Long-term prognosis of renal transplantation after preemptive treatment of cytomegalovirus infection.

Abstract:

:A role for cytomegalovirus (CMV) infection in the etiologies of acute and chronic rejection in renal allograft recipients has been suggested. We previously reported that preemptive treatment of CMV infection with ganciclovir in kidney transplant patients was safe and effective. We now present a retrospective analysis of 169 consecutive renal transplant patients, of whom 87 (51.5%) received preemptive treatment with ganciclovir (CMV(+) group). No patient died of CMV infection. Actuarial graft and patient survival rates were not different between the CMV(+) and the CMV(-) groups (graft survival: 68% and 69%; patient survival: 89% and 88%, respectively). At the end of the study, the mean plasma creatinine levels were not statistically different between the two groups (185+/-13 and 166+/-12 micromol/L for the CMV(+) group and the CMV(-) group, respectively). These results suggest that preemptive treatment of CMV infection with ganciclovir may prevent the CMV-induced renal injury and graft loss.

journal_name

Transplantation

journal_title

Transplantation

authors

Akposso K,Rondeau E,Haymann JP,Peraldi MN,Marlin C,Sraer JD

doi

10.1097/00007890-199704150-00012

subject

Has Abstract

pub_date

1997-04-15 00:00:00

pages

974-6

issue

7

eissn

0041-1337

issn

1534-6080

journal_volume

63

pub_type

杂志文章
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    authors: Fritze D,Kern DH,Drogemuller CR,Pilch YH

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  • Anemia after kidney transplantation; its prevalence, risk factors, and independent association with graft and patient survival: a time-varying analysis.

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    pub_type: 杂志文章

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    authors: Jones H,Talwar M,Nogueira JM,Ugarte R,Cangro C,Rasheed H,Klassen DK,Weir MR,Haririan A

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    authors: Arora S,Ueland T,Wennerblom B,Sigurdadottir V,Eiskjær H,Bøtker HE,Ekmehag B,Jansson K,Mortensen SA,Saunamaki K,Simonsen S,Gude E,Bendz B,Solbu D,Aukrust P,Gullestad L

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    pub_type: 杂志文章

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  • The effect of acute rejection and cyclosporin A-treatment on induction of platelet-derived growth factor and its receptors during the development of chronic rat renal allograft rejection.

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    journal_title:Transplantation

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    doi:10.1097/00007890-200202270-00003

    authors: Savikko J,Kallio EA,Taskinen E,von Willebrand E

    更新日期:2002-02-27 00:00:00

  • Heterotopic Abdominal Rat Heart Transplantation as a Model to Investigate Volume Dependency of Myocardial Remodeling.

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    pub_type: 杂志文章,评审

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  • Cyclosporine formulation and Kaposi's sarcoma after renal transplantation.

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    pub_type: 杂志文章

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    pub_type: 杂志文章

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  • Pancreatitis following liver transplantation.

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    journal_title:Transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1097/TP.0000000000002681

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  • Regulatory influence of thymopentin on splenic T cell sets of thymectomized and aged mice.

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    pub_type: 杂志文章

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  • Anti-CD25 monoclonal antibody therapy affects the death signals of graft-infiltrating cells after clinical heart transplantation.

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    pub_type: 杂志文章

    doi:10.1097/00007890-198001000-00009

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    pub_type: 杂志文章

    doi:10.1097/00007890-199808270-00010

    authors: Hanafusa T,Ichikawa Y,Kishikawa H,Kyo M,Fukunishi T,Kokado Y,Okuyama A,Shinji Y,Nagano S

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    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198101000-00013

    authors: Shaw J,Pilarski LM,Al Adra AR,Leigh JB,Wilkins J,Hogarth PM,McKenzie IF,Paetkau V

    更新日期:1981-01-01 00:00:00

  • Trends in Lung Transplantation Practices Across the United States During the COVID-19 Pandemic.

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    pub_type: 杂志文章

    doi:10.1097/TP.0000000000003522

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    更新日期:2021-01-01 00:00:00