TNF-alpha signaling is not required for in vivo transcriptional reactivation of latent murine cytomegalovirus.

abstract：BACKGROUND:Fetal pancreatic tissue has been suggested to be less immunogenic than adult islets. Thus, transplantation of human fetal pancreatic tissue as treatment for type 1 diabetes has been gaining interest. To investigate this question, we tested the peripheral blood mononuclear cell (PBMC) responses from different...

journal_title：Transplantation

authors： Brooks-Worrell BM,Peterson KP,Peterson CM,Palmer JP,Jovanovic L

更新日期：2000-05-15 00:00:00

abstract：BACKGROUND:The role of changes in peri-operative blood lactate levels in recipients of living-related liver transplants has not yet been clarified. METHODS:Forty-three recipients were included in this study. Blood lactate, plasma total bilirubin, aminotransferase, body temperature, and gastric mucosal PCO2 levels were...

journal_title：Transplantation

authors： Orii R,Sugawara Y,Hayashida M,Yamada Y,Kubota K,Takayama T,Harihara Y,Makuuchi M,Hanaoka K

更新日期：2000-05-27 00:00:00

abstract：BACKGROUND:The shortage of livers for transplantation has prompted transplant centers to seek alternatives to conventional cadaveric liver transplantation. Left lateral segmentectomy from living donors has proven to be a safe operation for the donor with excellent results in the pediatric population. Left lobectomy, co...

journal_title：Transplantation

authors： Marcos A,Fisher RA,Ham JM,Shiffman ML,Sanyal AJ,Luketic VA,Sterling RK,Posner MP

更新日期：1999-09-27 00:00:00

abstract：:CD4+ T cells are obvious targets for immunotherapy since they appear to be pivotal in rejection responses. Current interest in clinical transplantation is focused on the potential use of nondepleting anti-CD4 antibodies largely because depletion of CD4+ T cells may lead to prolonged periods of nonspecific immunosuppre...

journal_title：Transplantation

authors： Darby CR,Bushell A,Morris PJ,Wood KJ

更新日期：1994-05-27 00:00:00

abstract：BACKGROUND:Human cytomegalovirus (CMV) uses different strategies to escape from human host defense reactions. Previously we have observed that infection of endothelial cells with CMV in vitro leads to enhanced activity of endothelial ectonucleotidases. These ectoenzymes are responsible for hydrolysis of extracellular a...

journal_title：Transplantation

authors： Zandberg M,van Son WJ,Harmsen MC,Bakker WW

更新日期：2007-11-27 00:00:00

abstract：:We have used a polymerase chain reaction-based assay measuring polymorphic (CA)n repeats, a class of simple sequence repeats, to assess the success of allogeneic canine marrow transplants. Results were compared with those obtained with karyotype analysis of dividing cells in recipients that were sex mismatched with th...

journal_title：Transplantation

authors： Yu C,Ostrander E,Bryant E,Burnett R,Storb R

更新日期：1994-09-27 00:00:00

abstract：BACKGROUND:Recently, methylxanthines such as pentoxifylline (PTX) were shown to be immunosuppressive in vitro. Unfortunately, when used in transplant patients, PTX was poorly active as an immunosuppressant. Here we report that the new methylxanthine derivative A802715 not only is more active than PTX, it also suppresse...

journal_title：Transplantation

authors： Lin Y,Goebels J,Rutgeerts O,Kasran A,Van Gool S,Ceuppens J,Schönharting M,Waer M

更新日期：1997-06-27 00:00:00

abstract：BACKGROUND:The novel agent sirolimus (SRL; Rapamune; rapamycin) inhibits the immune response by a mechanism distinct from those of calcineurin antagonists or antimetabolites. This randomized, controlled, multicenter, single blind, phase II trial examined the combination of SRL, steroids, and full versus reduced doses o...

journal_title：Transplantation

authors： Kahan BD,Julian BA,Pescovitz MD,Vanrenterghem Y,Neylan J

更新日期：1999-11-27 00:00:00

abstract：BACKGROUND:To stimulate organ donation, an organ procurement organization (OPO)-wide effort was undertaken to increase donors after cardiac death (DCD) over a 5-year period. This included commonality of protocols, pulsatile perfusion of kidneys, centralization of data and a regional allocation variance designed to mini...

journal_title：Transplantation

authors： Whiting JF,Delmonico F,Morrissey P,Basadonna G,Johnson S,Lewis WD,Rohrer R,O'Connor K,Bradley J,Lovewell TD,Lipkowitz G

更新日期：2006-05-27 00:00:00

abstract：BACKGROUND:Graft coronary arteriosclerosis (GCA) is the major limiting factor for long-term survival after heart transplantation. In this study, we investigated the effect of Multiglycosidorum tripterygii (MT) on GCA and platelet-derived growth factor A (PDGF-A) mRNA expression of transplanted hearts. METHODS:Two grou...

