Abstract:
:Use of pulsatile perfusion to optimize outcomes in deceased donor kidney transplantation remains controversial. This study is a retrospective analysis of all cadaveric renal allografts procured locally by our center over a 3-year period. Kidney pairs were identified in which one kidney underwent pulsatile perfusion and transplantation at our center, whereas the contra-lateral kidney underwent cold storage and transplantation at another center. Eighty-eight percent of the exported kidneys were six-antigen matches. Study outcomes included 1-year graft and patient survival, delayed graft function, and need for posttransplant dialysis. Recipients had similar demographic and disease characteristics. Survival for pulsatile perfusion and cold storage were 95% and 88% (graft, P=0.43) and 98% and 90% (patient, P=0.36), respectively. The incidence of delayed graft function was 5% and 35% (P<0.01), whereas posttransplant dialysis was 5% and 30% (P<0.01), for pulsatile perfusion and cold storage, respectively. These data support routine use of pulsatile perfusion.
journal_name
Transplantationjournal_title
Transplantationauthors
Shah AP,Milgrom DP,Mangus RS,Powelson JA,Goggins WC,Milgrom MLdoi
10.1097/TP.0b013e318187b978subject
Has Abstractpub_date
2008-10-15 00:00:00pages
1006-9issue
7eissn
0041-1337issn
1534-6080pii
00007890-200810150-00022journal_volume
86pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::Polyclonal rabbit antirat thymocyte serum (ATS) has been shown to form in situ glomerular immune aggregates following perfusion into normal rat kidney ex vivo. This may be due to the presence of T-cell-like epitopes in the rat kidney, or it may be a result of contaminating anti-connective-tissue antibodies in ATS. To ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198606000-00015
更新日期:1986-06-01 00:00:00
abstract:BACKGROUND:Operational tolerance is defined as long-term acceptance of a transplanted organ after complete cessation of immunosuppression (IS), but may not always protect against antigen-dependent changes in graft morphology. METHOD:IS free patients after living-donor liver transplantation (LDLT) underwent protocol bi...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318195a7cb
更新日期:2009-02-27 00:00:00
abstract::We studied major histocompatibility complex (MHC) and cytokine mRNA induction after renal injury in the absence of interferon-gamma (IFN-gamma) using IFN-gamma gene knockout (GKO) mice. The left renal pedicle of normal (wild-type) and GKO BALB/c mice was clamped for 60 minutes; cytokine and MHC mRNA expression were mo...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199560120-00031
更新日期:1995-12-27 00:00:00
abstract::We have previously demonstrated that subclinical chronic rejection (CR) induces structural and functional alterations in enteric smooth muscle and nerves in a rat model of small intestinal transplantation. This study was designed to investigate the effect of prolonged FK506 rescue therapy on these sequelae of CR. Immu...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1995-01-27 00:00:00
abstract:BACKGROUND:As T-cell receptor-major histocompatibility complex (MHC) class I/self peptide interaction regulates T-cell development in the thymus, we reasoned that presentation of peptides by self dendritic cells (DC) to developing T cells in the thymus might induce acquired thymic tolerance. This hypothesis is based on...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200001270-00005
更新日期:2000-01-27 00:00:00
abstract::Islets were isolated from the pancreata of Sprague-Dawley rats and transplanted into streptozotocin-induced diabetic outbred Wistar rats. The effect of transplantation of islets into the cisterna magna on the diabetic state of the recipients was compared with that of the conventional transplantation of islets into liv...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199203000-00003
更新日期:1992-03-01 00:00:00
abstract::The immune response to cytomegalovirus (CMV) infection is highly complex, including humoral, cellular, innate, and adaptive immune responses. Detection of CMV by the innate immune system triggers production of type I IFNs and inflammatory cytokines which initiate cellular and humoral responses that are critical during...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000001095
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:T lymphocyte activation mediated by CD28 costimulation plays a critical role in graft rejection. Plant alkaloid tetrandrine, purified from a Chinese antirheumatic herb, is a potent immunosuppressant. Here, we examined its effects on several CD28-costimulated T-cell activities. In addition, such effects were ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199911150-00027
