Early induction of immune resistance against leukemia in mice after lethal irradiation followed by syngeneic bone marrow transplantation and injection of syngeneic leukocytes.

abstract：:The development of erythrocytosis following renal transplantation has been reported to be caused by a number of factors. These include acute and chronic rejection, hydronephrosis and renal artery stenosis. In this study, seven patients were noted to have erythrocytosis with hematocrits ranging between 53.5 and 66%. Se...

journal_title：Transplantation

authors： Dagher FJ,Ramos E,Erslev AJ,Alongi SV,Karmi SA,Caro J

更新日期：1979-12-01 00:00:00

abstract：:Diarrhea is a frequent but overlooked complication of kidney transplantation. Diarrhea is repeatedly neglected, often considered by patients and clinicians an unavoidable side effect of immunosuppressive regimens. It is, however, associated with a significant impairment in life quality. Severe and chronic posttranspla...

journal_title：Transplantation

authors： Aulagnon F,Scemla A,DeWolf S,Legendre C,Zuber J

更新日期：2014-10-27 00:00:00

abstract：:Arterial ketone body ratio (AKBR [acetoacetate/beta-hydroxybutyrate]) was measured in nineteen patients under medical supportive therapy for fulminant hepatic failure (FHF), in order to evaluate its predictive value relative to liver transplantation. Of the 19 patients 8 (42%) were salvaged and 11 (58%) died. Seven of...

journal_title：Transplantation

authors： Saibara T,Onishi S,Sone J,Yamamoto N,Shimahara Y,Mori K,Ozawa K,Yamamoto Y

更新日期：1991-04-01 00:00:00

abstract：:The response to IL-2 and IL-4 of several functionally defined lymphoid cell types was assessed at the individual responding cell level in limiting dilution experiments in which exogenous IL-2 or IL-4 was used to promote cellular activation and expansion. Splenic precursors that give rise to alloreactive CTL in LDA sup...

journal_title：Transplantation

authors： Widmer MB,Voice RF,Conlon PJ,Grabstein KH

更新日期：1990-04-01 00:00:00

abstract：BACKGROUND:The long-term outcome of lung transplantation is impeded by the development of obliterative bronchiolitis (OB). We sought to investigate the relationship between the apoptosis of tracheal epithelial cells and bone marrow-derived myofibroblasts in the process of OB. METHODS:The mouse orthotopic tracheal tran...

journal_title：Transplantation

authors： Wang C,Xia T,Jiang K,Qiao X,Zhang X,Li J,Wang J,Nie J

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:In 2006, Northwestern Medicine implemented a culturally targeted and linguistically congruent Hispanic Kidney Transplant Program (HKTP). The HKTP has been associated with a reduction in Hispanic/Latino disparities in live donor kidney transplantation. This paper assessed the financial feasibility of implemen...

journal_title：Transplantation

authors： Wang A,Caicedo JC,McNatt G,Abecassis M,Gordon EJ

更新日期：2020-04-09 00:00:00

abstract：:: Hepatitis C virus (HCV) infection is common in solid organ allograft recipients and is a significant cause of morbidity and mortality after transplantation, so effective management will improve outcomes. In this review, we discuss the extent of the problem associated with HCV infection in donors and kidney, heart, a...

journal_title：Transplantation

authors： Carbone M,Mutimer D,Neuberger J

更新日期：2013-03-27 00:00:00

abstract：BACKGROUND:Humanized Fc receptor (FcR)-nonbinding antibodies against CD3 are promising immunosuppressive agents that may overcome both the neutralizing response to and the cytokine release syndrome seen with conventional monoclonal antibodies against CD3. In addition, evidence from several murine models suggests that t...

journal_title：Transplantation

authors： Chau LA,Tso JY,Melrose J,Madrenas J

更新日期：2001-04-15 00:00:00

abstract：BACKGROUND:Pancreas transplantation (PTX) improves lipids in patients with type 1 diabetes mellitus. However, there are patients who have persistent abnormal lipids or develop new hyperlipidemia despite PTX. One factor that may influence the lipid profile is apolipoprotein E (Apo E) genotype. Apo E polymorphism, partic...

journal_title：Transplantation

authors： Balakrishnan S,Colling C,Burkman T,Erickson J,Lyden E,Maheshwari H,Mack-Shipman L,Lane J,Larsen J

更新日期：2002-10-15 00:00:00

abstract：:Cyclosporine, but not its nonimmunosuppressive analog cyclosporine H (CsH), caused in a variety of hematopoietic cell types a growth arrest in the G0/G1 phase of the cell cycle. This arrest was associated with a significant reduction in the c-myc mRNA levels, which could be observed already 1 hr following CsA treatmen...

