Proapoptotic Bax is hyperexpressed in isolated human islets compared with antiapoptotic Bcl-2.

abstract：:The use of real-time reverse transcription polymerase chain reaction to compare gene expression in different tissues and conditions requires normalization to an internal control that must be expressed at a constant level. Although a previous validation step is required to confirm that an internal control is appropriat...

journal_title：Transplantation

authors： Rodriguez-Mulero S,Montanya E

更新日期：2005-09-15 00:00:00

abstract：:Fine-needle aspiration biopsies were used for clinical monitoring of liver allografts; 21 patients with an inflammatory episode of acute rejection (12.0 +/- 3.3 CIU at the peak) were studied; all episodes were reversible. The inflammatory infiltrate consisted mainly of lymphoid cells, including lymphoid blasts, with i...

journal_title：Transplantation

authors： Lautenschlager I,Höckerstedt K,Salmela K,Isoniemi H,Holmberg C,Jalanko H,Häyry P

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:This study aimed to determine factors associated with body composition changes shortly after liver transplantation (LTx), including the influence of immunosuppressive agents. The combined resting energy expenditure (REE) and handgrip strength provided a valuable assessment in data interpretation of body comp...

journal_title：Transplantation

authors： Brito-Costa A,Pereira-da-Silva L,Papoila AL,Alves M,Mateus É,Nolasco F,Barroso E

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Solid-organ transplant recipients with pretransplant malignancies (PTM) have worse overall survival (OS) compared to recipients without history of malignancy. However, it is unknown whether the increased risk of mortality is due to recurrent cancer-related deaths. METHODS:All solid-organ transplant recipien...

journal_title：Transplantation

authors： Acuna SA,Sutradhar R,Kim SJ,Baxter NN

更新日期：2018-07-01 00:00:00

abstract：:A novel, water-soluble metabolite of cyclosporine, a sulphate conjugate, present in high concentrations in human bile and plasma was evaluated for its immunosuppressive properties. The direct binding of the conjugate to surface molecules on lymphocytes was studied. The effect of the metabolite was tested in several in...

journal_title：Transplantation

authors： Johansson A,Henricsson S,Möller E

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND:In patients with cytomegalovirus (CMV) disease, regular monitoring of viral loads and treatment until negative are recommended. However, with more sensitive polymerase chain reaction (PCR) assays and cellular peripheral sample types, detection of low-level viremia is achievable. We compared a whole blood rea...

journal_title：Transplantation

authors： Lisboa LF,Asberg A,Kumar D,Pang X,Hartmann A,Preiksaitis JK,Pescovitz MD,Rollag H,Jardine AG,Humar A

更新日期：2011-01-27 00:00:00

abstract：BACKGROUND:Membrane CD30 is an important costimulatory molecule for activated T lymphocytes, and serum level of soluble CD30 (sCD30) is considered a marker for predicting outcome in kidney transplantation. METHODS:We investigated the kinetics of CD30 expression on CD4 and CD8 T-cell populations and the source of sCD30...

journal_title：Transplantation

authors： Velásquez SY,García LF,Opelz G,Alvarez CM,Süsal C

更新日期：2013-07-27 00:00:00

abstract：BACKGROUND:Recent studies have described submandibular gland allografts in animal models; however, the amount of saliva secretion or nervous regeneration in those animals have not been reported. Herein, we investigated saliva secretion from submandibular gland allografts in beagle dogs. METHODS:Using a vascularized su...

journal_title：Transplantation

authors： Isomura ET,Yoshitomi K,Hamaguchi M,Kogo M

更新日期：2007-03-27 00:00:00

abstract：BACKGROUND:Altered expression of murine MD-1, a molecule controlling expression of members of the interleukin (IL)-1 receptor family of signaling proteins, regulates antigen-presenting cell-induced alloreactions. We investigated the effect of treatment with antisense deoxyoligonucleotides or antibodies to MD-1 in vivo ...

journal_title：Transplantation

authors： Hadidi S,Chen Z,Phillips J,Yu K,Gorczynski RM

更新日期：2002-06-15 00:00:00

abstract：:Disseminated varicella-zoster (VZV) infection is a rare complication after renal allotransplantation in adults. We report four patients, among them one with combined VZV and cytomegalovirus infection. The main complications were hepatitis, pneumonitis, and disseminated intravascular coagulation. A review of the litera...

journal_title：Transplantation

authors： Fehr T,Bossart W,Wahl C,Binswanger U

更新日期：2002-02-27 00:00:00

abstract：BACKGROUND:Given growth in kidney transplant waitlists and discard rates, donor kidney acceptance is an important problem. We used network analysis to examine whether organ procurement organization (OPO) network centrality affects discard and outcomes. METHODS:We identified 106,160 deceased donor kidneys recovered for...

