY,Lutz CT

更新日期：1997-07-27 00:00:00

abstract：BACKGROUND:To maximize the renal donor pool, cadaveric pediatric en bloc kidneys have been transplanted as a dual unit by some transplant centers. We compared the short- and long-term outcomes of adult recipients of cadaveric pediatric en bloc renal transplants versus those of matched recipients of cadaveric adult kidn...

journal_title：Transplantation

authors： Hobart MG,Modlin CS,Kapoor A,Boparai N,Mastroianni B,Papajcik D,Flechner SM,Goldfarb DA,Fischer R,O'Malley KJ,Novick AC

更新日期：1998-12-27 00:00:00

abstract：BACKGROUND:Motexafin lutetium (Lu-Tex) is a photodynamic therapy (PDT) agent that localizes in atheromatous plaque in which it can be activated by far-red light. Lu-Tex biolocalization was examined in graft coronary artery disease (GCAD) with a rodent allograft model. After photoactivation, the effect on intimal prolif...

journal_title：Transplantation

authors： Yamaguchi A,Woodburn KW,Hayase M,Hoyt G,Robbins RC

更新日期：2001-06-15 00:00:00

abstract：:Natural anti-carbohydrate antibodies are central to hyperacute rejection in ABO-incompatible allotransplantation and in discordant xenotransplantation. ABO-incompatible rejection has been inhibited successfully using intravenous soluble carbohydrates as antibody inhibitors. The approach has been less successful previo...

journal_title：Transplantation

authors： Cairns T,Lee J,Goldberg L,Cook T,Simpson P,Spackman D,Palmer A,Taube D

更新日期：1995-12-15 00:00:00

abstract：:Solid organ and allogeneic hematopoietic cell transplantation have become standard therapeutic interventions that save patient lives and improve quality of life. Our enhanced understanding of transplantation immunobiology has refined clinical management and improved outcomes. However, organ rejection and graft-versus-...

journal_title：Transplantation

authors： Radojcic V,Maillard I

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:It has been proposed that hyperacute rejection (HAR) of pig-to-primate vascularized xenografts is due in large part to ineffective regulation of recipient complement by pig complement regulatory proteins (CRPs), and indeed transgenic expression of human CRPs in pigs can prevent hyperacute rejection. However,...

journal_title：Transplantation

authors： Fisicaro N,Aminian A,Hinchliffe SJ,Morgan BP,Pearse MJ,D'Apice AJ,Cowan PJ

更新日期：2000-09-27 00:00:00

abstract：:Acute antibody-mediated rejection (AAR) of mouse skin allografts was studied in nine donor-recipient combinations with increasing histoincompatibility ranging from an H-Y to a complete H-2 plus on-H-2 disparity. AAR was induced by the injection of specific alloantiserum along with a heterologous complement on day 7 af...

journal_title：Transplantation

authors： Berden JH,Gerlag PG,Hagemann JF,Koene RA

更新日期：1977-09-01 00:00:00

abstract：BACKGROUND:Strong correlations have been described between persistently elevated proportions of CD57+ (CD28-) CD8+high T lymphocytes and cytomegalovirus (CMV) infection, in healthy individuals as well as in transplant patients. We investigated whether secondary exposure to CMV triggers recall responses within the CD8 T...

journal_title：Transplantation

authors： Hazzan M,Labalette M,Noel C,Lelievre G,Dessaint JP

更新日期：1997-03-15 00:00:00

abstract：BACKGROUND:Circulating transthyretin (TTR) is derived from the liver, and orthotopic liver transplantation (OLT) is widely performed for variant TTR-associated familial amyloid polyneuropathy (FAP). The effect of OLT on FAP-related cardiac amyloid is of particular interest because wild-type TTR can itself be deposited ...

journal_title：Transplantation

authors： Stangou AJ,Hawkins PN,Heaton ND,Rela M,Monaghan M,Nihoyannopoulos P,O'Grady J,Pepys MB,Williams R

