Measuring compliance with drug regimens after renal transplantation: comparison of self-report and clinician rating with electronic monitoring.

abstract：BACKGROUND:Mammalian target of rapamycin inhibitors may confer cardioprotective advantages, but clinical data are limited. METHODS:In the open-label ELEVATE trial, kidney transplant patients were randomized at 10 to 14 weeks after transplant to convert from calcineurin inhibitor (CNI) to everolimus or remain on standa...

journal_title：Transplantation

authors： Holdaas H,de Fijter JW,Cruzado JM,Massari P,Nashan B,Kanellis J,Witzke O,Gutierrez-Dalmau A,Turkmen A,Wang Z,Lopez P,Bernhardt P,Kochuparampil J,van der Giet M,Murbraech K,ELEVATE Study Group.

更新日期：2017-10-01 00:00:00

abstract：:The fungal metabolite FK506 was discovered because it shared an important property, the ability to inhibit production of IL-2, with another well-known immunosuppressive fungal metabolite, CsA. FK506 has, since its isolation, also been shown to share other immunosuppressive effects with CsA. This study was performed to...

journal_title：Transplantation

authors： Johansson A,Möller E

更新日期：1990-12-01 00:00:00

abstract：:Three hundred thirty-two marrow graft recipients and 241 healthy marrow donors were studied by skin testing with recall and neoantigens. Two hundred thirty patients with leukemia and seventy-eight patients with aplastic anemia received allogeneic HLA-identical sibling marrow. Twenty-four patients with leukemia receive...

journal_title：Transplantation

authors： Witherspoon RP,Matthews D,Storb R,Atkinson K,Cheever M,Deeg HJ,Doney K,Kalbfleisch J,Noel D,Prentice R

更新日期：1984-02-01 00:00:00

abstract：BACKGROUND:As T-cell receptor-major histocompatibility complex (MHC) class I/self peptide interaction regulates T-cell development in the thymus, we reasoned that presentation of peptides by self dendritic cells (DC) to developing T cells in the thymus might induce acquired thymic tolerance. This hypothesis is based on...

journal_title：Transplantation

authors： Ali A,Garrovillo M,Jin MX,Hardy MA,Oluwole SF

更新日期：2000-01-27 00:00:00

abstract：BACKGROUND:Graft-versus-host disease (GVHD) is a major complication after bone marrow transplantation, which may be refractory to immunosuppressive drugs. As preliminary case reports suggested that extracorporeal photochemotherapy (ECP) using a Therakos device might be beneficial, we conducted a pilot study to assess t...

journal_title：Transplantation

authors： Besnier DP,Chabannes D,Mahé B,Mussini JM,Baranger TA,Muller JY,Milpied N,Esnault VL

更新日期：1997-07-15 00:00:00

abstract：:Lethally irradiated (850 rads) DBA/2 mice which had been transplanted 10 months previously with 2 times 10-6 bone marrow cells from 3-week-old donors of the H-2-histocompatible NZB, BALB/c and DBA/2 strains were examined for manifestations of autoimmune disease. Also studied were lethally irradiated (950 rads) NZB mic...

journal_title：Transplantation

authors： Morton JI,Siegel BV,Moore RD

更新日期：1975-06-01 00:00:00

abstract：BACKGROUND:According to a pooled analysis of three randomized clinical studies concerning the prevention of acute rejection in cadaveric renal transplantation, mycophenolate mofetil (MMF) proved superior to azathioprine or placebo in conjunction with cyclosporine (CsA) and steroids. MMF-treated patients showed reduced ...

journal_title：Transplantation

authors： Kim YS,Moon JI,Kim SI,Park K

更新日期：1999-08-27 00:00:00

abstract：BACKGROUND:Epitopes are the sites to which antibodies bind. Both alpha and beta peptide chains of the human leukocyte antigen-DQ heterodimers (DQA1 and DQB1, respectively) contain polymorphic regions. We can identify DQA1 and DQB1 epitopes by DQ single antigen beads assay of the antibodies, correlating the beads' react...

journal_title：Transplantation

authors： Deng CT,El-Awar N,Ozawa M,Cai J,Lachmann N,Terasaki PI

更新日期：2008-08-15 00:00:00

abstract：:A severe shortage of organs is one of the major barriers facing transplantation today. One of the proposals designed to overcome this serious problem is to increase the use of genetically unrelated living kidney donors. Excellent results have been achieved with these volunteers and cogent arguments have been made that...

journal_title：Transplantation

authors： Spital A

更新日期：2000-04-27 00:00:00

abstract：:Clinical observations suggest that recipients of multiorgan transplants from the same donor can have disparate immunological reactions to each organ. We studied this phenomenon in 36 diabetic (streptozotocin-induced), bilaterally nephrectomized immunosuppressed (cyclosporine, azathioprine, prednisone) pig recipients o...

journal_title：Transplantation

authors： Gruessner RW,Nakhleh R,Tzardis P,Schechner R,Platt JL,Gruessner A,Tomadze G,Najarian JS,Sutherland DE

