Human peripheral blood leukocyte-reconstituted severe combined immunodeficient mouse: analysis of the human immune response against porcine islet transplantation.

abstract：:Thymectomy of mice aged 6-8 weeks causes a disproportion of splenic T cell sets, the Ly123 set being relatively decreased and the Ly23 set relatively increased (Ly123 decrease: Ly23 increase). A similar disproportion of splenic T cell sets was found to occur spontaneously with advancing age (12-18 months). By PA-SRBC ...

journal_title：Transplantation

authors： Newcomb EW,Goldberg EH,de Sousa M,Goldstein G,Boyse EA,Scheid MP

更新日期：1985-11-01 00:00:00

abstract：:Plasma levels of main granulocyte components of patients after cadaveric renal transplantation were compared 9 days postoperative with the plasma levels of patients undergoing aortofemoral and iliacofemoral bypass operation or abdominal surgery. Lactoferrin values were significantly lower in patients under immunosuppr...

journal_title：Transplantation

authors： Hörl WH,Wanner C,Riegel W,Schlosser W,Wilms H,Schollmeyer P

更新日期：1989-01-01 00:00:00

abstract：:To determine if cold preservation time continues to affect renal transplant outcome, prospectively collected data from 17,937 cadaveric renal transplants performed between 1982 and 1991 were analyzed. Cold preservation intervals of 1-16, 16-32, 32-48, and greater than 48 hr were studied by multi- and univariate method...

journal_title：Transplantation

authors： Peters TG,Shaver TR,Ames JE 4th,Santiago-Delpin EA,Jones KW,Blanton JW

更新日期：1995-01-27 00:00:00

abstract：BACKGROUND:Although the elderly represents a rapidly growing population among transplant recipients, age-specific aspects have not been considered sufficiently in clinical trials. Moreover, age-specific effects of immunosuppressive therapies remain poorly understood. METHODS:Here, we assessed the impact of rapamycin o...

journal_title：Transplantation

authors： Quante M,Heinbokel T,Edtinger K,Minami K,Uehara H,Nian Y,Azuma H,Abdi R,Elkhal A,Tullius SG

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Our aim was to evaluate the effect of FTY720 in discordant islet xenotransplantation. METHODS:Fetal porcine islet-like cell clusters (ICCs) were transplanted into normoglycemic rats that were either left untreated or treated with FTY720 only, with FTY720 plus cyclosporine A (CsA) or with CsA only. Twelve or...

journal_title：Transplantation

authors： Maeda A,Goto M,Zhang J,Bennet W,Groth CG,Korsgren O,Wennberg L

更新日期：2003-04-27 00:00:00

abstract：BACKGROUND:Posttransplant diabetes mellitus (PTDM) is common after liver transplantation and was recently identified as a risk factor for hepatitis C progression. Increased levels of oxidative stress have been identified in diabetes and hepatitis C. The aim of this study was to evaluate the relationship among PTDM, oxi...

journal_title：Transplantation

authors： Cotler SJ,Kallwitz E,TenCate V,Bhushan A,Berkes J,Benedetti E,Layden-Almer J,Layden TJ,Valyi-Nagy T,Guzman G

更新日期：2007-09-15 00:00:00

abstract：BACKGROUND:The genetic modification of pigs is a powerful strategy that may ultimately enable successful xenotransplantation of porcine organs into humans. METHODS:Transgenic pigs were produced by microinjection of gene constructs for human complement regulatory proteins CD55 and CD59 and the enzyme alpha1,2-fucosyltr...

journal_title：Transplantation

authors： Cowan PJ,Aminian A,Barlow H,Brown AA,Chen CG,Fisicaro N,Francis DM,Goodman DJ,Han W,Kurek M,Nottle MB,Pearse MJ,Salvaris E,Shinkel TA,Stainsby GV,Stewart AB,d'Apice AJ

更新日期：2000-06-27 00:00:00

abstract：BACKGROUND:Hypoalbuminemia is associated with poorer outcomes in renal transplantation. Diabetes can compound hypoalbuminemia's detrimental effects. Kidney-pancreas transplantation alters the diabetic milieu; yet, some patients continue to be hypoalbuminemic. METHODS:We retrospectively analyzed 232 patients who underw...

journal_title：Transplantation

authors： Becker BN,Becker YT,Heisey DM,Leverson GE,Collins BH,Odorico JS,D'Alessandro AM,Knechtle SJ,Pirsch JD,Sollinger HW

更新日期：1999-07-15 00:00:00

abstract：BACKGROUND:Cytomegalovirus (CMV) replication has been associated with more risk for solid organ graft rejection. We wondered whether this association still holds when patients at risk receive prophylactic treatment for CMV. METHODS:We correlated CMV infection, biopsy-proven graft rejection, and graft loss in 1,414 pat...

journal_title：Transplantation

authors： Stern M,Hirsch H,Cusini A,van Delden C,Manuel O,Meylan P,Boggian K,Mueller NJ,Dickenmann M,Members of Swiss Transplant Cohort Study.

