Aspergillus infection in single and double lung transplant recipients.

Abstract:

:To investigate the clinical manifestations of Aspergillus infections in lung transplant recipients, we reviewed the mycology and autopsy reports of all double (DLT=93) and single (SLT=48) lung transplant recipients from November 1983 to May 1993. Positive Aspergillus cultures were identified in 22% of the recipients (DLT=21, SLT=10). Colonization alone was present in 19 recipients (DLT=16, SLT=3). Complicated Aspergillus infection included Aspergillus bronchitis (DLT=1, SLT=1), aspergilloma (SLT=2), pulmonary invasive aspergillosis (DLT=1, SLT=2), disseminated aspergillosis (DLT=1, SLT=2), empyema (DLT=1), and a retroperitoneal abscess (DLT=1). Symptoms were seen only in patients with complicated lung infections and CXR abnormalities began in the native lung of four SLT recipients. Twenty patients survived (DLT=17, SLT=3) and 11 died (DLT=4, SLT=7) of disseminated aspergillosis (SLT=2), pulmonary invasive disease (DLT=1), bronchiolitis obliterans (DLT=2, SLT=2, CMV pneumonitis (SLT=1), diffuse alveolar damage (SLT=2), and hyperacute rejection (DLT=1). Complicated infection and mortality were more common in SLTs than DLTs (P<0.05). We conclude that infection with Aspergillus is not infrequent in the lung transplantation population. Single lung recipients develop more complicated infection than double lung recipients after Aspergillus infection with native lung being a potential source of infection.

journal_name

Transplantation

journal_title

Transplantation

authors

Westney GE,Kesten S,De Hoyos A,Chapparro C,Winton T,Maurer JR

doi

10.1097/00007890-199603270-00013

subject

Has Abstract

pub_date

1996-03-27 00:00:00

pages

915-9

issue

6

eissn

0041-1337

issn

1534-6080

journal_volume

61

pub_type

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    pub_type: 杂志文章

    doi:10.1097/01.TP.0000061768.98058.EC

    authors: Knight RJ,Kerman RH,Zela S,Podder H,Van Buren CT,Katz S,Kahan BD

    更新日期:2003-04-27 00:00:00

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    pub_type: 杂志文章

    doi:10.1097/00007890-198512000-00004

    authors: Shapiro JI,Cheung C,Itabashi A,Chan L,Schrier RW

    更新日期:1985-12-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3181b4ac2f

    authors: Hernández D,Sánchez-Fructuoso A,González-Posada JM,Arias M,Campistol JM,Rufino M,Morales JM,Moreso F,Pérez G,Torres A,Serón D,Spanish Late Allograft Dysfunction Study Group.

    更新日期:2009-09-27 00:00:00

  • Randomized trial of tacrolimus + mycophenolate mofetil or azathioprine versus cyclosporine + mycophenolate mofetil after cadaveric kidney transplantation: results at three years.

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    journal_title:Transplantation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/01.TP.0000069831.76067.22

    authors: Gonwa T,Johnson C,Ahsan N,Alfrey EJ,Halloran P,Stegall M,Hardy M,Metzger R,Shield C 3rd,Rocher L,Scandling J,Sorensen J,Mulloy L,Light J,Corwin C,Danovitch G,Wachs M,VanVeldhuisen P,Leonhardt M,Fitzsimmons WE

    更新日期:2003-06-27 00:00:00