Results of conversion from cyclosporine to azathioprine in cadaveric renal transplantation.

Abstract:

:Between December 1983 and August 1985, 110 cadaver transplants were performed at our institution. All were started on cyclosporine (CsA) and prednisone (P) for immunosuppressive therapy. Of the 110 patients, 46 were converted from CsA to azathioprine (AZA) for a variety of reasons (cost, toxicity, patient preference, prolonged dysfunction posttransplant, or nonresponsive rejection). The course and outcome of these patients are described. The only group of patients who had consistent benefit and stable course following the CsA-to-AZA switch were primary cadaver transplants with stable renal function (serum creatinine less than 2 mg/dl) who were converted an average of 7.97 months posttransplant. All other groups of patients had severe problems or graft loss postconversion.

journal_name

Transplantation

journal_title

Transplantation

authors

Gonwa TA,Nghiem DD,Schulak JA,Corry RJ

doi

10.1097/00007890-198702000-00012

subject

Has Abstract

pub_date

1987-02-01 00:00:00

pages

225-8

issue

2

eissn

0041-1337

issn

1534-6080

journal_volume

43

pub_type

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