Twenty-four-hour preservation of the pig heart by a portable hypothermic perfusion system.

abstract：BACKGROUND:Ischemia/reperfusion (I/R) injury is a limiting factor in liver transplantation. We have recently shown that pyruvate (PY) inhibits intestinal and renal I/R injury. This study aims to evaluate the protective effect of PY on hepatic I/R injury. METHODS:ACI rats were treated with PY, whereas control animals r...

journal_title：Transplantation

authors： Sileri P,Schena S,Morini S,Rastellini C,Pham S,Benedetti E,Cicalese L

更新日期：2001-07-15 00:00:00

abstract：BACKGROUND:Anemia after kidney transplantation has been associated with poor transplant outcomes. We hypothesized that intravenous (IV) iron may more rapidly correct anemia than oral (PO) iron. METHODS:One hundred four kidney transplant recipients were prospectively randomized to IV iron polymaltose (500 mg single dos...

journal_title：Transplantation

authors： Mudge DW,Tan KS,Miles R,Johnson DW,Badve SV,Campbell SB,Isbel NM,van Eps CL,Hawley CM

更新日期：2012-04-27 00:00:00

abstract：:Active regulation or suppression of donor reactive cells is emerging as a key mechanism for inducing and maintaining unresponsiveness to donor alloantigens. Accumulating evidence suggests that a balance between immunoregulation and deletion of donor alloantigen reactive T cells can provide effective control of immune ...

journal_title：Transplantation

authors： Wood KJ,Luo S,Akl A

更新日期：2004-01-15 00:00:00

abstract：:The value of percutaneous core needle biopsy in the immunohistological evaluation of renal allograft dysfunction was studied in 72 consecutive biopsies performed in 42 patients. The phenotypes of infiltrating cells mediating graft destruction were identified with monoclonal antibodies and immunoperoxidase staining tec...

journal_title：Transplantation

authors： Waltzer WC,Miller F,Arnold A,Anaise D,Rapaport FT

更新日期：1987-01-01 00:00:00

abstract：:Transcription factors of the nuclear factor of activated T cells (NFAT) family regulate both immune activation and insulin production. Calcineurin inhibitors (CNIs) target NFAT activation. Hence, CNIs not only prevent organ transplant rejection but also contribute to the development of new-onset diabetes after transpl...

journal_title：Transplantation

authors： Chen Y,Sampaio MS,Yang JW,Min D,Hutchinson IV

更新日期：2012-02-15 00:00:00

abstract：BACKGROUND:Live liver donation requires extended liver resection in the donor with transection of the middle hepatic vein. This leads to focal outflow obstruction in the remnant liver or the partial graft. This study was designed to characterize the pathophysiological correlate of focal outflow obstruction in a small-f...

journal_title：Transplantation

authors： Dirsch O,Madrahimov N,Chaudri N,Deng M,Madrahimova F,Schenk A,Dahmen U

更新日期：2008-03-15 00:00:00

abstract：BACKGROUND:New strategies for improving durable functional islet mass will be instrumental in facilitating islet transplantation as a cure for type 1 diabetes mellitus. The ability to transfer immunoregulatory or cytoprotective genes into pancreatic islets may enhance survival. Adenoviral vectors (Ad5) have been used w...

journal_title：Transplantation

authors： Contreras JL,Wu H,Smyth CA,Eckstein CP,Young CJ,Seki T,Bilbao G,Curiel DT,Eckhoff DE

更新日期：2003-07-15 00:00:00

abstract：:Pregraft transfusion combined with immunosuppression at the time of grafting improves the survival of clinical and experimental allografts. The mechanisms responsible for this effect were investigated in the murine model of cardiac transplantation, combining transfusions 7 to 30 days prior to transplantation with cycl...

journal_title：Transplantation

authors： Mottram PL,Mirisklavos A,Dumble LJ,Clunie GJ

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND:Kidney donors and transplant recipients may be at risk of complications from glomerular hyperfiltration of the single kidney. It has been assumed that tests of the existence of renal functional reserve [delta glomerular filtration rate (deltaGFR), delta effective renal plasma flow (deltaERPF)] can be used to...

journal_title：Transplantation

authors： Englund M,Berg U

更新日期：2000-11-15 00:00:00

abstract：:The H-Y (male) antigen is detectable on 50% of eight-cell mouse embryos. We show that 82% of the offspring resulting from the transfer of (C57BL/6 X A/J)F1 embryos surviving treatment with H-Y antibody and complement to the uteruses of pseudopregnant mice are female. The increased ratio of female-to-male births indica...

journal_title：Transplantation

authors： Shelton JA,Goldberg EH

更新日期：1984-01-01 00:00:00

abstract：:Invasive aspergillosis and mucormycosis are life-threatening infections in solid organ and hematopoietic cell transplant recipients. Despite medical advancements in the care of these patients and the availability of new mold-active drugs, the outcomes remain suboptimal. Therefore, there has been increased interest in ...

