Abstract:
BACKGROUND:We examined whether oral administration of alloantigen could induce the prolonged survival of cardiac allografts. METHODS:Hearts from CBK (H2k+Kb) transgenic or (C57BL/10xCBA)F1 (H2bxH2k) mice were transplanted into CBA (H2k) recipients pretreated orally with 1 x 10(7) donor splenocytes in the presence or absence of a nondepleting anti-CD4 (YTS 177, 200 microg/dose). RESULTS:Modest prolongation of CBK cardiac grafts was induced in CBA mice fed with multiple doses of CBK splenocytes (MST 42 days compared with controls fed with syngeneic CBA splenocytes, 12 days). When the CD4 monoclonal antibody, YTS177, was administered for 2 days before the first oral delivery of CBK splenocytes, all mice accepted their grafts indefinitely (MST > 100 days versus mice treated with anti-CD4 alone, 11.5 days). To determine if feeding multiple doses of alloantigen was essential, CBA mice were given CBK splenocytes orally on a single occasion in combination with the anti-CD4. The majority of the grafts survived indefinitely (MST >100 days). This oral treatment regimen also induced indefinite prolongation of (C57BL/10xCBA)F1 cardiac grafts. CONCLUSION:The induction of unresponsiveness by oral administration of alloantigen can be augmented by a nondepleting anti-CD4, YTS177, when given before the first oral delivery of allogeneic cells.
journal_name
Transplantationjournal_title
Transplantationauthors
Niimi M,Witzke O,Bushell A,Hara M,Morris PJ,Wood KJdoi
10.1097/00007890-200011270-00021subject
Has Abstractpub_date
2000-11-27 00:00:00pages
1524-8issue
10eissn
0041-1337issn
1534-6080journal_volume
70pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract:BACKGROUND:Current desensitization (DES) methods are not always effective. Thus, novel, more effective approaches are desirable. Interleukin (IL)-6 is an attractive target as it promotes B-cell differentiation to plasma cells, is important for immunoglobulin production, and induces Th17 cells. Here, we undertook a phas...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000741
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Alpha-glutathione-S-transferase (alphaGST) has been suggested as a sensitive marker of acute cellular rejection in liver transplantation. This study evaluated the usefulness of alphaGST as a marker of acute rejection in comparison with standard liver function tests. METHODS:Daily measurements of liver funct...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199802150-00019
更新日期:1998-02-15 00:00:00
abstract:BACKGROUND:Although human herpesvirus (HHV)-6 is now recognized as a frequent pathogen after transplantation, the real impact of this infection in patients undergoing transplantation remains unclear. METHODS:During 27 months, 30 consecutive heart-lung- and lung-transplant recipients were included on the day of transpl...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000058809.42027.66
更新日期:2003-06-27 00:00:00
abstract:BACKGROUND:Oral ingestion of potassium dichromate produces a complex spectrum of complications. It has an extremely poor prognosis and usually leads to rapid death. METHODS:We report the case of a 16-year-old male patient who was admitted to hospital after oral ingestion of potassium dichromate with suicidal intention...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200006150-00044
更新日期:2000-06-15 00:00:00
abstract::In 2007, the islet community was notified that the collagenase product most commonly used for human islet isolations contained bovine neural tissue contaminants. To minimize this potential hazard, we adapted our human islet processing procedure to use a GMP-manufactured, bovine neural tissue-free collagenase blend. He...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0b013e3181b443ae
更新日期:2009-09-27 00:00:00
abstract:BACKGROUND:Deoxyspergualin (DSG), a potent immunosuppressive drug, has been clinically used as a rescue therapy for acute graft rejection. However, DSG has severe adverse effects that limits its use. Here, we examined the optimized therapeutic protocol for DSG using chronopharmacological profiles of it. METHODS:First,...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199905150-00012
更新日期:1999-05-15 00:00:00
abstract::The rat aortic transplant model was modified to investigate whether the vascular wall changes on chronic rejection are reversible. DA (RT1a) aortas were first transplanted to WF (RT1a) recipients. The first transplantation was accompanied, as described earlier, by an increase in intimal cellularity and thickness and t...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199608270-00016
更新日期:1996-08-27 00:00:00
