Primary integumentary allograft reactivity in the American cockroach, Periplaneta americana.

abstract：:T cells play an important role in protective immunity against tuberculosis. As patients are not reimmunized with BCG after BMT, the question arises as to whether PPD-specific memory T cells are transferred from the marrow donor to the recipient and persist in the long-term. We studied long-term survivors of non-T cell...

journal_title：Transplantation

authors： Rouleau M,Senik A,Leroy E,Vernant JP

更新日期：1993-01-01 00:00:00

abstract：METHODS:Two hundred twenty-three recipients of first cadaveric kidney allografts were randomized to receive tacrolimus (TAC) + mycophenolate mofetil (MMF), TAC + azathioprine (AZA), or cyclosporine (Neoral; CsA) + MMF. All regimens contained corticosteroids, and antibody induction was used only in patients who experien...

journal_title：Transplantation

authors： Gonwa T,Johnson C,Ahsan N,Alfrey EJ,Halloran P,Stegall M,Hardy M,Metzger R,Shield C 3rd,Rocher L,Scandling J,Sorensen J,Mulloy L,Light J,Corwin C,Danovitch G,Wachs M,VanVeldhuisen P,Leonhardt M,Fitzsimmons WE

更新日期：2003-06-27 00:00:00

abstract：:The interpretation of cellular infiltrate from renal transplant recipients with borderline (BL) changes is still a challenging problem. To analyze the immune phenotype of such infiltrate, we quantified the mRNA expression of Foxp3 and interleukinL-10 and granzyme B (GB) in 15 kidney biopsies with BL changes. Controls ...

journal_title：Transplantation

authors： Grimbert P,Mansour H,Desvaux D,Roudot-Thoraval F,Audard V,Dahan K,Berrehar F,Dehoulle-Poillet C,Farcet JP,Lang P,Le Gouvello S

更新日期：2007-02-15 00:00:00

abstract：:Extrinsic denervation and lymphatic disruption impair nutrient absorption after small bowel transplantation. The present study was undertaken to determine whether adding the ileocecal valve with or without the ascending colon would improve the function of a segmental intestinal graft. Five groups of Lewis rats (n = 10...

journal_title：Transplantation

authors： Black RT,Hashimoto T,Zhong RZ,Behme RJ,Garcia BM,Duff JH,Grant DR

更新日期：1994-04-15 00:00:00

abstract：:Most patients with secondary hypertension due to renal disease or on maintenance hemodialysis have lost the physiologic fall of blood pressure during sleep. To test the notion that kidney transplantation normalizes the blood pressure profile, we monitored ambulatory blood pressure over 24 hr in 45 patients (29 males a...

journal_title：Transplantation

authors： Gatzka CD,Schobel HP,Klingbeil AU,Neumayer HH,Schmieder RE

更新日期：1995-05-15 00:00:00

abstract：:Pregnancy after solid organ transplantation, although considered high risk for maternal, fetal, and neonatal complications, has been quite successful. Tacrolimus pharmacokinetic changes during pregnancy make interpretation of whole blood trough concentrations particularly challenging. There are multiple factors that c...

journal_title：Transplantation

authors： Hebert MF,Zheng S,Hays K,Shen DD,Davis CL,Umans JG,Miodovnik M,Thummel KE,Easterling TR

更新日期：2013-04-15 00:00:00

abstract：BACKGROUND:Increasing use of kidney grafts for simultaneous liver and kidney (SLK) transplants is causing concern about the most effective utilization of scarce kidney graft resources. This study evaluated the impact of implementing the proposed United Network for Organ Sharing SLK transplant policy on outcomes for end...

journal_title：Transplantation

authors： Chang Y,Gallon L,Shetty K,Chang Y,Jay C,Levitsky J,Ho B,Baker T,Ladner D,Friedewald J,Abecassis M,Hazen G,Skaro AI

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Only four centers have reported their results with renal transplantation in human immunodeficiency virus (HIV)+ recipients on highly active antiretroviral therapy, and acute rejection (AR) rates have consistently ranged from 43% to 67%. METHODS:We examined the outcomes of eight adult HIV+ primary renal allo...

journal_title：Transplantation

authors： Gruber SA,Doshi MD,Cincotta E,Brown KL,Singh A,Morawski K,Alangaden G,Chandrasekar P,Losanoff JE,West MS,El-Amm JM

更新日期：2008-07-27 00:00:00

abstract：:Deposition of the C4d complement degradation product has been shown to be a marker of antibody-mediated rejection of solid organ allografts, including kidney, heart, liver, and lung. We investigated whether C4d deposition also would be useful in monitoring rejection in human composite tissue allografts. A total of 60 ...

journal_title：Transplantation

authors： Kanitakis J,McGregor B,Badet L,Petruzzo P,Morelon E,Devauchelle B,Dubernard JM