journal_title：Transplantation

authors： Yonish-Rouach E,Kimchi A,Rubinstein M

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND:Transplant vasculopathy in kidney and heart allografts is associated with marked elevation of endothelin-1 (ET-1), but a role for ET-1 in the pathogenesis of transplant vasculopathy and chronic rejection has not been established. We, therefore, tested whether inhibition of ET-1-converting enzyme by phosphora...

journal_title：Transplantation

authors： Simonson MS,Herman WH,Robinson A,Schulak J,Hricik DE

更新日期：1999-06-27 00:00:00

abstract：:SLT presents an interesting concept to alleviate the organ shortage for children with end-stage liver disease. The procedure has, however, not gained wide acceptance. This is not only related to the complexity of the procedure, but also to the poorer results and the complications reported on the right side graft. We r...

journal_title：Transplantation

authors： Rogiers X,Malago M,Habib N,Knoefel WT,Pothmann W,Burdelski M,Meyer-Moldenhauer WH,Broelsch CE

更新日期：1995-04-27 00:00:00

abstract：:Natural anti-carbohydrate antibodies are central to hyperacute rejection in ABO-incompatible allotransplantation and in discordant xenotransplantation. ABO-incompatible rejection has been inhibited successfully using intravenous soluble carbohydrates as antibody inhibitors. The approach has been less successful previo...

journal_title：Transplantation

authors： Cairns T,Lee J,Goldberg L,Cook T,Simpson P,Spackman D,Palmer A,Taube D

更新日期：1995-12-15 00:00:00

abstract：:Erythropoietin (EPO) is widely used among patients with end-stage renal disease awaiting transplantation. Data suggest that EPO therapy may be immunomodulatory. The purpose of this study was to assess the effects of pretransplant EPO therapy on renal allograft outcome. We evaluated 120 consecutive renal transplant rec...

journal_title：Transplantation

authors： Vasquez EM,Pollak R

更新日期：1996-10-15 00:00:00

abstract：BACKGROUND:Human T-cell lymphotropic virus type I (HTLV-I) causes a subacute myelopathy in less than 5% of chronic carriers. However, the risk of neurologic disease appears to increase in persons infected through blood transfusion. METHODS:We report three recipients of solid organ transplants who developed a subacute ...

journal_title：Transplantation

authors： Toro C,Rodés B,Poveda E,Soriano V

更新日期：2003-01-15 00:00:00

abstract：:OKT3 is considered to be effective in the prophylaxis and treatment of rejection. However, anti-OKT3 immunization is still a major side-effect. Only the IgG antiidiotypic component of the response is responsible for neutralization of OKT3 therapeutic activity by inhibiting OKT3's binding to T cells (i.e., blocking ant...

journal_title：Transplantation

authors： Legendre C,Kreis H,Bach JF,Chatenoud L

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Conversion from tacrolimus to cyclosporin has not previously been reported as routine clinical practice, but only as indicated by rejection or adverse effects. METHODS:The safety and metabolic outcome of elective conversion from tacrolimus to cyclosporin was examined in 19 recipients of cadaver renal transp...

journal_title：Transplantation

authors： Higgins RM,Hart P,Lam FT,Kashi H

更新日期：2000-07-15 00:00:00

abstract：:Three groups of patients were reviewed. Primary carcinomas were found in donors kidneys of 47 recipients. In 30 instances a tumor was present at harvesting. When a neoplasm was removed immediately pretransplantation or early posttransplantation there were no recurrences in 14 recipients. In another two instances, a tu...

journal_title：Transplantation

authors： Penn I

更新日期：1995-02-27 00:00:00

abstract：:Interferon gamma and tumor necrosis factor alpha play a significant role in the upregulation of host immunity and inflammation, for example by induction and enhancement of the expression of major histocompatibility complex class I and II antigens on a wide variety of cell types, both in vitro and in vivo. In this stud...

journal_title：Transplantation

authors： Stevens HP,van der Kwast TH,van der Meide PH,Vuzevski VD,Buurman WA,Jonker M

更新日期：1990-11-01 00:00:00

abstract：:Alloreactive T cells are often specific for individual peptides that are bound to allogeneic major histocompatibility complex (MHC) molecules. Other alloreactive T cells are reported to be peptide-independent or to recognize MHC conformational changes that are induced by multiple peptides. We tested 12 anti-HLA-B7 all...

journal_title：Transplantation

authors： Smith KD,Huczko E,Engelhard VH,Li YY,Lutz CT

更新日期：1997-07-27 00:00:00

abstract：:Humoral or antibody-mediated rejection in cardiac transplant recipients is mediated by donor-specific cytotoxic antibodies and is histologically defined by linear deposits of immunoglobulin and complement in the myocardial capillaries. Antibody-mediated rejection often is accompanied by hemodynamic compromise and is a...