更新日期：2014-11-15 00:00:00

abstract：:A 44-year-old man was maintained on prednisone and azathioprine after renal transplantation. One and a half years after transplantation, he developed multiple perianal Escherichia coli abscesses. These became chronic and resisted antibiotic therapy. Histologically, the lesions were typical of malakoplakia. Peripheral ...

journal_title：Transplantation

authors： Biggar WD,Keating A,Bear RA

更新日期：1981-02-01 00:00:00

abstract：BACKGROUND:We previously reported the novel activity of alloprimed CD8 T cells that suppress posttransplant alloantibody production. The purpose of the study is to investigate the expression and role of CXCR5 on antibody-suppressor CD8 T-cell function. METHODS:C57BL/6 mice were transplanted with FVB/N hepatocytes. All...

journal_title：Transplantation

authors： Zimmerer JM,Ringwald BA,Elzein SM,Avila CL,Warren RT,Abdel-Rasoul M,Bumgardner GL

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Urolithiasis occurs in approximately 6% of adult kidney transplant (KTx) recipients. Limited data are available on urolithiasis after pediatric KTx. We report the incidence, management of, and risk factors for stone development in children after KTx. METHODS:We reviewed the medical records of 399 children w...

journal_title：Transplantation

authors： Khositseth S,Gillingham KJ,Cook ME,Chavers BM

更新日期：2004-11-15 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) after living donor liver transplantation (LDLT) is associated with increased mortality. We sought to identify associations between intraoperative hemodynamic variables and postoperative AKI. METHODS:We retrospectively reviewed 734 cases of LDLT. Intraoperative hemodynamic variables...

journal_title：Transplantation

authors： Kim WH,Oh HW,Yang SM,Yu JH,Lee HC,Jung CW,Suh KS,Lee KH

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:The cascade of immunological effects brought about by donor bone marrow cell (DBMC) infusions in human organ transplantation, especially in the context of continuous pharmacologic immunosuppression, is not fully understood. Yet, in inbred rodents and even primates, administration of specific bone marrow cell...

journal_title：Transplantation

authors： Mathew JM,Carreno M,Zucker K,Fuller L,Kenyon N,Esquenazi V,Ricordi C,Tzakis AG,Miller J

更新日期：1998-04-15 00:00:00

abstract：BACKGROUND:Acute rejection (AR) of the transplanted kidney has been identified as the major risk factor for the development of chronic rejection and immunological graft loss. However, the clinical presentation and response to AR therapy can vary considerably between recipients. METHODS:We studied the first AR episode ...

journal_title：Transplantation

authors： Ishikawa A,Flechner SM,Goldfarb DA,Myles JL,Modlin CS,Boparai N,Papajcik D,Mastroianni B,Novick AC

更新日期：1999-11-15 00:00:00

abstract：:Pulmonary complications are often lethal components of acute graft-vs.-host disease (GVHD). Although interstitial pneumonitis and lymphocytic bronchitis have been implicated as elements of acute GVHD, previous studies have not determined a correlation between the onset of these histopathologies or their contribution t...

journal_title：Transplantation

authors： Workman DL,Clancy J Jr

更新日期：1994-07-27 00:00:00

abstract：:Murine lymphoid cells sensitized against allografts express two types of cytotoxicity measured in vitro in short-term assays of 2 to 3 hr by 51Cr release. One type of cytotoxicity is specific against target cells carrying the sensitizing alloantigens, and the other type is nonspecific against both syngeneic and unrela...

journal_title：Transplantation

authors： Bonavida B,Bradley TP

更新日期：1976-02-01 00:00:00

abstract：BACKGROUND:We studied whether T-cell clones, which appear in the periphery as a result of the failure of thymic negative selection during graft-versus-host disease (GVHD), have any in vivo anti-host reactivity and can cause GVHD in an adoptive transfer model. METHODS:We performed our studies in a murine model (B10.BR ...

journal_title：Transplantation

authors： van den Brink MR,Moore E,Ferrara JL,Burakoff SJ

更新日期：2000-02-15 00:00:00

abstract：BACKGROUND:Sensitization to human leukocyte antigens (HLA) is a significant barrier to transplantation. Currently, no proven therapy exists to improve access to transplantation for highly sensitized patients. Here, we report a novel approach using intravenous immune globulin to modulate anti-HLA antibody and improve th...

journal_title：Transplantation

authors： Jordan SC,Vo A,Bunnapradist S,Toyoda M,Peng A,Puliyanda D,Kamil E,Tyan D

更新日期：2003-08-27 00:00:00

abstract：BACKGROUND:The deleterious effect of steatosis on transplanted livers is mainly related to a microcirculation impairment. We investigated the effect of preservation duration on the recovery of isolated perfused rat steatotic livers and tested the effect of pentoxifylline (PTX), known to have a beneficial effect on hepa...

journal_title：Transplantation

authors： Arnault I,Bao YM,Sebagh M,Anjo A,Dimicoli JL,Lemoine A,Delvart V,Adam R

更新日期：2003-07-15 00:00:00

abstract：OBJECTIVE:The aim of this prospective, multicenter, noncomparative, open-label trial was to evaluate the prophylactic use of caspofungin in adult liver transplant recipients at high risk of developing invasive fungal infections (IFI). METHODS:Patients received caspofungin for at least 21 days. A successful treatment o...

journal_title：Transplantation

authors： Fortún J,Martín-Dávila P,Montejo M,Muñoz P,Cisneros JM,Ramos A,Aragón C,Blanes M,San Juan R,Gavaldá J,Llinares P,GESITRA Study Group.