更新日期：2007-07-27 00:00:00

abstract：BACKGROUND:In hamster-to-rat cardiac xenografts, long-term survival (LTS) is obtained in 60% of recipients if vascular rejection is overcome by cobra venom factor and cyclosporine (CsA). It has been suggested that this accommodation state could be due to the Th2 response. METHODS:We examined the infiltrate by using im...

journal_title：Transplantation

authors： Brouard S,Blancho G,Moreau A,Heslan JM,Cuturi MC,Soulillou JP

更新日期：1998-06-27 00:00:00

abstract：BACKGROUND:Previous studies have demonstrated that long-term tolerance of class I mismatched renal allografts in miniature swine is induced by a short course of cyclosporine (CyA), and that a total thymectomy 21 days before transplantation abrogates the induction of stable tolerance. We have now examined the effects of...

journal_title：Transplantation

authors： Yamada K,Ierino FL,Gianello PR,Shimizu A,Colvin RB,Sachs DH

更新日期：1999-04-27 00:00:00

abstract：:Chronic pulmonary disease is associated with varying degrees of cardiac dysfunction. Because of the potentially predominant effect of severe lung disease on right ventricular (RV) size and function, a reliable method to assess RV mechanics before and after lung transplantation may provide information of long-term sign...

journal_title：Transplantation

authors： Vigneswaran WT,McDougall JC,Olson LJ,Breen JF,McGregor CG,Rumberger JA

更新日期：1993-05-01 00:00:00

abstract：:An isolated vascularized bone marrow transplant (iVBMT) model was previously developed in the rat to specifically study the role of bone marrow and its environment in a composite tissue allotransplant. An extraperitoneal model was successfully created to avoid laparotomy and cross-clamping of the great vessels. The ex...

journal_title：Transplantation

authors： Tai CY,France MA,Strande LF,Eydelman R,Sheng X,Matthews MS,Dalsey R,Hewitt CW

更新日期：2003-05-15 00:00:00

abstract：:The humanization of animals is a powerful tool for the exploration of human disease pathogenesis in biomedical research, as well as for the development of therapeutic interventions with enhanced translational potential. Humanized models enable us to overcome biologic differences that exist between humans and other spe...

journal_title：Transplantation

authors： Adigbli G,Ménoret S,Cross AR,Hester J,Issa F,Anegon I

更新日期：2020-11-01 00:00:00

abstract：:Patients with short-gut syndrome may develop total parenteral nutrition-associated liver disease, which may preclude them from isolated intestinal transplantation and require combined liver and intestinal transplantation. Traditionally, these multiorgan transplantations are performed using en bloc liver and intestinal...

journal_title：Transplantation

authors： Fishbein T,Florman S,Gondolesi G,Decker R

更新日期：2003-02-27 00:00:00

abstract：:Heterotopic renal allografts following bilateral nephrectomies were placed in 21 healthy mongrel dogs. One group of 11 dogs received cyclosporine (5 mg/kg/24 hr, orally), and 1 group of 10 dogs received cyclosporine and mizoribine (5 mg/kg and 3 mg/kg/24 hr, orally). Body weights, blood cell counts, serum chemistry pr...

journal_title：Transplantation

authors： Gregory CR,Gourley IM,Cain GR,Broaddus TW,Cowgill LD,Willits NH,Patz JD,Ishizaki G

更新日期：1988-05-01 00:00:00

abstract：BACKGROUND:Gene targeting in large animals has the potential to be useful in medicine as well as in agriculture. Previously, we reported the first successful targeting of the bovine alpha1,3-galactosyltransferase (alpha1,3GT) gene and establishment of a heterozygous knockout cell line. In this report, we generated both...

journal_title：Transplantation

authors： Sendai Y,Sawada T,Urakawa M,Shinkai Y,Kubota K,Hoshi H,Aoyagi Y

更新日期：2006-03-15 00:00:00

abstract：BACKGROUND:At present, autologous intestinal segments are often used for bladder reconstruction. However, the gastrointestinal mucosa often causes various complications. METHODS:Oral mucosal tissues were obtained from the buccal cavity of beagle dogs. Primary oral mucosal epithelial cells were cultured on temperature-...

journal_title：Transplantation

authors： Watanabe E,Yamato M,Shiroyanagi Y,Tanabe K,Okano T

更新日期：2011-04-15 00:00:00

abstract：BACKGROUND:The hallmark of humoral rejection is the presence of subendothelial C4d in the allograft. A simultaneous determination of vascular C4d with soluble C4d in broncho-alveolar lavage fluid (BAL) and circulating anti-human leukocyte antigen (HLA) antibodies (HLA-Ab) has not been reported in lung transplantation. ...

journal_title：Transplantation

authors： Girnita AL,Lee TM,McCurry KR,Baldwin WM 3rd,Yousem SA,Detrick B,Pilewski J,Toyoda Y,Jelinek L,Lomago J,Zaldonis D,Spichty KJ,Zeevi A

更新日期：2008-07-27 00:00:00

abstract：:Following liver transplantation bile formation may be influenced by hepatic denervation and cyclosporine therapy. To better establish any effect of liver transplantation on bile secretion, 6 mongrel dogs were studied: 3 underwent liver denervation by a modified autotransplantation procedure and insertion of a Thomas c...

