Abstract:
BACKGROUND:Obesity is a common problem following renal transplantation. Rimonabant, a cannabinoid-1 receptor blocker, offers a new approach for reducing obesity. METHODS:The potential pharmacokinetic interaction between rimonabant and cyclosporine A (CsA, n=10) and tacrolimus (Tac, n=8) was assessed in stable renal transplant recipients 6.2 (0.9-21.7) years posttransplant. A 12-hour pharmacokinetic profile was obtained before and after two months of concomitant treatment with 20 mg rimonabant each morning. RESULTS:Rimonabant treatment induced a moderate, but significant increase in CsA AUC0-12 (19.8+/-16.1 %, P=0.005). Cmax and C2 values tended to increase whereas C0 remained unaffected. Tac pharmacokinetics was not significantly affected by rimonabant treatment. Eleven of 18 patients experienced adverse events. Two patients reported depressions and one reported severe nightmares. CONCLUSIONS:The effect on CsA pharmacokinetics is probably of marginal clinical relevance since trough concentrations were unaltered, but CsA concentrations should probably be more closely monitored if rimonabant treatment is initiated, preferably by C2 monitoring.
journal_name
Transplantationjournal_title
Transplantationauthors
Amundsen R,Asberg A,Robertsen I,Vethe NT,Bergan S,Hartmann A,Midtvedt Kdoi
10.1097/TP.0b013e31819f1001subject
Has Abstractpub_date
2009-04-27 00:00:00pages
1221-4issue
8eissn
0041-1337issn
1534-6080pii
00007890-200904270-00018journal_volume
87pub_type
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