Abstract:
:The requirement for effective, minimally toxic immunosuppression remains a major obstacle to performing human composite tissue allotransplantation. The skin component of composite tissue (e.g., limb) allografts is especially antigenic, necessitating toxic immunosuppressant doses to prevent or reverse acute rejection. In previous experiments, RS-61443, an experimental mycophenolic acid ester that inhibits lymphocyte proliferation with minimal toxicity, prevented acute limb allograft rejection in rats for more than 8 months when started on the day of transplantation. In this study, the ability of RS-61443 to reverse established acute rejection was tested in a rat model of hindlimb allotransplantation. Brown-Norway donors and Fischer 344 recipients provided a MHC mismatch for orthotopic midfemur limb transplants that were performed with microsurgical repair of femoral vessels and sciatic nerve. Three groups were studied: untreated allografts (n = 6); allografts receiving RS-61443 at 30 mg/kg/day, started on postoperative day 7 (n = 11); and allografts receiving RS-61443 at 30 mg/kg/day, started on postoperative day 9 (n = 9). Skin and soft tissues were biopsied periodically to assess rejection. Untreated allografts had complete acute rejection within 12-13 days. Animals in both the 7- and 9-day groups developed moderate to severe rejection clinically and histologically before initiation of immunosuppressive therapy. In both groups, RS-61443 was able to reverse rejection completely in all animals from which biopsies were obtained at the time of death at 9-16 weeks after transplantation (P < 0.007). RS-61443 was highly effective as a primary immunosuppressant for reversing established acute rejection in rat hindlimb allografts.
journal_name
Transplantationjournal_title
Transplantationauthors
van den Helder TB,Benhaim P,Anthony JP,McCalmont TH,Mathes SJdoi
10.1097/00007890-199402150-00020subject
Has Abstractpub_date
1994-02-01 00:00:00pages
427-33issue
3eissn
0041-1337issn
1534-6080journal_volume
57pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract:BACKGROUND:Reactivation of cytomegalovirus (CMV) is frequently observed in recipients of solid organs and bone marrow transplants and is associated with increased risk of acute and chronic allograft rejection, opportunistic infection, graft failure, and patient mortality. The molecular mechanisms by which reactivation ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181b242a7
更新日期:2009-09-15 00:00:00
abstract::In human organ transplantation, the correct diagnosis of rejection may be difficult using clinical and/or histopathologic criteria, and immunologic assays should therefore be considered. We have applied monoclonal antibodies in 2-color flow cytometric (FACS) analysis to study phenotypic patterns of kidney-infiltrating...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198905000-00014
更新日期:1989-05-01 00:00:00
abstract:BACKGROUND:The role of natural killer (NK) cells and macrophages (Møs) in the absence of T cell immunity in discordant xenograft (xg) rejection was investigated. METHODS:Guinea pig hearts were transplanted into athymic nude rats receiving no treatment or antixenoantibody (xAb), anticomplement (C), antinatural killer (...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:2000-07-15 00:00:00
abstract:BACKGROUND:To date, the outcomes of transplant tourism have not been reported extensively. In addition, data about the accuracy of urine cytology for the detection and the role of the BK virus (BKV) in the carcinogenesis of urothelial carcinoma (UC) after renal transplantation are lacking. METHODS:Three hundred seven ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000023
更新日期:2014-07-15 00:00:00
abstract:BACKGROUND:Early allograft dysfunction (EAD) defined by serum total bilirubin (TB) of 10 mg/dL or greater or prothrombin time-international normalized ratio (PT-INR) of 1.6 or greater on postoperative day 7 (POD 7) or aminotransferase greater than 2000 IU/L within the first week, is associated with early graft loss aft...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001959
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to identify pretransplantation and posttransplantation indicators for the development of diabetes mellitus in the first 2 months after renal transplantation and to examine the influence of a cyclosporine A (CsA)-based versus a tacrolimus-based immunosuppressive regimen on these r...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000084295.67371.11
更新日期:2003-11-15 00:00:00
abstract::Electrolytic lesions were produced in the tuberal hypothalamus and amygdala of male Fischer and female BNLF1 rats, and in male Fischer and female BNLF1 rats that had received antecedent hypophysectomies. Skin grafts from Lewis rats survived less well on tuberal-lesioned male Fischer rats than similar grafts on sham-op...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197904000-00002
