Abstract:
:The antibody response to the pregnancy-associated (Pa) antigen in the pregnant female segregated with the major histocompatibility complex (MHC) when the female progeny in the (PVG x WF)F1 x PVG testcross, in which the PVG strain is a low responder to Pa and the WF strain is a high responder, were mated to DA male rats. These results show that non-MHC immune response genes do not play a role, or at least any significant role, in the immune response to the paternal component of the placental antigens: the response approximates a unigenic trait with simple Mendelian segregation. Serological analysis showed that the antibodies formed by both the high responder (GMT 15, titer 1:32,768) and low responder (GMT 3, titer 1:8) female rats were directed against the Pa antigen. These findings show that the genetic control mechanism and the specificity of the antibody elicited by the placental antigen Pa are different from those in the responses to organ grafts and to soluble antigens.
journal_name
Transplantationjournal_title
Transplantationauthors
Kunz HW,Gill TJ 3rddoi
10.1097/00007890-198608000-00022subject
Has Abstractpub_date
1986-08-01 00:00:00pages
217-9issue
2eissn
0041-1337issn
1534-6080journal_volume
42pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract:BACKGROUND:Reactivation of cytomegalovirus (CMV) is frequently observed in recipients of solid organs and bone marrow transplants and is associated with increased risk of acute and chronic allograft rejection, opportunistic infection, graft failure, and patient mortality. The molecular mechanisms by which reactivation ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181b242a7
更新日期:2009-09-15 00:00:00
abstract::In 33 renal allograft recipient-donor pairs, B and T lymphocyte complement-dependent cytotoxicity crossmatches and mixed lymphocyte culture (MLC) blocking experiments were performed and the results were correlated with graft outcome. MLC blocking particularly in the unidirectional culture against donor-stimulating cel...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197804000-00002
更新日期:1978-04-01 00:00:00
abstract::The effect of cyclosporin A was tested in a heterotopic cardiac xenograft model, in which hamster hearts were implanted into LEW rats. Despite the presence of low titers of rat anti-hamster lymphocytotoxic antibodies immediate rejection of the hamster hearts did not occur, suggesting that this model represented a xeno...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198103000-00004
更新日期:1981-03-01 00:00:00
abstract::As a consequence of its large volume, a microencapsulated islet graft can be implanted only into the peritoneal cavity. The graft volume can be reduced by using small capsules. However, reduction of the diameter of the capsules holds a certain risk, because with smaller capsules, more islets may be found to protrude f...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199610150-00004
更新日期:1996-10-15 00:00:00
abstract:BACKGROUND:The rate of acute rejection (AR) has decreased significantly, but whether this is associated with improvement in long-term graft survival is controversial. METHODS:We analyzed 1445 consecutive adult deceased donor kidney transplant recipients from 1985 to 2005, over two periods (1985-1995 vs. 1996-2005) to ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181c892dd
更新日期:2010-03-27 00:00:00
abstract:BACKGROUND:Despite early skepticism, the field of vascularized composite allotransplantation (VCA) has demonstrated feasibility. The ethics of VCA have moved past doubts about the morality of attempting such transplants to how to conduct them ethically. METHODS:Leaders of each program performing and/or evaluating VCA ...
