Abstract:
:The term "accommodation" was invoked to describe endothelial cell resistance to antibody-mediated rejection after ABO-incompatible kidney or experimental xenograft transplantation. Currently, there is much interest in how to achieve successful human leukocyte antigen (HLA)-incompatible allograft transplantation in HLA-sensitized patients and how to treat antibody-mediated rejection after ABO-compatible HLA-incompatible allotransplantation. The term "accommodation" is often used interchangeably to describe patients who have donor-specific ABO or HLA alloantibodies in the absence of damage to their allograft. Here, we suggest that there are important differences between the immune responses to protein versus carbohydrate antigens and that graft HLA molecules may respond differently to antibodies (and antibody isotypes) than ABO antigens. Neither the mechanisms nor a phenotype of accommodation have been defined fully. Further research is needed to define mechanisms of both resistance and susceptibility to antibody-mediated injury and to predict under which circumstances allograft accommodation may occur.
journal_name
Transplantationjournal_title
Transplantationauthors
Rose ML,West LJdoi
10.1097/TP.0b013e31823f468csubject
Has Abstractpub_date
2012-02-15 00:00:00pages
244-6issue
3eissn
0041-1337issn
1534-6080journal_volume
93pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract:BACKGROUND:Although it is generally considered that livers with moderate steatosis can be safely used in the setting of living-donor liver transplantation, the effect of the regenerative process of such a graft on postoperative liver function is incompletely understood. We assessed the morphologic and functional altera...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000109777.51902.09
更新日期:2004-02-15 00:00:00
abstract::In a murine strain combination disparate in both H-2 antigens and minor histocompatibility antigens consisting of C57BL/6 (B6; H-2b, Mls-1b) mice as recipients and AKR/J (AKR; H-2k, Mls-1a) mice as donors, we reported that the administration of anti-TCR-alpha beta mAb nonspecifically suppresses the ability to reject a...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1995-02-15 00:00:00
abstract:BACKGROUND:Chronic lung disease and pulmonary failure are complications that can occur after bone marrow transplantation (BMT) and are associated with severe morbidity and mortality. METHODS:We report on four patients who developed chronic, progressive, and irreversible lung disease 1 to 3 years after allogeneic BMT i...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200112270-00020
更新日期:2001-12-27 00:00:00
abstract::Cultured neonatal rat islets were transplanted across six strain combinations into nonimmunosuppressed allogeneic recipients. Islets were isolated nonenzymatically by an in vitro method and were cultured at 37 degrees C in 5% CO2 in air for 10 days prior to transplant. Transplants to nondiabetic recipients across four...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198712000-00003
更新日期:1987-12-01 00:00:00
abstract::Increasing numbers of sensitized patients are either precluded from receiving an allograft or experience accelerated rejection which may be refractory to conventional therapy. Using a rat model, we have shown that accelerated (24 hr) rejection of LBN cardiac Tx in LEW rats sensitized with BN skin grafts 7 days earlier...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199002000-00037
更新日期:1990-02-01 00:00:00
abstract:BACKGROUND:The currently used macrolide immunosuppressants, i.e., cyclosporine and tacrolimus, exert considerable nephrotoxicity. We aimed to avoid the nephrotoxic effects by applying a cyclosporine-free regimen for the induction as well as for the maintenance treatment of renal allograft recipients using mycophenolate...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/00007890-199807150-00007
更新日期:1998-07-15 00:00:00
abstract:BACKGROUND:Apoptosis is a well-documented pathway for islet cell death. One potential mechanism is overexpression of death-promoting Bax compared with antiapoptotic Bcl-2 in islets. METHODS:We isolated islets from 10 human pancreata and measured the expression of Bax mRNA and Bcl-2 mRNA by real-time quantitative polym...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200212150-00003
更新日期:2002-12-15 00:00:00
abstract:BACKGROUND:U.S. allocation policies currently place less emphasis on human leukocyte antigen (HLA) matching in pediatric kidney transplant candidates to minimize dialysis time. The impact this may have on pediatric recipients after graft failure has not been extensively examined. METHODS:Using the Scientific Registry ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318288ca14
更新日期:2013-05-27 00:00:00
abstract:BACKGROUND:The use of calcineurin inhibitors is associated with chronic nephrotoxicity and lower glomerular filtration rate (GFR). As a result, one strategy of transplant immunosuppression is calcineurin inhibitor elimination. METHODS:The aim of this study was to determine the outcome of a prospective randomized trial...