journal_title：Transplantation

authors： Butala NM,King MD,Reitsma W,Formica RN,Abt PL,Reese PP,Parikh CR

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Immunological unresponsiveness of T cells to alloantigen can be induced by intrathymic injection of donor-specific antigen in small-animal models. Intrathymic tolerance to vascularized grafts in large animals has not previously been reported. METHODS:Thirty-two dogs were allocated into dog leukocyte antigen...

journal_title：Transplantation

authors： Horton PJ,Hawthorne WJ,Walters S,Patel T,Stewart GJ,Allen RD,Chapman JR

更新日期：2008-12-27 00:00:00

abstract：:Deposition of the C4d complement degradation product has been shown to be a marker of antibody-mediated rejection of solid organ allografts, including kidney, heart, liver, and lung. We investigated whether C4d deposition also would be useful in monitoring rejection in human composite tissue allografts. A total of 60 ...

journal_title：Transplantation

authors： Kanitakis J,McGregor B,Badet L,Petruzzo P,Morelon E,Devauchelle B,Dubernard JM

更新日期：2007-07-27 00:00:00

abstract：:The survival of semiallogeneic or fully allogeneic rat kidney allografts was prolonged in some strain combinations with immune complexes formed with hapten-conjugated alloantigens (TNP-Ag) of donor origin and a mouse monoclonal antihapten antibody (anti-TNP). Complexes were administered i.v. at the time of operation--...

journal_title：Transplantation

authors： Barber WH,Hutchinson IV,Morris PJ

更新日期：1983-11-01 00:00:00

abstract：:There is a striking consistency in the total number of heart beats accrued over a lifetime across a range of animal species despite vast differences in size. Moreover, an inverse relationship is observed between heart rate and lifespan, leading to speculation that elevated heart rate could significantly affect longevi...

journal_title：Transplantation

authors： Critchley WR,Yonan N,Shaw SM,Fildes JE

更新日期：2013-01-27 00:00:00

abstract：BACKGROUND:Recurrent hepatitis C virus (HCV) after liver transplantation (OLT) is a major cause of graft loss in HCV-positive patients. In this study, we evaluated the efficacy and safety of pegylated interferon alfa-2b (peginterferon) and ribavirin treatment for recurrent HCV after OLT and analyzed the influence of an...

journal_title：Transplantation

authors： Neumann U,Puhl G,Bahra M,Berg T,Langrehr JM,Neuhaus R,Neuhaus P

更新日期：2006-07-15 00:00:00

abstract：:A sensitive micromethod for generating and assaying allogeneically induced cytotoxic human lymphocytes in vitro is described. Responding lymphocytes are cultured with mitomycin-C treated allogeneic stimulating cells in wells of replicate microtrays for both one-way mixed leukocyte culture (MLC) and cell-mediated lymph...

journal_title：Transplantation

authors： Zarling JM,McKeough M,Bach FH

更新日期：1976-06-01 00:00:00

abstract：BACKGROUND:Airway complications continue to be an important source of morbidity and mortality after lung transplantation (LTx). Different approaches have been used for their nonsurgical management. We describe our experience using self-expandable metallic stents (SEMSs) in patients with airway complications post-LTx. ...

journal_title：Transplantation

authors： Saad CP,Ghamande SA,Minai OA,Murthy S,Pettersson G,DeCamp M,Mehta AC

更新日期：2003-05-15 00:00:00

abstract：BACKGROUND:Mixed lymphohematopoietic chimerism can provide an effective means of inducing longterm immunological tolerance and has been documented in a monkey allograft model. A conditioning regimen including nonmyeloablative or myeloablative irradiation and splenectomy has been used to induce chimerism in a pig-to-pri...

journal_title：Transplantation

authors： Kozlowski T,Monroy R,Xu Y,Glaser R,Awwad M,Cooper DK,Sachs DH

更新日期：1998-07-27 00:00:00

abstract：:There is substantial evidence that increased cellular calcium may activate processes that lead to cellular injury and death, and calcium entry blockers (CEB) have been shown to protect against renal ischemic injury. This approach has been used experimentally to enhance kidney preservation during both warm and cold isc...

journal_title：Transplantation

authors： Nakamoto M,Shapiro JI,Mills SD,Schrier RW,Chan L

更新日期：1988-02-01 00:00:00

abstract：BACKGROUND:Plasma level of plasminogen activator inhibitor (PAI)-1 is genetically determined by a polymorphism in the promoter region, involving two alleles, 4G and 5G. Plasma PAI-1 concentrations are higher in subjects homozygous for the 4G allele than other genotypes (5G/5G and 4G/5G). Such genetic variation in fibri...