更新日期:1999-11-15 00:00:00
abstract:BACKGROUND:Bone marrow stromal cells (BMSC) transplantation offers promise in the treatment of chronic paraplegia in rodents. Here, we report the effect of this cell therapy in adult pigs suffering chronic paraplegia. METHODS:Three months after spinal cord injury, autologous BMSC in autologous plasma was injected into...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318186198f
更新日期:2008-09-27 00:00:00
abstract::Currently it is not feasible to isolate sufficient numbers of islets from a single pancreas for clinical transplantation. We examined whether small numbers of islets obtained from multiple donors could be used for transplantation. Islets were isolated from four inbred strains of mice (DBA/2, DBA/1, C3H, and A.SW) by a...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1988-06-01 00:00:00
abstract:BACKGROUND:Although chronic kidney disease (CKD) is still a common complication, the prognosis of kidney function after liver transplantation (LT) is not well known. Moreover, kidney function after LT in children with renal involvement is unknown. METHODS:We retrospectively analyzed patients aged <20 years who underwe...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002548
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Neutrophilic tubulitis accompanied by intratubular neutrophil clusters in the renal allograft is a surrogate marker for urinary tract infection (UTI). Overlapping histologic findings can occur in antibody-mediated rejection, which is characterized by peritubular capillary (PTC) deposition of C4d. This study ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31819ca304
更新日期:2009-04-15 00:00:00
abstract::Governmental and private programs that pay next of kin who give permission for the removal of their deceased relative's organs for transplantation exist in a number of countries. Such payments, which may be given to the relatives or paid directly for funeral expenses or hospital bills unrelated to being a donor, aim t...
journal_title:Transplantation
pub_type: 指南,杂志文章
doi:10.1097/TP.0000000000001198
更新日期:2016-09-01 00:00:00
abstract::In the literature, varying terminology for living organ donation can be found. However, there seems to be a need for a new classification to avoid confusion. Therefore, we assessed existing terminology in the light of current living organ donation practices and suggest a more straightforward classification. We propose...
journal_title:Transplantation
pub_type: 社论
doi:10.1097/TP.0b013e3182129236
更新日期:2011-05-15 00:00:00
abstract:BACKGROUND:Alpha-glutathione-S-transferase (alphaGST) has been suggested as a sensitive marker of acute cellular rejection in liver transplantation. This study evaluated the usefulness of alphaGST as a marker of acute rejection in comparison with standard liver function tests. METHODS:Daily measurements of liver funct...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199802150-00019
更新日期:1998-02-15 00:00:00
abstract:BACKGROUND:Recipients with multiple (more than one) acute rejection (AR) episodes have significantly lower graft survival rates than those with no AR or only one treated episode. However, fewer than 50% of recipients treated for one AR episode will have another episode. METHODS:We studied recipients with at least one ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200006150-00024
更新日期:2000-06-15 00:00:00
abstract::For maximum use of left liver plus caudate lobe grafts, the short hepatic vein draining the caudate lobe should be reconstructed. We devised a new venoplasty technique. On the graft side, a wide venous orifice with a long cuff was formed by gathering the left, middle, and short hepatic veins using a conduit vein graft...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/01.tp.0000244729.39485.7c
更新日期:2007-01-27 00:00:00
abstract::Cyclosporine CsA nephrotoxicity was examined in male Sprague-Dawley rats with or without prior uninephrectomy, injected daily with 12.5 mg/kg CsA, and fed a salt-depleted or normal diet for 3-10 weeks. Control rats received the CsA vehicle. CsA induced a fall in creatinine clearance in salt-depleted rats, from 1.3 +/-...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199002000-00041
更新日期:1990-02-01 00:00:00
abstract::Infectious complications in patients with recurrent hepatitis C virus (HCV) hepatitis after liver transplantation were prospectively assessed and compared with those of all other liver transplant recipients without HCV hepatitis operated on during the same period. Major infections occurred in 64% (14/22) of the patien...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199602150-00014