更新日期:1979-04-01 00:00:00
abstract:BACKGROUND:The deceased donor score (DDS), expanded criteria donor (ECD) definition, and resistive index (RI) were developed for pretransplant evaluation of donors. DDS and ECD are determined by a calculation of risk from donor variables, while RI is determined from flow characteristics of kidneys during machine preser...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000173798.04043.af
更新日期:2005-10-15 00:00:00
abstract::T cell receptor (TCR) beta-chain usage by HLA-DR1 alloreactive T cell lines was examined to determine whether common TCR gene segments were used preferentially. We have demonstrated previously that a DR1-specific, human renal allograft-derived T cell line and replicate, anti-DR1 mixed lymphocyte reactions (MLR), estab...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199604150-00017
更新日期:1996-04-15 00:00:00
abstract::Although solid organ transplant results have improved significantly in recent decades, a pivotal cause of impaired long-term outcome is the development of antibody-mediated rejection (AMR), a condition characterized by the presence of donor specific antibodies to human leukocyte antigen (HLA) or non-HLA antigens. High...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003551
更新日期:2020-11-17 00:00:00
abstract:BACKGROUND:In France, the need for continuous monitoring of transplant center performance has recently become apparent. Cumulative sum (CUSUM) monitoring of transplantation is already been used to monitor transplant outcomes in the United Kingdom and in the United States. Because CUSUM monitoring can be applied by diff...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002591
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:The rate of acute rejection (AR) has decreased significantly, but whether this is associated with improvement in long-term graft survival is controversial. METHODS:We analyzed 1445 consecutive adult deceased donor kidney transplant recipients from 1985 to 2005, over two periods (1985-1995 vs. 1996-2005) to ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181c892dd
更新日期:2010-03-27 00:00:00
abstract::Until recently, islet allotransplantation for type 1 diabetic patients has been largely unsuccessful. Previous pharmacologic studies of single drugs have suggested that one factor contributing to this poor success is toxicity of immunosuppressive drugs on transplanted islets. However, no comprehensive study of agents ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200202150-00007
更新日期:2002-02-15 00:00:00
abstract::A major impediment to the wider application of clinical liver transplantation is the paucity of acceptable organs. Most centers refuse organs that come from donors who are hepatitis B core antibody positive because of a fear of transmission of hepatitis B virus (HBV) infection to the recipient. The risk related to the...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199908270-00013
更新日期:1999-08-27 00:00:00
abstract::We report the observation that the major sources of variation in cadaver renal allograft survival rates are not related to the technique of donor organ preservation but are related solely to other factors including pretransplant blood transfusion of the recipient, antilymphocyte serum (ALS) treatment of the recipient,...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198112000-00008
更新日期:1981-12-01 00:00:00
abstract::The individual effects of verapamil and 2 antioxidants on perfused rat liver nucleoside triphosphate (NTP) recovery following cold storage in University of Wisconsin (UW) solution was assessed using 31P nuclear magnetic resonance spectroscopy. The pharmacological agents were added to UW solution and were present only ...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1994-06-15 00:00:00
abstract::A technique for simplified heterotopic rat heart transplantation having only aorto-aortic anastomosis is presented. The heterotopic rt heart survives and functions well when one lung lobe is attached t the transplantation and functions as a reservoir. Iso- and allotransplants are compared by electrocardiogram (ECG) de...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198204000-00020
更新日期:1982-04-01 00:00:00
abstract:INTRODUCTION:Factors contributing to kidney transplant fibrosis remain incompletely understood, particularly in the absence of acute complications. METHODS:Baseline and 1-year surveillance biopsies from 15 uncomplicated living donor kidney transplants were subjected to microarray and quantitative reverse transcription...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000265501.33362.d3
更新日期:2007-06-15 00:00:00
