Prophylaxis with caspofungin for invasive fungal infections in high-risk liver transplant recipients.

abstract：:The purpose of this study was to investigate two promising immunosuppressive agents, didemnin B (DB) and FK506 (FK), during pregnancy to assess potential adverse maternal or fetal effects. Pregnant C3H mice were randomized into control and high- and low-dose treatment groups for each drug. Animals received daily injec...

journal_title：Transplantation

authors： Farley DE,Shelby J,Alexander D,Scott JR

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:The currently used macrolide immunosuppressants, i.e., cyclosporine and tacrolimus, exert considerable nephrotoxicity. We aimed to avoid the nephrotoxic effects by applying a cyclosporine-free regimen for the induction as well as for the maintenance treatment of renal allograft recipients using mycophenolate...

journal_title：Transplantation

authors： Zanker B,Schneeberger H,Rothenpieler U,Hillebrand G,Illner WD,Theodorakis I,Stangl M,Land W

更新日期：1998-07-15 00:00:00

abstract：BACKGROUND:Kidney donors and transplant recipients may be at risk of complications from glomerular hyperfiltration of the single kidney. It has been assumed that tests of the existence of renal functional reserve [delta glomerular filtration rate (deltaGFR), delta effective renal plasma flow (deltaERPF)] can be used to...

journal_title：Transplantation

authors： Englund M,Berg U

更新日期：2000-11-15 00:00:00

abstract：:Because of the inherent difficulties in allele assignment with HLA-DR serological typing, in 1993 our organ procurement organization-based HLA laboratory replaced serology with the molecular method of polymerase chain reaction using sequence-specific primer mixes (PCR-SSP) to type for DR and DQ at a resolution level e...

journal_title：Transplantation

authors： Bryan CF,Harrell KM,Nelson PW,Pierce GE,Ross G,Shield CF 3rd,Warady BA,Aeder MI,Helling TS,Landreneau MD,Luger AM

更新日期：1996-12-27 00:00:00

abstract：BACKGROUND:Graft vascular disease, a major cause of late graft failure in cardiac transplant patients, is associated with the presence of class II major histocompatibility complex molecules on the endothelium. 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors, e.g., simvastatin, have been shown to reduce the in...

journal_title：Transplantation

authors： Sadeghi MM,Tiglio A,Sadigh K,O'Donnell L,Collinge M,Pardi R,Bender JR

更新日期：2001-05-15 00:00:00

abstract：BACKGROUND:Altered expression of murine MD-1, a molecule controlling expression of members of the interleukin (IL)-1 receptor family of signaling proteins, regulates antigen-presenting cell-induced alloreactions. We investigated the effect of treatment with antisense deoxyoligonucleotides or antibodies to MD-1 in vivo ...

journal_title：Transplantation

authors： Hadidi S,Chen Z,Phillips J,Yu K,Gorczynski RM

更新日期：2002-06-15 00:00:00

abstract：:In keeping with the in vitro mitogenic properties of anti-CD3 MoAbs, the first injections of anti-CD3 are invariably responsible for an in vivo cellular activation. This activation induces a massive cytokine release in the circulation (TNF, IFN gamma, IL-2, IL-6, and IL-3). Paralleling this release, a severe clinical ...

journal_title：Transplantation

authors： Ferran C,Dy M,Merite S,Sheehan K,Schreiber R,Leboulenger F,Landais P,Bluestone J,Bach JF,Chatenoud L

更新日期：1990-10-01 00:00:00

abstract：BACKGROUND:Recently, peptides derived from the heavy chain of HLA-B2702 have been shown to modulate immune responses. In this study, we examined the use of these peptides for immunosuppression in a pig to mouse islet xenograft model. METHODS:Purified porcine islets were transplanted in autoimmune (non-obese diabetic) ...

journal_title：Transplantation

authors： Squiers EC,Hodell M,Tice D,Buelow R

更新日期：1998-12-15 00:00:00

abstract：BACKGROUND:Several technical modifications in portal vein (PV) reconstruction have shown excellent outcomes in pediatric liver transplantation (LT); however, which procedure is the best for PV reconstruction of the hypoplastic PV in pediatric LT remains unclear. METHODS:One hundred sixteen pediatric patients aged 1 or...

journal_title：Transplantation

authors： Sakamoto S,Uchida H,Kitajima T,Shimizu S,Yoshimura S,Takeda M,Hirata Y,Fukuda A,Kasahara M

更新日期：2020-01-01 00:00:00

abstract：:Cadaveric kidney transplants with delayed graft function have poorer graft survival by an unknown mechanism. Nitric oxide, produced by nitric oxide synthase (NOS), has a proven role in both recovery of ischemia and promotion of rejection. We therefore wished to study the patterns of NOS activity in a model of renal is...

