Nutritional markers in liver allograft recipients.

abstract：:Allotransplantation into immunosuppressed individuals results in long-term survival of grafts. However, the grafts are damaged, probably at many stages before, during and after implantation. The hypothesis to be presented is that release of antigens and autoantigens from the chronically damaged graft results in breaki...

journal_title：Transplantation

authors： Rose ML

更新日期：2005-02-15 00:00:00

abstract：BACKGROUND:The aim of this single-center study was to investigate whether trough level adjusted mycophenolate mofetil (MMF) is more efficacious in combination with tacrolimus (TAC) or cyclosporine (CsA) and to evaluate the impact of either drug on MMF dosage. METHODS:Sixty patients (TAC, n = 30; CsA, n = 30) undergoin...

journal_title：Transplantation

authors： Meiser BM,Groetzner J,Kaczmarek I,Landwehr P,Müller M,Jung S,Uberfuhr P,Fraunberger P,Stempfle HU,Weis M,Reichart B

更新日期：2004-08-27 00:00:00

abstract：:Antibodies against B lymphocytes were found in the serum of the majority of 59 kidney transplant recipients and of 22 eluates obtained from kidney allografts undergoing rejection. To characterize these B cell lymphocytotoxins we have used a mouse monoclonal anti-DR antibody (L227) that inhibits cytotoxicity of antibod...

journal_title：Transplantation

authors： Nunez G,McPhaul JJ Jr,Stastny P

更新日期：1983-05-01 00:00:00

abstract：BACKGROUND:In the present study we examined the effect of the timing of marrow infusion on engraftment in nonmyeloablatively conditioned mice. METHODS:B10 mice were conditioned with decreasing doses of total body irradiation (TBI) and reconstituted with bone marrow cells (BMCs) from major histocompatibility complex-di...

journal_title：Transplantation

authors： Xu H,Exner BG,Chilton PM,Tanner MK,Mueller YM,Rezzoug F,Ildstad ST

更新日期：2004-03-27 00:00:00

abstract：BACKGROUND:Everolimus reduces the progression of cardiac allograft vasculopathy (CAV) in de novo heart transplant (HTx) recipients, but the influence on established CAV is unknown. METHODS:In this Nordic Certican Trial in Heart and lung Transplantation substudy, 111 maintenance HTx recipients (time post-HTx 5.8 ± 4.3 ...

journal_title：Transplantation

authors： Arora S,Ueland T,Wennerblom B,Sigurdadottir V,Eiskjær H,Bøtker HE,Ekmehag B,Jansson K,Mortensen SA,Saunamaki K,Simonsen S,Gude E,Bendz B,Solbu D,Aukrust P,Gullestad L

更新日期：2011-07-27 00:00:00

abstract：:Preexisting diabetes mellitus (DM) has been regarded as a contraindication to heart transplantation (HT). This prejudice has been based upon concern over increased infection rates and worsening DM with the initiation of prednisone immunosuppression. To better evaluate these suppositions, we reviewed our experience wit...

journal_title：Transplantation

authors： Ladowski JS,Kormos RL,Uretsky BF,Griffith BP,Armitage JM,Hardesty RL

更新日期：1990-02-01 00:00:00

abstract：:KM2210, a conjugate of estradiol and chlorambucil (CBL), which was originally developed as an anti-breast cancer agent, inhibits proliferative response of human mononuclear cells to alloantigens in mixed lymphocyte culture in a dose-dependent manner, but has no effect on their response to phytohemagglutinin. Neither e...

journal_title：Transplantation

authors： Matsudaira T,Kodo H,Okamoto S,Tani K,Tojo A,Ozawa K,Asano K,Asano S

更新日期：1992-10-01 00:00:00

abstract：:Transient pure red cell aplasia (PRCA) in three consecutive patients receiving ATG for management of kidney graft rejection prompted a systematic study of the effects on erythropoiesis of the ATG preparation used at our institution. We found that 90% of patients treated with rabbit anti-T lymphoblast globulin develope...

journal_title：Transplantation

authors： Schaffner A,Thomann B,Zala GF,Rüegg R,Keusch G,Fehr J,Gmür J

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND:Focal segmental glomerulosclerosis (FSGS) recurs after kidney transplantation in more than 30% of cases and can lead to allograft loss. Serum soluble urokinase-type plasminogen activator receptor (suPAR) is implicated in the pathogenesis of native and recurrent FSGS. METHODS:We conducted a retrospective stu...

journal_title：Transplantation

authors： Alachkar N,Wei C,Arend LJ,Jackson AM,Racusen LC,Fornoni A,Burke G,Rabb H,Kakkad K,Reiser J,Estrella MM

更新日期：2013-10-15 00:00:00

abstract：:We report the successful application of a hybrid artificial pancreas device for the treatment of severe diabetes mellitus induced by total pancreatectomy in two dogs. Control of the blood sugar was achieved for more than 1 year in these two animals without any immunosuppressive therapy. Although exogenous insulin was ...

