Enhancement of rat kidney allografts using haptenated alloantigens and antihapten antibody.

Abstract:

:The survival of semiallogeneic or fully allogeneic rat kidney allografts was prolonged in some strain combinations with immune complexes formed with hapten-conjugated alloantigens (TNP-Ag) of donor origin and a mouse monoclonal antihapten antibody (anti-TNP). Complexes were administered i.v. at the time of operation--and, in some cases, on subsequent days. Complexes using TNP-modified alloantigen in various forms--donor whole spleen lymphocytes, cellular membrane sonicate, or papain-solubilized-were all found to be effective in enhancing graft survival in specific donor-recipient combinations. Indefinite survival was obtained in some recipient groups with semiallogenic donors, and a more modest degree of enhancement was seen with fully allogeneic kidneys. The enhancing effect was shown to be donor-specific and highly dependent on the ratio of anti-TNP antibody to TNP alloantigen.

journal_name

Transplantation

journal_title

Transplantation

authors

Barber WH,Hutchinson IV,Morris PJ

doi

10.1097/00007890-198311000-00001

subject

Has Abstract

pub_date

1983-11-01 00:00:00

pages

475-9

issue

5

eissn

0041-1337

issn

1534-6080

journal_volume

36

pub_type

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