Chronopharmacology for deoxyspergualin: toxicity and efficacy in the rat.

abstract：BACKGROUND:Bone complications after hematopoietic stem-cell transplantation (HSCT) are relatively frequent. Evaluation of biomarkers of bone turnover and dual energy x-ray absorptiometry (DEXA) are not known in this context. METHODS:We prospectively evaluated bone mineral density, biomarkers of bone turnover, and the ...

journal_title：Transplantation

authors： Petropoulou AD,Porcher R,Herr AL,Devergie A,Brentano TF,Ribaud P,Pinto FO,Rocha V,Peffault de Latour R,Orcel P,Socié G,Robin M

更新日期：2010-06-15 00:00:00

abstract：BACKGROUND:The induction of tolerance to pig antigens in primates may facilitate the development of successful clinical xenotransplantation protocols. The infusion of mobilized porcine peripheral blood leukocytes (PBPCs, comprised of approximately 2% peripheral blood progenitor cells) into splenectomized preconditioned...

journal_title：Transplantation

authors： Appel JZ 3rd,Alwayn IP,Correa LE,Cooper DK,Robson SC

更新日期：2001-10-15 00:00:00

abstract：BACKGROUND:Prophylactic administration of anti-HBs intravenous immunoglobulins (IVIg) in hepatitis B infected-liver transplant patients protects against acute rejection. To explore the suitability of intravenous immunoglobulins (IVIg) as prophylaxis of acute rejection and graft-versus-host disease (GVHD) after allograf...

journal_title：Transplantation

authors： Tha-In T,Metselaar HJ,Tilanus HW,Boor PP,Mancham S,Kuipers EJ,de Man RA,Kwekkeboom J

更新日期：2006-06-27 00:00:00

abstract：:Children who experience acute liver failure following liver transplantation will have multiple organ failure and a high rate of mortality unless emergency retransplantation can be performed. Transplant hepatectomy with portocaval shunting has been described as a bridge to transplantation in the most severe cases, as w...

journal_title：Transplantation

authors： Hammer GB,So SK,Al-Uzri A,Conley SB,Concepcion W,Cox KL,Berquist WE,Esquivel CO

更新日期：1996-07-15 00:00:00

abstract：:The term "accommodation" was invoked to describe endothelial cell resistance to antibody-mediated rejection after ABO-incompatible kidney or experimental xenograft transplantation. Currently, there is much interest in how to achieve successful human leukocyte antigen (HLA)-incompatible allograft transplantation in HLA...

journal_title：Transplantation

authors： Rose ML,West LJ

更新日期：2012-02-15 00:00:00

abstract：BACKGROUND:Posttransplant lymphoproliferative disease (PTLD) after pediatric liver transplantation has been associated with high mortality rates. METHODS:The present study examined 282 consecutive pediatric liver transplant recipients from October 1989 to June 1996 who received primary tacrolimus immunosuppression. Th...

journal_title：Transplantation

authors： Cacciarelli TV,Green M,Jaffe R,Mazariegos GV,Jain A,Fung JJ,Reyes J

更新日期：1998-10-27 00:00:00

abstract：BACKGROUND:Some statins have been reported to suppress the immune system and increase the expression of bone morphogenetic protein-2 gene that plays a pivotal role in bone regeneration. METHODS:The effects of cerivastatin on skeletal reconstruction by vascularized bone allograft were investigated in a rat tibia-fibula...

journal_title：Transplantation

authors： Ohno T,Shigetomi M,Ihara K,Matsunaga T,Hashimoto T,Kawano H,Sugiyama T,Kawai S

更新日期：2003-09-15 00:00:00

abstract：:Low-affinity, cold-reactive antibodies easily removed by washing were not detected by the antiglobulin technique but killed T lymphocytes when washing was omitted, incubation was prolonged, and cytotoxic tests were incubated at room temperature or at 4 degrees C. These antibodies were present in approximately 25% of s...

journal_title：Transplantation

authors： Pettaway CA,Freeman C,Helderman JH,Stastny P

更新日期：1987-10-01 00:00:00

abstract：BACKGROUND:In patients with acute liver failure (ALF) of unknown cause, viral infections are believed to be involved. This study investigates the involvement of human herpesvirus-6 (HHV-6). METHODS:Thirty-two patients with ALF who underwent transplantations during a 6-year period were studied for viruses in biopsies f...

journal_title：Transplantation

authors： Härmä M,Höckerstedt K,Lautenschlager I

更新日期：2003-08-15 00:00:00

abstract：BACKGROUND:In a recent trial, targeted mild hypothermia in brain-dead organ donors significantly reduced the incidence of delayed graft function after kidney transplantation. This trial was stopped early for efficacy. Here, we report long-term graft survival for all organs along with donor critical care end points. ME...