journal_title：Transplantation

authors： Maki T,Lodge JP,Carretta M,Ohzato H,Borland KM,Sullivan SJ,Staruk J,Muller TE,Solomon BA,Chick WL

更新日期：1993-04-01 00:00:00

abstract：:This study describes VG01, a monoclonal antibody to a novel lymphocyte activation antigen. The cells reacting with VG01 were first characterized by indirect immunofluorescence and fluorescence-activated cell sorter analysis. The antigen defined by VG01 was expressed on circulating T lymphocytes (23.8 +/- 9.0) and on t...

journal_title：Transplantation

authors： Denegri JF,Gilks CB,Altin M,Peterson J,Lafleur L

更新日期：1988-05-01 00:00:00

abstract：BACKGROUND:Data regarding the onset of puberty in children receiving mammalian target of rapamycin (mTOR) inhibitors are limited. METHODS:Kidney transplant patients aged <14 years were analyzed retrospectively to a maximum age of 18 years, with a minimal observation period of 1 year. Immunosuppression comprised (1) st...

journal_title：Transplantation

authors： Förster J,Ahlenstiel-Grunow T,Zapf A,Mynarek M,Pape L

更新日期：2016-11-01 00:00:00

abstract：:We report the largest single-center experience with extracorporeal photopheresis (ECP) for bronchiolitis obliterans syndrome (BOS) and recurrent acute rejection (AR) after lung transplantation. Lung transplant recipients undergoing ECP for BOS and recurrent AR were included (1997-2007). The rate of forced expiratory v...

journal_title：Transplantation

authors： Benden C,Speich R,Hofbauer GF,Irani S,Eich-Wanger C,Russi EW,Weder W,Boehler A

更新日期：2008-12-15 00:00:00

abstract：OBJECTIVES:Recent studies demonstrated that prolactin (PRL) has beneficial effects on beta cells for islet transplantation. We examined the effect of human recombinant PRL (rhPRL) supplementation to the culture media to determine its potential use in the context of clinical islet transplantation. MATERIALS AND METHODS...

journal_title：Transplantation

authors： Yamamoto T,Mita A,Ricordi C,Messinger S,Miki A,Sakuma Y,Timoneri F,Barker S,Fornoni A,Molano RD,Inverardi L,Pileggi A,Ichii H

更新日期：2010-06-15 00:00:00

abstract：BACKGROUND:We sought to determine the risk factors, molecular epidemiology, antibiotic therapy, and outcomes of bacteremia because of extensively drug-resistant (XDR) Pseudomonas aeruginosa in solid organ transplant (SOT) recipients. METHODS:All episodes of bacteremia occurring in SOT recipients were prospectively doc...

journal_title：Transplantation

authors： Bodro M,Sabé N,Tubau F,Lladó L,Baliellas C,González-Costello J,Cruzado JM,Carratalà J

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Survival of ABO-mismatched kidneys with stable renal function despite the persistence of anti-ABO antibodies is called accommodation. The mechanism of accommodation is unclear, but may involve complement regulatory proteins such as CD59. The development of alpha-1,3-galactosyltransferase knock-out (GalT-KO) ...

journal_title：Transplantation

authors： Griesemer AD,Okumi M,Shimizu A,Moran S,Ishikawa Y,Iorio J,Arn JS,Yamada K

更新日期：2009-05-15 00:00:00

abstract：:We have previously demonstrated that liver sinusoidal endothelial cells (LSECs) that endocytose portally injected allogeneic cells exert immunosuppressive effects on T cells with indirect allospecificity. In this study, we have demonstrated that invariant natural killer T cells plays a significant role in such immunos...

journal_title：Transplantation

authors： Shishida M,Ohdan H,Onoe T,Tanaka Y,Igarashi Y,Banshodani M,Asahara T

更新日期：2008-04-15 00:00:00

abstract：BACKGROUND:Fatty livers are more prone to primary nonfunction after transplantation. It is known that cell injury is strongly associated with alterations in the content and composition of membrane lipids. We assumed that plasma membrane (PM) fluidity, which is the most important property of the membrane, differed betwe...

journal_title：Transplantation

authors： Fukumori T,Ohkohchi N,Tsukamoto S,Satomi S

更新日期：1999-01-27 00:00:00

abstract：:Cyclosporine CsA nephrotoxicity was examined in male Sprague-Dawley rats with or without prior uninephrectomy, injected daily with 12.5 mg/kg CsA, and fed a salt-depleted or normal diet for 3-10 weeks. Control rats received the CsA vehicle. CsA induced a fall in creatinine clearance in salt-depleted rats, from 1.3 +/-...

journal_title：Transplantation

authors： Rosen S,Greenfeld Z,Brezis M

更新日期：1990-02-01 00:00:00

abstract：BACKGROUND:Finding the best combination of immunosuppression is an important challenge in kidney transplantation. Current short-term (1- and 3-year) allograft survival is quite good, making it difficult to determine differences in therapeutic regimens without large sample sizes. Using data from the United Network for O...