abstract::The current shortage of donor organs has stimulated investigation of pig-to-human xenotransplantation as a practical alternative to allotransplantation. However, a major obstacle to this xenotransplantation is hyperacute rejection, which is believed to be initiated by the interaction of natural anti-alpha-galactosyl (...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199611150-00026
更新日期:1996-11-15 00:00:00
abstract:BACKGROUND:The significance of late urinary tract infections (UTIs) after renal transplantation and their association with scarring and graft dysfunction remains controversial. We sought to define the prevalence of renal scarring in allograft recipients with a history of late recurrent UTIs, to determine whether the pr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000275377.09660.fa
更新日期:2007-08-15 00:00:00
abstract::Moderate hyperhomocysteinemia, an independent cardiovascular risk factor, has been reported in renal transplant recipients. In the present study, plasma concentrations of total homocysteine were significantly increased in 120 renal transplant recipients as compared with 60 healthy controls (19.0 +/- 6.9 vs. 11.6 +/- 2...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199602150-00034
更新日期:1996-02-15 00:00:00
abstract:BACKGROUND:The established method of pretransplant cross-matching does not detect IgA antibodies, and IgA antibodies have thus been ignored when assessing patients for transplantation. The aim of this study was to detect IgA allo- and autoreactive antibodies using flow cytometry and to correlate the results with transp...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199901270-00022
更新日期:1999-01-27 00:00:00
abstract::The CD154-CD40 pathway is one of the critical costimulatory pathways that are required for full activation of T cells during alloimmune responses. Blockade of this pathway with anti-CD154 antibodies has been reported to prolong allograft survival in experimental transplantation models and to induce tolerance in some i...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/00007890-200201151-00012
更新日期:2002-01-15 00:00:00
abstract::We report the successful application of a hybrid artificial pancreas device for the treatment of severe diabetes mellitus induced by total pancreatectomy in two dogs. Control of the blood sugar was achieved for more than 1 year in these two animals without any immunosuppressive therapy. Although exogenous insulin was ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199304000-00005
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND:In previous studies of cynomolgus monkey lung allograft recipients, we demonstrated significant immunosuppressive efficacy but reduced tolerability after combined treatment with high doses of microemulsion cyclosporine (CsA) and SDZ RAD (40-O-(2-hydroxyethyl)-rapamycin). The current study was designed to com...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200002270-00005
更新日期:2000-02-27 00:00:00
abstract::To test the importance of B lymphocytes in immunity to major histocompatibility complex class I alloantigens, B cell-deficient mice were generated by reconstituting severe combined immunodeficiency mice, which lack functional B and T lymphocytes, with T cells or with both T and B cells. The reconstituted mice were cha...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1993-06-01 00:00:00
abstract::Antithymocyte globulin (ATG) has been used successfully for induction therapy as well as for treatment of established allograft rejection. However, this therapy has often been associated with problems of overimmunosuppression and increased costs. In a randomized clinical trial, we compared the immunosuppressive benefi...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1995-06-15 00:00:00
abstract:BACKGROUND:Little is known about innate lymphoid cell (ILC) populations in the human gut, and the turnover of these cells and their subsets after transplantation has not been described. METHODS:Intestinal samples were taken from 4 isolated intestine and 3 multivisceral transplant recipients at the time of any operativ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001593
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Recently published pediatric trial of Rituximab for the treatment of CD20+ acute renal allograft rejection (AR) demonstrated transient depletion of circulating/intragraft B cells (Zarkhin et al., Am J Transplant 2008; 8: 2607). In this study, we have evaluated phenotypic definition of circulating B-cell subs...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318213df29
更新日期:2011-05-15 00:00:00
abstract:BACKGROUND:Optical coherence tomography (OCT) revealed that cells lining proximal convoluted tubules of living donor kidneys (LDKs) procured by laparoscopic procedures were very swollen in response to the brief period of ischemia experienced between the time of arterial vessel clamping and flushing the excised kidney w...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000154