journal_title：Transplantation

authors： Sutherland FR,Preshaw RM,Shaffer EA

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:Endomyocardial biopsy (EMB) remains the gold standard for acute cellular rejection (ACR) diagnosis in cardiac transplantation yet is subject to interobserver variability. A method that could avoid discordant EMB analysis would be desirable. The apoptosis rate in EMB correlates with ACR severity. Apollon inhi...

journal_title：Transplantation

authors： Aharinejad S,Andrukhova O,Gmeiner M,Thomas A,Krenn K,Zuckermann A,Grimm M

更新日期：2010-01-27 00:00:00

abstract：:Survival times of allogeneic fetal pancreases were determined across various immunogenetic barriers using several inbred rat strains. Pancreases from 17-day-old embryos transplanted beneath the kidney capsule of normal, nonimmunosuppressed recipients were richly vascularized within a short period regardless of histoin...

journal_title：Transplantation

authors： Mullen Y,Shintaku IP

更新日期：1980-01-01 00:00:00

abstract：:Created by the US National Organ Transplant Act in 1984, the Scientific Registry of Transplant Recipients (SRTR) is obligated to publicly report data on transplant program and organ procurement organization performance in the United States. These reports include risk-adjusted assessments of graft and patient survival,...

journal_title：Transplantation

authors： Snyder JJ,Salkowski N,Kim SJ,Zaun D,Xiong H,Israni AK,Kasiske BL

更新日期：2016-02-01 00:00:00

abstract：:The effect of long-term pharmacologic immunosuppression (PI) on anti-Galalpha1-3Gal (alphaGal) antibody (Ab) levels has not been determined previously in humans. In this study, we measured alpha Gal Ab levels by ELISA in 14 healthy volunteers (controls) and in 70 patients with grafts (kidney, heart, liver) who had rec...

journal_title：Transplantation

authors： Gojo S,Bartholomew A,Xu Y,Neethling FA,Awwad M,Saidman S,Cosimi AB,Cooper DK

更新日期：2000-03-15 00:00:00

abstract：BACKGROUND:Recently published pediatric trial of Rituximab for the treatment of CD20+ acute renal allograft rejection (AR) demonstrated transient depletion of circulating/intragraft B cells (Zarkhin et al., Am J Transplant 2008; 8: 2607). In this study, we have evaluated phenotypic definition of circulating B-cell subs...

journal_title：Transplantation

authors： Zarkhin V,Lovelace PA,Li L,Hsieh SC,Sarwal MM

更新日期：2011-05-15 00:00:00

abstract：:The length of time after syngeneic bone marrow reconstitution when tolerance to alloantigens can be induced in adult mice during T cell differentiation from bone marrow cells was studied by exposing those T cells to (recipient x donor)F1 spleen cells. Supralethally irradiated C3H/He Slc(C3H; H-2k) mice were reconstitu...

journal_title：Transplantation

authors： Tomita Y,Himeno K,Mayumi H,Tokuda N,Nomoto K

更新日期：1989-06-01 00:00:00

abstract：:Pretreatment of LEW rats with cyclosporin A (10 mg/kg/day orally for 14 days) plus 10(8) DA or (DA X LEW)F1 spleen lymphocytes on two occasions markedly prolonged the survival of subsequent DA renal allografts. The lymphocytotoxic antibody response was suppressed completely and renal biopsies showed a marked mononucle...

journal_title：Transplantation

authors： Homan WP,Williams KA,Millard PR,Morris PJ

更新日期：1981-06-01 00:00:00

abstract：:Electrolytic lesions were produced in the tuberal hypothalamus and amygdala of male Fischer and female BNLF1 rats, and in male Fischer and female BNLF1 rats that had received antecedent hypophysectomies. Skin grafts from Lewis rats survived less well on tuberal-lesioned male Fischer rats than similar grafts on sham-op...

journal_title：Transplantation

authors： Dann JA,Wachtel SS,Rubin AL

更新日期：1979-04-01 00:00:00

abstract：:The response to IL-2 and IL-4 of several functionally defined lymphoid cell types was assessed at the individual responding cell level in limiting dilution experiments in which exogenous IL-2 or IL-4 was used to promote cellular activation and expansion. Splenic precursors that give rise to alloreactive CTL in LDA sup...

journal_title：Transplantation

authors： Widmer MB,Voice RF,Conlon PJ,Grabstein KH

更新日期：1990-04-01 00:00:00

abstract：:Nine recombinant H-2 mouse strains with crossovers in the I region between I-E-negative haplotypes f,q and I-E-positive haplotypes p,k were examined for I-E expression by microcytotoxicity dye exclusion assay. These recombinants were found to be negative for I-E expression. There are two possible genotypes in these re...

journal_title：Transplantation

authors： Lafuse WP,Savarirayan S,McCormick JF,David CS

更新日期：1987-02-01 00:00:00