Abstract:
BACKGROUND:Bone marrow stromal cells (BMSC) transplantation offers promise in the treatment of chronic paraplegia in rodents. Here, we report the effect of this cell therapy in adult pigs suffering chronic paraplegia. METHODS:Three months after spinal cord injury, autologous BMSC in autologous plasma was injected into lesion zone and adjacent subarachnoid space in seven paraplegic pigs. On the contrary, three paraplegic pigs only received autologous plasma. Functional outcome was measured weekly until the end of the follow-up, 3 months later. RESULTS:Our present study showed progressive functional recovery in transplanted pigs. At this time, intramedullary posttraumatic cavities were filled by a neoformed tissue containing several axons, together with BMSC that expressed neuronal or glial markers. Furthermore, in the treated animals, electrophysiological studies showed recovery of the previously abolished somatosensory-evoked potentials. CONCLUSIONS:These findings confirm previous observations in rodents and support the possible utility of BMSC transplantation in humans suffering chronic paraplegia.
journal_name
Transplantationjournal_title
Transplantationauthors
Zurita M,Vaquero J,Bonilla C,Santos M,De Haro J,Oya S,Aguayo Cdoi
10.1097/TP.0b013e318186198fsubject
Has Abstractpub_date
2008-09-27 00:00:00pages
845-53issue
6eissn
0041-1337issn
1534-6080pii
00007890-200809270-00015journal_volume
86pub_type
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