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:Anticytomegalovirus (CMV) prophylaxis prevents the acute disease but its impact on subclinical infection and allograft outcome is unknown. We sought to determine whether CMV prophylaxis administered for three months after heart transplant would improve patient outcomes. METHODS:This prospective cohort study...

journal_title：Transplantation

authors： Potena L,Holweg CT,Chin C,Luikart H,Weisshaar D,Narasimhan B,Fearon WF,Lewis DB,Cooke JP,Mocarski ES,Valantine HA

更新日期：2006-08-15 00:00:00

abstract：BACKGROUND:The pathogenesis of acute pulmonary xenograft injury has not yet been determined. The present study evaluates the role of complement in mediating pulmonary xenograft dysfunction by using cobra venom factor (CVF) to deplete recipient complement and transgenic swine, which express human regulators of complemen...

journal_title：Transplantation

authors： Yeatman M,Daggett CW,Parker W,Byrne GW,Logan JS,Platt JL,Davis RD

更新日期：1998-04-27 00:00:00

abstract：BACKGROUND:Postoperative damage of the urethral rhabdosphincter and nerve-vascular networks is a major complication of radical prostatectomy and generally causes incontinence and/or erectile dysfunction. The human skeletal muscle-derived stem cells, which have a synchronized reconstitution capacity of muscle-nerve-bloo...

journal_title：Transplantation

authors： Nakajima N,Tamaki T,Hirata M,Soeda S,Nitta M,Hoshi A,Terachi T

更新日期：2017-10-01 00:00:00

abstract：:The CD154-CD40 pathway is one of the critical costimulatory pathways that are required for full activation of T cells during alloimmune responses. Blockade of this pathway with anti-CD154 antibodies has been reported to prolong allograft survival in experimental transplantation models and to induce tolerance in some i...

journal_title：Transplantation

authors： Yamada And A,Sayegh MH

更新日期：2002-01-15 00:00:00

abstract：:A total of 151 potential recipients of kidney grafts from one-HLA-haplotype-mismatched MLC-positive (RR greater than 20%) donors treated during 1980-1984 was investigated. The recipients were divided retrospectively into four groups: (A) 42 patients who received pretransplant donor-specific transfusions (DST) and post...

journal_title：Transplantation

authors： Leivestad T,Albrechtsen D,Flatmark A,Thorsby E

更新日期：1986-07-01 00:00:00

abstract：INTRODUCTION:The use of liver allografts from elderly donors (≥70 years) has increased because of organ shortage and increased life expectancy. The aim of this study is to evaluate the current utilization of elderly donors in United States, recipient selection, and their posttransplant outcomes. METHODS:A linkage betw...

journal_title：Transplantation

authors： Paterno F,Wima K,Hoehn RS,Cuffy MC,Diwan TS,Woodle SE,Abbott DE,Shah SA

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Neuromuscular blockade (NMB) reversal with neostigmine and glycopyrrolate has been reported to cause cardiac arrest in patients with a history of cardiac transplantation. The purpose of this study was to examine the safety of NMB reversal with acetylcholinesterase inhibitors and muscarinic anticholinergics i...

journal_title：Transplantation

authors： Barbara DW,Christensen JM,Mauermann WJ,Dearani JA,Hyder JA

更新日期：2016-12-01 00:00:00

abstract：:Of 2457 patients in the North American Pediatric Renal Transplant Cooperative Study registry who were followed for 5481 patient-years after the index transplantation, we observed 136 deaths, for an average annual rate of 24.8 deaths per 1000 patient-years. Death resulted primarily from infection (n = 55, 40%), cardiov...

journal_title：Transplantation

authors： Tejani A,Sullivan EK,Alexander S,Fine R,Harmon W,Lilienfeld D

更新日期：1994-02-27 00:00:00

abstract：BACKGROUND:The long-term outcome of simultaneous kidney pancreas transplant recipients is not well established. METHODS:We retrospectively reviewed all patients who underwent simultaneous kidney-pancreas transplantation with bladder drainage at our center between January 1989 and December 1991. A total of 57 patients ...

journal_title：Transplantation

authors： Sudan D,Sudan R,Stratta R

更新日期：2000-02-27 00:00:00

abstract：BACKGROUND:To reduce the side effects of long-term immunosuppressive therapy, stable renal transplant patients were routinely converted from cyclosporine to either azathioprine or mycophenolate mofetil. Thereafter, the azathioprine and mycophenolate mofetil dose was reduced to 75% at 4 months and to 50% at 8 months aft...

journal_title：Transplantation

authors： van Besouw NM,van der Mast BJ,de Kuiper P,Smak Gregoor PJ,Vaessen LM,IJzermans JN,van Gelder T,Weimar W

更新日期：2000-07-15 00:00:00

abstract：BACKGROUND:During allograft rejection, up-regulation of cytokine-inducible nitric oxide synthase (iNOS) leads to the production of large amounts of nitric oxide (NO). The net effect of NO on the alloimmune response is, however, difficult to predict because of its diverse biological effects, which include potentially op...