journal_title:Transplantation
pub_type: 杂志文章,随机对照试验
doi:10.1097/TP.0b013e31822805d7
更新日期:2011-10-15 00:00:00
abstract:BACKGROUND:The risk associated with transplantation of renal allografts from hepatitis B virus core antibody-positive (HBcAb(+)), hepatitis B virus surface antigen-negative (HBsAg(-)) donors is not well defined. METHODS:Over 4 years, we performed 45 kidney transplants from IgG HBcAb(+), IgM HBcAb(-), HBsAg(-) donors i...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199712270-00027
更新日期:1997-12-27 00:00:00
abstract::The results of kidney retransplantation in the cyclosporine era remain to be determined. Over a 42-month period, 76 nonprimary renal transplants (66 second, 7 third, 3 fourth allografts) were performed in 73 recipients under cyclosporine immunosuppression. The patient population was predominantly white (90.4%) with a ...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract::In a DBA/2 (H-2d) pancreatic islet-to-B6AF1 (H-2b/k.d) recipient combination, the graft survival of hand-picked islets was compared with that of "crude digested" islets that were prepared simply by collagenase digestion and Ficoll gradient separation and were contaminated with lymph nodes and vascular and ductal tissu...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198610000-00011
更新日期:1986-10-01 00:00:00
abstract:BACKGROUND:The clinical symptoms, histological findings, and treatments for antibody-mediated rejection (AMR), which is the leading cause of graft loss in adult ABO-incompatible liver transplantation (ABO-I-LT), have rarely been discussed. METHODS:We performed adult living donor ABO-I-LT on six patients. We used anti-...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31815e9672
更新日期:2008-01-27 00:00:00
abstract:BACKGROUND:The need to find a safe, effective liver support system for patients with fulminant hepatic failure (FHF) continues to be unmet. A system using immortalized human hepatocytes was originally developed in the early 1990s. A modified version of the initial extracorporeal liver-assist device (ELAD) was recently ...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/00007890-200212270-00016
更新日期:2002-12-27 00:00:00
abstract::A study was designed to assess the cellular immune competence of Lewis rats with streptozotocin-induced diabetes. First-set Fischer skin allografts were rejected in 10.9 days by nondiabetic Lewis recipients and in 12.0 days by diabetic Lewis recipients. Second-set skin allografts in the same strain combination, utiliz...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197711000-00008
更新日期:1977-11-01 00:00:00
abstract::Hepatitis C viral recurrence after orthotopic liver transplantation is almost universal. Hepatitis C induced graft failure may occur, but the clinical and histologic profiles are not well defined. The aim of this study was to describe the pattern of early graft failure in patients with recurrent hepatitis C after live...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199603150-00005
更新日期:1996-03-15 00:00:00
abstract:BACKGROUND:Hepatitis B virus (HBV) infection after liver transplantation may occur in patients previously not exposed to the virus, but who receive an organ from a surface antigen (HBsAg)-negative, core antibody (HBcAb)-positive donor. The risk of HBV reactivation after liver transplantation in recipients that are HBsA...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200202150-00027
更新日期:2002-02-15 00:00:00
abstract:BACKGROUND:Previous studies have demonstrated that long-term tolerance of class I mismatched renal allografts in miniature swine is induced by a short course of cyclosporine (CyA), and that a total thymectomy 21 days before transplantation abrogates the induction of stable tolerance. We have now examined the effects of...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199904270-00005
更新日期:1999-04-27 00:00:00
abstract::Nuclear imaging is used to evaluate renal allografts demonstrating delayed function after transplantation. Interpretation of the nuclear scan in the context of clinical data, provides helpful information in the management of the transplant recipient. The better quality of images obtained with technetium-99m mercaptoac...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199711270-00023
更新日期:1997-11-27 00:00:00
