Abstract:
:Programmed cell death (PCD) is currently one of the most intensively studied areas in cell biology. Substantial evidence now exists demonstrating the integral role of PCD in many fundamental immunologic processes; therefore, understanding the mechanisms of PCD may provide advances with broad implications in immunobiology. This Overview provides a definition of PCD, a description of known PCD biochemical pathways, and finally a discussion of the implications of PCD in transplantation.
journal_name
Transplantationjournal_title
Transplantationauthors
Woodle ES,Kulkarni Sdoi
10.1097/00007890-199809270-00001subject
Has Abstractpub_date
1998-09-27 00:00:00pages
681-91issue
6eissn
0041-1337issn
1534-6080journal_volume
66pub_type
杂志文章,评审相关文献
TRANSPLANTATION文献大全abstract:BACKGROUND:Infections and acute graft-versus-host disease (GvHD) represent major complications of allogeneic stem-cell transplantation (SCT). Dendritic cells (DCs) display an extraordinary capacity to induce innate and adaptive immune responses. Therefore, they play a crucial role in the elimination of pathogens and in...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31824fd8b4
更新日期:2012-06-27 00:00:00
abstract::Several studies have reported the development of antiidiotypic antibodies to anti-HLA alloantibodies in renal allograft transplant recipients, postulating their potential beneficial role in allograft survival. In order to evaluate the role of anti-HLA antiidiotypic antibodies in human liver transplant recipients and t...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199308000-00037
更新日期:1993-08-01 00:00:00
abstract:BACKGROUND:Many models of transplant tolerance have been found to depend on the induction of regulatory T cells (Tregs). Innate immune signals are known to suppress Tregs thereby augmenting immunity by abrogating Treg function. Such signals may also provide a barrier to transplantation tolerance mediated by Tregs. A nu...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181ba6f85
更新日期:2009-11-27 00:00:00
abstract:BACKGROUND:Allogeneic bone marrow transplantation (BMT) and donor lymphocyte infusion (DLI) provide valuable treatments for a range of diseases. However, the therapeutic utility of BMT and DLI is reduced by the high incidence of graft-versus-host disease (GvHD) mediated by activated donor T lymphocytes directed against...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000229435.58898.c5
更新日期:2006-08-27 00:00:00
abstract:BACKGROUND:Decapeptides derived from human HLA class I sequences have been shown to prolong allograft survival. The mechanism of action of these peptides has been uncertain, because they act in an MHC unrestricted manner. Recently, it was found that these peptides bind heme oxygenase 1 (HO-1). In the present study, we ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200001150-00021
更新日期:2000-01-15 00:00:00
abstract::A technique for orthotopic bone transplantation in mice has been developed. A section of recipient tibia was removed and replaced by a similar section from the donor animal. The graft was held in place by internal fixation. Bone healing was assessed clinically, histologically, radiologically, and by torsion testing. T...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1979-06-01 00:00:00
abstract:BACKGROUND:Recently published pediatric trial of Rituximab for the treatment of CD20+ acute renal allograft rejection (AR) demonstrated transient depletion of circulating/intragraft B cells (Zarkhin et al., Am J Transplant 2008; 8: 2607). In this study, we have evaluated phenotypic definition of circulating B-cell subs...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318213df29
更新日期:2011-05-15 00:00:00
abstract:BACKGROUND:After cold ischemia, electrons transferred in the electron transport chain may leak out of the mitochondria in proportion to the deterioration of mitochondrial oxidative phosphorylation. This seems to be one major cause of the lipid peroxidation that occurs mainly in the hepatocytes at reperfusion in liver t...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199904270-00015
更新日期:1999-04-27 00:00:00
abstract:BACKGROUND:Cidofovir (CDV) is a nucleotide analogue with proven in vitro effects against cytomegalovirus (CMV) and adenovirus and has been successfully used in the treatment of CMV retinitis in AIDS patients. METHODS:We performed a prospective study to evaluate the efficacy of CDV in 17 patients with hematological mal...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200104150-00010
更新日期:2001-04-15 00:00:00
abstract::Antigenic requirements for the induction of T cell-independent primary splenic IgM antibody responses (plaque-forming cell responses) to H-2Dd alloantigens were studied. Results show that some functional activity or structural property of the donor cells is required for immunogenicity, because antigens are not active ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198302000-00014
更新日期:1983-02-01 00:00:00
abstract::The mortality rates for CVDs in transplant recipients are greater than those in the general population (13). CVDs are a major cause of both patient and graft loss in renal transplant recipients, and improving cardiovascular health may help to extend both patient and graft survival. A complication of chronic renal fail...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:
更新日期:2000-12-15 00:00:00
abstract::Three hundred thirty-two marrow graft recipients and 241 healthy marrow donors were studied by skin testing with recall and neoantigens. Two hundred thirty patients with leukemia and seventy-eight patients with aplastic anemia received allogeneic HLA-identical sibling marrow. Twenty-four patients with leukemia receive...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198402000-00006
更新日期:1984-02-01 00:00:00
abstract::First cadaver, unrelated kidney graft survival at one year from 50 Eurotransplant centers was analyzed and found to show marked changes in survival rates over the 20-year period from 1967 to 1986 inclusive. Full information on HLA-A, -B, and -DR matching and use of cyclosporine therapy was only available for the perio...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198811000-00012
更新日期:1988-11-01 00:00:00
abstract:BACKGROUND:Ischemia/reperfusion (I/R) injury is a limiting factor in liver transplantation. We have recently shown that pyruvate (PY) inhibits intestinal and renal I/R injury. This study aims to evaluate the protective effect of PY on hepatic I/R injury. METHODS:ACI rats were treated with PY, whereas control animals r...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200107150-00008
更新日期:2001-07-15 00:00:00
