Rapid development of subacute myelopathy in three organ transplant recipients after transmission of human T-cell lymphotropic virus type I from a single donor.

Abstract:

BACKGROUND:Human T-cell lymphotropic virus type I (HTLV-I) causes a subacute myelopathy in less than 5% of chronic carriers. However, the risk of neurologic disease appears to increase in persons infected through blood transfusion. METHODS:We report three recipients of solid organ transplants who developed a subacute myelopathy within 2 years after becoming infected with HTLV-I from a single asymptomatic HTLV-I donor. Genetic studies were performed in and sequences in proviral DNA, and HTLV-I proviral load was measured by real-time quantitative polymerase chain reaction. RESULTS:HTLV-I sequences were obtained in two of these individuals, and they were almost identical and clustered within the Cosmopolitan A HTLV-I subtype, which indicates a common source. All typical changes in Tax amino acid sequence of the HTLV-I Cosmopolitan A were identified, plus two additional changes were noted. Although A has been associated with a greater risk of neurologic disease, both patients were positive for human leukocyte antigen-A*02, which is considered a protective factor. CONCLUSION:Rapid development of subacute myelopathy may occur in recipients of organ transplants from asymptomatic HTLV-I donors. A particular virulence of the virus strain, the large size of the virus inoculum, and the immunosuppressed condition after transplantation may have contributed to produce this unusual rapid development of HTLV-I associated myelopathy.

journal_name

Transplantation

journal_title

Transplantation

authors

Toro C,Rodés B,Poveda E,Soriano V

doi

10.1097/00007890-200301150-00019

subject

Has Abstract

pub_date

2003-01-15 00:00:00

pages

102-4

issue

1

eissn

0041-1337

issn

1534-6080

journal_volume

75

pub_type

评论,杂志文章
  • Biochemical characterization of human vascular endothelial cell-monocyte antigens defined by monoclonal antibodies.

    abstract::Although the clinical relevance of endothelial cell-monocyte (E-M) antigens has been demonstrated in organ graft transplantation, very limited data exist describing the nature of these antigens. The current study presents biochemical characterization of three different surface antigens of endothelial cells and monocyt...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198804000-00024

    authors: Wood NL,Schook LB,Studer EJ,Mohanakumar T

    更新日期:1988-04-01 00:00:00

  • Preservation of Microvascular Integrity in Murine Orthotopic Tracheal Allografts by Clopidogrel.

    abstract:BACKGROUND:Survival after lung transplantation is mainly limited by the development of chronic lung allograft dysfunction (CLAD). The aim of this study was to investigate if platelet inhibition by clopidogrel has a functionally relevant influence on the microvascular integrity of orthotopic tracheal allografts as an an...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000002571

    authors: Heim C,Khan MA,von Silva-Tarouca B,Kuckhahn A,Stamminger T,Ramsperger-Gleixner M,Nicolls MR,Weyand M,Ensminger SM

    更新日期:2019-05-01 00:00:00

  • Population pharmacokinetics of tacrolimus in children who receive cut-down or full liver transplants.

    abstract:BACKGROUND:The aim of this study was to investigate the population pharmacokinetics of tacrolimus in pediatric liver transplant recipients and to identify factors that may explain pharmacokinetic variability. METHODS:Data were collected retrospectively from 35 children who received oral immunosuppressant therapy with ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200109270-00013

    authors: Staatz CE,Taylor PJ,Lynch SV,Willis C,Charles BG,Tett SE

    更新日期:2001-09-27 00:00:00

  • A method for early detection of graft failure in pancreas transplantation.

    abstract::Pancreatic transplantation is intended to normalize carbohydrate metabolism in insulin-dependent diabetics by restoring endogenous insulin release, and it is usually performed together with kidney transplantation in patients with end-stage renal failure. A major problem in these patients is the daily control of the gr...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198304000-00016

    authors: Secchi A,Pontiroli AE,Traeger J,Dubernard JM,Touraine JL,Ruitton A,Blanc N,Pozza G