journal_title：Transplantation

authors： Hachida M,Zhang XL,Lu H,Hoshi H,Koyanagi H

更新日期：1998-06-15 00:00:00

abstract：:To determine the impact of different flush and reperfusion techniques on postreperfusion syndrome (PRS) and postoperative graft function, 100 transplants were randomly assigned into four groups as follows: group 1 (n=31), portal vein flush, no vena caval venting; group 2 (n=21), hepatic arterial flush, no vena caval v...

journal_title：Transplantation

authors： Millis JM,Melinek J,Csete M,Imagawa DK,Olthoff KM,Neelankanta G,Braunfeld MY,Sopher MJ,Chan SM,Pregler JL,Yersiz H,Busuttil AA,Shackleton CR,Shaked A,Busuttil RW

更新日期：1997-02-15 00:00:00

abstract：:Endothelial injury plays a central role in the pathophysiologic mechanisms underlying cardiac allograft vasculopathy (CAV). Although the accelerated course of CAV and its localization to the allograft support an important role for the alloimmune response, there is considerable evidence implicating lipoprotein abnormal...

journal_title：Transplantation

authors： Valantine HA

更新日期：2003-09-27 00:00:00

abstract：BACKGROUND:Chronic cyclosporine (CsA) nephropathy, which has been unequivocally documented in recipients of heart, heart-lung, liver, or bone marrow transplants, as well as in nontransplant situations, usually results in a progressive deterioration of renal function. In this study, we assessed the potential reversibili...

journal_title：Transplantation

authors： Mourad G,Vela C,Ribstein J,Mimran A

更新日期：1998-03-15 00:00:00

abstract：:Twenty eight consecutive combined renal and pancreatic transplantations with enteric exocrine diversion were performed between June 1984 and May 1986. The one-year actuarial patient survival and renal and pancreatic graft survival were 90%, 67%, and 69%, respectively. Nineteen pancreatic grafts and eighteen renal graf...

journal_title：Transplantation

authors： Tydén G,Brattström C,Lundgren G,Ostman J,Gunnarsson R,Groth CG

更新日期：1987-05-01 00:00:00

abstract：BACKGROUND:Pediatric liver transplant recipients have traditionally been grouped according to age. Age-based classification schemes are useful in identifying clinical problems in selected age groups and also for developing solutions to these problems. Although infants in the first 3 months of life have not traditionall...

journal_title：Transplantation

authors： Woodle ES,Millis JM,So SK,McDiarmid SV,Busuttil RW,Esquivel CO,Whitington PF,Thistlethwaite JR

更新日期：1998-09-15 00:00:00

abstract：BACKGROUND:It remains unknown whether low-grade hyperparathyroidism persisting beyond the first year postrenal transplantation has any impact on bone density. METHODS:Parathyroid hormone (PTH), glomerular filtration rate (GFR), and bone density (by dual-energy x-ray absorptiometry [DXA]) were monitored in the follow-u...

journal_title：Transplantation

authors： Akaberi S,Lindergård B,Simonsen O,Nyberg G

更新日期：2006-09-27 00:00:00

abstract：BACKGROUND:Localization of inflammatory stimuli may direct lung allografts to different phenotypes of chronic dysfunction, such as bronchiolitis obliterans syndrome (BOS) or restrictive allograft syndrome (RAS). We hypothesized that airway stimulation with lipopolysaccharide (LPS) in rats leads to airway-centered infla...

journal_title：Transplantation

authors： Takahagi A,Sato M,Chen-Yoshikawa TF,Miyamoto E,Saito M,Gochi F,Hamaji M,Yoshizawa A,Terasaki Y,Urushiyama H,Aoyama A,Sonobe M,Date H

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Intracellular concentration of reactive oxygen species is held within tight physiological limits by enzymes with scavenging and repair functions. Under extreme conditions such as prolonged cold ischemia, these enzymes may be unable to adequately protect the organ, resulting in reperfusion injury that renders...

journal_title：Transplantation

authors： St Peter SD,Imber CJ,Jones DC,Fuggle SV,Watson CJ,Friend PJ,Marshall SE

更新日期：2002-09-27 00:00:00

abstract：:: Hepatitis C virus (HCV) infection is common in solid organ allograft recipients and is a significant cause of morbidity and mortality after transplantation, so effective management will improve outcomes. In this review, we discuss the extent of the problem associated with HCV infection in donors and kidney, heart, a...

journal_title：Transplantation

authors： Carbone M,Mutimer D,Neuberger J

更新日期：2013-03-27 00:00:00

abstract：:Pulmonary complications are often lethal components of acute graft-vs.-host disease (GVHD). Although interstitial pneumonitis and lymphocytic bronchitis have been implicated as elements of acute GVHD, previous studies have not determined a correlation between the onset of these histopathologies or their contribution t...

