Abstract:
BACKGROUND:Airway complications continue to be an important source of morbidity and mortality after lung transplantation (LTx). Different approaches have been used for their nonsurgical management. We describe our experience using self-expandable metallic stents (SEMSs) in patients with airway complications post-LTx. METHODS:We present a retrospective analysis of stent related-data of all the LTx patients who received SEMSs to treat postoperative airway complications. RESULTS:Between January 1992 and December 2001, 36 of 253 patients (14.2%) developed post-LTx airway complications involving 40 of 348 anastomoses (11.5%). A total of 15 SEMSs were placed in 12 patients (mean age 47.3+/-9.6 years) for tracheobronchomalacia, stenosis, and anastomotic dehiscence, including one patient referred from an outside hospital. Mean follow-up was 20.1+/-19.5 months (range 1.2-58 months). Patency and symptom improvement were achieved in 11 of 12 patients. Stenting of the airway led to successful weaning of two patients who were on prolonged mechanical ventilation. Suture dehiscence was effectively managed in two patients who were not candidates for surgical repair. Overall, the complication rate was 0.040 complications per patient per month (total number of complications and total number of months using the stent). Bacterial bronchitis (four patients) and obstructive granulomas (three patients) were the most frequent complications. The survival of LTx patients with airway SEMSs was similar when compared with the survival of all other LTx patients (P=0.74). CONCLUSIONS:SEMSs are safe and effective in the management of airway complications in selected patients post-LTx. Weaning from mechanical ventilation and management of anastomotic dehiscence are the unique attributes of this device.
journal_name
Transplantationjournal_title
Transplantationauthors
Saad CP,Ghamande SA,Minai OA,Murthy S,Pettersson G,DeCamp M,Mehta ACdoi
10.1097/01.TP.0000061229.83500.A0subject
Has Abstractpub_date
2003-05-15 00:00:00pages
1532-8issue
9eissn
0041-1337issn
1534-6080journal_volume
75pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::Graft-versus-host disease (GVHD) is a common complication of bone marrow transplantation and often involves the gastrointestinal system. It is unclear whether there can be severe enough damage by GVHD to permanently injure the bowel and thereby prevent mucosal regeneration. We describe a patient who had successful tre...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199612150-00028
更新日期:1996-12-15 00:00:00
abstract:BACKGROUND & AIMS:Direct-acting antiviral (DAA) therapy made possible the novel practice of utilizing HCV-viremic (HCV-RNA-positive) donors into HCV-negative recipients in the United States. Although initial reports of outcomes have been satisfactory, higher-quality longer-term outcomes remain to be elucidated. METHOD...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003382
更新日期:2020-06-29 00:00:00
abstract::Numerous studies have reported successful allotransplantation of hepatocytes. However, none have shown long-term correction of a liver-related metabolic defect. In this study, we used a method of regional hepatocyte transplantation and subsequent induction of transplanted cell proliferation by regeneration response in...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199609150-00008
更新日期:1996-09-15 00:00:00
abstract::Nonmajor histocompatibility complex (non-MHC) antigens are important targets of graft rejection and graft-versus-host disease in clinical transplantation. Little is known regarding immunity to non-MHC antigens. To study this problem we evaluated the effect of antihuman thymocyte globulin (ATG) on reactivity in autolog...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198102000-00001
更新日期:1981-02-01 00:00:00
abstract:BACKGROUND:The currently used macrolide immunosuppressants, i.e., cyclosporine and tacrolimus, exert considerable nephrotoxicity. We aimed to avoid the nephrotoxic effects by applying a cyclosporine-free regimen for the induction as well as for the maintenance treatment of renal allograft recipients using mycophenolate...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/00007890-199807150-00007
更新日期:1998-07-15 00:00:00
abstract:BACKGROUND:Donor-specific immune tolerance has been reported in isolated cases of kidney transplantation associated with bone marrow transplantation. The following is a description of a living donor liver transplantation for a hilar cholangiocarcinoma in a previous recipient of an allogeneic bone marrow transplant. ME...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000083981.82522.13
更新日期:2003-09-27 00:00:00
abstract:BACKGROUND:The authors studied the relationship between the dynamics of Epstein-Barr virus (EBV) load, CD8 T-cell activation and differentiation, and EBV-associated symptoms in 25 children after kidney transplantation (Tx). METHODS:Twenty-two patients were enrolled at the time of Tx and three at diagnosis of EBV-induc...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000131168.21930.5c
