Abstract:
BACKGROUND:Some statins have been reported to suppress the immune system and increase the expression of bone morphogenetic protein-2 gene that plays a pivotal role in bone regeneration. METHODS:The effects of cerivastatin on skeletal reconstruction by vascularized bone allograft were investigated in a rat tibia-fibula graft model. After transplantation, the recipient rats were treated with vehicle, low-dose cerivastatin, high-dose cerivastatin, or cyclosporine A. RESULTS:Transplanted bones treated with low-dose cerivastatin and vehicle failed to unite with the recipient bones. In contrast, high-dose cerivastatin induced the bone union as effectively as cyclosporine A. Histologically, high-dose cerivastatin-treated transplanted bones were nonvital, but new bone formation occurred at the outer layer of the nonvital cortex. CONCLUSION:These results indicate that statins could promote fracture healing. Because transplant recipients have the increased risks of osteoporotic fracture and hypercholesterolemia, statins may be a good choice in the treatment of these patients.
journal_name
Transplantationjournal_title
Transplantationauthors
Ohno T,Shigetomi M,Ihara K,Matsunaga T,Hashimoto T,Kawano H,Sugiyama T,Kawai Sdoi
10.1097/01.TP.0000074992.49236.58subject
Has Abstractpub_date
2003-09-15 00:00:00pages
869-71issue
5eissn
0041-1337issn
1534-6080journal_volume
76pub_type
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