journal_title：Transplantation

authors： Workman DL,Clancy J Jr

更新日期：1994-07-27 00:00:00

abstract：BACKGROUND:Thromboembolism has been reported as a frequent complication after cardiac transplantation. Many risk factors for thrombosis may explain this, such as metabolic alterations and the use of cyclosporine. In the general population, two single nucleotide polymorphisms (SNPs), factor V Leiden and prothrombin G202...

journal_title：Transplantation

authors： Miriuka SG,Langman LJ,Evrovski J,Miner SE,Kozuszko S,D'Mello N,Delgado DH,Wong BY,Ross HJ,Cole DE

更新日期：2005-09-15 00:00:00

abstract：BACKGROUND:The autonomic storm accompanying brain death leads to neurogenic pulmonary edema and triggers development of systemic and pulmonary inflammatory responses. Neurogenic vasoplegia exacerbates the pulmonary injury caused by brain death and primes the lung for ischemia reperfusion injury and primary graft dysfun...

journal_title：Transplantation

authors： Rostron AJ,Avlonitis VS,Cork DM,Grenade DS,Kirby JA,Dark JH

更新日期：2008-02-27 00:00:00

abstract：BACKGROUND:Hyperparathyroidism is reported in 10% to 66% of renal transplant recipients (RTR). The influence of persisting hyperparathyroidism on long-term clinical outcomes in RTR has not been examined in a large prospective study. METHODS:We investigated the association between baseline parathyroid hormone (PTH) lev...

journal_title：Transplantation

authors： Pihlstrøm H,Dahle DO,Mjøen G,Pilz S,März W,Abedini S,Holme I,Fellström B,Jardine AG,Holdaas H

更新日期：2015-02-01 00:00:00

abstract：:Class I molecules of the MHC affect target cell sensitivity to NK cell repertoire. In the mouse, absence of MHC class I molecules on target cells is associated with an increased susceptibility to NK cell-mediated lysis, while syngeneic class I molecules confer protection. In contrast to the protective role of syngenei...

journal_title：Transplantation

authors： Salcedo M,Höglund P,Ljunggren HG

更新日期：1995-08-15 00:00:00

abstract：:CD2 is a 50-kDa transmembrane glycoprotein that plays an important role in T and natural killer (NT) lymphocyte functions. CD2 serves as both an adhesion molecule and as a costimulatory molecule through interactions with its ligand, CD58, on antigen presenting or target cells. Consistent with earlier studies using a r...

journal_title：Transplantation

authors： Branco L,Barren P,Mao SY,Pfarr D,Kaplan R,Postema C,Langermann S,Koenig S,Johnson S

更新日期：1999-11-27 00:00:00

abstract：:It was the objective of these experiments to study the time-related changes in the responsiveness of the cellular elements of the immune system following contact with single non-H-2 or multiple H-2 histocompatibility antigens. The reactivity of spleen cells from mice that received injections of spleen cells bearing H-...

journal_title：Transplantation

authors： Graff RJ,Kurtz ME,Russell H,Martin-Morgan D

更新日期：1988-02-01 00:00:00

abstract：:Two infants born to mothers who had been given a renal transplant and who were receiving azathioprine and prednisone have been followed up for over 2 years. Initially both had lower than normal lymphocyte counts and cortisol levels. Chromosomal aberrations similar to those found in the lymphocytes of the mothers were ...

journal_title：Transplantation

authors： Price HV,Salaman JR,Laurence KM,Langmaid H

更新日期：1976-04-01 00:00:00

abstract：BACKGROUND:We assess whether remote ischemic preconditioning (rIPC) of the recipient can modify ischemia-reperfusion (IR) injury in the donor heart following orthotopic heart transplantation from brain dead donors and to examine potential mechanisms of protection. METHODS:Sixteen pigs weighing from 26 to 34.2 (mean 29...

journal_title：Transplantation

authors： Konstantinov IE,Li J,Cheung MM,Shimizu M,Stokoe J,Kharbanda RK,Redington AN

更新日期：2005-06-27 00:00:00

abstract：:To evaluate the efficacy of University of Wisconsin (UW) solution for lung preservation, we performed canine lung allotransplantation with lungs preserved in UW solution. Donor lungs from eight dogs were flushed with UW solution and lungs from four dogs with Euro-Collins solution, and these were preserved for 24 hr in...

journal_title：Transplantation

authors： Kawahara K,Itoyanagi N,Takahashi T,Akamine S,Kobayashi M,Tomota M

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Community respiratory viruses such as respiratory syncytial virus (RSV), adenovirus, influenza A, influenza B, and the parainfluenza group are frequent causes of respiratory disease in bone marrow transplant (BMT) patients. MATERIAL AND METHODS:During the period from March 1993 to August 1999, 810 samples o...

journal_title：Transplantation

authors： Raboni SM,Nogueira MB,Tsuchiya LR,Takahashi GA,Pereira LA,Pasquini R,Siqueira MM

更新日期：2003-07-15 00:00:00