journal_title：Transplantation

authors： Cherikh WS,Myron Kauffman H,Maghirang J,Bleyer AJ,Johnson CP

更新日期：2003-08-15 00:00:00

abstract：:In the present study the functional and morphologic effects of two pulmoplegic solutions are evaluated. Single left-lung allotransplantation with ligation of the right pulmonary artery was performed in 15 piglets (13-20 kg). The lungs were preserved after donor prostaglandin E-1 treatment with single pulmonary artery ...

journal_title：Transplantation

authors： Lehtola A,Harjula A,Heikkilä L,Hämmäinen P,Taskinen E,Kurki T,Salmenperä M,Mattila S

更新日期：1990-06-01 00:00:00

abstract：BACKGROUND:Cyclosporine A (CsA)-associated oxidative stress has been proposed as an important mechanism of renal injury. This study was designed to examine whether N-acetylcysteine (NAC), a well-known antioxidant, affects Klotho, antiaging gene, expression and its signaling pathway in an experimental model of chronic C...

journal_title：Transplantation

authors： Piao SG,Kang SH,Lim SW,Chung BH,Doh KC,Heo SB,Jin L,Li C,Yang CW

更新日期：2013-07-27 00:00:00

abstract：BACKGROUND:We examined whether oral administration of alloantigen could induce the prolonged survival of cardiac allografts. METHODS:Hearts from CBK (H2k+Kb) transgenic or (C57BL/10xCBA)F1 (H2bxH2k) mice were transplanted into CBA (H2k) recipients pretreated orally with 1 x 10(7) donor splenocytes in the presence or a...

journal_title：Transplantation

authors： Niimi M,Witzke O,Bushell A,Hara M,Morris PJ,Wood KJ

更新日期：2000-11-27 00:00:00

abstract：BACKGROUND:In the background of availability of better treatments for specific liver diseases and listing of nonalcoholic steatohepatitis (NASH) as an etiology for liver transplantation (LT), data are unclear on the impact of disease etiology on the frequency of LT and liver posttransplantation outcomes. METHODS:The U...

journal_title：Transplantation

authors： Singal AK,Guturu P,Hmoud B,Kuo YF,Salameh H,Wiesner RH

更新日期：2013-03-15 00:00:00

abstract：BACKGROUND:In an effort to define reliable assays that might predict postimmunosuppressant-withdrawal development of chronic rejection (CR), despite conditioning for tolerance induction, we evaluated various immunological responses in nonhuman primate renal allograft recipients. METHODS:Fourteen Cynomolgus monkeys rec...

journal_title：Transplantation

authors： Boskovic S,Kawai T,Smith RN,Wee SL,Nadazdin O,Koyama I,Saidman S,Cardarelli F,Elias N,Sykes M,Strom T,Colvin RB,Sachs DH,Cosimi AB

更新日期：2006-09-27 00:00:00

abstract：BACKGROUND:Cold preservation is the most practical method to maintain the viability of isolated lungs. However, rapid cooling may affect pulmonary endothelial function. We examined the effects of microtubule stabilization with paclitaxel on pulmonary endothelial barrier integrity under cold temperature. METHODS:Human ...

journal_title：Transplantation

authors： Suzuki S,Bing H,Sugawara T,Matsuda Y,Tabata T,Hoshikawa Y,Saijo Y,Kondo T

更新日期：2004-08-27 00:00:00

abstract：BACKGROUND:Anemia after kidney transplantation has been associated with poor transplant outcomes. We hypothesized that intravenous (IV) iron may more rapidly correct anemia than oral (PO) iron. METHODS:One hundred four kidney transplant recipients were prospectively randomized to IV iron polymaltose (500 mg single dos...

journal_title：Transplantation

authors： Mudge DW,Tan KS,Miles R,Johnson DW,Badve SV,Campbell SB,Isbel NM,van Eps CL,Hawley CM

更新日期：2012-04-27 00:00:00

abstract：:Renal allograft recipients treated with cyclosporine (CsA) have increased renal vascular resistance that falls when CsA is stopped. With the aim of identifying whether CsA-treated patients with excellent renal function also have an alteration in renal vascular tone and to investigate which vessels are affected, we hav...

journal_title：Transplantation

authors： Cairns HS,Raval U,Neild GH

更新日期：1988-07-01 00:00:00

abstract：:A model for immediate vascularization of skin was devised to examine one of the possible explanations for the differential survival rates of transplants of freely grafted skin and organs, i.e., the increased vulnerability of skin to early ischemic necrosis prior to revascularization. Female Fischer (F) rat skin was tr...

journal_title：Transplantation

authors： Perloff LJ,Barker CF

更新日期：1979-08-01 00:00:00

abstract：BACKGROUND:Liver transplantation from donation after cardiac death (DCD) donors is an increasingly common approach for expansion of the donor organ supply. However, transplantation with DCD livers results in inferior graft survival. In this study, we examined donor and recipient characteristics that are associated with...

journal_title：Transplantation

authors： Lee KW,Simpkins CE,Montgomery RA,Locke JE,Segev DL,Maley WR

更新日期：2006-12-27 00:00:00