Abstract:
:We report the observation that the major sources of variation in cadaver renal allograft survival rates are not related to the technique of donor organ preservation but are related solely to other factors including pretransplant blood transfusion of the recipient, antilymphocyte serum (ALS) treatment of the recipient, and high HLA match. In contrast to prior studies which used univariate methods to analyze similar data, our analysis shows that it is imperative that comparisons of different methods of cadaver preservation must include adjustments for the effects of pretransplant blood transfusions, antilymphocyte serum, and HLA match.
journal_name
Transplantationjournal_title
Transplantationauthors
Vaughn WK,Mendez-Picon G,Humphries AL,Spees EKdoi
10.1097/00007890-198112000-00008subject
Has Abstractpub_date
1981-12-01 00:00:00pages
490-4issue
6eissn
0041-1337issn
1534-6080journal_volume
32pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract:BACKGROUND:Two patients with end-stage renal disease secondary to multiple myelomas were treated with combined kidney and bone marrow transplantation in an effort to achieve donor-specific allotolerance through the induction of mixed lymphohematopoietic chimerism. METHODS:Two female patients (55 and 50 years of age) w...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200211270-00011
更新日期:2002-11-27 00:00:00
abstract:BACKGROUND:Specific tolerance after combined kidney and bone marrow transplantation for multiple myeloma with end-stage renal disease through mixed lymphohematopoietic chimerism has been achieved, as evidenced by prolonged normal renal function without ongoing immunosuppression. METHODS:To achieve potent antimyeloma r...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31820a3068
更新日期:2011-03-27 00:00:00
abstract:BACKGROUND:Donor-derived cell-free DNA (dd-cfDNA) is a potential noninvasive molecular marker of graft rejection after kidney transplant, whose diagnostic accuracy remains controversial. METHODS:We performed a systematic review and meta-analysis to evaluate the diagnostic accuracy of dd-cfDNA. Relevant literature was ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003443
更新日期:2020-09-02 00:00:00
abstract::To determine whether a disparity at a single miH genetic loci are sufficient to generate GVHD in mice, we focused on well-known genetic alleleic differences at the miH gene loci, H3 and H4. For H3 congenic GVHD studies, C57BL/10 (H2b) mice were used as recipients of miH-disparate B10.LP-H3b donor cells. For H4 congeni...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199602270-00017
更新日期:1996-02-27 00:00:00
abstract::India with a population of 1.2 billion has a renal transplantation rate of 3.25 per million population. The major cause of chronic kidney disease is hypertension and diabetes. The crude and age-adjusted incidence rates of end-stage renal disease are estimated to be 151 and 232 per million population, respectively, in ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182469b91
更新日期:2012-04-27 00:00:00
abstract:BACKGROUND:The liver is an immunologic privileged organ; liver allografts are accepted across major histocompatibility complex barriers in many species. However, hepatocyte transplants are acutely rejected, suggesting a role for liver nonparenchymal cells in regulating the immunoresponse. We have shown potent immunoreg...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318294caae
更新日期:2013-07-15 00:00:00
abstract:BACKGROUND:Organ scarcity continues in solid organ transplantation, such that the availability of organs limits the number of people able to benefit from transplantation. Medical advancements in managing end-stage organ disease have led to an increasing demand for multiorgan transplant, wherein a patient with multiorga...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002788
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Survival of ABO-mismatched kidneys with stable renal function despite the persistence of anti-ABO antibodies is called accommodation. The mechanism of accommodation is unclear, but may involve complement regulatory proteins such as CD59. The development of alpha-1,3-galactosyltransferase knock-out (GalT-KO) ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181a19afc
更新日期:2009-05-15 00:00:00
abstract::Loss of renal mass has been associated with the development of glomerular sclerosis in animals and human beings. The pathophysiology of this renal injury is unknown, but glomerular sclerosis in animals can be aggravated or accelerated following exposure to nephrotoxic antibodies, puromycin aminoglycoside or renal irra...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198410000-00006
更新日期:1984-10-01 00:00:00
abstract::Programmed cell death (PCD) is currently one of the most intensively studied areas in cell biology. Substantial evidence now exists demonstrating the integral role of PCD in many fundamental immunologic processes; therefore, understanding the mechanisms of PCD may provide advances with broad implications in immunobiol...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/00007890-199809270-00001
更新日期:1998-09-27 00:00:00
abstract::The results presented in this report demonstrate that T cells, isolated from AGUS rats bearing long-term (WAG X AGUS)F1 spleen allografts adoptively transferred to irradiated AGUS recipients could not mediate the rejection of WAG hearts but rejected PVG. A hearts in acute fashion. Further, unresponsive T cells were ab...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198709000-00024
更新日期:1987-09-01 00:00:00
abstract:BACKGROUND:The majority of chronic hepatitis is ascribable to hepatitis C virus (HCV) infection, whereas the clinical impact has not been understood in kidney transplant recipients. Our current study was carried out to assess the impact of HCV infection on kidney recipients over the long-term, and to investigate the ef...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199808270-00010
更新日期:1998-08-27 00:00:00
abstract:BACKGROUND:Monocarboxylate transporter (MCT)-1, a member of a family of molecules, transports monocarboxylates such as lactate. Inhibiting MCT-1 leads to long-term graft survival in rodent heart transplantation and induces tolerance. We evaluated an MCT-1 inhibitor, AS2495674, in a rat heart transplant model and analyz...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181ff8818
更新日期:2010-12-27 00:00:00
abstract::Apoptotic cells are endowed with immunomodulatory properties. The authors propose infusing apoptotic cells as a cell-based therapy product to facilitate allogeneic hematopoietic engraftment after a nonmyeloablative conditioning regimen. Such an approach may be used to obtain macrochimerism in combined hematopoietic ce...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.TP.0000067951.90241.54