journal_title：Transplantation

authors： Chow KM,Szeto CC,Szeto CY,Poon P,Lai FM,Li PK

更新日期：2002-12-27 00:00:00

abstract：:Rat recipients of renal allografts and unilaterally nephrectomized control rats were studied to evaluate the response in blood pressure to prednisolone in diverse doses, and to determine the dosage required to achieve adequate immunosuppression without undue complication of hypertension. While a continuous infusion of...

journal_title：Transplantation

authors： de Keijzer MH,Provoost AP,Van Aken M,Wolff ED,Molenaar JC

更新日期：1987-03-01 00:00:00

abstract：:The purpose of this study was to investigate two promising immunosuppressive agents, didemnin B (DB) and FK506 (FK), during pregnancy to assess potential adverse maternal or fetal effects. Pregnant C3H mice were randomized into control and high- and low-dose treatment groups for each drug. Animals received daily injec...

journal_title：Transplantation

authors： Farley DE,Shelby J,Alexander D,Scott JR

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:We reviewed the incidence of and risk factors for venous thromboembolic complications in our population of kidney (KTx) and simultaneous kidney-pancreas transplant (SPK) recipients. METHODS:Information was collected retrospectively from a database on 1833 KTx and 276 SPK recipients who underwent transplant ...

journal_title：Transplantation

authors： Humar A,Johnson EM,Gillingham KJ,Sutherland DE,Payne WD,Dunn DL,Wrenshall LE,Najarian JS,Gruessner RW,Matas AJ

更新日期：1998-01-27 00:00:00

abstract：BACKGROUND:Current desensitization (DES) methods are not always effective. Thus, novel, more effective approaches are desirable. Interleukin (IL)-6 is an attractive target as it promotes B-cell differentiation to plasma cells, is important for immunoglobulin production, and induces Th17 cells. Here, we undertook a phas...

journal_title：Transplantation

authors： Vo AA,Choi J,Kim I,Louie S,Cisneros K,Kahwaji J,Toyoda M,Ge S,Haas M,Puliyanda D,Reinsmoen N,Peng A,Villicana R,Jordan SC

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Infectious complications still represent a major cause of morbidity and mortality in patients with organ transplantation. In particular, small bowel or multivisceral transplantation is complicated to a greater extent than other grafts as a consequence of infectious complications including sepsis. METHODS:Th...

journal_title：Transplantation

authors： Guaraldi G,Cocchi S,Codeluppi M,Di Benedetto F,De Ruvo N,Masetti M,Venturelli C,Pecorari M,Pinna AD,Esposito R

更新日期：2005-12-27 00:00:00

abstract：:Endothelial cells, one of several in vivo host cells for cytomegalovirus (CMV), participate in solid organ allograft rejection in part through the expression of leukocyte adhesion molecules. The hypothesis that CMV infection alters the constitutive and induced expression of ELAM-1, ICAM-1, and VCAM-1 on infected human...

journal_title：Transplantation

authors： Sedmak DD,Knight DA,Vook NC,Waldman JW

更新日期：1994-12-27 00:00:00

abstract：BACKGROUND:Immunomodulatory protocols including intravenous immunoglobulin/rituximab (IVIG/R) are employed to decrease anti-human leukocyte antigen (HLA) antibody levels for patients broadly sensitized to HLA and increase chances for transplantation with a compatible deceased donor (DD). The aim of our study was to ide...

journal_title：Transplantation

authors： Lai CH,Cao K,Ong G,Naim M,Wang Q,Mirocha J,Vo A,Jordan SC,Reinsmoen NL

更新日期：2011-07-15 00:00:00

abstract：BACKGROUND:Previous studies have indicated that patients on maintenance hemodialysis have worse survival compared with kidney transplant (KTx) recipients. However, none of these studies have compared mortality of the US patients using alternative dialysis modalities such as home hemodialysis (HHD) with KTx recipients. ...

journal_title：Transplantation

authors： Molnar MZ,Ravel V,Streja E,Kovesdy CP,Mehrotra R,Kalantar-Zadeh K

更新日期：2016-10-01 00:00:00

abstract：:In light of the transplant community's efforts to increase living donation, preserving donor autonomy is essential. Understanding how often and the reasons why potential living kidney donors opt out of the donor evaluation process for nonmedical reasons is important for assessing donor voluntariness. The experiences o...

journal_title：Transplantation

authors： Thiessen C,Kulkarni S,Reese PP,Gordon EJ

更新日期：2016-12-01 00:00:00