journal_title：Transplantation

authors： Shoskes DA,Xie Y,Gonzalez-Cadavid NF

更新日期：1997-02-27 00:00:00

abstract：:Dendritic-shaped cells (Thy-1+DC) characterized by the surface phenotype of Thy-1+, asialo GM1+, Ia- are reported to exist exclusively in mice. However, Thy-1+ dendritic cells were observed in the skin of normal athymic nude F344, euthymic F344, and WKAH rats. Their phenotypic markers were Thy-1+, asialo GM1+, Ia-, W3...

journal_title：Transplantation

authors： Ueda A,Ito M,Ishiguro N,Miura Y,Asai J,Miura T

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:Renal ischemia-reperfusion (I/R) injury causes renal tubular necrosis, apoptosis, and inflammation leading to acute renal dysfunction. Recent studies have revealed that deletion of Gα12 mitigates the renal damage due to I/R injury. Our previous study showed that activation of dopamine D3 receptor (D3R) incre...

journal_title：Transplantation

authors： Wang Z,Guan W,Han Y,Ren H,Tang X,Zhang H,Liu Y,Fu J,He D,Asico LD,Jose PA,Zhou L,Chen L,Zeng C

更新日期：2015-11-01 00:00:00

abstract：:In 2007, the islet community was notified that the collagenase product most commonly used for human islet isolations contained bovine neural tissue contaminants. To minimize this potential hazard, we adapted our human islet processing procedure to use a GMP-manufactured, bovine neural tissue-free collagenase blend. He...

journal_title：Transplantation

authors： Szot GL,Lee MR,Tavakol MM,Lang J,Dekovic F,Kerlan RK,Stock PG,Posselt AM

更新日期：2009-09-27 00:00:00

abstract：:EBVirus-associated B cell lymphoproliferative disorder (BLPD) is a recognized complication of primary immunodeficiency and organ as well as bone marrow transplantation. Although the nature of the immune defects that predispose to the development of BLPD are unknown, it is postulated that aberrant T cell responses are ...

journal_title：Transplantation

authors： Mathur A,Kamat DM,Filipovich AH,Steinbuch M,Shapiro RS

更新日期：1994-04-15 00:00:00

abstract：:A series of three synthetic peptides spanning H-2E alpha k chain residues (90-110), (110-130), and (130-150) were synthesized and purified. Mice representative of H-2E- (B6, B10, B10.M, B10.Q, B10.S) and H-2E+ (B10.D2, B10.K, B10.RIII) were immunized with individual peptides and lymph node cells challenged in vitro. B...

journal_title：Transplantation

authors： Krco CJ,Beito TG,David CS

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Patients with von Hippel-Lindau (VHL) disease are at risk for the development of end-stage renal failure from the treatment of localized renal cell carcinoma. Transplantation with its attendant immunosuppression may predispose patients to tumor recurrence; however, there is little information regarding the o...

journal_title：Transplantation

authors： Goldfarb DA,Neumann HP,Penn I,Novick AC

更新日期：1997-12-27 00:00:00

abstract：BACKGROUND:Cardiac allograft vasculopathy (CAV) is a major limitation in long-term graft survival after heart transplantation (HTx). Its prediction and detection at an early stage is a challenge because an accurate, minimally invasive blood test is lacking. The aim of this study was to analyze the relationship of Tact ...

journal_title：Transplantation

authors： Roldán C,Mirabet S,Cecilia C,Brossa V,Roig E,Martín C,Gelpí C

更新日期：2015-07-01 00:00:00

abstract：:The early detection of allograft rejection remains elusive after solitary pancreas transplantation (PTX). We have previously described a modified technique of cystoscopic transduodenal PTX biopsy using the Biopty gun under ultrasound guidance. During the last 2 years, we performed 24 solitary PTXs with prospective pro...

journal_title：Transplantation

authors： Stratta RJ,Taylor RJ,Grune MT,Sindhi R,Sudan D,Castaldo P,Cushing KA,Radio SJ,Wisecarver JL,Matamoros A

更新日期：1995-12-27 00:00:00

abstract：BACKGROUND:To reduce the side effects of long-term immunosuppressive therapy, stable renal transplant patients were routinely converted from cyclosporine to either azathioprine or mycophenolate mofetil. Thereafter, the azathioprine and mycophenolate mofetil dose was reduced to 75% at 4 months and to 50% at 8 months aft...

journal_title：Transplantation

authors： van Besouw NM,van der Mast BJ,de Kuiper P,Smak Gregoor PJ,Vaessen LM,IJzermans JN,van Gelder T,Weimar W

更新日期：2000-07-15 00:00:00

abstract：BACKGROUND:Cyclosporine (CsA) therapy must often be continued during pregnancy to maintain maternal health in such conditions as organ transplantation and autoimmune disease. This meta-analysis was performed to determine whether CsA exposure during pregnancy is associated with an increased risk of congenital malformati...

