Abstract:
BACKGROUND:We previously reported that posttransplant lymphoproliferative disorders (PTLD) occurred more frequently in non-African American (AF) kidney transplant recipients. An in-depth analysis of racial differences in the development of PTLD has not been reported. METHODS:We assessed Medicare claims for PTLD in a retrospective cohort of 53,719 patients who underwent transplantation from January 2000 to September 2006 and followed up through December 2007. RESULTS:There were 719 (1.3%) patients with claims for PTLD. Non-AF recipient race (including all races analyzed separately, adjusted hazard ratio [AHR] 1.38, 95% confidence interval [CI] 1.13-1.68), recipient Epstein-Barr virus (EBV) immunoglobulin G (IgG) seronegative status (AHR 1.88, 95% CI 1.53-2.34), and de novo sirolimus (AHR 1.22, 95% CI 1.03-1.45) were associated with an increased risk of PTLD. Furthermore, de novo sirolimus showed a significant interaction with EBV IgG; among EBV IgG-negative recipients, sirolimus use was significant (P = 0.003), but among EBV IgG-positive recipients, it was not significant (P = 0.18). EBV IgG-seronegative status was significant in all races except for AFs, and racial differences were a significant effect modifier for EBV IgG status and risk of PTLD. Mortality subsequent to PTLD did not differ by race. CONCLUSIONS.: AF kidney transplant recipients were at lower risk for PTLD, irrespective of the recipient EBV IgG serostatus. On the contrary, recipient EBV IgG-seronegative status was associated with a higher risk of PTLD in the non-AF population. De novo sirolimus therapy was associated with increased risk of PTLD in EBV IgG-negative recipients, regardless of race.
journal_name
Transplantationjournal_title
Transplantationauthors
Nee R,Hurst FP,Dharnidharka VR,Jindal RM,Agodoa LY,Abbott KCdoi
10.1097/TP.0b013e3182200e8asubject
Has Abstractpub_date
2011-07-27 00:00:00pages
190-5issue
2eissn
0041-1337issn
1534-6080journal_volume
92pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract:BACKGROUND:Circulation of leukocytes via blood, tissue and lymph is integral to adaptive immunity. Afferent lymphatics form CCL21 gradients to guide dendritic cells and T cells to lymphatics and then to draining lymph nodes (dLN). Vascular endothelial growth factor C and vascular endothelial growth factor receptor 3 (V...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000561
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Mycophenolic acid (MPA) is an inhibitor of lymphocyte proliferation and is well established as an immunosuppressive agent in solid organ transplantation. The initial formulation of the drug was a prodrug formulation, mycophenolate mofetil (MMF, Cellcept), which is well absorbed and rapidly converted to mycop...
journal_title:Transplantation
pub_type: 杂志文章,meta分析
doi:10.1097/01.tp.0000242137.68863.89
更新日期:2006-12-15 00:00:00
abstract::Nuclear imaging is used to evaluate renal allografts demonstrating delayed function after transplantation. Interpretation of the nuclear scan in the context of clinical data, provides helpful information in the management of the transplant recipient. The better quality of images obtained with technetium-99m mercaptoac...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199711270-00023
更新日期:1997-11-27 00:00:00
abstract::We have investigated the influence of phenobarbitone ([PB]; 40 mg/kg/day), an inducer of hepatic drug metabolism, on high-dose cyclosporine ([CsA] 40 mg/kg/day) nephrotoxicity in normal Lewis (Lew) and renal allografted (DA X Lew F1----Lew) rats of both sexes. In untreated normal animals, CsA nephrotoxicity, assessed ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198804000-00005
更新日期:1988-04-01 00:00:00
abstract:BACKGROUND:There are limited experimental data on the nature of the humoral response elicited in humans against pig antigens. In this study, we have examined the xenoantibody (XAb) response in eight patients with acute liver failure exposed to pig hepatocytes after treatment with the bioartificial liver (BAL). METHODS...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199901150-00003
更新日期:1999-01-15 00:00:00
abstract::We have recently demonstrated that three synthetic peptides corresponding to the donor class I RT1.Aa molecule induce long-term survival of cardiac allografts in the PVG.R8-to-PVG.1U rat strain combination (disparate for one isolated class I, RT1.A, molecule) when presented to the recipient immune system in the thymus...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199712270-00007
更新日期:1997-12-27 00:00:00
abstract::Dendritic cell (DC) progenitors were propagated in liquid culture from nonparenchymal cells resident in normal mouse (B10.BR; H-2k, I-E+) liver in response to granulocyte-macrophage colony stimulating factor (GM-CSF). The liver-derived DC progenitors were MHC class II-/dim and did not express counter receptors for CTL...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199502270-00019
