Abstract:
:The purpose of this study was to investigate two promising immunosuppressive agents, didemnin B (DB) and FK506 (FK), during pregnancy to assess potential adverse maternal or fetal effects. Pregnant C3H mice were randomized into control and high- and low-dose treatment groups for each drug. Animals received daily injections from day 1 to day 16, and on day 17 of gestation the maternal condition, litter size, fetal resorption rates, and fetal/placental unit weights were determined. Immunoglobulin (IgG) levels were obtained for DB treatment groups. Delayed type hypersensitivity was assessed in virgin females. Both DB and FK had dose-dependent immunosuppressive activity in the DTH assay, and DB caused elevated IgG concentrations. High doses of DB caused diarrhea and maternal wasting with no fetal survival; with low-dose DB, maternal weight gain was depressed, but pregnancy outcome was not different from control animals. High-dose FK had no obvious detrimental effects on maternal health but caused resorption of all fetuses; administration of low-dose FK resulted in a higher number of resorptions, but fetuses that survived did not appear different from controls. We conclude that these immunosuppressive drugs can have adverse effects on pregnancy, but the maternal and fetal toxicity are dose-dependent.
journal_name
Transplantationjournal_title
Transplantationauthors
Farley DE,Shelby J,Alexander D,Scott JRdoi
10.1097/00007890-199107000-00022subject
Has Abstractpub_date
1991-07-01 00:00:00pages
106-10issue
1eissn
0041-1337issn
1534-6080journal_volume
52pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract:BACKGROUND:Human islet transplantation is a great potential therapy for type I diabetes. To investigate islet graft survival and function, we recently showed the improved effects after co-culture and co-transplantation with vascular endothelial cells (ECs) in diabetic rats. METHODS:ECs were isolated, and the viability...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182356ca7
更新日期:2011-12-15 00:00:00
abstract:BACKGROUND:An artificial neural networks (ANNs) model was developed to predict 5-year graft survival of living-donor kidney transplants. Predictions from the validated ANNs were compared with Cox regression-based nomogram. METHODS:Out of 1900 patients with living-donor kidney transplant; 1581 patients were used for tr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31818b221f
更新日期:2008-11-27 00:00:00
abstract:OBJECTIVES:To retrospectively compare the accuracy of pretransplant panel of reactivity antibodies (PRA) and serum level of soluble CD30 (sCD30) in predicting early (<6 months) acute rejection (AR) in living-donor and deceased-donor kidney-transplant (KT) patients. METHODS:Pretransplant sera of 24 KT recipients were r...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:2005-05-15 00:00:00
abstract:BACKGROUND:Umbilical cord blood transplantation (UCBT) is increasingly used and produces similar results to matched unrelated donor transplantation. METHODS:We performed a retrospective single-center analysis of 50 umbilical cord blood transplantations UCBTs performed from 2001 to 2010, including 37 single and 13 doub...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31826c39b2
更新日期:2012-11-27 00:00:00
abstract::Liver transplantation (LT) is the most effective treatment for small and unresectable hepatocellular carcinomas (HCCs). With scarcity of deceased donor livers, living donor LT (LDLT) is the alternative to deceased donor LT (DDLT). Animal studies have suggested that regeneration of the partial liver graft encourages HC...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.tp.0000446266.42019.28
更新日期:2014-04-27 00:00:00
abstract:BACKGROUND:The long-term metabolic function of microencapsulated xenogeneic adult porcine islets (API) was assessed in a murine model of type 1 diabetes mellitus. METHODS:API were encapsulated in barium-gelled alginate and transplanted intraperitoneally in diabetic nonobese diabetic (NOD) mice given no immunosuppressi...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181abbfc1
更新日期:2009-07-27 00:00:00
abstract:BACKGROUND:We began a clinical trial in African Americans comparing sirolimus-tacrolimus to standard immunosuppression. We report two African American male living donor kidney recipients who developed acute renal failure after exposure to sirolimus-tacrolimus. METHODS:Both patients received similar doses of sirolimus ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200301150-00029
更新日期:2003-01-15 00:00:00
abstract::The major role of anti-alphaGal antibodies in the hyperacute rejection of pig organs by humans and baboons has been clearly demonstrated. Spacered alpha-galactose disaccharide (Gal(alpha1)-3Gal) hapten was produced by chemical synthesis and covalently attached to a flexible, hydrophilic polymer (PAA), which in turn wa...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199611270-00001