journal_title：Transplantation

authors： Bar Oz B,Hackman R,Einarson T,Koren G

更新日期：2001-04-27 00:00:00

abstract：:Controversy exists as to the type of cells present in the urine during renal allograft rejection. In order to resolve this controversy as well as to evaluate the value of urine sediment examination as a means of detecting AR, we quantitated the different cells present in urine during AR using an immunoperoxidase techn...

journal_title：Transplantation

authors： Segasothy M,Birch DF,Fairley KF,Kincaid-Smith P

更新日期：1989-03-01 00:00:00

abstract：OBJECTIVES:To determine whether humoral autoimmune responses associated with dilated cardiomyopathy (DCM) influence the postoperative clinical course following cardiac transplantation. METHODS:ELISA levels of preformed cardiac myosin (CM) autoantibodies (Abs) in patients with a pretransplant diagnosis of dilated cardi...

journal_title：Transplantation

authors： Warraich RS,Pomerance A,Stanley A,Banner NR,Dunn MJ,Yacoub MH

更新日期：2000-04-27 00:00:00

abstract：:Clearance studies were performed in 32 transplanted children treated with CsA in combination with low-dose prednisolone (CsA group), and the results were compared with those of 29 children transplanted earlier and treated with azathioprine and prednisolone (CIS group). Serum creatinine and urea levels 6 weeks and 1 ye...

journal_title：Transplantation

authors： Hoyer PF,Krohn HP,Offner G,Byrd DJ,Brodehl J,Wonigeit K,Pichlmayr R

更新日期：1987-04-01 00:00:00

abstract：BACKGROUND:Organ donors are frequently trauma victims, but the impact of donor hemorrhagic shock and resuscitation (HSR) on pulmonary graft function has not been assessed. L-arginine treatment during reperfusion increases the production of endothelial nitric oxide and thus ameliorates ischemia-reperfusion injury. Objec...

journal_title：Transplantation

authors： Preissler G,Löhe F,Ebersberger U,Huff I,Bittmann I,Messmer K,Jauch KW,Angele MK

更新日期：2009-06-15 00:00:00

abstract：BACKGROUND:Both chemokines and adhesion molecules mediate allograft rejection by recruiting leukocytes into the allograft. We investigated the association of six single nucleotide polymorphisms (SNPs) located in interleukin (IL)-8, CXCR1, CXCR2, and selectin with kidney allograft outcomes. METHODS:The promoter regions...

journal_title：Transplantation

authors： Ro H,Hwang YH,Kim H,Jeong JC,Lee H,Doh YS,Park HC,Oh KH,Park MH,Ha J,Yang J,Ahn C

更新日期：2011-01-15 00:00:00

abstract：:The aim of this study was to investigate excretion of urinary and pancreatic juice neopterin in patients after combined pancreas-kidney transplantation and to relate it to the clinical course. The study design was a prospective observation study. Thirty consecutive patients with end-stage diabetic disease received a s...

journal_title：Transplantation

authors： Tilg H,Königsrainer A,Krausler R,Aulitzky WE,Margreiter R,Reibnegger G,Wachter H,Huber C

更新日期：1992-04-01 00:00:00

abstract：BACKGROUND:The management of ureteral strictures in transplanted kidney is challenging. Open surgical treatment is effective but entails significant convalescence. Holmium:yttrium-aluminum-garnet (Ho:YAG) laser endoureterotomy is useful for other types of ureteral obstruction, and we aimed to assess its long-term succe...

journal_title：Transplantation

authors： Gdor Y,Gabr AH,Faerber GJ,Wolf JS Jr

更新日期：2008-05-15 00:00:00

abstract：BACKGROUND:Upon the availability of a cadaveric donor kidney, a delicate allocation process precedes every transplantation. A remodeled Eurotransplant Kidney Allocation System (ETKAS)-derived from simulation studies-was installed in March 1996. The purpose was to adjust long waiting times and international exchange bal...

journal_title：Transplantation

authors： De Meester J,Persijn GG,Wujciak T,Opelz G,Vanrenterghem Y

更新日期：1998-11-15 00:00:00

abstract：:In a prospective randomized double-blind placebo-controlled trial, the effect of rh-SOD, given in a dose of 200 mg intravenously during surgery to cyclosporine-treated recipients of cadaveric renal allografts, on both acute and chronic rejection events as well as patient and graft survival was investigated by analyzin...

journal_title：Transplantation

authors： Land W,Schneeberger H,Schleibner S,Illner WD,Abendroth D,Rutili G,Arfors KE,Messmer K

更新日期：1994-01-01 00:00:00

abstract：INTRODUCTION:The purpose of the current study was to investigate the capacity of CD4+, CD8+, or non-T cells to independently initiate acute rejection of allogeneic hepatocytes using reconstituted SCID, CD4 or CD8 knockout (KO) recipient mice. METHODS:Allogeneic hepatocytes (FVB/N, H-2q) were transplanted into C57BL/6....

journal_title：Transplantation

authors： Bumgardner GL,Gao D,Li J,Baskin JH,Heininger M,Orosz CG

更新日期：2000-12-27 00:00:00