The Safety of Neuromuscular Blockade Reversal in Patients With Cardiac Transplantation.

abstract：:Islets were isolated using neutral red as a dye to exclude lymphatic and acinar impurities in the transplant preparation. In a one donor-one recipient model, intraportally transplanted isogeneic islets survived indefinitely. Mean graft survival could be prolonged from 5 to 90 days, using a 3-dose rejection prophylaxis...

journal_title：Transplantation

authors： Dibelius A,Königsberger H,Walter P,Permanetter W,Brendel W,von Specht BU

更新日期：1986-04-01 00:00:00

abstract：BACKGROUND:Hepatitis C virus (HCV) infection is common in kidney transplantation and is known to affect long-term patient and graft survival, as is time in renal-replacement therapy (RRT). The aim of this study was to investigate HCV in relation to time in RRT and its impact on outcome after transplantation. METHODS:A...

journal_title：Transplantation

authors： Bruchfeld A,Wilczek H,Elinder CG

更新日期：2004-09-15 00:00:00

abstract：BACKGROUND:Posttransplantation bone disease is a well-described phenomenon; among its etiology is immunosuppressant-induced bone disease. Mycophenolate mofetil (MMF) has emerged as a promising new immunosuppressant. Our study was designed to investigate the effect of MMF on in vivo bone mineral metabolism. METHODS:Twe...

journal_title：Transplantation

authors： Dissanayake IR,Goodman GR,Bowman AR,Ma Y,Pun S,Jee WS,Epstein S

更新日期：1998-01-27 00:00:00

abstract：BACKGROUND:A combined liver and kidney transplantation (CLKT) is advocated for selected individuals with chronic kidney disease undergoing liver transplantation (LT). The aim was to develop a risk score to identify the patients whose estimated glomerular filtration rate (eGFR) would decline during the year post-LT to a...

journal_title：Transplantation

authors： O'Riordan A,Donaldson N,Cairns H,Wendon J,O'Grady JG,Heaton N,Hendry BM

更新日期：2010-06-15 00:00:00

abstract：BACKGROUND:Subclinical T cell-mediated rejection (subTCMR) is commonly found after liver transplantation and has a good short-term prognosis, even when it is left untreated. Donor-specific antibodies (DSA) are putatively associated with a worse prognosis for recipient and graft after liver transplantation. METHODS:To ...

journal_title：Transplantation

authors： Höfer A,Jonigk D,Hartleben B,Verboom M,Hallensleben M,Hübscher SG,Manns MP,Jaeckel E,Taubert R

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:The deceased donor score (DDS), expanded criteria donor (ECD) definition, and resistive index (RI) were developed for pretransplant evaluation of donors. DDS and ECD are determined by a calculation of risk from donor variables, while RI is determined from flow characteristics of kidneys during machine preser...

journal_title：Transplantation

authors： Nyberg SL,Baskin-Bey ES,Kremers W,Prieto M,Henry ML,Stegall MD

更新日期：2005-10-15 00:00:00

abstract：BACKGROUND:The induction of tolerance to pig antigens in primates may facilitate the development of successful clinical xenotransplantation protocols. The infusion of mobilized porcine peripheral blood leukocytes (PBPCs, comprised of approximately 2% peripheral blood progenitor cells) into splenectomized preconditioned...

journal_title：Transplantation

authors： Appel JZ 3rd,Alwayn IP,Correa LE,Cooper DK,Robson SC

更新日期：2001-10-15 00:00:00

abstract：BACKGROUND:The deleterious effect of steatosis on transplanted livers is mainly related to a microcirculation impairment. We investigated the effect of preservation duration on the recovery of isolated perfused rat steatotic livers and tested the effect of pentoxifylline (PTX), known to have a beneficial effect on hepa...

journal_title：Transplantation

authors： Arnault I,Bao YM,Sebagh M,Anjo A,Dimicoli JL,Lemoine A,Delvart V,Adam R

更新日期：2003-07-15 00:00:00

abstract：BACKGROUND:We developed a nonviral gene transfer method using rapid injection of naked DNA targeting the liver and applied it in a rat model of liver transplantation. METHODS:Inbred Dark Agouti and Lewis rats were used. To test the efficacy and adverse effects of systemic or local (catheter-based) injection, different...

journal_title：Transplantation

authors： Inoue S,Hakamata Y,Kaneko M,Kobayashi E

更新日期：2004-04-15 00:00:00

abstract：BACKGROUND:Strong correlations have been described between persistently elevated proportions of CD57+ (CD28-) CD8+high T lymphocytes and cytomegalovirus (CMV) infection, in healthy individuals as well as in transplant patients. We investigated whether secondary exposure to CMV triggers recall responses within the CD8 T...