更新日期:2003-05-15 00:00:00
abstract:BACKGROUND:Patients with pretransplantation strong donor-specific anti-human leukocyte antigen (HLA) antibodies (DSA) are at higher risk for rejection. We aimed to study the safety of kidney transplantation in patients with lower strength DSAs in a prospective cohort study. METHODS:Three hundred and seventy-three cons...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000191
更新日期:2014-11-27 00:00:00
abstract::The frequency of donor-reactive and of third party-reactive cytotoxic T lymphocyte precursors (CTLp) was determined by limiting dilution analysis in the peripheral blood of 13 liver allograft recipients before (pre-tpx) and at various intervals (4 to 22 months) after (post-tpx) transplantation. In 6 of 13 patients wit...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1994-06-27 00:00:00
abstract::To investigate whether graft-versus-host reactivity (GVHR) and the graft-versus-leukemia (GVL) effect can be differentiated, C3H-->AKR mixed bone marrow (BM) chimeras were prepared using two different conditioning regimens. Total body irradiation (TBI) chimeras were induced by infusing 5 x 1O(6) T cell depleted syngen...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199603150-00025
更新日期:1996-03-15 00:00:00
abstract:BACKGROUND:Successful islet transplantation can result in insulin independence in many patients with type 1 diabetes mellitus, but it often requires more than one islet infusion. The ability to achieve insulin independence with a single donor is an important goal in clinical islet transplantation due to the limited org...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181c478fd
更新日期:2010-02-27 00:00:00
abstract::The survival of semiallogeneic or fully allogeneic rat kidney allografts was prolonged in some strain combinations with immune complexes formed with hapten-conjugated alloantigens (TNP-Ag) of donor origin and a mouse monoclonal antihapten antibody (anti-TNP). Complexes were administered i.v. at the time of operation--...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198311000-00001
更新日期:1983-11-01 00:00:00
abstract:BACKGROUND:Abrupt temperature shift from hypothermia to normothermia incurred on reperfusion of organ grafts has been delineated as a genuine factor contributing to reperfusion injury and graft dysfunction after transplantation. METHODS:In a first clinical series of 6 patients, cold-stored livers, all allocated by the...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000915
更新日期:2016-01-01 00:00:00
abstract::Up-regulated expression of adhesion molecules on vascular endothelial cells (ECs) is an initial event in leukocyte adhesion to ECs, which is a crucial step in the process of inflammatory or immune reaction leading to organ transplant rejection. Verapamil and other calcium channel blockers have been reported to improve...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199703150-00024
更新日期:1997-03-15 00:00:00
abstract:BACKGROUND:Cytomegalovirus (CMV) replication has been associated with more risk for solid organ graft rejection. We wondered whether this association still holds when patients at risk receive prophylactic treatment for CMV. METHODS:We correlated CMV infection, biopsy-proven graft rejection, and graft loss in 1,414 pat...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/TP.0000000000000160
更新日期:2014-11-15 00:00:00
abstract:BACKGROUND:Live liver donation requires extended liver resection in the donor with transection of the middle hepatic vein. This leads to focal outflow obstruction in the remnant liver or the partial graft. This study was designed to characterize the pathophysiological correlate of focal outflow obstruction in a small-f...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31816631f9
更新日期:2008-03-15 00:00:00
abstract:BACKGROUND:Short-term outcomes using steroid-free immunosuppression after renal transplantation have been promising. No studies have examined the incidence of and reasons for steroid-avoidance protocol failures. METHODS:We present a single-center analysis of steroid-free immunosuppression failures among 129 pediatric ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181a5df60
更新日期:2009-06-15 00:00:00
abstract::If transplantation of endocrine tissue is to become a therapy for a significant number of insulin-dependent diabetic individuals, tissue sources other than adult human islets will be required. Because human fetal pancreatic cells may offer that alternative, we have tried to find the optimal combination of tissue cultu...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199312000-00011
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND:Obesity is a common problem following renal transplantation. Rimonabant, a cannabinoid-1 receptor blocker, offers a new approach for reducing obesity. METHODS:The potential pharmacokinetic interaction between rimonabant and cyclosporine A (CsA, n=10) and tacrolimus (Tac, n=8) was assessed in stable renal tr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31819f1001
更新日期:2009-04-27 00:00:00
abstract::Experimental studies of vein homografts in rats have shown prolonged patency resulting from an attenuated immune response. This study examined the response to Golden Syrian hamster vein xenografts. While one group of Sprague-Dawley rats served as a control, a second group was sensitized with 5 X 10(6) viable hamster s...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198511000-00011
更新日期:1985-11-01 00:00:00
abstract:BACKGROUND:Impaired pretransplant performance status (PS) is associated with chronic liver disease (CLD). We studied its impact on hospital length of stay (LOS), complications and readmissions in the first year after liver transplantation. METHOD:The Standard National Liver Transplant Registry was linked to a hospital...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003484
更新日期:2020-10-08 00:00:00
abstract:BACKGROUND:To confirm the results of a number of studies conducted in Europe, the United States, and Japan, this multicenter, randomized trial compared the 12-month efficacy and safety of tacrolimus- and cyclosporine-based immunosuppressive regimens in the prevention of renal allograft rejection. METHODS:A total of 44...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1097/00007890-199708150-00012
更新日期:1997-08-15 00:00:00
abstract::Incompatibility for DBA/2 (D2) minor histocompatibility antigens (MiHA) alone leads to a severe lethal graft-versus-host reaction (GVHR) in irradiated (D2 X B10.D2)F1 mice receiving a bone-marrow-plus-spleen-cell graft from B10.D2 donors. This mortality is abrogated when the donors are preimmunized simultaneously agai...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198309000-00016
更新日期:1983-09-01 00:00:00