Abstract:
:Antigenic requirements for the induction of T cell-independent primary splenic IgM antibody responses (plaque-forming cell responses) to H-2Dd alloantigens were studied. Results show that some functional activity or structural property of the donor cells is required for immunogenicity, because antigens are not active in subcellular forms. An unexpected finding was that allogeneic red blood cells were exceptionally highly immunogenic, and any lymphoid tissues including purified macrophages and tumor cell lines that were not contaminated with red blood cells were virtually nonimmunogenic. The definite role of red blood cells in donor tissues as immunogens was confirmed by water or ammonium chloride treatment that abolished immunogenicity, as well as by phenotyping of the immunogenic cells with antisera. Thus immunogenic cells were positive for erythrocyte-specific and H-2D antigens and negative for Thy-1, Ig, and NK-1. The possible roles of erythrocytes in induction and regulation of transplantation immunity and in B cell activation in general are discussed.
journal_name
Transplantationjournal_title
Transplantationauthors
Nakashima I,Clark EA,Lake P,Kato N,Nagase F,Mizoguchi K,Isobe KI,Saito Mdoi
10.1097/00007890-198302000-00014subject
Has Abstractpub_date
1983-02-01 00:00:00pages
180-4issue
2eissn
0041-1337issn
1534-6080journal_volume
35pub_type
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