abstract::Pseudoaneurysms of the hepatic artery are a rare complication of liver transplantation. Early diagnosis and treatment are essential to avoid life-threatening hemorrhage. Conventional treatment consists of surgical resection and vascular reconstruction or transarterial coil embolization. More recently, percutaneous thr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000063936.94587.10
更新日期:2003-05-27 00:00:00
abstract::Kidney transplantation in elderly patients is a good therapeutic option, but the incidence of infections compared to younger patients must be studied. Case and control study was performed with 40 cases (patients older than 65) and 40 controls (younger than 65) receiving a kidney transplant between January 2000 and Aug...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000173822.05877.d7
更新日期:2005-10-15 00:00:00
abstract:BACKGROUND:Endothelial dysfunction (ED) has a major role in the cardiovascular outcome of patients with chronic kidney disease (CKD). The aim of this study was to investigate the relation between fetuin A levels and ED in kidney transplant recipients. METHODS:Forty-two living donor kidney transplant recipients, 21 (11...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000251647.72673.c7
更新日期:2007-02-27 00:00:00
abstract:BACKGROUND:We herein investigate critical ischemia times and the effect of novel preservation solutions such as new histidine-tryptophan-ketoglutarate (HTK-N) and TiProtec on the individual tissues of a rat limb isograft. METHODS:Orthotopic hind-limb transplantations were performed in male Lewis rats after 2 hours, 6 ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001845
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Diagnosing acute rejection (AR) in kidney transplant recipients typically requires an invasive kidney biopsy. A previous study has suggested that expression of five genes in peripheral blood can indicate the presence of AR in American pediatric kidney transplant recipients. This study aims to validate if the...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000138
更新日期:2014-10-15 00:00:00
abstract::The ability of concanavalin-A (Con-A) to activate lymphocytes to secrete human lymphotoxin (LT) was tested in the presence of agents known to modify the intracellular levels of cyclic nucleotides (cAMP and cGMP). Lymphocytes were treated with these agents at different stages of activation: (1) during the first encount...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197510000-00010
更新日期:1975-10-01 00:00:00
abstract:BACKGROUND:We investigated a novel immunosuppressive protocol including thymoglobulin induction in combination with sirolimus and corticosteroids, followed by introduction of markedly reduced exposures to cyclosporine to prevent pancreas-transplant rejection. METHODS:A 7-day course of thymoglobulin (1.5 mg/kg per day)...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000061768.98058.EC
更新日期:2003-04-27 00:00:00
abstract::Immunomodulatory properties are attributed to apoptotic cells. These properties have been used to modulate allogeneic immune responses in experimental transplantation settings. In independent studies, apoptotic cell infusion has been shown to favor hematopoietic cell engraftment, to increase heart graft survival, and ...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.tp.0000269113.59857.d6
更新日期:2007-07-15 00:00:00
abstract:BACKGROUND:Current grading systems in acute graft-versus-host disease (GVHD) are not able to identify patients with poor prognosis at time of onset, because they take into account maximal grade. The aim of this study was to evaluate potential predictors for overall survival at disease onset. METHODS:The study sample w...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181bc2583
更新日期:2009-11-15 00:00:00
abstract:BACKGROUND:Human cytomegalovirus (HCMV) infection is associated with allograft vasculopathy and rejection. One potential mechanism is vascular injury from immunologically mediated processes. HCMV infection has been shown to increase the constitutive expression of intercellular adhesion molecule-1 (ICAM-1). The objectiv...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199901150-00023
更新日期:1999-01-15 00:00:00
abstract::The effects of mismatching for DR antigens on renal allograft survival rates have largely been restricted to analyses of cadaver transplant results. Analyses of HLA matching in recipients of transplants from related donors have focused on the number of haplotypes shared between the recipients without regard to DR, or ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198336060-00011
更新日期:1983-12-01 00:00:00