The role of T suppressor cells in the maintenance of spontaneously accepted orthotopic rat liver allografts.

abstract：:Enhancement of skin grafts in mice by passively administered alloantiserum was examined in conjunction with the simultaneous use of other immunosuppressive regimens. It could be clearly shown that when a "weak" antilymphocyte serum (ALS) was used, a significant further prolongation of graft survival occurred over that...

journal_title：Transplantation

authors： Koene RA,Gerlag PG,McKenzie IF,Hagemann JF,Wijdeveld PG

更新日期：1975-09-01 00:00:00

abstract：:A prospective study of intentional stopping of steroids 6 months after transplantation was done with 29 pediatric renal transplant recipients with a mean age of 10.4 +/- 3.4 years. Immunosuppression consisted of cyclosporine and methylprednisolone. We stopped giving MP to 24 children: to twenty after six months, four ...

journal_title：Transplantation

authors： Ghio L,Tarantino A,Edefonti A,Mocciaro A,Giani M,Guerra L,Berardinelli L,Vegeto A

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Second-set rejection is generally regarded as a phenomenon mainly mediated by humoral cytotoxic antibodies, although a few discordant data have been presented. In the reported experiments, we have taken advantage of the absence of production of specific cytotoxic alloantibodies contrasting with the normal de...

journal_title：Transplantation

authors： Yoshimura R,Chargui J,Aitouche A,Veyron P,Touraine JL

更新日期：2000-04-15 00:00:00

abstract：BACKGROUND:Renal ischemia-reperfusion (I/R) injury causes renal tubular necrosis, apoptosis, and inflammation leading to acute renal dysfunction. Recent studies have revealed that deletion of Gα12 mitigates the renal damage due to I/R injury. Our previous study showed that activation of dopamine D3 receptor (D3R) incre...

journal_title：Transplantation

authors： Wang Z,Guan W,Han Y,Ren H,Tang X,Zhang H,Liu Y,Fu J,He D,Asico LD,Jose PA,Zhou L,Chen L,Zeng C

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:The administration of systemic immunosuppressive agents to recipients of solid organ or bone marrow transplants results in an immunocompromised status. As the number of organ recipients and their life span increase with recent progress in organ transplantation, ocular complications tend to become more divers...

journal_title：Transplantation

authors： Chung H,Kim KH,Kim JG,Lee SY,Yoon YH

更新日期：2007-03-27 00:00:00

abstract：BACKGROUND:Focal segmental glomerulosclerosis (FSGS) recurs after kidney transplantation in more than 30% of cases and can lead to allograft loss. Serum soluble urokinase-type plasminogen activator receptor (suPAR) is implicated in the pathogenesis of native and recurrent FSGS. METHODS:We conducted a retrospective stu...

journal_title：Transplantation

authors： Alachkar N,Wei C,Arend LJ,Jackson AM,Racusen LC,Fornoni A,Burke G,Rabb H,Kakkad K,Reiser J,Estrella MM

更新日期：2013-10-15 00:00:00

abstract：BACKGROUND:Ischemia-reperfusion injury (IRI) plays key roles in graft viability and posttransplantation function. Caspase-3 associated with apoptosis and inflammation is up-regulated by IRI. We propose that naked small interfering RNA (siRNA) targeting caspase-3 may prevent IRI and improve kidney preservation. METHODS...

journal_title：Transplantation

authors： Yang B,Hosgood SA,Nicholson ML

更新日期：2011-03-15 00:00:00

abstract：BACKGROUND:In December 2018, United Network for Organ Sharing approved an allocation scheme based on recipients' geographic distance from a deceased donor (acuity circles [ACs]). Previous analyses suggested that ACs would reduce waitlist mortality overall, but their impact on pediatric subgroups was not considered. ME...

journal_title：Transplantation

authors： Mogul DB,Perito ER,Wood N,Mazariegos GV,VanDerwerken D,Ibrahim SH,Mohammad S,Valentino PL,Gentry S,Hsu E

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:The liver plays a central role in glucose homeostasis by releasing glucose in the fasting state and by taking up and converting into glycogen part of the glucose absorbed from the gastrointestinal tract after meal ingestion. METHODS:To determine whether the hepatic denervation that accompanies liver transpl...

journal_title：Transplantation

authors： Schneiter P,Gillet M,Chioléro R,Wauters JP,Berger M,Tappy L

更新日期：2000-03-15 00:00:00

abstract：BACKGROUND:Posttransplantation measurement of soluble CD30 (sCD30) may be useful for identifying kidney graft recipients at risk of impending graft rejection in the early posttransplantation period. METHODS:We measured plasma sCD30 levels and evaluated the levels in relation to the diagnosis of rejection. RESULTS:Rec...

