Abstract:
:The intestinal phase of the graft-versus-host reaction (GVHR) has been investigated in adult F1 mice bearing grafts of fetal gut using an H-2-incompatible and an H-2-compatible, Mls-incompatible combination. The results indicate that the mitotic activity of the intestinal crypts and the number of intraepithelial lymphocytes are sensitive parameters of the mucosal cell-mediated immune response in the GVHR. Using these indices, indirect evidence has been obtained that soluble factors may be responsible for the damage to the intestine in the GVHR. Possible pathways of lymphocyte activation and migration to the gut are proposed to explain the role of gut-associated T cells in the production of these mediators.
journal_name
Transplantationjournal_title
Transplantationauthors
Mowat AM,Ferguson Adoi
10.1097/00007890-198109000-00011subject
Has Abstractpub_date
1981-09-01 00:00:00pages
238-43issue
3eissn
0041-1337issn
1534-6080journal_volume
32pub_type
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