更新日期：1998-07-27 00:00:00

abstract：BACKGROUND:There is an increasing appreciation of the deleterious effects of antibody and B cells on acute and chronic transplant outcomes. Many effector functions of antibody are mediated by a family of receptors (FcγRs) that are expressed on most immune cells, including neutrophils, natural killer cells, and B cells....

journal_title：Transplantation

authors： Clatworthy MR,Matthews RJ,Doehler B,Willcocks LC,Opelz G,Smith KGC

更新日期：2014-08-15 00:00:00

abstract：:Governmental and private programs that pay next of kin who give permission for the removal of their deceased relative's organs for transplantation exist in a number of countries. Such payments, which may be given to the relatives or paid directly for funeral expenses or hospital bills unrelated to being a donor, aim t...

journal_title：Transplantation

authors： Capron AM,Delmonico FL,Dominguez-Gil B,Martin DE,Danovitch GM,Chapman J

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Delayed xenograft rejection (DXR) remains a roadblock to successful xenotransplantation. A feature of DXR is early recruitment of monocytes to the xenograft. Naïve human monocytes can recognize and adhere to unstimulated porcine aortic endothelial cells (PAEC) more than human aortic endothelial cells, partly...

journal_title：Transplantation

authors： Greenwald AG,Jin R,Waddell TK

更新日期：2009-01-15 00:00:00

abstract：:OKT3, an anti-CD3 MAB, depletes T cells in vivo and is among the most potent inhibitors of acute allograft rejection. The mechanism of this inhibition is unknown. The present studies investigate whether anti-CD3 antibodies have the ability to crosslink CD3 on two different cells and induce TCR-dependent antibody-bridg...

journal_title：Transplantation

authors： Wong JT,Eylath AA,Ghobrial I,Colvin RB

更新日期：1990-10-01 00:00:00

abstract：:The results of OKT3 use for steroid-resistant rejection rescue in adult liver transplantation were analyzed retrospectively from a single transplant center. Comparison was made with concurrent patients who had no rejection (NR) or steroid-responsive rejections (SR). The records of 290 patients who underwent 323 liver ...

journal_title：Transplantation

authors： Solomon H,Gonwa TA,Mor E,Holman MJ,Gibbs J,Watemberg I,Netto G,Goldstein RM,Husberg BS,Klintmalm GB

更新日期：1993-01-01 00:00:00

abstract：:The potential usefulness of verapamil, a calcium channel blocker to renal allograft preservation, was investigated using the isolated perfused rat kidney. Two models of ischemic injury were used. In the first model, rat kidneys were exposed to 40 min of 37 degrees C ischemia on the perfusion circuit. Addition of verap...

journal_title：Transplantation

authors： Shapiro JI,Cheung C,Itabashi A,Chan L,Schrier RW

更新日期：1985-12-01 00:00:00

abstract：:The overall incidence of malignancy in renal transplant recipients is 100-fold higher compared with age matched controls. Routine clinical evaluation therefore often includes the determination of serum tumor markers AFP, CA19-9, CEA, CA125, CA15-3, PSA, and calcitonin. We evaluated the specificity and the sensitivity ...

journal_title：Transplantation

authors： Oberbauer R,Banyai S,Schmidt A,Kornek G,Scheithauer W,Mayer G

更新日期：1996-11-27 00:00:00

abstract：:Recipients of solid organ allografts require lifelong immunosuppression in order to prevent graft rejection and to maintain graft function. In general, such immunosuppression greatly impairs the cellular immune system, as this level of the immune system is principally responsible for self and non-self recognition. The...

journal_title：Transplantation

authors： Van Thiel DH,Finkel R,Friedlander L,Gavaler JS,Wright HI,Gordon R

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND:The objectives of this study are to investigate the impact of cytomegalovirus (CMV) donor (D)/recipient (R) serostatus on kidney transplant outcomes in recipients who received CMV prophylaxis and to investigate the association of individual antiviral agents (acyclovir, ganciclovir, and valganciclovir) with o...

journal_title：Transplantation

authors： Kuo HT,Ye X,Sampaio MS,Reddy P,Bunnapradist S

更新日期：2010-11-27 00:00:00

abstract：OBJECTIVE:The aim of this prospective, multicenter, noncomparative, open-label trial was to evaluate the prophylactic use of caspofungin in adult liver transplant recipients at high risk of developing invasive fungal infections (IFI). METHODS:Patients received caspofungin for at least 21 days. A successful treatment o...

journal_title：Transplantation

authors： Fortún J,Martín-Dávila P,Montejo M,Muñoz P,Cisneros JM,Ramos A,Aragón C,Blanes M,San Juan R,Gavaldá J,Llinares P,GESITRA Study Group.