journal_title:Transplantation
pub_type: 共识发展会议,杂志文章,评审
doi:10.1097/TP.0000000000002478
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Some statins have been reported to suppress the immune system and increase the expression of bone morphogenetic protein-2 gene that plays a pivotal role in bone regeneration. METHODS:The effects of cerivastatin on skeletal reconstruction by vascularized bone allograft were investigated in a rat tibia-fibula...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000074992.49236.58
更新日期:2003-09-15 00:00:00
abstract:BACKGROUND:Graft versus host disease (GvHD) is the main complication after hematopoietic stem-cell transplantation.Extracorporeal photochemotherapy (ECP) is a cell therapy currently used for the treatment of T-cell–mediated diseases and seems as a valuable second-line therapy for patients suffering from steroid-refract...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/tp.0b013e3181fa4eb6
更新日期:2010-12-15 00:00:00
abstract:BACKGROUND:Strong correlations have been described between persistently elevated proportions of CD57+ (CD28-) CD8+high T lymphocytes and cytomegalovirus (CMV) infection, in healthy individuals as well as in transplant patients. We investigated whether secondary exposure to CMV triggers recall responses within the CD8 T...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199703150-00014
更新日期:1997-03-15 00:00:00
abstract:BACKGROUND:Localization of inflammatory stimuli may direct lung allografts to different phenotypes of chronic dysfunction, such as bronchiolitis obliterans syndrome (BOS) or restrictive allograft syndrome (RAS). We hypothesized that airway stimulation with lipopolysaccharide (LPS) in rats leads to airway-centered infla...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003097
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:To reduce the morbidity of living kidney donors we introduced ketorolac-based analgesia for patients undergoing open donor nephrectomy in August 1999. There are no prior reports on the use of ketorolac for patients undergoing donor nephrectomy. METHODS:We conducted a retrospective review of all 198 consecut...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200203150-00014
更新日期:2002-03-15 00:00:00
abstract:BACKGROUND:The role of CD20+ B cells in renal allograft rejection has been reappreciated. Importantly, recent studies suggest a relation between CD20+ B cell aggregates and poorer clinical outcome. In the present study, we attempted to confirm these early reports in a tightly controlled patient population and to differ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181860a74
更新日期:2008-09-27 00:00:00
abstract::The safety of the use of kidneys procured from a hepatitis C virus (HCV)-positive cadaver donors in transplantation has recently been the subject of controversy. One factor that is important in determining the transmission of the virus and/or viral liver disease is the total viral inoculum to which the renal allograft...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199403270-00011
更新日期:1994-03-27 00:00:00
abstract::Numerous studies have reported successful allotransplantation of hepatocytes. However, none have shown long-term correction of a liver-related metabolic defect. In this study, we used a method of regional hepatocyte transplantation and subsequent induction of transplanted cell proliferation by regeneration response in...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199609150-00008
更新日期:1996-09-15 00:00:00
abstract:BACKGROUND:Acute rejection (AR) of the transplanted kidney has been identified as the major risk factor for the development of chronic rejection and immunological graft loss. However, the clinical presentation and response to AR therapy can vary considerably between recipients. METHODS:We studied the first AR episode ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199911150-00017
更新日期:1999-11-15 00:00:00
abstract:INTRODUCTION:We investigated the putative candidate biomarkers of graft rejection in peripheral blood of intestinal transplant patients. MATERIALS AND METHODS:Peripheral blood gene expression analysis was performed in intestinal transplant patients. The results were matched with concurrent graft biopsies using bioinfo...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182370db1
更新日期:2011-12-27 00:00:00
abstract::Predictors of survival after lung transplant were analyzed in a large cohort of 990 lung transplanted patients from a single center. The overall survival was 41.6%, (41.5% in males, and 41.8% in females), the average length of the follow up was 45.84+/-51.98 months (range 0-282.47 months). Females tend to live longer ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31816c2fae
更新日期:2008-04-27 00:00:00
abstract:BACKGROUND:Infectious complications still represent a major cause of morbidity and mortality in patients with organ transplantation. In particular, small bowel or multivisceral transplantation is complicated to a greater extent than other grafts as a consequence of infectious complications including sepsis. METHODS:Th...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000185622.91708.57