    更新日期:1983-04-01 00:00:00

  • Risk factors for liver transplantation across the ABO barrier.

    abstract::A retrospective study was performed to identify risk factors affecting the fate of liver allografts transplanted across the ABO barrier. Over a 5-year period, 30 patients received 31 emergency OLTs with ABO-incompatible allografts. One-year graft and patient survival rates were 37.1% and 48.4%, respectively. This grou...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199409150-00003

    authors: Lo CM,Shaked A,Busuttil RW

    更新日期:1994-09-15 00:00:00

  • Variations of the lymphocytotoxicity test. An evaluation of sensitivity and specificity.

    abstract::Multiple variations of the basic lymphocytotoxicity test have been reported to increase test sensitivity. Although these modifications are used routinely in crossmatch tests, as required by federal regulation, there has been no methodical assessment of the relative sensitivities and specificities of these techniques w...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199509000-00016

    authors: Zachary AA,Klingman L,Thorne N,Smerglia AR,Teresi GA

    更新日期:1995-09-15 00:00:00

  • Transfer of tolerance to collagen type V suppresses T-helper-cell-17 lymphocyte-mediated acute lung transplant rejection.

    abstract:BACKGROUND:Rat lung allograft rejection is mediated by collagen type V (col(V)) specific T-helper-cell 17 (Th17) cells. Adoptive transfer of these cells is sufficient to induce rejection pathology in isografts, whereas tolerance to col(V) suppresses allograft rejection. Therefore, we tested whether regulatory T cells f...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3181bcde7b

    authors: Braun RK,Molitor-Dart M,Wigfield C,Xiang Z,Fain SB,Jankowska-Gan E,Seroogy CM,Burlingham WJ,Wilkes DS,Brand DD,Torrealba J,Love RB

    更新日期:2009-12-27 00:00:00

  • ICAM-1 induction on hepatocytes as a marker for immune activation of acute liver allograft rejection.

    abstract::Intercellular adhesion molecule-1 (ICAM-1) induction on hepatocytes was investigated in relation to acute liver allograft rejection, CMV infection, and systemic bacterial infections. Twenty-four liver transplant recipients underwent an episode of acute rejection, 13 developed a symptomatic clinical CMV infection, and ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199312000-00041

    authors: Lautenschlager IT,Höckerstedt KA

    更新日期:1993-12-01 00:00:00

  • Allograft rejection in athymic nude rats by transferred T cell subsets. II. The response of naive CD4+ and CD8+ thoracic duct lymphocytes to an isolated MHC class I disparity.

    abstract::Athymic PVG-rnu/rnu (RT1c) rats were grafted with skin bearing isolated MHC disparities 7-14 days in advance of cell transfer. The ability of naive CD4+ or CD8+ thoracic duct lymphocytes to induce rejection was assessed by adoptive transfer of one or both T cell subsets into nude recipients bearing congenic PVG.r1 (MH...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: Bell EB,Rejali D,Whitby EH,Sparshott SM,Yang CP

    更新日期:1990-10-01 00:00:00

  • Isoenzyme characterization in isolated elevation of alkaline phosphatase after liver transplantation in children.

    abstract:BACKGROUND:Isolated transient elevation of alkaline phosphatase (ALP) in the absence of bone or liver disease has been reported in children including liver transplant patients. Specific isoenzyme patterns have been associated with this phenomenon in healthy children but have not been reported after liver transplantatio...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200210150-00023

    authors: O'Riordan S,Baker AJ,Sherwood RA

    更新日期:2002-10-15 00:00:00

  • A randomized long-term trial of tacrolimus/sirolimus versus tacrolimus/mycophenolate mofetil versus cyclosporine (NEORAL)/sirolimus in renal transplantation. II. Survival, function, and protocol compliance at 1 year.