journal_title：Transplantation

authors： Pelzl S,Opelz G,Daniel V,Wiesel M,Süsal C

更新日期：2003-02-15 00:00:00

abstract：:Graft rejection remains an important cause of renal allograft failure, despite improvements in immunosuppression and HLA typing. Although HLA matching is beneficial, ensuring an exact match it is often impractical. Thus, a reliable in vitro method for quantitating and qualitating alloreactivity is an important goal. I...

journal_title：Transplantation

authors： Kaminski ER,Kaminski A,Bending MR,Chang R,Heads A,Szydlo RM,Pereira RS

更新日期：1995-10-15 00:00:00

abstract：BACKGROUND:There is a lack of information about survival after dropout from the liver transplant waiting list. Therefore, we aimed to assess the overall survival, and risk factors for death, after waiting list dropout due to hepatocellular carcinoma (HCC) progression. METHODS:We assessed patients who dropped out of th...

journal_title：Transplantation

authors： Gorgen A,Rosales R,Sadler E,Beecroft R,Knox J,Dawson LA,Ghanekar A,Grant D,Greig PD,Sapisochin G

更新日期：2019-10-01 00:00:00

abstract：INTRODUCTION:Cytomegalovirus infection after heart transplantation is considered as risk factor for the development of transplant arteriosclerosis. Therefore, the aim of this study was to investigate the effect of murine cytomegalovirus (MCMV) as a single risk factor on transplant arteriosclerosis in an experimental ao...

journal_title：Transplantation

authors： Heim C,Abele-Ohl S,Eckl S,Ramsperger-Gleixner M,Mahmoudian S,Weyand M,Stamminger T,Ensminger SM

更新日期：2010-08-27 00:00:00

abstract：:Eight patients with chronic myeloid leukemia relapse after allogeneic BMT were treated with IFN-alpha and buffy coat transfusions (BC) of the bone marrow donor. The antileukemic effect of this treatment was directly demonstrated in 4 patients by the disappearance of Philadelphia chromosome-positive metaphases or the l...

journal_title：Transplantation

authors： Hertenstein B,Wiesneth M,Novotny J,Bunjes D,Stefanic M,Heinze B,Hübner G,Heimpel H,Arnold R

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:Transplant recipients who develop COVID-19 may be at increased risk for morbidity and mortality. Determining the status of antibodies against SARS-CoV-2 in both candidates and recipients will be important to understand the epidemiology and clinical course of COVID-19 in this population. While there are multi...

journal_title：Transplantation

authors： Bray RA,Lee JH,Brescia P,Kumar D,Nong T,Shih R,Woodle ES,Maltzman JS,Gebel HM

更新日期：2021-01-01 00:00:00

abstract：:T cells must be activated before they can elicit damage to allografts, through interaction of their T cell receptor (TCR) with peptide-MHC complex and through accessory molecules. Signaling through accessory molecules or costimulatory molecules is a critical way for the immune system to fine tune T cell activation. An...

journal_title：Transplantation

authors： Kinnear G,Jones ND,Wood KJ

更新日期：2013-02-27 00:00:00

abstract：:Nonadherence to immunosuppressants in renal transplant recipients is a major factor affecting graft survival, but it is difficult to detect accurately in clinical practice. Adherence was measured in 153 adult renal transplant recipients using self-report questionnaires and interview, clinician rating, and cyclosporine...

journal_title：Transplantation

authors： Butler JA,Peveler RC,Roderick P,Horne R,Mason JC

更新日期：2004-03-15 00:00:00

abstract：BACKGROUND:Few studies have examined the effectiveness of a risk-stratified approach to screening kidney transplantation candidates for ischemic heart disease (IHD). METHODS:We retrospectively reviewed records from all adult patients (n = 514) placed on the deceased donor kidney transplantation waiting list at a singl...

journal_title：Transplantation

authors： Kasiske BL,Malik MA,Herzog CA

更新日期：2005-09-27 00:00:00

abstract：BACKGROUND:A successful kidney transplant from a living-related donor (LRD) remains the most effective renal replacement therapy for children with end-stage renal failure. The use of LRD kidneys results in decreased time on dialysis, increased graft survival, and better function compared with kidneys transplanted from ...

journal_title：Transplantation

authors： Ishitani M,Isaacs R,Norwood V,Nock S,Lobo P

更新日期：2000-07-27 00:00:00

abstract：BACKGROUND:Avascular osteonecrosis (AVN) is a serious complication of allogeneic stem cell transplantation (SCT). Graft-versus-host disease and its treatment with steroids are the main risk factors; underlying diagnosis, age and gender are further risk factors. It has been speculated that low baseline bone mineral dens...

journal_title：Transplantation

authors： Schulte CM,Beelen DW

更新日期：2005-06-27 00:00:00

abstract：BACKGROUND:The novel agent sirolimus (SRL; Rapamune; rapamycin) inhibits the immune response by a mechanism distinct from those of calcineurin antagonists or antimetabolites. This randomized, controlled, multicenter, single blind, phase II trial examined the combination of SRL, steroids, and full versus reduced doses o...