journal_title：Transplantation

authors： Casey JJ,Wei XQ,Orr DJ,Gracie JA,Huang FP,Bolton EM,Liew FY,Bradley JA

更新日期：1997-08-27 00:00:00

abstract：BACKGROUND:BK polyomavirus infection has been reported in 10% to 60% of renal transplant recipients with progression to BK nephropathy (BKN) occurring in 1% to 5% of patients. Graft loss occurs in up to 60% of renal transplant recipients with BKN. Because BK polyomavirus infection is believed, in part, to be a manifest...

journal_title：Transplantation

authors： Guasch A,Roy-Chaudhury P,Woodle ES,Fitzsimmons W,Holman J,First MR,FK778 BK Nephropathy Study Group.

更新日期：2010-10-27 00:00:00

abstract：BACKGROUND:It has been suggested that T cells primed by processed donor major histocompatibility complex antigen (the "indirect" pathway of allorecognition) may be responsible for mediating chronic allograft rejection. The purpose of this study was to develop a clinically useful assay to study the occurrence of indirec...

journal_title：Transplantation

authors： Vella JP,Spadafora-Ferreira M,Murphy B,Alexander SI,Harmon W,Carpenter CB,Sayegh MH

更新日期：1997-09-27 00:00:00

abstract：BACKGROUND AND METHODS:To investigate the frequency of apoptosis and the expression of Fas/Fas ligand (FasL) in liver allografts, we examined 97 biopsy specimens from 62 patients after orthotopic liver transplantation. The results of the biopsies were as follows: acute allograft rejection (n=32); hepatitis C virus (HCV...

journal_title：Transplantation

authors： Tannapfel A,Kohlhaw K,Ebelt J,Hauss J,Liebert U,Berr F,Wittekind C

更新日期：1999-04-15 00:00:00

abstract：BACKGROUND:Metrics for evaluating low-quality kidneys have failed to predict outcomes or reduce the kidney refusal and discard rates. Kidneys from extended-criteria donors (ECDs) and kidneys with ≥85% kidney donor profile indexes (KDPIs) might have different sensitivities to the proinflammatory milieu generated by brai...

journal_title：Transplantation

authors： Florim GMS,Caldas HC,Gonçalves NN,Bueno GOBE,Baptista MASF,Fernandes-Charpiot IMM,Abbud-Filho M

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Interleukin- (IL) 10 may be a potent regulator for controlling of allograft rejection. A single administration of IL-10 is not effective for controlling graft rejection. Gene transfer is an attractive vehicle for prolonging the expression of short-lived proteins. METHODS:Donor or recipient livers were trans...

journal_title：Transplantation

authors： Tashiro H,Shinozaki K,Yahata H,Hayamizu K,Okimoto T,Tanji H,Fudaba Y,Yamamoto H,Fan X,Ito H,Asahara T

更新日期：2000-07-27 00:00:00

abstract：BACKGROUND:Ischemia-reperfusion injury (IRI) significantly contributes to delayed graft function and inflammation, leading to graft loss. Ischemia-reperfusion injury is exacerbated by the thrombospondin-1-CD47 system through inhibition of nitric oxide signaling. We postulate that CD47 blockade and prevention of nitric ...

journal_title：Transplantation

authors： Lin Y,Manning PT,Jia J,Gaut JP,Xiao Z,Capoccia BJ,Chen CC,Hiebsch RR,Upadhya G,Mohanakumar T,Frazier WA,Chapman WC

更新日期：2014-08-27 00:00:00

abstract：:Recent suggestions that the rat prostate is an alymphatic, immunologically privileged site stimulated further investigation of its status using a variety of techniques. Fixation of certain organs by vascular perfusion of glutaraldehyde followed by plastic embedding avoids the distortion and stromal reorganization that...

journal_title：Transplantation

authors： Neaves WB,Billingham RE

更新日期：1979-02-01 00:00:00

abstract：:We have studied organ allograft survival in rhesus monkeys conditioned with myeloablative total-body irradiation and T cell-depleted autologous bone marrow transplantation then given a heterotopic MHC-mismatched cardiac allograft in the immediate postmyeloablative period. This model has enabled us to investigate the r...

journal_title：Transplantation

authors： Moses RD,Sundeen JT,Orr KS,Roberts RR,Gress RE

更新日期：1989-11-01 00:00:00

abstract：:We initiated a policy of using RSLT in critically ill patients in June of 1988. Since that time we have performed 30 RSLTs in 29 patients, including 28 children and 1 adult. The mean age of the children was 27 months (range 1 month to 10 years) with 14 (52%) being 1 year of age or less. The mean weight was 11.3 kg (ra...

journal_title：Transplantation

authors： Langnas AN,Marujo WC,Inagaki M,Stratta RJ,Wood RP,Shaw BW Jr

更新日期：1992-02-01 00:00:00