更新日期：2009-02-15 00:00:00

abstract：BACKGROUND:A regimen consisting of antilymphocyte serum (ALS), sirolimus, and donor bone-marrow-cell (BMC) infusion induces indefinite skin allograft survival across fully mismatched mouse strain combinations. We investigated the role of chimerism in this transplantation tolerance model. MATERIALS:B10.A (H-2a) mice we...

journal_title：Transplantation

authors： Kanamoto A,Monaco AP,Maki T

更新日期：2004-09-27 00:00:00

abstract：:The cytotoxicity of tumour-bearer serum against a transplanted aminoazodye-induced rat hepatoma was revealed using normal rat serum as the source of complement as assessed using a short-term 51Cr release test. The tumour-bearing rat was not deficient in a functional complement system and direct cytolysis against hepat...

journal_title：Transplantation

authors： Price MR,Höffken K,Baldwin RW

更新日期：1979-08-01 00:00:00

abstract：BACKGROUND:Lower liver transplant success is observed when the donor is female. Intracellular acidosis during ischemia is proposed to contribute to the injury sustained by the transplanted organ and its role in livers obtained from nonheartbeating donors is unclear. Research has shown that livers of female rats develop...

journal_title：Transplantation

authors： Soric S,Belanger MP,Askin N,Wittnich C

更新日期：2007-09-27 00:00:00

abstract：:We examined graft and patient survival rates of 47,146 patients in the United Network for Organ Sharing registry following transplants between donors and recipients who were cytomegalovirus (CMV) antibody negative and positive. CMV positivity increased with age to about 80% in patients over 60. Seropositivity was seen...

journal_title：Transplantation

authors： Hirata M,Terasaki PI,Cho YW

更新日期：1996-07-15 00:00:00

abstract：:The potent immunosuppressive action of rabbit antithymocyte globulin (RATG) in allotransplant recipients has been recognized for many years. Some of the antibody specificities and immunoregulatory effects of RATG have been described, but a comprehensive definition of RATG components has not been reported previously. I...

journal_title：Transplantation

authors： Rebellato LM,Gross U,Verbanac KM,Thomas JM

更新日期：1994-03-15 00:00:00

abstract：:The nephrotoxic effects of cyclosporine (CsA) seem to be augmented by co-existing renal injury. A high rate of prolonged delayed function (acute tubular necrosis [ATN]) and non-function (NF) has been associated with the use of CsA prior to and following renal transplantation. Cyclosporine has also been associated with...

journal_title：Transplantation

authors： Sommer BG,Henry M,Ferguson RM

更新日期：1987-01-01 00:00:00

abstract：:Experimental evidence suggests storing lungs inflated with oxygen and with oxidizable substrate improves results of lung transplantation. Glucose is included in the low-potassium-dextran (LPD) solution Perfadex to achieve this goal. The authors hypothesized that other substrates might be more effective. Rat lungs were...

journal_title：Transplantation

authors： Peltz M,He TT,Adams GA 4th,Chao RY,Meyer DM,Jessen ME

更新日期：2005-08-15 00:00:00

abstract：:The recipients of combined kidney-pancreas transplants (SPK) are unique because they routinely receive two allografts from the same donor. In a previous study, we found that the long-term graft survival of the two allografts was different, with better graft survival seen in the pancreas allograft. In an attempt to und...

journal_title：Transplantation

authors： Tesi RJ,Henry ML,Elkhammas EA,Davies EA,Ferguson RM

更新日期：1994-08-27 00:00:00