journal_title：Transplantation

authors： Malinoski D,Patel MS,Axelrod DA,Broglio K,Lewis RJ,Groat T,Niemann CU

更新日期：2019-11-01 00:00:00

abstract：:The value of percutaneous core needle biopsy in the immunohistological evaluation of renal allograft dysfunction was studied in 72 consecutive biopsies performed in 42 patients. The phenotypes of infiltrating cells mediating graft destruction were identified with monoclonal antibodies and immunoperoxidase staining tec...

journal_title：Transplantation

authors： Waltzer WC,Miller F,Arnold A,Anaise D,Rapaport FT

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:The full potential of pancreatic islet transplantation (PIT) has not been realized because of the difficulties associated with islet isolation, particularly when associated with a remote islet isolation center. Herein, we describe the principles of pancreatic procurement for PIT, which have allowed us to ach...

journal_title：Transplantation

authors： Lee TC,Barshes NR,Brunicardi FC,Alejandro R,Ricordi C,Nguyen L,Goss JA

更新日期：2004-08-15 00:00:00

abstract：:A prospective study of intentional stopping of steroids 6 months after transplantation was done with 29 pediatric renal transplant recipients with a mean age of 10.4 +/- 3.4 years. Immunosuppression consisted of cyclosporine and methylprednisolone. We stopped giving MP to 24 children: to twenty after six months, four ...

journal_title：Transplantation

authors： Ghio L,Tarantino A,Edefonti A,Mocciaro A,Giani M,Guerra L,Berardinelli L,Vegeto A

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Antipig antibodies are a barrier to clinical xenotransplantation. We evaluated antibody binding of waitlisted renal transplant patients to 3 glycan knockout (KO) pig cells and class I swine leukocyte antigens (SLA). METHODS:Peripheral blood mononuclear cells from SLA identical wild type (WT), α1, 3-galactos...

journal_title：Transplantation

authors： Martens GR,Reyes LM,Li P,Butler JR,Ladowski JM,Estrada JL,Sidner RA,Eckhoff DE,Tector M,Tector AJ

更新日期：2017-04-01 00:00:00

abstract：:Clinical observations suggest that recipients of multiorgan transplants from the same donor can have disparate immunological reactions to each organ. We studied this phenomenon in 36 diabetic (streptozotocin-induced), bilaterally nephrectomized immunosuppressed (cyclosporine, azathioprine, prednisone) pig recipients o...

journal_title：Transplantation

authors： Gruessner RW,Nakhleh R,Tzardis P,Schechner R,Platt JL,Gruessner A,Tomadze G,Najarian JS,Sutherland DE

更新日期：1993-12-01 00:00:00

abstract：:The frequencies of circulating donor-reactive cytotoxic lymphocyte precursors (CLP) and Il-2-producing helper lymphocyte precursors (HLP) were determined by limiting dilution analysis in 19 kidney allograft recipients before and at various intervals (up to 2 years) after transplantation. A significant, selective, and ...

journal_title：Transplantation

authors： Zanker B,Jooss-Rüdiger J,Franz HE,Wagner H,Kabelitz D

更新日期：1993-09-01 00:00:00

abstract：:Liver transplantation is the most effective treatment for selected patients with hepatocellular carcinoma. However, cancer recurrence, posttransplantation, remains to be the critical issue that affects the long-term outcome of hepatocellular carcinoma recipients. In addition to tumor biology itself, increasing evidenc...

journal_title：Transplantation

authors： Li CX,Man K,Lo CM

更新日期：2017-11-01 00:00:00

abstract：:A prospective controlled study was carried out in 60 consecutive cadaver renal donors comparing cold storage to pulsatile machine-perfusion preservation. Each donor served as its own control, by allocating one of the kidneys to each of the two preservation methods. There were 51 evaluable pairs of kidneys. Recipient a...

journal_title：Transplantation

authors： Merion RM,Oh HK,Port FK,Toledo-Pereyra LH,Turcotte JG

更新日期：1990-08-01 00:00:00

abstract：BACKGROUND:Ischemia-reperfusion (I/R) injury is a multifactorial phenomenon that occurs during the transplant event and frequently compromises early graft function after liver transplantation (LT). Current comprehension of molecular mechanisms and regulation processes of I/R injury lacks clarity. MicroRNA (miRNA) regul...

journal_title：Transplantation

authors： Gehrau RC,Mas VR,Dumur CI,Ladie DE,Suh JL,Luebbert S,Maluf DG

更新日期：2013-11-27 00:00:00

abstract：:We have done a comparative analysis of two consecutive clinical trials at our center: the first in 56 patients who received blood transfusions from their prospective donors (DST group), and the second in 36 patients who received such transfusions while they were taking Imuran in an attempt to reduce the incidence of s...