journal_title：Transplantation

authors： Haidar G,Singh N

更新日期：2018-11-01 00:00:00

abstract：:Fetal liver cells (FLC) were obtained from beagle fetuses 52 days postconception, and were cryopreserved prior to transplantation into ten sibling recipients that had previously been exposed to total-body irradiation delivered in 3 fractions of 6 Gy each at 4 days, 2 days, and 2 hr before grafting. Donors and hosts we...

journal_title：Transplantation

authors： Prümmer O,Raghavachar A,Werner C,Calvo W,Carbonell F,Steinbach I,Fliedner TM

更新日期：1985-04-01 00:00:00

abstract：BACKGROUND:The currently used macrolide immunosuppressants, i.e., cyclosporine and tacrolimus, exert considerable nephrotoxicity. We aimed to avoid the nephrotoxic effects by applying a cyclosporine-free regimen for the induction as well as for the maintenance treatment of renal allograft recipients using mycophenolate...

journal_title：Transplantation

authors： Zanker B,Schneeberger H,Rothenpieler U,Hillebrand G,Illner WD,Theodorakis I,Stangl M,Land W

更新日期：1998-07-15 00:00:00

abstract：BACKGROUND:Bone marrow stromal cells (BMSC) transplantation offers promise in the treatment of chronic paraplegia in rodents. Here, we report the effect of this cell therapy in adult pigs suffering chronic paraplegia. METHODS:Three months after spinal cord injury, autologous BMSC in autologous plasma was injected into...

journal_title：Transplantation

authors： Zurita M,Vaquero J,Bonilla C,Santos M,De Haro J,Oya S,Aguayo C

更新日期：2008-09-27 00:00:00

abstract：INTRODUCTION:We investigated the putative candidate biomarkers of graft rejection in peripheral blood of intestinal transplant patients. MATERIALS AND METHODS:Peripheral blood gene expression analysis was performed in intestinal transplant patients. The results were matched with concurrent graft biopsies using bioinfo...

journal_title：Transplantation

authors： Andreev VP,Tryphonopoulos P,Blomberg BB,Tsinoremas N,Weppler D,Neuman DR,Volsky A,Nishida S,Tekin A,Selvaggi G,Levi DM,Tzakis AG,Ruiz P

更新日期：2011-12-27 00:00:00

abstract：BACKGROUND:Our goal was to test the intragraft mRNA expression and production of two chemokines that are potent chemoattractants for antigen-primed T cells, interferon-gamma inducible protein 10 (IP-10) and monokine-induced by IFN-gamma, (Mig), in allogeneic heart grafts. METHODS:Syngeneic or allogeneic A/J (H-2a) hea...

journal_title：Transplantation

authors： Kapoor A,Morita K,Engeman TM,Koga S,Vapnek EM,Hobart MG,Fairchild RL

更新日期：2000-03-27 00:00:00

abstract：BACKGROUND:Urolithiasis occurs in approximately 6% of adult kidney transplant (KTx) recipients. Limited data are available on urolithiasis after pediatric KTx. We report the incidence, management of, and risk factors for stone development in children after KTx. METHODS:We reviewed the medical records of 399 children w...

journal_title：Transplantation

authors： Khositseth S,Gillingham KJ,Cook ME,Chavers BM

更新日期：2004-11-15 00:00:00

abstract：BACKGROUND:The role of CD20+ B cells in renal allograft rejection has been reappreciated. Importantly, recent studies suggest a relation between CD20+ B cell aggregates and poorer clinical outcome. In the present study, we attempted to confirm these early reports in a tightly controlled patient population and to differ...

journal_title：Transplantation

authors： Scheepstra C,Bemelman FJ,van der Loos C,Rowshani AT,van Donselaar-Van der Pant KA,Idu MM,ten Berge IJ,Florquin S

更新日期：2008-09-27 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is the most common primary malignant liver tumor. Currently, liver transplantation may be the optimal treatment for HCC in cirrhotic patients. Patient selection is currently based on tumor size. We developed a program to offer liver transplantation to selected patients with HCC...

journal_title：Transplantation

authors： Victor DW 3rd,Monsour HP Jr,Boktour M,Lunsford K,Balogh J,Graviss EA,Nguyen DT,McFadden R,Divatia MK,Heyne K,Ankoma-Sey V,Egwim C,Galati J,Duchini A,Saharia A,Mobley C,Gaber AO,Ghobrial RM

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:We sought to compare the immunoreactive potential of human cord blood (CB) versus normal adult bone marrow (BM) versus mobilized blood (peripheral blood stem cells; PBSC) from cancer patients. METHODS:Forty mice were randomized to receive a range of doses of T cell-replete cell preparations from one of the ...

journal_title：Transplantation

authors： Leung W,Ramírez M,Mukherjee G,Perlman EJ,Civin CI

更新日期：1999-09-15 00:00:00

abstract：OBJECTIVES:To determine whether humoral autoimmune responses associated with dilated cardiomyopathy (DCM) influence the postoperative clinical course following cardiac transplantation. METHODS:ELISA levels of preformed cardiac myosin (CM) autoantibodies (Abs) in patients with a pretransplant diagnosis of dilated cardi...