更新日期:1996-11-27 00:00:00
abstract::Serologic evidence of resolved hepatitis B virus (HBV) infection (HBV surface antigen negative, anti-HBV core antibody [HBc] positive) in a liver donor can be regarded as an occult infection with episomal HBV in the liver. The purpose of this study was to evaluate the safety of anti-HBc-positive living donors. Between...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000047030.38665.0D
更新日期:2003-02-15 00:00:00
abstract:BACKGROUND:To stimulate organ donation, an organ procurement organization (OPO)-wide effort was undertaken to increase donors after cardiac death (DCD) over a 5-year period. This included commonality of protocols, pulsatile perfusion of kidneys, centralization of data and a regional allocation variance designed to mini...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000179641.82031.ea
更新日期:2006-05-27 00:00:00
abstract::Forty-three human liver allograft biopsies and normal liver were directly analyzed for inflammatory and immunoregulatory cytokine gene expression by polymerase chain reaction (PCR). IL-5 gene expression was predominantly present in biopsies from liver allografts with histopathological evidence of acute rejection. IL-2...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199202010-00035
更新日期:1992-02-01 00:00:00
abstract::In organ transplantation, blood borne cells and macromolecules (e.g., antibodies) of the host immune system are brought into direct contact with the endothelial cell lining of graft vessels. In this location, graft endothelial cells play several roles in allograft rejection, including the initiation of rejection respo...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0b013e3181891d8b
更新日期:2008-11-27 00:00:00
abstract::Mandatory continuous monitoring of early transplant outcome with centralized oversight was introduced in 2004 for all 23 UK adult kidney transplant units. Risk-adjusted cumulative sum charts are used to assess 30-day graft and patient survival against past performance for each center, and change in transplant center p...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181b997de
更新日期:2009-10-27 00:00:00
abstract::We have recently shown that a single intrathymic injection of synthetic 25mer peptides, representing full sequences of the hypervariable domain of RT1.BuB (4 peptides) and RT1.Du beta (4 peptides) WF class II MHC molecules, 48 hr before transplantation induces donor-specific unresponsiveness to WF rat renal allografts...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1994-07-27 00:00:00
abstract::If ABO antigens/antibodies play any role in the pathogenesis of acute graft-versus-host disease (GVHD), one would expect the highest incidence of GVHD in recipients of minor ABO-mismatched grafts, followed by ABO-matched grafts, and the lowest incidence in major ABO-mismatched transplants. To test this hypothesis 174 ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198806000-00018
更新日期:1988-06-01 00:00:00
abstract:BACKGROUND:Assays of drug blood levels are used for therapeutic immunosuppressive drug monitoring (pharmacokinetics, PK). We monitored lymphocyte functions (pharmacodynamics, PD) in allograft recipients treated with mycophenolic acid (MPA) to determine its mechanisms and the relationships among dose levels, PK, PD, and...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200010150-00009
更新日期:2000-10-15 00:00:00
abstract::The requirement for effective, minimally toxic immunosuppression remains a major obstacle to performing human composite tissue allotransplantation. The skin component of composite tissue (e.g., limb) allografts is especially antigenic, necessitating toxic immunosuppressant doses to prevent or reverse acute rejection. ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199402150-00020
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND:Our goal was to test the intragraft mRNA expression and production of two chemokines that are potent chemoattractants for antigen-primed T cells, interferon-gamma inducible protein 10 (IP-10) and monokine-induced by IFN-gamma, (Mig), in allogeneic heart grafts. METHODS:Syngeneic or allogeneic A/J (H-2a) hea...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200003270-00020
更新日期:2000-03-27 00:00:00
abstract:BACKGROUND:In France, foreign patients, whether resident or not in France, can register on the national waiting list under certain conditions. We compared waiting time to kidney transplantation, the level of HLA matching and graft cold ischemia time between foreign patients and French patients living in mainland France...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000205182.96861.3a