journal_title：Transplantation

authors： Glass NR,Miller DT,Sollinger HW,Belzer FO

更新日期：1983-12-01 00:00:00

abstract：BACKGROUND:In 2013, the public health service (PHS) changed the criteria intended to identify organ donors that put the associated organ recipients at increased risk for acquiring human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV). The changing donor demographics, organ utilization...

journal_title：Transplantation

authors： Pruett TL,Clark MA,Taranto SE

更新日期：2017-07-01 00:00:00

abstract：:Graft-versus-host disease (GvHD), a life-threatening complication of bone marrow transplantation, is initiated by donor T cells reacting to recipient dendritic cells (DC). GvHD can be controlled by attenuating donor T cells, but few strategies exist to target DC, particularly resident tissue DC, despite recent evidenc...

journal_title：Transplantation

authors： Collin MP,Munster D,Clark G,Wang XN,Dickinson AM,Hart DN

更新日期：2005-03-27 00:00:00

abstract：:T cell receptor (TCR) beta-chain usage by HLA-DR1 alloreactive T cell lines was examined to determine whether common TCR gene segments were used preferentially. We have demonstrated previously that a DR1-specific, human renal allograft-derived T cell line and replicate, anti-DR1 mixed lymphocyte reactions (MLR), estab...

journal_title：Transplantation

authors： Hand SL,Alter MD,Finn OJ

更新日期：1996-04-15 00:00:00

abstract：BACKGROUND:To optimize the methods used for human islet isolation for transplantation, it is important to improve our understanding of the structure of the islet-exocrine interface. In this study, the composition of collagen subtypes in the interface have been characterized and quantified in human pancreas. METHODS:Hu...

journal_title：Transplantation

authors： Hughes SJ,Clark A,McShane P,Contractor HH,Gray DW,Johnson PR

更新日期：2006-02-15 00:00:00

abstract：BACKGROUND:Historically, ex vivo physiological evaluation of cadaveric renal allografts has been limited to assessing perfusate flow (PF) during hypothermic perfusion preservation (HPP). Using a small animal model, we have previously described a method for continuous monitoring of glomerular filtration rate (GFR) durin...

journal_title：Transplantation

authors： Inman SR,Osgood RW,Plott WK,Richardson BF,Lewis RM

更新日期：1999-11-27 00:00:00

abstract：BACKGROUND:In cases where hyperacute rejection has been prevented, pig to primate organ transplantation results in a delayed rejection mediated by graft-infiltrating leukocytes. The migration of human leukocytes across porcine endothelium is poorly characterized, but may offer targets for species-specific antirejection...

journal_title：Transplantation

authors： Hauzenberger E,Hauzenberger D,Hultenby K,Holgersson J

更新日期：2000-05-15 00:00:00

abstract：:In order to study further whether a relationship exists between the extent of ischemia-preservation-reperfusion injury (IPRI) and acute rejection (AR) events in liver allografts, we retrospectively reviewed 213 consecutive cyclosporine-treated patients who received their first liver allograft between 1/1/93 and 12/31/...

journal_title：Transplantation

authors： Shackleton CR,Martin P,Melinek J,Stothers L,Millis JM,Olthoff KM,Imagawa DK,Kinkhabwala M,Rudich S,Seu P

更新日期：1995-09-27 00:00:00

abstract：BACKGROUND:An increase in serum alpha-glutathione S-transferase concentration (GST) has been shown to be a more sensitive and specific marker of hepatocellular damage than equivalent increases in transaminase activities. A randomized clinical trial of 60 liver transplants in 49 patients was carried out to assess the cl...

journal_title：Transplantation

authors： Hughes VF,Trull AK,Gimson A,Friend PJ,Jamieson N,Duncan A,Wight DG,Prevost AT,Alexander GJ

更新日期：1997-11-27 00:00:00

abstract：:Phenotype, donor-specific cytolytic activity, and helper activity to release cytokines of cells infiltrating within renal allografts of hosts rendered unresponsive by perioperative administration of donor lymphocytes via the portal vein (p.v.) were investigated in order to analyze the mechanism of prolongation of allo...

journal_title：Transplantation

authors： Hamashima T,Yoshimura N,Matsui S,Lee CJ,Ohsaka Y,Oka T

更新日期：1990-01-01 00:00:00

abstract：:We recently reported that reconstitution of lethally irradiated B10 mouse recipients with 40 x 10(6) untreated WF rat bone marrow cells resulted in stable fully xenogeneic chimerism (WF rat----B10 mouse). In these animals, the tolerance induced for skin xenografts was highly MHC specific in that donor-specific WF rat ...

journal_title：Transplantation

authors： Zeng YJ,Ricordi C,Tzakis A,Rilo HL,Carroll PB,Starzl TE,Ildstad ST

更新日期：1992-02-01 00:00:00