journal_title：Transplantation

authors： Warraich RS,Pomerance A,Stanley A,Banner NR,Dunn MJ,Yacoub MH

更新日期：2000-04-27 00:00:00

abstract：:Although liver transplantation (LT) is the best treatment for patients with localized hepatocellular carcinoma (HCC), recurrence occurs in 6%-18% of patients. Several factors, particularly morphological criteria combined with dynamic parameters, known before LT modify this risk and combined in prediction models may be...

journal_title：Transplantation

authors： Berenguer M,Burra P,Ghobrial M,Hibi T,Metselaar H,Sapisochin G,Bhoori S,Kwan Man N,Mas V,Ohira M,Sangro B,van der Laan LJW

更新日期：2020-06-01 00:00:00

abstract：:Spleen cells obtained from C57BL/Ks (Ks, H-2d) mice carrying passively enhanced Sarcoma I (Sa I, H-2a) tumors were tested for alloantibody formation, lymphocyte blastogenesis, antibody-dependent cellular cytotoxicity, and cell to cell cytotoxicity. Assays were usually performed approximately 6 weeks after tumor inocul...

journal_title：Transplantation

authors： Giorgi JV,Tokuda S,Goldberg EH,Shen FW

更新日期：1978-03-01 00:00:00

abstract：BACKGROUND:Carbon monoxide (CO) inhalation protects organ by reducing inflammation and cell death during transplantation processes in animal model. However, using CO in clinical transplantation is difficult due to its delivery in a controlled manner. A manganese-containing CO releasing molecules (CORM)-401 has recently...

journal_title：Transplantation

authors： Bhattacharjee RN,Richard-Mohamed M,Sun Q,Haig A,Aboalsamh G,Barrett P,Mayer R,Alhasan I,Pineda-Solis K,Jiang L,Alharbi H,Saha M,Patterson E,Sener A,Cepinskas G,Jevnikar AM,Luke PPW

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Human cytomegalovirus (CMV) uses different strategies to escape from human host defense reactions. Previously we have observed that infection of endothelial cells with CMV in vitro leads to enhanced activity of endothelial ectonucleotidases. These ectoenzymes are responsible for hydrolysis of extracellular a...

journal_title：Transplantation

authors： Zandberg M,van Son WJ,Harmsen MC,Bakker WW

更新日期：2007-11-27 00:00:00

abstract：BACKGROUND:Cyclosporine A (CsA)-induced chronic nephrotoxicity is characterized by renal dysfunction and interstitial fibrosis. Early and progressive renal macrophage influx, correlating with latter interstitial fibrotic areas, has been associated with CsA treatment. This study investigated the role of macrophages, the...

journal_title：Transplantation

authors： Carlos CP,Mendes GE,Miquelin AR,Luz MA,da Silva CG,van Rooijen N,Coimbra TM,Burdmann EA

更新日期：2010-06-15 00:00:00

abstract：BACKGROUND:The aim was to compare efficacy of multiple daily injections (MDI), continuous subcutaneous insulin infusion (CSII) and islet transplantation to reduce hypoglycemia and glycemic variability in type 1 diabetes subjects with severe hypoglycemia. METHODS:This was a within-subject, paired comparison of MDI and ...

journal_title：Transplantation

authors： Holmes-Walker DJ,Gunton JE,Hawthorne W,Payk M,Anderson P,Donath S,Loudovaris T,Ward GM,Kay TW,OʼConnell PJ

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Hypoalbuminemia is associated with poorer outcomes in renal transplantation. Diabetes can compound hypoalbuminemia's detrimental effects. Kidney-pancreas transplantation alters the diabetic milieu; yet, some patients continue to be hypoalbuminemic. METHODS:We retrospectively analyzed 232 patients who underw...

journal_title：Transplantation

authors： Becker BN,Becker YT,Heisey DM,Leverson GE,Collins BH,Odorico JS,D'Alessandro AM,Knechtle SJ,Pirsch JD,Sollinger HW

更新日期：1999-07-15 00:00:00

abstract：BACKGROUND:Detection of markers predicting allograft rejection is important for risk assessment before kidney transplantation, as well as to minimize posttransplantation immunosuppression. METHODS:We studied the expression of CD25, HLA-DR, CD134, CD62L, and CD44 by flow cytometry in CD4, CD8, and CD3 cells, from pretr...

journal_title：Transplantation

authors： Hueso M,Mestre M,Benavente Y,Bas J,Grinyó JM,Navarro E

更新日期：2011-09-15 00:00:00

abstract：:Diarrhea is a frequent but overlooked complication of kidney transplantation. Diarrhea is repeatedly neglected, often considered by patients and clinicians an unavoidable side effect of immunosuppressive regimens. It is, however, associated with a significant impairment in life quality. Severe and chronic posttranspla...

journal_title：Transplantation

authors： Aulagnon F,Scemla A,DeWolf S,Legendre C,Zuber J

更新日期：2014-10-27 00:00:00