更新日期:1996-02-15 00:00:00
abstract::The role of TNF in the expression of GVHD and GVHD-related immunodeficiency was studied in a well-established murine GVHD model of bone marrow transplantation across minor histocompatibility barriers (B10.BR-->GBA/J) both in vitro and in vivo. Splenocytes from animals with GVHD profoundly inhibited the proliferation o...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199401001-00021
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:The ability to induce tolerance, or at least minimize the need for immunosuppressive therapy, is a high priority in organ transplantation. Accomplishing this goal requires a novel method for determining when a patient has become tolerant to or is rejecting their graft. Here, we sought to develop an efficient...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182696a5b
更新日期:2012-10-27 00:00:00
abstract:BACKGROUND:We hypothesized that solitary pancreas transplants could be performed successfully even in the presence of poor HLA matching if an aggressive approach were taken with regard to immunosuppressive protocol and the performance of allograft biopsy. METHODS:Seven pancreas-after-kidney transplants and seven pancr...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/00007890-200007270-00028
更新日期:2000-07-27 00:00:00
abstract::The influence of methotrexate on the development of immunity to the line 10 hepatoma was studied in guinea pigs. Chronic methotrexate treatment had no apparent effect on the ability of immune guinea pigs to suppress the growth of inoculated tumor cells. In contrast, the same methotrexate regimen inhibited the developm...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198301000-00011
更新日期:1983-01-01 00:00:00
abstract::The results of OKT3 use for steroid-resistant rejection rescue in adult liver transplantation were analyzed retrospectively from a single transplant center. Comparison was made with concurrent patients who had no rejection (NR) or steroid-responsive rejections (SR). The records of 290 patients who underwent 323 liver ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199301000-00017
更新日期:1993-01-01 00:00:00
abstract:INTRODUCTION:Immune privilege provides a natural paradigm for potentially down-regulating allogeneic and xenogeneic inflammatory immune responses. Fas ligand has been suggested as a general underlying mechanism of immune privilege; the human Fas ligand has been shown to ligate murine Fas in vitro. METHODS:In this stud...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200003270-00010
更新日期:2000-03-27 00:00:00
abstract::The overall incidence of malignancy in renal transplant recipients is 100-fold higher compared with age matched controls. Routine clinical evaluation therefore often includes the determination of serum tumor markers AFP, CA19-9, CEA, CA125, CA15-3, PSA, and calcitonin. We evaluated the specificity and the sensitivity ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199611270-00021
更新日期:1996-11-27 00:00:00
abstract::A cluster of five cases of Legionnaires' disease in renal transplant patients is described. They were treated with erythromycin and rifampicin, and all five survived. Two of them had rejected their grafts prior to their Legionella pneumonia; two rejected their transplants after reduction of immunosuppressive therapy t...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1987-06-01 00:00:00
abstract::The improvement of graft survival over the past decade has mainly been due to the development of more highly specific immunosuppressive agents, such as cyclosporine (CsA) and FK506. CsA and FK506 inhibit T cell activation by interfering with the calcium-mediated pathway, one of two pathways needed for T cell activatio...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199606150-00015
更新日期:1996-06-15 00:00:00
abstract:BACKGROUND:Encapsulation of islets has been widely investigated as a treatment for diabetes. The characteristics and dynamics of insulin secretion by encapsulated islets in response to glucose and other secretagogues are not well understood. METHODS:In our study, macroencapsulated syngeneic islets at 3-4 wk after tran...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200101270-00006
更新日期:2001-01-27 00:00:00
abstract:BACKGROUND:Toxicity of current immunosuppressive agents to islet grafts is one of the major obstacles to clinical islet transplantation (Tx). This study was designed to assess the efficacy of FTY720, a novel immunomodulator with a unique mechanism of action, on islet graft survival and function in streptozotocin (STZ)-...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200205150-00011
更新日期:2002-05-15 00:00:00