更新日期:2006-04-27 00:00:00
abstract::The dose-response effect of cyclosporine on rat limb transplant prolongation was investigated across the LBN-to-LEW histocompatibility barrier. This composite tissue allograft model has been shown to represent a strong transplantation barrier. Median limb allograft survival times increased in a dose-dependent manner w...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198504000-00004
更新日期:1985-04-01 00:00:00
abstract:BACKGROUND:Deceased donor kidneys with acute kidney injury (AKI) and deceased after circulatory death kidneys are viable sources of organs. The outcomes of renal transplantation from deceased after circulatory death (DCD) donors with AKI are not known. METHODS:A retrospective review of deceased donor renal transplants...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003317
更新日期:2020-05-15 00:00:00
abstract::Although the cornea is considered to be an immunological privileged site, corneal transplantation can result in immunological rejection followed by graft failure, especially in patients with vascularized corneas. Several studies suggest a beneficial effect of matching for the HLA class I antigens on corneal graft surv...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199504150-00021
更新日期:1995-04-15 00:00:00
abstract:BACKGROUND:Infectious diseases are a major source of morbidity and mortality for immunosuppressed transplant recipients and the antimicrobial chemotherapy can be often less effective in these individuals, because the contribution of underlying host defenses is absent. METHODS:The influence of co-amoxiclav on the funct...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200102270-00016
更新日期:2001-02-27 00:00:00
abstract:BACKGROUND:Deep venous thrombosis (DVT) is a common problem with potentially devastating results in patients undergoing major surgical procedures. Certain renal transplant recipients are particularly at risk for allograft loss as a consequence of renal vein and artery thrombosis. Over the past few years, low molecular ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199808270-00020
更新日期:1998-08-27 00:00:00
abstract:BACKGROUND:Simultaneous liver-kidney (SLK) transplantation plays an important role in treating kidney failure in patients with end-stage liver disease. It used 5% of deceased donor kidney transplanted in 2015. We evaluated the utility, defined as posttransplant kidney allograft lifespan, of this practice. METHODS:Usin...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001491
更新日期:2017-05-01 00:00:00
abstract::Patients who require cystectomy are usually treated with an ileal conduit or intestinal neobladder for urinary control. In some of them, however, the bowel segment cannot be used because of previous abdominal surgery or radiation treatment. Bladder transplantation from cadavers may be beneficial to these patients, if ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199704150-00002
更新日期:1997-04-15 00:00:00
abstract:BACKGROUND:The incidence and impact of cytomegalovirus (CMV) disease that occurs despite CMV prophylaxis among liver transplant recipients have been incompletely defined. METHODS:The incidence and risk factors for CMV disease during the first posttransplant year in a cohort of liver transplant recipients who received ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000145989.22373.03
更新日期:2004-11-15 00:00:00
abstract::Cyclosporine (CsA) dose adjustment after renal transplantation is generally based on serum, plasma, or whole-blood trough level values. In the face of increased levels, the dosage is reduced in order to prevent CsA-induced nephrotoxicity. There is a paucity of data, however, on the kinetics of CsA in association with ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198512000-00006
更新日期:1985-12-01 00:00:00
abstract::Three hundred thirty-two marrow graft recipients and 241 healthy marrow donors were studied by skin testing with recall and neoantigens. Two hundred thirty patients with leukemia and seventy-eight patients with aplastic anemia received allogeneic HLA-identical sibling marrow. Twenty-four patients with leukemia receive...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198402000-00006
更新日期:1984-02-01 00:00:00
abstract::Alemtuzumab is a humanized CD52-specific monoclonal antibody that is increasingly used off-label as an induction agent in solid organ transplantation, particularly in the setting of maintenance immunosuppression minimization protocols. In this review, we briefly discuss this agent's mechanisms of action and summarize ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000296680.75175.67
更新日期:2007-12-27 00:00:00