更新日期:2005-12-27 00:00:00
abstract:BACKGROUND:Malnutrition is common in patients with end-stage liver disease considered for transplantation, but it is unclear whether this affects the outcome after transplantation. AIM.: To determine whether the severity of malnutrition in liver transplant candidates affects outcome after transplantation. METHODS:We d...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000150022.64564.c2
更新日期:2005-02-15 00:00:00
abstract::Conjugation of dextran-coated superparamagnetic iron oxide (SPIO) particles with transactivator protein (Tat)-peptide and fluorescein isothiocyanate (FITC) allows cells to readily uptake SPIO particles. This makes possible high-resolution, real-time imaging of these cells by magnetic resonance imaging (MRI). First, we...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000090164.42732.47
更新日期:2003-10-15 00:00:00
abstract:BACKGROUND:Cardiopulmonary resuscitation (CPR) of a person destined to become an organ donor has been associated with overall poor donor quality, especially for the intestinal donor, as splanchnic vasoconstriction that is intended to preserve coronary and cerebral blood flow may result in clinically relevant intestinal...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181852f9a
更新日期:2008-10-15 00:00:00
abstract::The participation of an immunologically compatible donor-intended recipient pair in a kidney exchange that is unnecessary for them can significantly increase the number of kidneys available for transplantation. Despite their utilitarian value transplant ethicists have condemned this type of organ exchange as morally i...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182047554
更新日期:2011-02-15 00:00:00
abstract:BACKGROUND:Tolerogenic dendritic cells (Tol-DCs) play a critical role in inducing and maintaining tolerance. Recognizing that both T-cell inactivation and activation are contingent on signals provided by DCs and that graft-specific activated T cells are major mediators of transplant rejection, we aimed to create an env...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182007bbf
更新日期:2010-12-27 00:00:00
abstract::Phenotype, donor-specific cytolytic activity, and helper activity to release cytokines of cells infiltrating within renal allografts of hosts rendered unresponsive by perioperative administration of donor lymphocytes via the portal vein (p.v.) were investigated in order to analyze the mechanism of prolongation of allo...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199001000-00038
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Bronchiolitis obliterans syndrome (BOS) is the leading cause of late mortality after lung transplantation. METHODS:We added azithromycin (AZI) (250 mg/day for 5 days, followed by 250 mg every other day) to the current immunosuppressive therapy in eight lung transplant recipients (mean age 36 years) with est...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/01.tp.0000122412.80864.43
更新日期:2004-05-15 00:00:00
abstract::To investigate the clinical manifestations of Aspergillus infections in lung transplant recipients, we reviewed the mycology and autopsy reports of all double (DLT=93) and single (SLT=48) lung transplant recipients from November 1983 to May 1993. Positive Aspergillus cultures were identified in 22% of the recipients (...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199603270-00013
更新日期:1996-03-27 00:00:00
abstract:BACKGROUND:Isolated transient elevation of alkaline phosphatase (ALP) in the absence of bone or liver disease has been reported in children including liver transplant patients. Specific isoenzyme patterns have been associated with this phenomenon in healthy children but have not been reported after liver transplantatio...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200210150-00023
更新日期:2002-10-15 00:00:00
abstract:BACKGROUND:Existing data indicate that non-human leukocyte antigen (HLA) immunogenetic polymorphisms influence the risk of complications after allogeneic hemopoietic stem-cell transplantation. However, prior studies have been limited by small sample size and limited genotyping. METHODS:We examined 22 polymorphisms in ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000111769.45088.a2
更新日期:2004-02-27 00:00:00
abstract::BACKGROUND.: Reduced levels of serum adiponectin, an adipokine, are associated with cardiovascular and obesity-related diseases; however, relations between adiponectin and hypertension are unclear. METHODS.: This cross-sectional study examined adiponectin and ambulatory blood pressure monitoring (ABPM) in 33 pediatric...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181b9e1ec
更新日期:2009-10-27 00:00:00
abstract::Acute antibody-mediated rejection (AAR) of mouse skin allografts was studied in nine donor-recipient combinations with increasing histoincompatibility ranging from an H-Y to a complete H-2 plus on-H-2 disparity. AAR was induced by the injection of specific alloantiserum along with a heterologous complement on day 7 af...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197709000-00002
更新日期:1977-09-01 00:00:00