更新日期:2014-10-27 00:00:00
abstract::Predictors of survival after lung transplant were analyzed in a large cohort of 990 lung transplanted patients from a single center. The overall survival was 41.6%, (41.5% in males, and 41.8% in females), the average length of the follow up was 45.84+/-51.98 months (range 0-282.47 months). Females tend to live longer ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31816c2fae
更新日期:2008-04-27 00:00:00
abstract::The United Network for Organ Sharing is poised to resolve geographic disparity in liver transplantation and promote allocation based on medical urgency. At the time of writing, United Network for Organ Sharing is considering redistricting the organ procurement and transplantation network so that patient model for end-...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000000656
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Significant disparity exists in the United Kingdom between the need for organ transplant and supply of deceased donor organs. In the recent years, efforts to increase donation has improved the rate of mainly deceased donors after circulatory death and from older donors. The rate of donation from pediatric po...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000575
更新日期:2015-09-01 00:00:00
abstract::Alloreactive T cells are often specific for individual peptides that are bound to allogeneic major histocompatibility complex (MHC) molecules. Other alloreactive T cells are reported to be peptide-independent or to recognize MHC conformational changes that are induced by multiple peptides. We tested 12 anti-HLA-B7 all...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199707270-00030
更新日期:1997-07-27 00:00:00
abstract:BACKGROUND:The induction of tolerance to pig antigens in primates may facilitate the development of successful clinical xenotransplantation protocols. The infusion of mobilized porcine peripheral blood leukocytes (PBPCs, comprised of approximately 2% peripheral blood progenitor cells) into splenectomized preconditioned...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200110150-00021
更新日期:2001-10-15 00:00:00
abstract:BACKGROUND:The need for renal replacement therapy (RRT) either before or after orthotopic liver transplant (OLTX) has been reported to be a poor prognostic indicator for survival. Use of continuous veno-venous hemodialysis (CVVHD) for RRT has been reported in three series of OLTX patients with high 90-day mortality rat...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200105270-00012
更新日期:2001-05-27 00:00:00
abstract::Cytomegalovirus (CMV) is a major pathogen in transplant recipients and AIDS patients, and the virus may also play a role in allograft rejection. Previous work from this laboratory demonstrated increased cell surface expression of the adhesion molecules ICAM-1 (CD54) and LFA-3 (CD58) following CMV infection in vitro. W...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199610270-00014
更新日期:1996-10-27 00:00:00
abstract:BACKGROUND:HLA-G is a nonclassical MHC class I molecule and its physiological expression restricted to placental extravillous trophoblasts contributes to maternal tolerance to the semiallogeneic fetus. Aberrant expression of HLA-G in human organ grafts has been proposed to contribute to graft acceptance. METHODS:We st...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000761
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Ventricular assist devices (VADs) are increasingly being used in pediatric patients to provide long-term cardiac support. One potential complication of VAD therapy is the development of antibodies directed against human leukocyte antigens (HLA). This phenomenon has not been well described with the Berlin Hea...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182925242
更新日期:2013-06-27 00:00:00
abstract::Acute rejection is a frequent cause of early graft dysfunction in renal transplantation, and serum creatinine is the most important measure of clinical response. However, there is little information on serum creatinine during rejection episodes. In this study, the determinants that might influence the clinical respons...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199507150-00006
更新日期:1995-07-15 00:00:00
abstract:BACKGROUND:Data regarding the onset of puberty in children receiving mammalian target of rapamycin (mTOR) inhibitors are limited. METHODS:Kidney transplant patients aged <14 years were analyzed retrospectively to a maximum age of 18 years, with a minimal observation period of 1 year. Immunosuppression comprised (1) st...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001037
更新日期:2016-11-01 00:00:00