Abstract:
BACKGROUND:Prolonged persistence of donor-derived T cells after organ transplantation has been proposed to improve long-term allograft survival. However, surviving transplant-derived T cells are also able to mediate devastating graft-versus-host disease (GvHD). Currently, GvHD after organ transplantation is usually refractory to conventional therapy and the disease outcome fatal. METHODS:Graft-reactive host T cells were generated ex vivo from a patient suffering from a severe and refractory liver-transplant-associated GvHD. To control GvHD, activated alloreactive host T cells were repetitively retransferred into the patient (activated host lymphocyte infusion [aHLI]). RESULTS:Adoptive transfer of ex vivo activated alloreactive host T cells (aHLI) led to the control and complete resolution of severe GvHD without inducing allograft rejection. CONCLUSIONS:aHLI opens a novel therapeutic window to control solid-organ transplant-associated GvHD while preserving allograft integrity.
journal_name
Transplantationjournal_title
Transplantationauthors
Kuball J,Theobald M,Ferreira EA,Hess G,Burg J,Maccagno G,Barreiros AP,Lüth S,Schimanski CC,Schuchmann M,Schwarting A,Neurath M,Otto G,Galle PR,Lohse AWdoi
10.1097/01.tp.0000144183.77279.ecsubject
Has Abstractpub_date
2004-12-27 00:00:00pages
1774-9issue
12eissn
0041-1337issn
1534-6080pii
00007890-200412270-00013journal_volume
78pub_type
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