journal_title：Transplantation

authors： Hazzan M,Labalette M,Noel C,Lelievre G,Dessaint JP

更新日期：1997-03-15 00:00:00

abstract：BACKGROUND:Increased use of pediatric deceased donor kidneys could enlarge the deceased donor kidney pool. Kidney transplant outcomes from small pediatric donors were compared with those from ideal kidney (IK) and expanded criteria kidney (ECK) donors to understand the optimal use of pediatric donor kidneys. METHODS:K...

journal_title：Transplantation

authors： Suneja M,Kuppachi S,Katz D,Hunsicker L

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:The rate of acute rejection (AR) has decreased significantly, but whether this is associated with improvement in long-term graft survival is controversial. METHODS:We analyzed 1445 consecutive adult deceased donor kidney transplant recipients from 1985 to 2005, over two periods (1985-1995 vs. 1996-2005) to ...

journal_title：Transplantation

authors： Sola E,Gonzalez-Molina M,Cabello M,Burgos D,Ramos J,Gutierrez C,Lopez V,Soler J,de la Vega E,Hernandez D

更新日期：2010-03-27 00:00:00

abstract：:Thirteen renal allograft recipients (6 patients on cyclosporine/7 patients on azathioprine) participated in a short-term oral protein-loading study to determine the effect of cyclosporine on an allograft's functional reserve. The baseline glomerular filtration rate of the two groups were similar (52 +/- 18 ml/min/1.73...

journal_title：Transplantation

authors： Nunley JR,King A,Comstock T,Posner M,Marshall C,Sica DA

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Longest bipolar length of the kidney graft is routinely measured for ultrasonographic assessment of graft size (GS), although the value of the graft length remains unclear. METHODS:In a single-center, observational study involving 319 deceased-donor kidney transplant recipients, we assessed variations in ab...

journal_title：Transplantation

authors： Černe S,Arnol M,Kandus A,Buturović-Ponikvar J

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Extracorporeal support (ECS) during organ procurement from donors after circulatory determination of death (DCDD) could increase the number of donor organs and decrease posttransplant complications. This study reports the experience of a large transplant center with controlled DCDD. METHODS:A retrospective ...

journal_title：Transplantation

authors： Rojas-Peña A,Sall LE,Gravel MT,Cooley EG,Pelletier SJ,Bartlett RH,Punch JD

更新日期：2014-08-15 00:00:00

abstract：BACKGROUND:Suppressive dendritic cells (DCs) are a promising tool for tolerance induction in transplantation. A human DCs subpopulation, which constitutively expresses indoleamine-2,3-dioxygenase (IDO), a molecule shown to prevent the rejection of fetus during pregnancy, has recently been described. This subset, charac...

journal_title：Transplantation

authors： Löb S,Ebner S,Wagner S,Weinreich J,Schäfer R,Königsrainer A

更新日期：2007-02-27 00:00:00

abstract：:Although solid organ transplant results have improved significantly in recent decades, a pivotal cause of impaired long-term outcome is the development of antibody-mediated rejection (AMR), a condition characterized by the presence of donor specific antibodies to human leukocyte antigen (HLA) or non-HLA antigens. High...

journal_title：Transplantation

authors： Kardol-Hoefnagel T,Otten HG

更新日期：2020-11-17 00:00:00

abstract：:Over the last decade there have been major advances in all aspects of liver transplantation with the consequence that the number of patients who could benefit from the procedure is increasing. As a result, the number of patients listed for liver transplantation is growing while the donor pool is remaining constant or ...

journal_title：Transplantation

authors： Neuberger J,Ubel PA

更新日期：2000-11-27 00:00:00

abstract：BACKGROUND:Accelerated arteriosclerosis limits the survival of transplanted hearts. We hypothesized that insulin-like growth factor-I (IGF-I) is crucial in accelerating transplant arteriosclerosis. Recently, we reported that exposure to IGF-I prior to transplantation accelerates transplant arteriosclerosis in the rat a...

journal_title：Transplantation

authors： Motomura N,Lou H,Orskov H,Ramwell PW,Foegh ML

更新日期：1998-04-27 00:00:00

abstract：:Gliotoxin is an immunosuppressive secondary metabolite produced by several pathogenic fungi. It has previously been shown to prevent graft-versus-host disease in transplantation of allogeneic mouse bone marrow and to reduce the immunogenicity of human fetal pancreas. We here report on the effect of gliotoxin on the pr...