abstract::If transplantation of endocrine tissue is to become a therapy for a significant number of insulin-dependent diabetic individuals, tissue sources other than adult human islets will be required. Because human fetal pancreatic cells may offer that alternative, we have tried to find the optimal combination of tissue cultu...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199312000-00011
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND:Clinical trial data suggest that continuous hypothermic machine perfusion (HMP) during the entire preservation period reduces the incidence of delayed graft function and improves graft survival. This study evaluates whether short-term MP after cold storage (CS) is also effective. METHODS:Kidney function aft...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182492201
更新日期:2012-04-27 00:00:00
abstract::Recent suggestions that the rat prostate is an alymphatic, immunologically privileged site stimulated further investigation of its status using a variety of techniques. Fixation of certain organs by vascular perfusion of glutaraldehyde followed by plastic embedding avoids the distortion and stromal reorganization that...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197902000-00011
更新日期:1979-02-01 00:00:00
abstract:BACKGROUND:The shortage of livers for transplantation has prompted transplant centers to seek alternatives to conventional cadaveric liver transplantation. Left lateral segmentectomy from living donors has proven to be a safe operation for the donor with excellent results in the pediatric population. Left lobectomy, co...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199909270-00012
更新日期:1999-09-27 00:00:00
abstract::Natural suppressor (NS) activity is detected in tissues undergoing intense hematopoietic regeneration. This includes the spleens of mice recovering from total lymphoid irradiation or cyclophosphamide treatment, or after induction of chronic graft-versus-host disease against minor histocompatibility antigens. NS cells ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199309000-00038
更新日期:1993-09-01 00:00:00
abstract::The in-vitro amino acid (AA) and alpha-keto acid (KA) metabolism of bioreactors initially seeded with 2.5 x 10(9) pig hepatocytes was investigated with a perfusion technique. Considerable changes in the culture medium concentrations of AA and KA were measured during the first days in culture. This is indicative of dyn...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199607270-00013
更新日期:1996-07-27 00:00:00
abstract:BACKGROUND:Extracorporeal membrane oxygenation (ECMO) can be used to maintain oxygen delivery and provide hemodynamic support in case of circulatory and/or respiratory failure. Although the role of ECMO has emerged in the setting of adult liver transplantation (LT), data in children are limited. We aimed to describe th...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003414
更新日期:2020-08-13 00:00:00
abstract::The study purpose was to identify risks, benefits and costs associated with an expanded donor protocol. The protocol design evaluated organs rescued using expanded donor criteria and weighed all costs associated with doing so. Costs were measured against conditions experienced with expanded and traditional criteria an...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199560120-00021
更新日期:1995-12-27 00:00:00
abstract::To investigate the role of natural killer (NK) cells in the induction and pathogenesis of graft-versus-host (GVH) disease, +/beige (+/bg; normal NK cell activity) and beige/beige (bg/bg; deficient NK cell activity) parental C57BL/6 (B6) lymphoid cells were used to induce GVH reactions in either B6 X C3H/Hej +/bg (+/bg...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198708000-00017
更新日期:1987-08-01 00:00:00
abstract:BACKGROUND:Diarrhea is a frequent complication of solid organ transplantation. Cryptosporidiosis is classically reported in patients with acquired immunodeficiency syndrome and emerged as a cause of persistent diarrhea in solid organ transplant patients. METHODS:Through the ANOFEL Cryptosporidium National Network and ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001503
更新日期:2017-04-01 00:00:00
abstract::There is a striking consistency in the total number of heart beats accrued over a lifetime across a range of animal species despite vast differences in size. Moreover, an inverse relationship is observed between heart rate and lifespan, leading to speculation that elevated heart rate could significantly affect longevi...
journal_title:Transplantation
pub_type: 社论,评审
doi:10.1097/TP.0b013e31826bc42a
更新日期:2013-01-27 00:00:00
abstract:BACKGROUND:Renal ischemia-reperfusion (I/R) injury is unavoidable in kidney transplantation and frequently influences both short- and long-term allograft survival rates. One of the major events in I/R injury is the generation of cytotoxic oxygen radicals. Recently, hydrogen gas has been reported to display antioxidant ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318255f8be
更新日期:2012-07-15 00:00:00
abstract::Sera obtained before transplantation from 52 consecutive renal allograft recipients were tested for antibody-dependent cell-mediated cytotoxicity (ADCC) and for complement-dependent cytotoxic antibodies (CDC). A D locus antigen-defined lymphoblastoid cell panel (B lymphoblastoid cell panel) was used as targets for the...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1979-05-01 00:00:00
abstract:BACKGROUND:The shortage of cadaveric livers has sparked an interest in adult-to-adult living donor transplantation. Right lobe donor hepatectomy is frequently required to obtain a graft of adequate size for adult recipients. Careful donor selection is necessary to minimize complications and assure a functional graft. ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200006150-00034
更新日期:2000-06-15 00:00:00
abstract:BACKGROUND:Blockade of the inducible costimulator (ICOS) pathway has been shown to prolong allograft survival; however, its utility in xenotransplantation is unknown. We hypothesize that local expression of ICOS-Ig by the xenograft will suppress the T-cell response resulting in significant prolonged graft survival. ME...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31821774e0
更新日期:2011-05-27 00:00:00
abstract:BACKGROUND:We have previously shown that recognition of human erythrocytes by porcine Kupffer cells is mediated by a carbohydrate-dependent mechanism. The present study explores the possible ligands existing on human glycophorin A and tests their ability to inhibit erythrocyte rosette formation. METHODS:Human erythroc...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000162974.94890.9f
更新日期:2005-08-15 00:00:00