journal_title：Transplantation

authors： Aranda JM Jr,Scornik JC,Normann SJ,Lottenberg R,Schofield RS,Pauly DF,Miles M,Hill JA,Sleasman JW,Skoda-Smith S

更新日期：2002-03-27 00:00:00

abstract：BACKGROUND:The objectives of this study are to investigate the impact of cytomegalovirus (CMV) donor (D)/recipient (R) serostatus on kidney transplant outcomes in recipients who received CMV prophylaxis and to investigate the association of individual antiviral agents (acyclovir, ganciclovir, and valganciclovir) with o...

journal_title：Transplantation

authors： Kuo HT,Ye X,Sampaio MS,Reddy P,Bunnapradist S

更新日期：2010-11-27 00:00:00

abstract：BACKGROUND:Pharmacokinetic modeling supports trough monitoring of everolimus, but prospective data comparing this approach versus mycophenolate mofetil (MMF) in de novo cardiac transplant recipients are currently unavailable. METHODS:In a 12-month multicenter open-label study, cardiac transplant patients received ever...

journal_title：Transplantation

authors： Lehmkuhl HB,Arizon J,Viganò M,Almenar L,Gerosa G,Maccherini M,Varnous S,Musumeci F,Hexham JM,Mange KC,Livi U,2411 Study Investigators.

更新日期：2009-07-15 00:00:00

abstract：:The effects of FK506 on exocrine function of the pancreas in Sprague-Dawley rats were examined and compared with those of cyclosporine. FK506 did not affect the levels of amylase and lipase in the pancreas of rats given the drug orally in a daily dose of 1 or 5 mg/kg for 2 weeks. Furthermore, the pancreas of the rats ...

journal_title：Transplantation

authors： Hirano Y,Hisatomi A,Ohara K,Noguchi H

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Both chemokines and adhesion molecules mediate allograft rejection by recruiting leukocytes into the allograft. We investigated the association of six single nucleotide polymorphisms (SNPs) located in interleukin (IL)-8, CXCR1, CXCR2, and selectin with kidney allograft outcomes. METHODS:The promoter regions...

journal_title：Transplantation

authors： Ro H,Hwang YH,Kim H,Jeong JC,Lee H,Doh YS,Park HC,Oh KH,Park MH,Ha J,Yang J,Ahn C

更新日期：2011-01-15 00:00:00

abstract：INTRODUCTION:Cytomegalovirus infection after heart transplantation is considered as risk factor for the development of transplant arteriosclerosis. Therefore, the aim of this study was to investigate the effect of murine cytomegalovirus (MCMV) as a single risk factor on transplant arteriosclerosis in an experimental ao...

journal_title：Transplantation

authors： Heim C,Abele-Ohl S,Eckl S,Ramsperger-Gleixner M,Mahmoudian S,Weyand M,Stamminger T,Ensminger SM

更新日期：2010-08-27 00:00:00

abstract：BACKGROUND:We have previously shown successful engraftment of allogeneic hematopoietic stem cells (HSCs) when transplanted across the major histocompatibility antigen barriers if transplanted along with a preparation of facilitator cells (osteoblasts). We have investigated whether or not fully allogeneic HSCs from heal...

journal_title：Transplantation

authors： El-Badri NS,Wang BY,Steele A,Cherry,Marikar Y,Mizobe K,Good RA

更新日期：2000-09-27 00:00:00

abstract：BACKGROUND:We report long-term outcomes and side effects after transplantation for hepatocellular carcinoma (HCC) using de novo, sirolimus-based immunosuppression (IS). METHODS:A total of 70 patients with HCC (mean age: 54.4+/-7 years, female/male: 12/58) were transplanted and included in the study. Immunosuppression ...

journal_title：Transplantation

authors： Toso C,Meeberg GA,Bigam DL,Oberholzer J,Shapiro AM,Gutfreund K,Ma MM,Mason AL,Wong WW,Bain VG,Kneteman NM

更新日期：2007-05-15 00:00:00

abstract：:The aim of this study was to investigate the combined effect of DLA matching and immunosuppressive therapy on the survival of segmental small-bowel allografts in dogs. Orthotopic segmental small-bowel transplantations (25 to 30% of total small bowel length) were performed in two stages: first a heterotopic segmental s...

journal_title：Transplantation

authors： Meijssen MA,Heineman E,de Bruin RW,Wolvekamp MC,Marquet RL,Molenaar JC

更新日期：1993-11-01 00:00:00

abstract：:Cytomegalovirus (CMV) is a major pathogen in transplant recipients and AIDS patients, and the virus may also play a role in allograft rejection. Previous work from this laboratory demonstrated increased cell surface expression of the adhesion molecules ICAM-1 (CD54) and LFA-3 (CD58) following CMV infection in vitro. W...

journal_title：Transplantation

authors： Craigen JL,Grundy JE

更新日期：1996-10-27 00:00:00