更新日期:2004-06-15 00:00:00
abstract:BACKGROUND:Infectious diseases are a major source of morbidity and mortality for immunosuppressed transplant recipients and the antimicrobial chemotherapy can be often less effective in these individuals, because the contribution of underlying host defenses is absent. METHODS:The influence of co-amoxiclav on the funct...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200102270-00016
更新日期:2001-02-27 00:00:00
abstract:BACKGROUND:Infectious complications occur in approximately 50% of cadaveric liver transplant (CDLT) recipients. Living-donor liver transplantation (LDLT) is an established alternative to shorten the waiting time. Currently, the incidence of pulmonary infections after LDLT and the microbiologic causes are unknown. In th...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31816f61a6
更新日期:2008-06-15 00:00:00
abstract::The interaction of T cell costimulatory molecules with their ligands is required for optimal T cell activation. Interference with such interactions can induce antigen unresponsiveness and delay xeno- and allograft rejection. We have previously shown that LFA3TIP, a soluble human lymphocyte function-associated antigen ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199602150-00004
更新日期:1996-02-15 00:00:00
abstract::Surgical site infection (SSI) is an important cause of morbidity after orthotopic liver transplantation (OLT). Perioperative antibiotic prophylaxis is one of the main modifiable risk factors. We prospectively investigated the epidemiology, risk factors, and prognosis of SSI in a cohort of 167 OLT. Two different schedu...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181735407
更新日期:2008-06-27 00:00:00
abstract::The nephrotoxic effects of cyclosporine (CsA) seem to be augmented by co-existing renal injury. A high rate of prolonged delayed function (acute tubular necrosis [ATN]) and non-function (NF) has been associated with the use of CsA prior to and following renal transplantation. Cyclosporine has also been associated with...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198701000-00019
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:The pig is currently considered to be the most likely candidate for a xenogenic-organ source. Anti-pig human T-cell response via co-stimulatory molecules has been studied with great interest. The soluble form of porcine CD80 has recently been cloned and characterized, but the sequence of the transmembrane fo...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000065298.81277.D9
更新日期:2003-06-15 00:00:00
abstract::Class I molecules of the MHC affect target cell sensitivity to NK cell repertoire. In the mouse, absence of MHC class I molecules on target cells is associated with an increased susceptibility to NK cell-mediated lysis, while syngeneic class I molecules confer protection. In contrast to the protective role of syngenei...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199508000-00013
更新日期:1995-08-15 00:00:00
abstract::BACKGROUND.: Reduced levels of serum adiponectin, an adipokine, are associated with cardiovascular and obesity-related diseases; however, relations between adiponectin and hypertension are unclear. METHODS.: This cross-sectional study examined adiponectin and ambulatory blood pressure monitoring (ABPM) in 33 pediatric...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181b9e1ec
更新日期:2009-10-27 00:00:00
abstract::Prominent components of vascularized xenograft rejection such as platelet activation and microvascular thrombosis may be dependent upon thrombin generation in vivo. To study potential therapeutic benefits of a synthetic low-molecular-weight thrombin inhibitor, SDZ MTH 958, in hyperacute porcine heart rejection by huma...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199603270-00003
更新日期:1996-03-27 00:00:00
abstract:BACKGROUND:Although used for more than 20 years, optimal dosing strategies of most immunosuppressants have never been determined. Tacrolimus, one of the newer agents used in solid-organ transplantation, is gaining increasing popularity because of its ability to reverse refractory rejection in cyclosporine-treated patie...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/00007890-200210270-00014
更新日期:2002-10-27 00:00:00
abstract::The term "accommodation" was invoked to describe endothelial cell resistance to antibody-mediated rejection after ABO-incompatible kidney or experimental xenograft transplantation. Currently, there is much interest in how to achieve successful human leukocyte antigen (HLA)-incompatible allograft transplantation in HLA...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31823f468c
更新日期:2012-02-15 00:00:00