更新日期:1995-02-27 00:00:00
abstract:BACKGROUND:Early enteral nutrition with solutions containing prebiotics (fiber) and probiotics (Lactobacillus) is suggested to reduce bacterial translocation and minimize the incidence of infections after liver transplantation. METHODS:In a prospective, randomized placebo-controlled trial consisting of 95 patients, we...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007890-200207150-00021
更新日期:2002-07-15 00:00:00
abstract:BACKGROUND:Spontaneous tolerance to liver allograft has been reported previously in outbred pig models, but the lack of genetic background did not allow to analyze the impact of the major histocompatibility complex (MHC) on tolerance induction. A model of semi-identical liver allograft was therefore developed in inbred...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200006150-00014
更新日期:2000-06-15 00:00:00
abstract:BACKGROUND:Detection of markers predicting allograft rejection is important for risk assessment before kidney transplantation, as well as to minimize posttransplantation immunosuppression. METHODS:We studied the expression of CD25, HLA-DR, CD134, CD62L, and CD44 by flow cytometry in CD4, CD8, and CD3 cells, from pretr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182283c58
更新日期:2011-09-15 00:00:00
abstract::Loss of bile ducts is a characteristic feature of chronic rejection in the liver allograft (also known as irreversible rejection and vanishing bile-duct syndrome). Typically, this occurs as a progressive lesion resulting in irreversible damage and graft failure requiring retransplantation. In this study, we describe 6...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199105000-00014
更新日期:1991-05-01 00:00:00
abstract::A novel, water-soluble metabolite of cyclosporine, a sulphate conjugate, present in high concentrations in human bile and plasma was evaluated for its immunosuppressive properties. The direct binding of the conjugate to surface molecules on lymphocytes was studied. The effect of the metabolite was tested in several in...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199003000-00027
更新日期:1990-03-01 00:00:00
abstract:BACKGROUND:Connective tissue growth factor (CTGF) is a key mediator of tissue fibrogenesis in kidney disease. Its involvement in renal allograft fibrosis was recently demonstrated in a mouse model. METHODS:We prospectively studied the association between urinary CTGF (CTGFu) levels and renal allograft fibrosis during ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31829b07e1
更新日期:2013-09-15 00:00:00
abstract:BACKGROUND:Accelerated arteriosclerosis limits the survival of transplanted hearts. We hypothesized that insulin-like growth factor-I (IGF-I) is crucial in accelerating transplant arteriosclerosis. Recently, we reported that exposure to IGF-I prior to transplantation accelerates transplant arteriosclerosis in the rat a...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199804270-00003
更新日期:1998-04-27 00:00:00
abstract:BACKGROUND:Dendritic cells (DC) can exert powerful immune stimulatory as well as regulatory functions and are therefore important tools for therapeutic strategies. Dexamethasone (Dex) was previously shown to inhibit DC maturation and to induce regulatory properties both in vitro and in vivo. Here, we investigated the i...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31818a6682
更新日期:2008-11-15 00:00:00
abstract:BACKGROUND:Combined liver and kidney transplantation (CLKT) is a surgical challenge in small children because of technical aspects, lack of pediatric donors, and restrictions related to the size of the abdominal cavity. We report outcomes after CLKT in this challenging group of smaller children. METHOD:A review of pro...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181b29f0c
更新日期:2009-09-15 00:00:00
abstract::Pulmonary endothelium is considered the compartment most susceptible to preservation damage. This investigation was designed to analyze the efficacy of an original, University of Parma low-potassium-albumin solution (SPAL UP) on cultured human pulmonary artery endothelial cells (HPAEC) and to compare its effects with ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199611150-00036
更新日期:1996-11-15 00:00:00
abstract::Using liposomes, multilamellar lipid vesicles (MLV), we have found that liposome-incorporated cyclosporine is not only less toxic but also more effective in prolonging survival of cardiac allografts in mice. Following intravenous injection of liposome-incorporated drug, cyclosporine levels in blood were shown to decre...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199111000-00002
更新日期:1991-11-01 00:00:00
abstract:BACKGROUND:In a recent trial, targeted mild hypothermia in brain-dead organ donors significantly reduced the incidence of delayed graft function after kidney transplantation. This trial was stopped early for efficacy. Here, we report long-term graft survival for all organs along with donor critical care end points. ME...