abstract::Leflunomide is a compound recently shown to reduce T and B cell-mediated responses in a number of experimental rat, mouse, and human systems. To explore its potential as an immunosuppressant, we studied leflunomide in 128 Brown-Norway/Lewis cardiac transplants and in 48 unoperated Lewis rats. At doses ranging from 0.6...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1994-04-27 00:00:00
abstract:BACKGROUND:All-cause mortality is high after kidney transplantation (KT), but no prognostic index has focused on predicting mortality in KT using baseline and emergent comorbidity after KT. METHODS:A total of 4928 KT recipients were used to derive a risk score predicting mortality. Patients were randomly assigned to t...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181b4ac2f
更新日期:2009-09-27 00:00:00
abstract:BACKGROUND:Heart transplantation (HTx) remains the most effective long-term treatment for advanced heart failure. Primary graft dysfunction (PGD) continues to be a potentially life-threatening early complication. In 2014, a consensus statement released by International Society for Heart and Lung Transplantation (ISHLT)...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002220
更新日期:2019-02-01 00:00:00
abstract::The effects of mismatching for DR antigens on renal allograft survival rates have largely been restricted to analyses of cadaver transplant results. Analyses of HLA matching in recipients of transplants from related donors have focused on the number of haplotypes shared between the recipients without regard to DR, or ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198336060-00011
更新日期:1983-12-01 00:00:00
abstract::Corneal grafts are more likely to be rejected when placed in a vascularized rather than in a normal host cornea. Using immunohistochemical techniques, normal rabbit cornea was found to contain measurable numbers of cells of hemopoietic origin, probably of either macrophage or dendritic lineage. After the deliberate in...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198612000-00017
更新日期:1986-12-01 00:00:00
abstract:BACKGROUND:Cold preservation is the most practical method to maintain the viability of isolated lungs. However, rapid cooling may affect pulmonary endothelial function. We examined the effects of microtubule stabilization with paclitaxel on pulmonary endothelial barrier integrity under cold temperature. METHODS:Human ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000131951.72851.57
更新日期:2004-08-27 00:00:00
abstract:INTRODUCTION:The importance of HLA matching for renal transplantation outcomes has been appreciated for several decades. It has been hypothesized that as pharmacologic immunosuppression becomes stronger and more specific, the impact of HLA matching may be vanishing. Mycophenolate Mofetil (MMF) has been demonstrated to ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200102150-00010
更新日期:2001-02-15 00:00:00
abstract:BACKGROUND:Mycophenolic acid (MPA) is an inhibitor of lymphocyte proliferation and is well established as an immunosuppressive agent in solid organ transplantation. The initial formulation of the drug was a prodrug formulation, mycophenolate mofetil (MMF, Cellcept), which is well absorbed and rapidly converted to mycop...
journal_title:Transplantation
pub_type: 杂志文章,meta分析
doi:10.1097/01.tp.0000242137.68863.89
更新日期:2006-12-15 00:00:00
abstract:BACKGROUND:The spleen is considered to be an important secondary lymphoid organ where acute graft-versus-host disease (GVHD) is initiated by donor T cells that recognize host alloantigens after allogeneic bone-marrow transplantation (BMT). The influence of splenectomy on the development of GVHD prior to BMT has yet to ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200205270-00027
更新日期:2002-05-27 00:00:00
abstract:BACKGROUND:Obliterative bronchiolitis poses a primary obstacle for long-term survival of lung transplant recipients and manifests clinically as bronchiolitis obliterans syndrome (BOS). Establishing a molecular level screening method to detect BOS-related proteome changes before its diagnosis by forced expiratory volume...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318224c109
更新日期:2011-08-27 00:00:00
abstract:BACKGROUND:Hemostatic complications are not uncommon after bone marrow transplantation (BMT). However, little is known about the frequency, localization, determinants, and outcome of hemostatic events in autologous and allogeneic BMT. METHODS:Four hundred forty-seven patients (364 allogeneic, 83 autologous transplants...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200211150-00018
更新日期:2002-11-15 00:00:00
abstract:BACKGROUND:Ischemia-reperfusion (I/R) injury is a multifactorial phenomenon that occurs during the transplant event and frequently compromises early graft function after liver transplantation (LT). Current comprehension of molecular mechanisms and regulation processes of I/R injury lacks clarity. MicroRNA (miRNA) regul...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182a20398
更新日期:2013-11-27 00:00:00