abstract:BACKGROUND:Preexisting IgG antibodies to donor human leukocyte antigens (HLA) are a risk factor for rapid allograft rejection. However, non-HLA antibodies, of the IgM class, also called autoreactive antibodies, are not believed to affect graft survival. The aim of this study was to determine the incidence and clinical ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31819a65fa
更新日期:2009-03-27 00:00:00
abstract::Organ donation after circulatory death (DCD) has been endorsed by the World Health Organization and is practiced worldwide. This overview examines current DCD practices, identifies problems and challenges, and suggests clinical strategies for possible improvement. Although there is uniform agreement on DCD donor candi...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.TP.0000437178.48174.db
更新日期:2014-02-15 00:00:00
abstract::We have analyzed HLA data from the UNOS registry on 20,230 patients on the renal waiting list in 1991 and 18,708 donors from 1988-1992. Significant differences were found in the distribution of HLA antigens for comparisons of the total donor pool and the various racial groups of patients as well as for inter- and intr...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1994-11-27 00:00:00
abstract::Four skin graft models are created which vary in the rates of lymphatic and vascular reconstitution. Rat allografts (Brown Norway or (L times BN)F1 hybrid) transplanted to Lewis recipients by conventional (immediate lymphatic, delayed vascular), surgical anastomosis (immediate lymphatic, immediate vascular) or isolate...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197502000-00008
更新日期:1975-02-01 00:00:00
abstract::A portable hypothermic perfusion system for storage of hearts has been developed. The system uses the airlift pump principle, whereby the flow of gas maintains circulation of the perfusate through the heart; no other energy source is required. Performance on ex vivo functional testing of 10 pig hearts stored for 20 to...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198211000-00002
更新日期:1982-11-01 00:00:00
abstract:BACKGROUND:Organ donors are frequently trauma victims, but the impact of donor hemorrhagic shock and resuscitation (HSR) on pulmonary graft function has not been assessed. L-arginine treatment during reperfusion increases the production of endothelial nitric oxide and thus ameliorates ischemia-reperfusion injury. Objec...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181a52ce1
更新日期:2009-06-15 00:00:00
abstract::The mode of action of glucocorticosteroids as immunosuppressive and antiinflammatory agents is not fully understood. Glucocorticosteroids block synthesis of interleukin 1 by interfering with the transcription of the IL-1 beta gene. Glucocorticosteroids may also induce rapid degradation of IL-1 mRNA. In the presence of...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199001000-00040
更新日期:1990-01-01 00:00:00
abstract::Exposure to the equine-derived polyclonal antithymocyte preparation, ATGAM, frequently elicits human anti-ATGAM antibody formation. The influence of concomitant immunosuppressants on this antiantibody response has not been established. We therefore evaluated IgG antibody formation to ATGAM in 47 patients receiving ATG...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007890-199560120-00001
更新日期:1995-12-27 00:00:00
abstract::CD4+ cells from CsA-treated DA rats with long-surviving PVG heart allografts specifically suppress the capacity of naive CD4+ cells to restore allograft rejection in irradiated DA rats, but have normal donor-specific alloreactivity in MLC. CD4+ suppressor cells from CsA-treated DA rats cultured for 3 days against eith...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199302000-00027
更新日期:1993-02-01 00:00:00
abstract::Retrospectively we analyzed the histocompatibility data and clinical results of bone marrow transplantation in 51 patients who received marrow from unrelated donors (UD) from 1977 to 1987 at one of four UK BMT centers. We compared the results with those obtained in 51 transplants carried out at the same centers using ...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1097/00007890-199003000-00015
更新日期:1990-03-01 00:00:00
abstract:BACKGROUND:Neonatal primates have been reported to receive pig hearts without hyperacute rejection (HAR). We examined the ontogeny of the anti-pig xenoantibody (XenoAb) and HAR in the neonatal and infant monkeys. METHODS:Twenty-six serum samples from 15 monkeys ages 14-192 days were subjected to hemagglutination titra...
journal_title:Transplantation
pub_type: 评论,杂志文章
doi:10.1097/00007890-200008270-00025
更新日期:2000-08-27 00:00:00
abstract::To improve long-term outcome after renal transplantation, attention should be placed on the tailored use of immunosuppressive regimens that have a more favorable impact on the immunological and nonimmunological risk profiles of an individual recipient. Tacrolimus is widely used for maintenance and rejection immunosupp...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200109271-00007
更新日期:2001-09-27 00:00:00