An extraperitoneal isolated vascularized bone marrow transplant model in the rat.

Abstract:

:An isolated vascularized bone marrow transplant (iVBMT) model was previously developed in the rat to specifically study the role of bone marrow and its environment in a composite tissue allotransplant. An extraperitoneal model was successfully created to avoid laparotomy and cross-clamping of the great vessels. The extraperitoneal iVBMT model consisted of a left donor femur that was harvested with its nutrient vessels, anastomosed to the right femoral vessels in a syngeneic host, and then placed subcutaneously in the abdominal wall. At explant, the graft vessels were grossly patent, and histology of the graft bones showed a viable marrow compartment. Polymerase chain reaction demonstrated peripheral chimerism in the recipients. This model is technically simple with minimal morbidity in the recipient animals. By using the iVBMT, future studies across semiallogeneic and allogeneic barriers will help define the role of the bone marrow compartment in composite tissue allotransplants to potentially induce immune tolerance.

journal_name

Transplantation

journal_title

Transplantation

authors

Tai CY,France MA,Strande LF,Eydelman R,Sheng X,Matthews MS,Dalsey R,Hewitt CW

doi

10.1097/01.TP.0000061490.85273.29

subject

Has Abstract

pub_date

2003-05-15 00:00:00

pages

1591-3

issue

9

eissn

0041-1337

issn

1534-6080

journal_volume

75

pub_type

杂志文章
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  • A schema for histologic grading of small intestine allograft acute rejection.

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    更新日期:1993-03-01 00:00:00

  • Trends in Lung Transplantation Practices Across the United States During the COVID-19 Pandemic.

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    journal_title:Transplantation

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    更新日期:2021-01-01 00:00:00

  • Antibodies to hepatitis C virus envelope proteins correlate with hepatitis C viraemia after liver transplantation.

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    pub_type: 杂志文章

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    pub_type: 杂志文章

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    更新日期:2001-07-15 00:00:00

  • Notch Signaling and Alloreactivity.

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  • Ischemic preconditioning: a defense mechanism against the reactive oxygen species generated after hepatic ischemia reperfusion.

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    journal_title:Transplantation

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    authors: Peralta C,Bulbena O,Xaus C,Prats N,Cutrin JC,Poli G,Gelpi E,Roselló-Catafau J

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  • Serum tumor markers after renal transplantation.

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    authors: Oberbauer R,Banyai S,Schmidt A,Kornek G,Scheithauer W,Mayer G

    更新日期:1996-11-27 00:00:00

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    authors: Oudshoorn-Snoek M,Iványi D,Démant P

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  • Correction of hyperoxaluria by liver repopulation with hepatocytes in a mouse model of primary hyperoxaluria type-1.

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    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e31816de49e

    authors: Jiang J,Salido EC,Guha C,Wang X,Moitra R,Liu L,Roy-Chowdhury J,Roy-Chowdhury N

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  • How deceased donor transplantation is impacting a decline in commercial transplantation-the Tamil Nadu experience.

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    pub_type: 杂志文章

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    authors: Abraham G,Reddy YN,Amalorpavanathan J,Daniel D,Roy-Chaudhury P,Shroff S,Reddy Y

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    pub_type: 杂志文章,评审

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  • CMV-specific Cell-mediated Immunity at 3-month Prophylaxis Withdrawal Discriminates D+/R+ Kidney Transplants at Risk of Late-onset CMV Infection Regardless the Type of Induction Therapy.

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    pub_type: 杂志文章

    doi:10.1097/TP.0000000000002421

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  • HLA antibody screening: comparison of a solid phase enzyme-linked immunoassay with antiglobulin-augmented lymphocytotoxicity.

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    journal_title:Transplantation

    pub_type: 临床试验,杂志文章

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    更新日期:2009-10-27 00:00:00

  • Renal transplant from very old donors: how far can we go?

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    更新日期:2009-06-27 00:00:00

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    doi:10.1097/01.tp.0000262607.95372.e0

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    更新日期:2007-05-15 00:00:00

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    doi:10.1097/00007890-199403270-00025

    authors: Valdivia LA,Fung JJ,Demetris AJ,Celli S,Pan F,Tsugita M,Starzl TE

    更新日期:1994-03-27 00:00:00

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    doi:10.1097/00007890-199012000-00021

    authors: Johansson A,Möller E

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