Abstract:
:We developed a multiplex, quantitative, real-time, polymerase chain reaction assay for cytomegalovirus (CMV) and used it to measure the CMV viral load in weekly blood specimens from 43 lung transplant recipients. The median viral load in blood samples immediately preceding bronchoscopy was 1150 copies/microg human DNA for 12 subjects with pneumonitis compared to 91 copies for 31 subjects without (P=0.02, Mann-Whitney U test). Each log10 increase in CMV viral load resulted in an increase of 1.92 in the odds ratio for CMV pneumonitis (95% confidence interval 1.03-3.56). CMV viral load was elevated (>100 copies/microg human DNA) for a median of 21 days before bronchoscopy in those subjects with pneumonitis versus 0 days in those without (P=0.004). We conclude that the risk of CMV pneumonitis after lung transplantation is related to the level of CMV DNA in blood. Quantitative PCR should be evaluated prospectively for the preemptive management of CMV in lung transplant recipients.
journal_name
Transplantationjournal_title
Transplantationauthors
Sanchez JL,Kruger RM,Paranjothi S,Trulock EP,Lynch JP,Hicks C,Shannon WD,Storch GAdoi
10.1097/00007890-200108270-00030subject
Has Abstractpub_date
2001-08-27 00:00:00pages
733-5issue
4eissn
0041-1337issn
1534-6080journal_volume
72pub_type
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