    abstract:BACKGROUND:In an attempt to reduce chronic calcineurin inhibitor induced allograft nephropathy in first cadaver and human leukocyte antigen non-identical living-donor renal transplantation, sirolimus (Siro) or mycophenolate mofetil (MMF) was tested as adjunctive therapy, with planned dose reductions of tacrolimus (Tacr...

    journal_title:Transplantation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/01.TP.0000101495.22734.07

    authors: Ciancio G,Burke GW,Gaynor JJ,Mattiazzi A,Roth D,Kupin W,Nicolas M,Ruiz P,Rosen A,Miller J

    更新日期:2004-01-27 00:00:00

  • Diabetes and hepatic oxidative damage are associated with hepatitis C progression after liver transplantation.

    abstract:BACKGROUND:Posttransplant diabetes mellitus (PTDM) is common after liver transplantation and was recently identified as a risk factor for hepatitis C progression. Increased levels of oxidative stress have been identified in diabetes and hepatitis C. The aim of this study was to evaluate the relationship among PTDM, oxi...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000279003.40279.0e

    authors: Cotler SJ,Kallwitz E,TenCate V,Bhushan A,Berkes J,Benedetti E,Layden-Almer J,Layden TJ,Valyi-Nagy T,Guzman G

    更新日期:2007-09-15 00:00:00

  • Metabolic syndrome and atherosclerotic events in renal transplant recipients.

    abstract:BACKGROUND:Metabolic syndrome (MS) is a known cardiovascular risk factor in the general population. We explored the influence of MS on the occurrence of atherosclerotic events (AEs) after renal transplantation. METHODS:Three hundred thirty-seven renal transplant recipients were included in the study. Various parameter...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000266898.93894.3d

    authors: Courivaud C,Kazory A,Simula-Faivre D,Chalopin JM,Ducloux D

    更新日期:2007-06-27 00:00:00

  • Marrow transplant studies in dogs with malignant lymphoma.

    abstract::Ninety-five dogs with spontaneous malignant lymphoma in chemotherapy-induced remission were treated with total-body irradiation (TBI) and bone marrow transplantation. Among 38 dogs treated with 8.4 Gy delivered at 4 cGy/min, 9 (24%) became long-term disease-free survivors. Ten of the 38 (26%) died of transplant-relate...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198505000-00008

    authors: Appelbaum FR,Deeg HJ,Storb R,Self S,Graham TC,Sale GE,Weiden PL

    更新日期:1985-05-01 00:00:00

  • Antileukocyte antibody in postpartum and renal transplant subjects. A comparison of capillary agglutination and lymphocytotoxicity reactions.

    abstract::Sera were obtained from 48 gravida II prenatal and 211 multiparous nonpregnant females and examined for leukocyte antibodies comparing a standard lymphocytotoxicity (CY) test with capillary agglutination (CA). Antibody was detected in 41% of the samples in both groups but only CA tests were positive with approximately...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-197602000-00001

    authors: Thompson JS,Jackson D,Greazel NA,Parmely MJ,Severson CD

    更新日期:1976-02-01 00:00:00

  • Gastrointestinal Endoscopy Is Safe in Patients Before and After Lung or Heart Transplantation.

    abstract:BACKGROUND:Gastrointestinal complications are common in patients after lung and heart transplantation. Endoscopy is a standard method for the assessment of gastrointestinal morbidities. The aim of this study was to analyze the number and type of complications during endoscopic procedures in patients before and after lu...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000000517

    authors: Lenzen H,Cieplik N,Elkharsawi AR,Negm AA,Avsar M,Bara CL,Gottlieb J,Manns MP,Lankisch TO

    更新日期:2015-07-01 00:00:00

  • Factors influencing the patterns of T lymphocyte allorecognition.