journal_title：Transplantation

authors： Sutton P,Moreland A,Hutchinson IV,Müllbacher A

更新日期：1995-11-15 00:00:00

abstract：BACKGROUND:Hemophagocytic syndrome (HPS) is a serious hematological disorder caused by activated T lymphocytes in immunologically compromised patients. There is no report of HPS in liver transplant recipients. METHODS:Among 135 patients who underwent living-related liver transplantation between June 1990 and October 2...

journal_title：Transplantation

authors： Chisuwa H,Hashikura Y,Nakazawa Y,Kamijo T,Nakazawa K,Nakayama J,Oh-Ishi T,Ikegami T,Terada M,Kawasaki S

更新日期：2001-12-15 00:00:00

abstract：BACKGROUND:Mycophenolate mofetil (MMF) therapy compared with azathioprine has not led to improved long-term renal allograft outcomes perhaps as MMF dose is limited by tolerability and dose reduction is associated with inferior graft outcome. The consequences, however, of dose reduction of mycophenolate mofetil relative...

journal_title：Transplantation

authors： Shah S,Collett D,Johnson R,Raftery M,Rudge C,Yaqoob MM

更新日期：2008-10-27 00:00:00

abstract：BACKGROUND:In 2006, Northwestern Medicine implemented a culturally targeted and linguistically congruent Hispanic Kidney Transplant Program (HKTP). The HKTP has been associated with a reduction in Hispanic/Latino disparities in live donor kidney transplantation. This paper assessed the financial feasibility of implemen...

journal_title：Transplantation

authors： Wang A,Caicedo JC,McNatt G,Abecassis M,Gordon EJ

更新日期：2020-04-09 00:00:00

abstract：:The antibody response to the pregnancy-associated (Pa) antigen in the pregnant female segregated with the major histocompatibility complex (MHC) when the female progeny in the (PVG x WF)F1 x PVG testcross, in which the PVG strain is a low responder to Pa and the WF strain is a high responder, were mated to DA male rat...

journal_title：Transplantation

authors： Kunz HW,Gill TJ 3rd

更新日期：1986-08-01 00:00:00

abstract：:Suppressor cell activity in the spleen of 4-5-day-old mice is high and can be assayed in mixed lymphocyte cultures. The suppressor cells inhibit the proliferation of adult mouse spleen cells responding in vitro to an allogeneic stimulus. This suppressor cell activity can be increased by injecting the mice, on the day ...

journal_title：Transplantation

authors： Argyris BF

更新日期：1984-09-01 00:00:00

abstract：BACKGROUND:Impaired pretransplant performance status (PS) is associated with chronic liver disease (CLD). We studied its impact on hospital length of stay (LOS), complications and readmissions in the first year after liver transplantation. METHOD:The Standard National Liver Transplant Registry was linked to a hospital...

journal_title：Transplantation

authors： Wallace D,Cowling TE,Walker K,Suddle A,Gimson A,Rowe I,Callaghan C,Heaton N,van der Meulen J,Bernal W

更新日期：2020-10-08 00:00:00

abstract：BACKGROUND:This study addresses the question of the mechanism for maintaining tolerance to donor alloantigen in the absence of antigen and the role of secondary lymphoid tissues. METHODS:Depleting anti-CD4 antibody administration in conjunction with allogeneic heart transplantation generates donor-specific operational...

journal_title：Transplantation

authors： Chosa E,Hara M,Watanabe A,Matsuzaki Y,Nakamura K,Hamano K,Wood KJ,Onitsuka T

更新日期：2007-05-15 00:00:00

abstract：BACKGROUND:Mycophenolic acid (MPA) is an inhibitor of lymphocyte proliferation and is well established as an immunosuppressive agent in solid organ transplantation. The initial formulation of the drug was a prodrug formulation, mycophenolate mofetil (MMF, Cellcept), which is well absorbed and rapidly converted to mycop...

journal_title：Transplantation

authors： Johnston A,He X,Holt DW

更新日期：2006-12-15 00:00:00

abstract：BACKGROUND:The novel agent sirolimus (SRL; Rapamune; rapamycin) inhibits the immune response by a mechanism distinct from those of calcineurin antagonists or antimetabolites. This randomized, controlled, multicenter, single blind, phase II trial examined the combination of SRL, steroids, and full versus reduced doses o...

journal_title：Transplantation

authors： Kahan BD,Julian BA,Pescovitz MD,Vanrenterghem Y,Neylan J

更新日期：1999-11-27 00:00:00

abstract：:Infection remains one of the major complications of nonspecific immunosuppression in renal transplant patients and accounts for significant morbidity and mortality. The incidence of infectious complications has been shown to be related to the degree of immunosuppression and correlated with the total steroid dosage, us...

journal_title：Transplantation

authors： Salama AD,Rogers T,Lord GM,Lechler RI,Mason PD

更新日期：1997-01-15 00:00:00