journal_title：Transplantation

authors： Kahan BD,Julian BA,Pescovitz MD,Vanrenterghem Y,Neylan J

更新日期：1999-11-27 00:00:00

abstract：:Predictors of survival after lung transplant were analyzed in a large cohort of 990 lung transplanted patients from a single center. The overall survival was 41.6%, (41.5% in males, and 41.8% in females), the average length of the follow up was 45.84+/-51.98 months (range 0-282.47 months). Females tend to live longer ...

journal_title：Transplantation

authors： Creel M,Studer SM,Schwerha J,Harper J,Ortiz L,Ragin C,Taioli E

更新日期：2008-04-27 00:00:00

abstract：BACKGROUND:Long-term acceptance of semi-identical orthotopic liver transplants (OLTs) in inbred swine is induced by a 12-day course of FK506. To study whether acceptance is attributable to central or peripheral immune mechanisms, the effect of complete thymectomy was determined. METHODS:Total thymectomy was performed ...

journal_title：Transplantation

authors： Uryuhara K,Ambiru S,Dehoux JP,Oike F,Talpe S,Gianello P

更新日期：2004-04-27 00:00:00

abstract：:The majority of skin tumors induced in mice by ultraviolet (UV) light are rejected when implanted into normal syngeneic recipients. Subcarcinogenic levels of UV light exposure render the normally resistant mice susceptible to tumor challenge. The immunoregulatory effect of UV light appears to be additive, since the gr...

journal_title：Transplantation

authors： Daynes RA,Spellman CW,Woodward JG,Stewart DA

更新日期：1977-04-01 00:00:00

abstract：BACKGROUND:Several technical modifications in portal vein (PV) reconstruction have shown excellent outcomes in pediatric liver transplantation (LT); however, which procedure is the best for PV reconstruction of the hypoplastic PV in pediatric LT remains unclear. METHODS:One hundred sixteen pediatric patients aged 1 or...

journal_title：Transplantation

authors： Sakamoto S,Uchida H,Kitajima T,Shimizu S,Yoshimura S,Takeda M,Hirata Y,Fukuda A,Kasahara M

更新日期：2020-01-01 00:00:00

abstract：:Heterotopic abdominal rat heart transplantation has been extensively used to investigate ischemic-reperfusion injury, immunological consequences during heart transplantations and also to study remodeling of the myocardium due to volume unloading. We provide a unique review on the latter and present a summary of the ex...

journal_title：Transplantation

authors： Benke K,Sayour AA,Mátyás C,Ágg B,Németh BT,Oláh A,Ruppert M,Hartyánszky I,Szabolcs Z,Radovits T,Merkely B,Szabó G

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:The quantitation of donor leukocyte chimerism may aid in establishing the etiology of neutropenia after liver transplantation. METHODS:The incidence and clinical and laboratory characteristics of severe neutropenia were studied in adults who have undergone liver transplantation at our institution over the l...

journal_title：Transplantation

authors： Jonsson JR,Gill D,Hogan PG,Clouston AD,Edwards-Smith C,Griffin AD,Balderson GA,Lynch SV,Strong RW,Powell EE

更新日期：1999-05-27 00:00:00

abstract：BACKGROUND:Patients with pretransplantation strong donor-specific anti-human leukocyte antigen (HLA) antibodies (DSA) are at higher risk for rejection. We aimed to study the safety of kidney transplantation in patients with lower strength DSAs in a prospective cohort study. METHODS:Three hundred and seventy-three cons...

journal_title：Transplantation

authors： Marfo K,Ajaimy M,Colovai A,Kayler L,Greenstein S,Lubetzky M,Gupta A,Kamal L,de Boccardo G,Masiakos P,Kinkhabwala M,Akalin E

更新日期：2014-11-27 00:00:00

abstract：:An increased frequency of kidney rejection has been reported in diabetic patients who have simultaneous pancreas and kidney transplantation compared with patients who have a kidney transplant alone. Kidney graft outcome is similar in the two groups. The mechanism for increased kidney graft rejection with a simultaneou...

journal_title：Transplantation

authors： Carroll PB,Ricordi C,Shapiro R,Rilo HR,Fontes P,Scantlebury V,Irish W,Tzakis AG,Starzl TE

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:Cytomegalovirus (CMV) replication has been associated with more risk for solid organ graft rejection. We wondered whether this association still holds when patients at risk receive prophylactic treatment for CMV. METHODS:We correlated CMV infection, biopsy-proven graft rejection, and graft loss in 1,414 pat...

journal_title：Transplantation

authors： Stern M,Hirsch H,Cusini A,van Delden C,Manuel O,Meylan P,Boggian K,Mueller NJ,Dickenmann M,Members of Swiss Transplant Cohort Study.

更新日期：2014-11-15 00:00:00