    abstract:BACKGROUND:Strong alloreactive T cell responses are a menace in transplantation surgery and their menagement requires understanding the basis of alloreactivity. Alloantigen recognition can be peptide independent, peptide specific, or peptide dependent. The mechanisms influencing each recognition pattern are largely unk...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200203150-00024

    authors: Nesić D,Marić M,Santori FR,Vukmanović S

    更新日期:2002-03-15 00:00:00

  • Fine specificity and idiotype diversity of the murine anti-HLA-A2, A28 monoclonal antibodies CR11-351 and KS1.

    abstract::The monoclonal antibodies (MoAb) CR11-351 and KS1 are secreted by hybridomas generated with splenocytes from BALB/c mice immunized with the cultured human B lymphoid cells LG-2 (HLA-A2,A2,B27,B27). The 2 monoclonal antibodies immunoprecipitated components with a superimposable 2-dimensional gel electrophoretic profile...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198803000-00026

    authors: Tsujisaki M,Sakaguchi K,Igarashi M,Richiardi P,Perosa F,Ferrone S

    更新日期:1988-03-01 00:00:00

  • Effect of poverty and other socioeconomic variables on renal allograft survival.

    abstract:BACKGROUND:Socioeconomic variables including low income and noncompliance impact negatively upon long-term renal allograft survival, especially in African Americans. We sought to determine whether other socioeconomic variables contributed to noncompliance and allograft survival. METHODS:A detailed history of socioecon...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200107270-00017

    authors: Butkus DE,Dottes AL,Meydrech EF,Barber WH

    更新日期:2001-07-27 00:00:00

  • Five-year follow-up of two siblings with aspartylglucosaminuria undergoing allogeneic stem-cell transplantation from unrelated donors.

    abstract:BACKGROUND:Aspartylglucosaminuria is a rare, inherited lysosomal disease characterized by a slowly progressive mental retardation and coarse facial and body features. With the intent to provide the deficient enzyme aspartylglucosaminidase, allogeneic stem-cell transplantation (ASCT) has been attempted. Only a few cases...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200408150-00015

    authors: Malm G,Månsson JE,Winiarski J,Mosskin M,Ringdén O

    更新日期:2004-08-15 00:00:00

  • Immunosenescence does not abrogate engraftment of murine allogeneic bone marrow.

    abstract:BACKGROUND:Allogeneic bone marrow transplantation is under investigation for a range of nonmalignant indications, including tolerance induction through mixed chimerism. This strategy has so far been tested experimentally only in young recipients. Due to immunosenescence, older patients have an increase in memory T cell...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3182954618

    authors: Hock K,Oberhuber R,Lee YL,Wrba F,Wekerle T,Tullius SG

    更新日期:2013-06-27 00:00:00

  • Cardiac allograft vasculopathy: central role of endothelial injury leading to transplant "atheroma".

    abstract::Endothelial injury plays a central role in the pathophysiologic mechanisms underlying cardiac allograft vasculopathy (CAV). Although the accelerated course of CAV and its localization to the allograft support an important role for the alloimmune response, there is considerable evidence implicating lipoprotein abnormal...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/01.TP.0000080981.90718.EB

    authors: Valantine HA

    更新日期:2003-09-27 00:00:00

  • Improving the prediction of donor kidney quality: deceased donor score and resistive indices.

    abstract:BACKGROUND:The deceased donor score (DDS), expanded criteria donor (ECD) definition, and resistive index (RI) were developed for pretransplant evaluation of donors. DDS and ECD are determined by a calculation of risk from donor variables, while RI is determined from flow characteristics of kidneys during machine preser...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000173798.04043.af

    authors: Nyberg SL,Baskin-Bey ES,Kremers W,Prieto M,Henry ML,Stegall MD

    更新日期:2005-10-15 00:00:00

  • Immunosuppression of the elderly kidney transplant recipient.

    abstract::The growing number of elderly patients with end-stage kidney disease awaiting transplantation has resulted in a corresponding rise in the number of elderly transplant recipients. In this paper, we review existing literature on age-related changes, transplant outcomes, and complications in the elderly in an attempt to ...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/01.tp.0000275423.69689.dc

    authors: Danovitch GM,Gill J,Bunnapradist S

    更新日期:2007-08-15 00:00:00

  • Predominant role of the Fab fragment in delaying hyperacute rejection in guinea pig-to-rat xenotransplantation.

