Abstract:
:A role for cytomegalovirus (CMV) infection in the etiologies of acute and chronic rejection in renal allograft recipients has been suggested. We previously reported that preemptive treatment of CMV infection with ganciclovir in kidney transplant patients was safe and effective. We now present a retrospective analysis of 169 consecutive renal transplant patients, of whom 87 (51.5%) received preemptive treatment with ganciclovir (CMV(+) group). No patient died of CMV infection. Actuarial graft and patient survival rates were not different between the CMV(+) and the CMV(-) groups (graft survival: 68% and 69%; patient survival: 89% and 88%, respectively). At the end of the study, the mean plasma creatinine levels were not statistically different between the two groups (185+/-13 and 166+/-12 micromol/L for the CMV(+) group and the CMV(-) group, respectively). These results suggest that preemptive treatment of CMV infection with ganciclovir may prevent the CMV-induced renal injury and graft loss.
journal_name
Transplantationjournal_title
Transplantationauthors
Akposso K,Rondeau E,Haymann JP,Peraldi MN,Marlin C,Sraer JDdoi
10.1097/00007890-199704150-00012subject
Has Abstractpub_date
1997-04-15 00:00:00pages
974-6issue
7eissn
0041-1337issn
1534-6080journal_volume
63pub_type
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