更新日期：2009-02-15 00:00:00

abstract：BACKGROUND:For cyclosporine (CsA), 2-hr postdose level (C2) is the best single time point predictor of the area under the curve and a critical measure for effective dosing. The therapeutic CsA microemulsion (Neoral) C2 range in de novo heart transplant patients remains to be determined. PURPOSE:The purpose of this stu...

journal_title：Transplantation

authors： Cantarovich M,Ross H,Arizón JM,Gómez MA,Straatman L,Orús J,Alonso-Pulpón L,Molina BD,Wang S,Lage E,Crespo MG,Manito N,Howlett J,Haddad H,Motown Study Group.

更新日期：2008-04-15 00:00:00

abstract：:Islets were isolated from the pancreata of Sprague-Dawley rats and transplanted into streptozotocin-induced diabetic outbred Wistar rats. The effect of transplantation of islets into the cisterna magna on the diabetic state of the recipients was compared with that of the conventional transplantation of islets into liv...

journal_title：Transplantation

authors： Lee HC,Ahn KJ,Lim SK,Kim KR,Ahn YS,Lee KE,Huh KB

更新日期：1992-03-01 00:00:00

abstract：:A role for cytomegalovirus (CMV) infection in the etiologies of acute and chronic rejection in renal allograft recipients has been suggested. We previously reported that preemptive treatment of CMV infection with ganciclovir in kidney transplant patients was safe and effective. We now present a retrospective analysis ...

journal_title：Transplantation

authors： Akposso K,Rondeau E,Haymann JP,Peraldi MN,Marlin C,Sraer JD

更新日期：1997-04-15 00:00:00

abstract：BACKGROUND:Epitopes are the sites to which antibodies bind. Both alpha and beta peptide chains of the human leukocyte antigen-DQ heterodimers (DQA1 and DQB1, respectively) contain polymorphic regions. We can identify DQA1 and DQB1 epitopes by DQ single antigen beads assay of the antibodies, correlating the beads' react...

journal_title：Transplantation

authors： Deng CT,El-Awar N,Ozawa M,Cai J,Lachmann N,Terasaki PI

更新日期：2008-08-15 00:00:00

abstract：:In a murine strain combination disparate in both H-2 antigens and minor histocompatibility antigens consisting of C57BL/6 (B6; H-2b, Mls-1b) mice as recipients and AKR/J (AKR; H-2k, Mls-1a) mice as donors, we reported that the administration of anti-TCR-alpha beta mAb nonspecifically suppresses the ability to reject a...

journal_title：Transplantation

authors： Nomoto K,Yung-Yun K,Omoto K,Umesue M,Murakami Y,Matsuzaki G,Nomoto K

更新日期：1995-02-15 00:00:00

abstract：BACKGROUND:This study aims to verify the condition of recipients of solid organs from donors with central nervous system (CNS) tumors and determine the risk of disease transmission due to transplantation. METHODS:Twenty-eight brain-dead organ donors with CNS tumors and 91 recipients who received solid organs from Janu...

journal_title：Transplantation

authors： Lee MS,Cho WH,Ha J,Yu ES,Jeong YS,Oh JS,Lee JR,Lee JM

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Transplantation enhances the risk of malignancies, due to the chronic use of antirejection medication. In the case of Kaposi's sarcoma (KS) the permissive effect of immunosuppression has been extensively studied, and cyclosporine (CsA) appears to play a key role. Here we have compared the incidence of KS in ...

journal_title：Transplantation

authors： Cattaneo D,Gotti E,Perico N,Bertolini G,Kainer G,Remuzzi G

更新日期：2005-09-27 00:00:00

abstract：BACKGROUND:In December 2018, United Network for Organ Sharing approved an allocation scheme based on recipients' geographic distance from a deceased donor (acuity circles [ACs]). Previous analyses suggested that ACs would reduce waitlist mortality overall, but their impact on pediatric subgroups was not considered. ME...

journal_title：Transplantation

authors： Mogul DB,Perito ER,Wood N,Mazariegos GV,VanDerwerken D,Ibrahim SH,Mohammad S,Valentino PL,Gentry S,Hsu E

更新日期：2020-08-01 00:00:00

abstract：:Portal vein thrombosis is the most common cause of portal hypertension in noncirrhotic patients. Variceal bleeding is difficult to treat in these patients, especially those with prehepatic diffuse portal mesenteric thrombosis. In a patient with refractory esophagogastroduodenal variceal bleeding as a result of diffuse...

journal_title：Transplantation

authors： Vianna R,Giovanardi RO,Fridell JA,Tector AJ

更新日期：2005-08-27 00:00:00