    abstract:BACKGROUND:Human intravenous immunoglobulin G delayed xenogeneic hyperacute rejection (HAR) in the guinea pig-to-rat combination. We investigated the respective roles of the Fc and Fab fragments of the IgG molecule in this inhibitory effect. METHODS:By using a guinea pig-to-rat heart transplantation model, the efficie...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199808150-00018

    authors: Urbani L,Fabre M,Cardoso J,Lambin P,Devillier P,Soubrane O,Houssin D,Gautreau C

    更新日期:1998-08-15 00:00:00

  • Associations of characteristics of renal transplant recipients with clinicians' perceptions of adherence to immunosuppressant therapy.

    abstract:BACKGROUND:The objective of the study was to determine surveillance criteria for renal transplant recipients (RTRs) at highest risk for immunosuppressant therapy nonadherence. METHODS:Retrospective analyses were performed on follow-up data in the United States Renal Data System. Those who received transplants between ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000287189.33074.c8

    authors: Chisholm MA,Kwong WJ,Spivey CA

    更新日期:2007-11-15 00:00:00

  • Treatment of graft-versus-host disease by extracorporeal photochemotherapy: a pilot study.

    abstract:BACKGROUND:Graft-versus-host disease (GVHD) is a major complication after bone marrow transplantation, which may be refractory to immunosuppressive drugs. As preliminary case reports suggested that extracorporeal photochemotherapy (ECP) using a Therakos device might be beneficial, we conducted a pilot study to assess t...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199707150-00010

    authors: Besnier DP,Chabannes D,Mahé B,Mussini JM,Baranger TA,Muller JY,Milpied N,Esnault VL

    更新日期:1997-07-15 00:00:00

  • CMV-specific Cell-mediated Immunity at 3-month Prophylaxis Withdrawal Discriminates D+/R+ Kidney Transplants at Risk of Late-onset CMV Infection Regardless the Type of Induction Therapy.

    abstract:BACKGROUND:Whether cytomegalovirus (CMV)-specific cell-mediated immunity (CMI) at prophylaxis cessation predicts D+/R+ kidney transplants at risk of late-onset CMV infection after receiving distinct induction therapies is still not well characterized. METHODS:We prospectively assessed CMV-specific CMI predicting late-...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000002421

    authors: Jarque M,Melilli E,Crespo E,Manonelles A,Montero N,Torras J,Cruzado JM,Luque S,Gil-Vernet S,Grinyó JM,Bestard O

    更新日期:2018-11-01 00:00:00

  • Prope tolerance: the future of organ transplantation--from the laboratory to the clinic.

    abstract::This is a short review of tolerance from the point of view of the clinician. Various examples of tolerance occurring in patients and animal models that relate to the clinical experience are described. There may be different mechanisms by which tolerance is achieved, but from the patient's point of view operational tol...

    journal_title:Transplantation

    pub_type: 历史文章,杂志文章

    doi:10.1097/01.tp.0000117776.14277.03

    authors: Calne RY

    更新日期:2004-03-27 00:00:00

  • Human allogeneic vascular rejection after arterial transplantation and peripheral lymphoid reconstitution in severe combined immunodeficient mice.

    abstract:BACKGROUND:Interspecies differences create important shortcomings in existing animal models used to describe in vivo events responsible for allograft rejection. Alloimmune destruction of human dermal microvessels, histologically consistent with rejection, has been demonstrated in human skin-grafted severe combined immu...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199903270-00018

    authors: Lorber MI,Wilson JH,Robert ME,Schechner JS,Kirkiles N,Qian HY,Askenase PW,Tellides G,Pober JS

    更新日期:1999-03-27 00:00:00