journal_title:Transplantation
pub_type: 杂志文章,随机对照试验
doi:10.1097/TP.0000000000002890
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:Mycophenolic acid, the active metabolite of mycophenolate mofetil, inhibits the glycosylation of cell membrane glycoproteins. We hypothesized that impaired glycosylation of cell adhesion molecules on endothelial cells in vivo results in decreased susceptibility to inflammation or immunogenicity after allogen...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200002150-00006
更新日期:2000-02-15 00:00:00
abstract:BACKGROUND:Matrix metalloproteinases (MMPs) play a key role in extracellular matrix remodeling events associated with hepatic regeneration after partial hepatectomy. We therefore hypothesized that urinary MMPs and their endogenous tissue inhibitors of matrix metalloproteinases (TIMPs) might also provide important infor...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000137935.81103.a2
更新日期:2004-10-27 00:00:00
abstract:BACKGROUND:It is unclear to what extent cancer history affects posttransplantation mortality in solid organ transplant recipients. METHODS:We identified a Swedish population-based cohort of solid organ transplant recipients in the National Patient Register 1970 to 2008 and linked it to the Cancer and Cause-of-Death Re...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31829854b7
更新日期:2013-08-15 00:00:00
abstract::Orthotopic liver allografts from BN donors to LEW recipients are spontaneously accepted, and the recipients develop donor-specific immunological unresponsiveness. This unresponsiveness may be mediated by suppressor T cells. Immunomagnetically purified splenic T cells from LEW rats bearing BN liver grafts were shown to...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199212000-00019
更新日期:1992-12-01 00:00:00
abstract::Islet transplantation is currently being explored as a treatment for patients with type 1 diabetes. At present, the number of patients becoming insulin-independent is rapidly increasing world-wide applying the transplantation protocol originally described by the group in Edmonton. A hallmark in this procedure is repea...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.tp.0000157273.60147.7c
更新日期:2005-05-27 00:00:00
abstract:BACKGROUND:Endomyocardial biopsy (EMB) remains the gold standard for acute cellular rejection (ACR) diagnosis in cardiac transplantation yet is subject to interobserver variability. A method that could avoid discordant EMB analysis would be desirable. The apoptosis rate in EMB correlates with ACR severity. Apollon inhi...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181c3c690
更新日期:2010-01-27 00:00:00
abstract:BACKGROUND:Cardiac allograft vasculopathy (CAV) still limits survival after heart transplantation. Currently available noninvasive tests are of inferior value to detect CAV, and thus invasive coronary angiography (ICA) is frequently performed. Cardiac dual-source computed tomography calcium scoring (DSCTCS) offers the ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318225281d
更新日期:2011-08-27 00:00:00
abstract::The majority of skin tumors induced in mice by ultraviolet (UV) light are rejected when implanted into normal syngeneic recipients. Subcarcinogenic levels of UV light exposure render the normally resistant mice susceptible to tumor challenge. The immunoregulatory effect of UV light appears to be additive, since the gr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197704000-00008
更新日期:1977-04-01 00:00:00
abstract::The complement system plays a major role in hyperacute rejection of discordant xenografts. In an immediately vascularized xenograft of a porcine organ to a primate, natural antibodies bind to the vascular endothelium of the graft, triggering activation of complement via the classical pathway. One consequence of antibo...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199311000-00024
更新日期:1993-11-01 00:00:00
abstract:BACKGROUND:Transplantation enhances the risk of malignancies, due to the chronic use of antirejection medication. In the case of Kaposi's sarcoma (KS) the permissive effect of immunosuppression has been extensively studied, and cyclosporine (CsA) appears to play a key role. Here we have compared the incidence of KS in ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000173803.97398.31
更新日期:2005-09-27 00:00:00
abstract:BACKGROUND:Both number and origin (donor vs. host) of dendritic cells (DC) are associated with acute graft-versus-host disease (aGvHD), relapse and graft failure after human allogeneic hematopoietic cell transplantation (aHCT). METHODS:We prospectively and simultaneously investigated skin and blood DC subtypes, their ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000203318.16224.57
更新日期:2006-03-27 00:00:00